Gene: LRRTM3

347731
-
leucine rich repeat transmembrane neuronal 3
protein-coding
10q21.3
Ensembl:ENSG00000198739 MIM:610869 Vega:OTTHUMG00000018332 UniprotKB:Q86VH5
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.034e-1 (AD)  3.411e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2394340chr10:67101514 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NBEA0.947
OLFM30.945
SCN2A0.944
KCND20.944
SCAI0.943
FGF140.943
LRRC4C0.942
SLC8A10.942
SLC4A100.941
PLCL20.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.589
RAB13-0.576
ROM1-0.559
FLT3LG-0.554
EMP3-0.552
AGTRAP-0.552
HEY2-0.55
RNF135-0.55
TGIF1-0.545
CHST14-0.542

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LRRTM3 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LRRTM3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LRRTM3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LRRTM3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LRRTM3 mRNA"25510870
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LRRTM3 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LRRTM3 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of LRRTM3 mRNA24465770
C006780bisphenol Abisphenol A results in decreased expression of LRRTM3 mRNA25181051|2717856
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of LRRTM3 mRNA28962523
D004026DieldrinDieldrin results in increased expression of LRRTM3 mRNA20438755
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of LRRTM3 mRNA"25510870
D010634PhenobarbitalPhenobarbital results in decreased expression of LRRTM3 mRNA19084549
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LRRTM3 mRNA25895662
D014403TubocurarineTubocurarine results in decreased expression of LRRTM3 mRNA19728367
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LRRTM3 gene25560391
C025643vinclozolinvinclozolin affects the expression of LRRTM3 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0051965positive regulation of synapse assembly-IEA-  
GO:1902004positive regulation of amyloid-beta formation-IMP17098871  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal