Gene: APOD

347
-
apolipoprotein D
protein-coding
3q29
Ensembl:ENSG00000189058 MIM:107740 Vega:OTTHUMG00000155854 UniprotKB:P05090
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.193e-1 (AD)  9.533e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDND10.83
MXI10.828
FBXO70.821
PTMA0.813
ADIPOR20.811
RTKN0.807
RBPJ0.798
RPS60.798
FNTA0.796
GLTP0.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.663
OR4F5-0.654
NPBWR1-0.333
CNGB1-0.332
CHRNA2-0.328
GPR26-0.306
FREM3-0.305
HS6ST3-0.299
EPHA6-0.297
SSTR4-0.297

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00162Vitamin ASmall Molecule68-26-8Approved|NutraceuticalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C05440011-(dansylamino)undecanoic acid11-(dansylamino)undecanoic acid binds to APOD protein16461020
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of APOD mRNA"26377693
C0271321-anilino-8-naphthalenesulfonate1-anilino-8-naphthalenesulfonate binds to APOD protein16461020
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of APOD mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of APOD mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of APOD mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of APOD mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of APOD mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of APOD mRNA"25510870
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone affects the expression of APOD mRNA"20206263
C0259463-methyladenine3-methyladenine affects the localization of APOD protein28182653
C4861844,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of APOD mRNA"26921789
C0275764-hydroxy-2-nonenalAPOD protein results in decreased abundance of 4-hydroxy-2-nonenal28182653
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of APOD mRNA15982314
C016601afimoxifeneafimoxifene results in increased expression of APOD mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of APOD gene27153756
C000188alachloralachlor affects the expression of APOD mRNA19425180
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of APOD mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APOD mRNA16483693
D001280AtrazineAtrazine results in increased expression of APOD mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of APOD mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APOD mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of APOD mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APOD mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APOD mRNA22300585
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of APOD mRNA19619570
D004958EstradiolEstradiol results in decreased expression of APOD mRNA16514628|2692178
D004958EstradiolEstradiol results in increased expression of APOD mRNA19619570
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of APOD mRNA17404688
C095105bexarotenebexarotene results in increased expression of APOD mRNA17849452
C006780bisphenol Abisphenol A results in decreased expression of APOD mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of APOD mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of APOD mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of APOD promoter22457795
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of APOD mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of APOD mRNA18804290
D002738ChloroquineChloroquine affects the localization of APOD protein28182653
D003024ClozapineClozapine results in increased expression of APOD mRNA11158250|1464739
D003024ClozapineClozapine results in increased expression of APOD protein11158250
D003300CopperAPOD protein binds to Copper23896426
D003375CoumestrolCoumestrol results in decreased expression of APOD mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of APOD mRNA26577399|2752363
C014347decitabine[decitabine co-treated with trichostatin A] affects the expression of APOD mRNA16865689
D003703DemecolcineDemecolcine results in increased expression of APOD mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of APOD mRNA28628672
C492519diarylpropionitrilediarylpropionitrile results in decreased expression of APOD mRNA26921789
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of APOD mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of APOD mRNA27392435
D002945CisplatinCisplatin results in increased expression of APOD mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of APOD mRNA25016146
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of APOD mRNA"22485181
D004237DiuronDiuron results in decreased expression of APOD mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of APOD mRNA21040762
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of APOD mRNA21040762
D005419FlavonoidsFlavonoids results in decreased expression of APOD mRNA18035473
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of APOD mRNA20713471
D005480FlurbiprofenFlurbiprofen results in increased expression of APOD mRNA16949054
D005557FormaldehydeFormaldehyde results in increased expression of APOD mRNA23649840
C070081fulvestrantfulvestrant results in increased expression of APOD mRNA16514628
C039281furanfuran results in increased methylation of APOD gene22079235
D019833GenisteinGenistein results in increased expression of APOD mRNA20884965
D006220HaloperidolHaloperidol results in increased expression of APOD mRNA14647396
D017313FenretinideFenretinide results in increased expression of APOD mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of APOD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of APOD mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of APOD mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of APOD mRNA27392435
D008062LipofuscinAPOD protein results in decreased abundance of Lipofuscin28182653
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of APOD mRNA20843944
D008694MethamphetamineMethamphetamine results in decreased expression of APOD mRNA28619521
D008727MethotrexateMethotrexate affects the expression of APOD mRNA18502557
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of APOD mRNA20713471
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of APOD mRNA18804290
C008493methylselenic acidmethylselenic acid affects the expression of APOD mRNA14617803
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of APOD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of APOD mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of APOD mRNA18978301
D009532NickelAPOD protein binds to Nickel23896426
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of APOD mRNA17616710
D010100OxygenAPOD protein results in decreased susceptibility to Oxygen deficiency18458334
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of APOD mRNA18636392
D017239PaclitaxelPaclitaxel results in increased expression of APOD mRNA19682730
D010269ParaquatAPOD protein results in decreased susceptibility to Paraquat18458334|2168832
D010269ParaquatParaquat results in increased expression of APOD mRNA21688324
D010269ParaquatParaquat results in increased expression of APOD protein21688324
D010269ParaquatParaquat results in increased uptake of and affects the localization of APOD protein28182653
D010269Paraquatpyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD mRNA]21688324
D010269Paraquatpyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD protein]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of ALOX15 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of AQR mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of EPX mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of GAB1 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of GPX2 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of IDH1 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of LPO mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of NOS2 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of NOX4 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of NOXO1 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in decreased expression of PTGS1 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of DUOX1 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of GDNF mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of GFAP protein]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of GPX3 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of IL19 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of MPP4 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of PTGS2 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of SOD2 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of SOD3 mRNA]21688324
D010269ParaquatAPOD protein affects the reaction [Paraquat results in increased expression of SRXN1 mRNA]21688324
D010269ParaquatAPOD protein affects the susceptibility to Paraquat21688324
D010269ParaquatAPOD protein inhibits the reaction [Paraquat results in decreased activity of CTSB protein]28182653
D010269ParaquatAPOD protein results in decreased susceptibility to Paraquat18419796
D010269ParaquatParaquat affects the reaction [APOD protein affects the expression of ALOX15 mRNA]21688324
D010269ParaquatParaquat affects the reaction [APOD protein affects the expression of HMOX1 protein]21688324
D010269ParaquatParaquat affects the reaction [APOD protein affects the expression of SOD2 protein]21688324
D010269Paraquat[Paraquat co-treated with APOD gene mutant form] results in increased expression of NOS2 mRNA21688324
D010269ParaquatParaquat results in increased expression of APOD mRNA18419796
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of APOD mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of APOD mRNA18804290
D010622PhencyclidinePhencyclidine results in increased expression of APOD mRNA17266109
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of APOD mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of APOD mRNA17404688|2086464
C005556propionaldehydepropionaldehyde results in increased expression of APOD mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of APOD mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD mRNA]21688324
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Paraquat results in increased expression of APOD protein]21688324
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of APOD mRNA16514628
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of APOD mRNA25895662
D020123SirolimusSirolimus affects the localization of APOD protein28182653
D053260SootSoot results in increased expression of APOD mRNA26551751
D013739TestosteroneTestosterone results in decreased expression of APOD mRNA19693291
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of APOD mRNA25172293
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of APOD mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APOD mRNA19619570
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of APOD mRNA19969065
D014212TretinoinAPOD protein binds to Tretinoin28182653
D014212TretinoinTretinoin results in increased expression of APOD mRNA15982314
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the expression of APOD mRNA16865689
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of APOD mRNA19042947
C057693troglitazonetroglitazone results in increased expression of APOD mRNA28973697
D014635Valproic AcidValproic Acid results in increased methylation of APOD gene29154799
D014635Valproic AcidValproic Acid results in increased expression of APOD mRNA23665938
D014750VincristineVincristine results in increased expression of APOD mRNA23649840
C017963vinyl carbamatevinyl carbamate results in decreased expression of APOD mRNA17849452
D014801Vitamin AVitamin A binds to APOD protein16461020
C016837zinc chloridezinc chloride results in decreased expression of APOD mRNA19683351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005319lipid transporter activity-NAS3453108  
GO:0005515protein binding-IPI7918467  25416956  25910212  
GO:0015485cholesterol binding-IBA21873635  
GO:0015485cholesterol binding-IDA9278274  
GO ID GO Term Qualifier Evidence PubMed
GO:0000302response to reactive oxygen species-IBA21873635  
GO:0000302response to reactive oxygen species-IDA18419796  
GO:0001525angiogenesis-NAS21705670  
GO:0006006glucose metabolic process-IDA19176353  
GO:0006629lipid metabolic process-IBA21873635  
GO:0006629lipid metabolic process-IDA19176353  
GO:0006869lipid transport-IEA-  
GO:0007420brain development-ISS-  
GO:0007568aging-NAS20023409  
GO:0010642negative regulation of platelet-derived growth factor receptor signaling pathway-IDA14551159  
GO:0014012peripheral nervous system axon regeneration-ISS-  
GO:0042246tissue regeneration-ISS-  
GO:0042308negative regulation of protein import into nucleus-IDA14551159  
GO:0042493response to drug-ISS-  
GO:0048662negative regulation of smooth muscle cell proliferation-IDA14551159  
GO:0048678response to axon injury-ISS-  
GO:0051895negative regulation of focal adhesion assembly-IMP21705670  
GO:0060588negative regulation of lipoprotein lipid oxidation-IDA18419796  
GO:0071638negative regulation of monocyte chemotactic protein-1 production-IDA18842892  
GO:1900016negative regulation of cytokine production involved in inflammatory response-IDA18842892  
GO:2000098negative regulation of smooth muscle cell-matrix adhesion-IMP21705670  
GO:2000405negative regulation of T cell migration-IDA18842892  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-NAS14718574  
GO:0005615extracellular space-HDA16502470  20551380  
GO:0005615extracellular space-IDA21705670  
GO:0005737cytoplasm-IBA21873635  
GO:0005783endoplasmic reticulum-ISS-  
GO:0022626cytosolic ribosome-ISS-  
GO:0030425dendrite-ISS-  
GO:0043025neuronal cell body-ISS-  
GO:0048471perinuclear region of cytoplasm-IDA14551159  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425397Transport of vitamins, nucleosides, and related moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-804914Transport of fatty acidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28031419Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study. (2017 Mar)Brahimaj ADiabetes Care