Gene: SERINC2

347735
FKSG84|PRO0899|TDE2|TDE2L
serine incorporator 2
protein-coding
1p35.2
Ensembl:ENSG00000168528 MIM:614549 Vega:OTTHUMG00000003796 UniprotKB:Q96SA4
NC_000001.11
PubMed|SNP Mapped
4   ANCO-SNPs
AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.576e-5 (AD)  3.383e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2275435chr1:31425689 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4949402chr1:31425387 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4478858chr1:31411078 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1039630chr1:31408625 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18280758chr1:31885025SERINC2Promoter2.356e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TREM10.734
ADAMTSL40.726
MYO1G0.723
PLP20.705
BCL2A10.703
GBP20.702
S100A100.698
PLAUR0.696
MAP3K80.69
PYGL0.687

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIT-0.503
WNT7A-0.468
MARCH4-0.452
LRRC38-0.449
NEUROD6-0.445
HAPLN1-0.443
SLC32A1-0.432
ZNF385D-0.427
FRMPD1-0.426
KCNQ4-0.425

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SERINC2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SERINC2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SERINC2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SERINC2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SERINC2 mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SERINC2 mRNA"28973690
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SERINC2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SERINC2 mRNA23630614
D001280AtrazineAtrazine results in increased expression of SERINC2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of SERINC2 mRNA22378314
D001379AzathioprineAzathioprine results in increased expression of SERINC2 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SERINC2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SERINC2 promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SERINC2 mRNA"20382639
D001622BetaineBetaine results in decreased expression of SERINC2 mRNA26391144
C006780bisphenol Abisphenol A affects the expression of SERINC2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased methylation of SERINC2 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of SERINC2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SERINC2 mRNA28628672
C100187chloropicrinchloropicrin results in decreased expression of SERINC2 mRNA26352163|2847649
D002994ClofibrateClofibrate results in increased expression of SERINC2 mRNA23811191|2527062
D019327Copper SulfateCopper Sulfate results in increased expression of SERINC2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of SERINC2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of SERINC2 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SERINC2 mRNA23640034
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SERINC2 mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SERINC2 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SERINC2 mRNA27392435
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SERINC2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of SERINC2 mRNA]19850644
D002117CalcitriolCalcitriol results in increased expression of SERINC2 mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SERINC2 mRNA21592394
D004237DiuronDiuron results in increased expression of SERINC2 mRNA25152437
D005485FlutamideFlutamide results in increased expression of SERINC2 mRNA24793618
C039281furanfuran results in increased expression of SERINC2 mRNA27387713
C071834glycidamideglycidamide results in increased expression of SERINC2 mRNA17822822
D017313FenretinideFenretinide results in increased expression of SERINC2 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of SERINC2 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SERINC2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SERINC2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SERINC2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of SERINC2 mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SERINC2 mRNA21641980
C568376MT19c compoundMT19c compound results in decreased expression of SERINC2 mRNA21781307
C500085muraglitazarmuraglitazar results in decreased expression of SERINC2 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SERINC2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SERINC2 mRNA"25554681
D009966OrphenadrineOrphenadrine affects the expression of SERINC2 mRNA23665939
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SERINC2 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of SERINC2 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of SERINC2 mRNA23091169
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of SERINC2 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of SERINC2 mRNA18301758|2081375
C045950propiconazolepropiconazole results in decreased expression of SERINC2 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of SERINC2 mRNA24780913
D011794QuercetinQuercetin results in increased expression of SERINC2 mRNA21632981
C089730rosiglitazonerosiglitazone results in increased expression of SERINC2 mRNA25572481
C089730rosiglitazonerosiglitazone results in decreased expression of SERINC2 mRNA21515302
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SERINC2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SERINC2 mRNA25895662
D012999SomanSoman results in increased expression of SERINC2 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SERINC2 mRNA21641980
C501413tesaglitazartesaglitazar results in decreased expression of SERINC2 mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SERINC2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SERINC2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SERINC2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERINC2 mRNA26377647|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERINC2 mRNA22298810
D013849ThimerosalThimerosal results in decreased expression of SERINC2 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of SERINC2 mRNA23411599
D014212TretinoinTretinoin results in decreased expression of SERINC2 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of SERINC2 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased expression of SERINC2 mRNA25549359
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SERINC2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SERINC2 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of SERINC2 mRNA21515302
D014635Valproic AcidValproic Acid affects the expression of SERINC2 mRNA17292431|1796380
D014635Valproic AcidValproic Acid results in increased expression of SERINC2 mRNA19136453|2142705
D014640VancomycinVancomycin results in decreased expression of SERINC2 mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006658phosphatidylserine metabolic process-IEA-  
GO:0006665sphingolipid metabolic process-IEA-  
GO:0015825L-serine transport-IEA-  
GO:1904219positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity-IEA-  
GO:1904222positive regulation of serine C-palmitoyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70614Amino acid synthesis and interconversion (transamination)TAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-977347Serine biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23778322Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. (2013 Aug)Zuo LPharmacogenet Genomics
25278008Genome-wide association discoveries of alcohol dependence. (2014 Nov-Dec)Zuo LAm J Addict
26173551A New Genomewide Association Meta-Analysis of Alcohol Dependence. (2015 Aug)Zuo LAlcohol Clin Exp Res
23455491NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. (2013 May 1)Zuo LDrug Alcohol Depend