Gene: LRRTM1

347730
-
leucine rich repeat transmembrane neuronal 1
protein-coding
2p12
Ensembl:ENSG00000162951 MIM:610867 Vega:OTTHUMG00000130021 UniprotKB:Q86UE6
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.118e-1 (AD)  6.391e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPHD20.915
WSCD20.907
GRIN2B0.906
LRTM20.905
TTC90.902
ABLIM20.902
DPP60.901
C2CD2L0.901
CCNA10.9
CAMKV0.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.593
YES1-0.572
REST-0.556
COPZ2-0.551
SEPT10-0.55
WWTR1-0.544
GNG11-0.54
CSAG1-0.534
HEY2-0.534
SNHG18-0.53

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of LRRTM1 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRTM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRTM1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRTM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRTM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRTM1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRTM1 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of LRRTM1 mRNA28959563
C015001arsenitearsenite results in increased methylation of LRRTM1 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of LRRTM1 mRNA22323515
C487081belinostatbelinostat results in increased expression of LRRTM1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRTM1 mRNA"27188386
D002220CarbamazepineCarbamazepine affects the expression of LRRTM1 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LRRTM1 gene20938992
D004041Dietary FatsDietary Fats results in increased expression of LRRTM1 mRNA25016146
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LRRTM1 gene20938992
D007052IbuprofenIbuprofen results in increased expression of LRRTM1 mRNA28201806
D007213IndomethacinIndomethacin results in increased expression of LRRTM1 mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of LRRTM1 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of LRRTM1 mRNA]26733615
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of LRRTM1 mRNA]26733615
D008627Mercuric ChlorideMercuric Chloride affects the expression of LRRTM1 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LRRTM1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LRRTM1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of LRRTM1 mRNA"20188158
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of LRRTM1 mRNA]26733615
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRTM1 mRNA"27188386
C496932panobinostatpanobinostat affects the expression of LRRTM1 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of LRRTM1 mRNA]26733615
D011374ProgesteroneProgesterone results in decreased expression of LRRTM1 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in decreased expression of LRRTM1 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LRRTM1 mRNA16443690
D014212TretinoinTretinoin results in decreased expression of LRRTM1 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of LRRTM1 mRNA24935251|2627250
D014635Valproic AcidValproic Acid affects the expression of LRRTM1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LRRTM1 mRNA24383497
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRTM1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of LRRTM1 mRNA27188386
C111237vorinostatvorinostat results in increased expression of LRRTM1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002091negative regulation of receptor internalization-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0008150biological_process-ND-  
GO:0035418protein localization to synapse-IEA-  
GO:0035640exploration behavior-IEA-  
GO:0050808synapse organization-IEA-  
GO:0051965positive regulation of synapse assembly-IEA-  
GO:0060291long-term synaptic potentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA17667961  
GO:0009986cell surfaceNOTIDA17667961  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030424axon-IDA17667961  
GO:0030426growth cone-IDA17667961  
GO:0045211postsynaptic membrane-IEA-  
GO:0060076excitatory synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28814981CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)Morandi LClin Epigenetics