Gene: EYS

346007
C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1
eyes shut homolog (Drosophila)
protein-coding
6q12
Ensembl:ENSG00000188107 MIM:612424 Vega:OTTHUMG00000014971 UniprotKB:Q5T1H1
NG_023443.2
PubMed|SNP Mapped
6   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.923e-2 (AD)  4.564e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6911837chr6:64787060 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs3003672chr6:64121227 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6921058chr6:63814258 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs756274chr6:63795320 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs319920chr6:63794359 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs319924chr6:63777354 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RFX70.575
CCSER10.571
CNTNAP50.568
NYAP20.56
SYT160.559
SHPRH0.555
CHD90.555
KLF120.552
KCNH70.548
ZNF910.546

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.295
IL25-0.271
ABHD1-0.264
IZUMO4-0.257
PLA2G5-0.245
FXYD3-0.242
C22orf31-0.242
FAM181A-0.235
OR4F5-0.228
ROM1-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001151ArsenicArsenic affects the methylation of EYS gene25304211
D001280AtrazineAtrazine results in increased expression of EYS mRNA22378314
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EYS mRNA"25102311
D010100OxygenOxygen deficiency results in decreased expression of EYS mRNA26516004
C046012pentanalpentanal results in decreased expression of EYS mRNA26079696
D011137PolystyrenesPolystyrenes results in decreased expression of EYS mRNA25102311
C005556propionaldehydepropionaldehyde results in decreased expression of EYS mRNA26079696

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0043403skeletal muscle tissue regeneration-IMP21826682  
GO:0050908detection of light stimulus involved in visual perception-IMP18836446  18976725  20696082  22363543  
GO ID GO Term Qualifier Evidence PubMed
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24961364Common PTP4A1-PHF3-EYS variants are specific for alcohol dependence. (2014 Jul-Aug)Zuo LAm J Addict
24479813ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma. (2014 Jan 31)Eckel-Passow JEBMC Urol
23324950Association of rare PTP4A1-PHF3-EYS variants with alcohol dependence. (2013 Mar)Zuo LJ Hum Genet