Gene: IGF1

3479
IGF-I|IGFI|MGF
insulin like growth factor 1
protein-coding
12q23.2
Ensembl:ENSG00000017427 MIM:147440 Vega:OTTHUMG00000149910 UniprotKB:P05019
NG_011713.1
PubMed|SNP Mapped
OD|ND|AD
28   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.440e-1 (AD)  5.445e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10778176chr12:102469201 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs5742629chr12:102463485 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAPLN10.878
PTHLH0.858
KIT0.851
ZNF385D0.844
ADAMTS50.831
VIP0.831
DLX10.823
VWC20.819
MYO5B0.807
PRLHR0.799

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLIN2-0.545
KIF19-0.541
ROM1-0.54
HEBP2-0.529
ATOH8-0.526
AGTRAP-0.517
TGFB3-0.509
TGIF1-0.503
UHRF1-0.501
PLEKHF1-0.499

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01890N,N-Bis(3-(D-gluconamido)propyl)deoxycholamideSmall Molecule86303-23-3ExperimentalTarget
DB02643N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0782191,2,3,4,7,8-hexachlorodibenzodioxin"1,2,3,4,7,8-hexachlorodibenzodioxin results in decreased expression of IGF1 protein"15703265
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of IGF1 mRNA"16269432
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of IGF1 mRNA"17690111
C0114391,2-diacylglycerol"Cycloheximide inhibits the reaction [IGF1 protein affects the metabolism of 1,2-diacylglycerol]"2120207
C0114391,2-diacylglycerol"IGF1 protein affects the metabolism of 1,2-diacylglycerol"2120207
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog results in decreased expression of IGF1 mRNA"24273086
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in decreased expression of IGF1 mRNA"24273086|2689491
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in decreased expression of IGF1 mRNA"26894911
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]"17458902
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]"17458902
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]"17458902
D0140131,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]"17458902
C0700461,2-dioleoyloxy-3-(trimethylammonium)propane"[1,2-dioleoyloxy-3-(trimethylammonium)propane co-treated with Cholesterol] results in increased expression of IGF1 protein"16034455
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of IGF1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of IGF1 mRNA"18281256
C0415071-methylphenanthrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGF1 mRNA17690111
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [[IL6 protein co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein]"23318440
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of IGF1 mRNA19933214
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of IGF1 mRNA"19101654
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of IGF1 protein"19101654
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of IGF1 protein"19327374
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IGF1 mRNA"21190954
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IGF1 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IGF1 protein"19464578
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]17458902
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]17458902
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK1 protein]]20064577
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK3 protein]]20064577
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]15297429
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]15297429
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the activity of IGF1 protein11548882
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of IGF1 mRNA"11509743
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of IGF1 mRNA"10965916
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of IGF1 mRNA"11509743
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of IGF1 mRNA]"19414516
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of IGF1 mRNA"25710175
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of IGF1 protein"19327374
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IGF1 mRNA"21190954
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of IGF1 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ascorbate-2-phosphate results in increased secretion of IGF1 protein]19416266
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein affects the localization of ESR1 protein]15947004
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]]20064577
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium]20064577
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]16465378
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]16682453
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]12569580
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]16682453
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]12569580
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]15297429
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]15297429
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of IGFBP3 protein]16682453
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]16682453
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of ascorbate-2-phosphate results in increased expression of IGF1 mRNA19416266
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]19657059
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]26254549
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]25597859
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]19105244
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]18388193
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]18388193
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]18388193
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased expression of IGF1 protein18775495
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene results in increased expression of IGF1 mRNA"26251320
C5250632'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone"2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]"25643584
C5250632'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone"2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]"25643584
C5250632'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone"2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]"25643584
C5250632'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone"2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]"25643584
C0179112-(methylamino)isobutyric acidIGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid1928324
C0179112-(methylamino)isobutyric acidoxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]1928324
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [IGF1 protein results in increased activity of ATM protein]20053781
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of GSK3B protein]20053781
C0299552-nitrotoluene2-nitrotoluene results in increased expression of IGF1 mRNA16460773
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IGF1 mRNA"28973690
C0230353,4,5,3',4'-pentachlorobiphenyl"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of IGF1 protein"19327374
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IGF1 mRNA"19692669|2319667
C0414773-hydroxyflavone3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]17458902
C0414773-hydroxyflavone3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]17458902
C0414773-hydroxyflavone3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]17458902
C0414773-hydroxyflavone3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]17458902
C0259463-methyladenine3-methyladenine inhibits the reaction [Azathioprine results in decreased activity of IGF1 protein]23958494
C0259463-methyladenine3-methyladenine results in increased activity of IGF1 protein23958494
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of IGF1 mRNA19191707
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of IGF1 mRNA15982314
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of IGF1 mRNA17011747
C4800266-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 protein]20889569
D000082AcetaminophenAcetaminophen results in decreased expression of IGF1 mRNA26497421|2776149
D000082AcetaminophenAcetaminophen results in increased expression of IGF1 mRNA17585979
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of IGF1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IGF1 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IGF1 protein]26138014
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]17458902
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]17458902
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]17458902
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]17458902
D020106AcrylamideAcrylamide results in increased expression of IGF1 mRNA15749267
C016601afimoxifeneafimoxifene results in increased expression of IGF1 mRNA10965916
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IGF1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IGF1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of IGF1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IGF1 mRNA19770486
C031143AICA ribonucleotideAICA ribonucleotide affects the reaction [IGF1 protein results in increased expression of STAR protein]17478073
C031143AICA ribonucleotideAICA ribonucleotide affects the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]17478073
C031143AICA ribonucleotideAICA ribonucleotide affects the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]17478073
C031143AICA ribonucleotideAICA ribonucleotide affects the reaction [IGF1 protein results in increased secretion of Progesterone]17478073
C031143AICA ribonucleotidePRKAA2 protein promotes the reaction [AICA ribonucleotide affects the reaction [IGF1 protein results in increased expression of STAR protein]]17478073
C031143AICA ribonucleotidePRKAA2 protein promotes the reaction [AICA ribonucleotide affects the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]]17478073
C031143AICA ribonucleotidePRKAA2 protein promotes the reaction [AICA ribonucleotide affects the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]]17478073
C031143AICA ribonucleotidePRKAA2 protein promotes the reaction [AICA ribonucleotide affects the reaction [IGF1 protein results in increased secretion of Progesterone]]17478073
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK1 protein]16020477
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased phosphorylation of MAPK3 protein]16020477
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]16020477
C103303alitretinoinalitretinoin results in decreased expression of IGF1 protein15994153
C103303alitretinoinalitretinoin results in increased expression of IGF1 mRNA15982314
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of IGF1 mRNA28522335
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [GH1 protein results in increased expression of IGF1 mRNA]"22067323
D013196Dihydrotestosteronebicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1 mRNA]16368782
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of IGF1 mRNA16368782
D013196DihydrotestosteroneDihydrotestosterone results in increased secretion of IGF1 protein16368782
D013196DihydrotestosteroneFlutamide inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1 mRNA]16368782
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of IGF1 mRNA17023530
D013196DihydrotestosteroneDihydrotestosterone results in increased secretion of IGF1 protein25667201
D013196Dihydrotestosteroneresveratrol inhibits the reaction [Dihydrotestosterone results in increased secretion of IGF1 protein]25667201
D000535AluminumAluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
C010845aluminum chloridealuminum chloride results in increased expression of IGF1 protein15202764
C010845aluminum chloridealuminum chloride results in decreased expression of IGF1 mRNA27470910
C010845aluminum chlorideginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of IGF1 mRNA]27470910
C010845aluminum chlorideIGF1 protein promotes the reaction aluminum chloride7806584
D000537Aluminum OxideAluminum Oxide affects the expression of IGF1 mRNA19464052
C041524aluminum sulfatealuminum sulfate results in increased secretion of IGF1 protein7685579
D000596Amino AcidsAmino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1 mRNA]25309793
D000596Amino AcidsH 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1 mRNA]]25309793
D000638AmiodaroneAmiodarone affects the expression of IGF1 mRNA19483382
D017311AmlodipineAmlodipine inhibits the reaction [IGF1 protein results in increased expression of AKT1 protein modified form]20530298
D000641AmmoniaAmmonia results in decreased expression of IGF1 mRNA22446827
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of IGF1 mRNA22750116
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IGF1 mRNA16483693
C078814anandamideanandamide results in increased expression of IGF1 protein17307377
D000735AndrostenedioneFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Androstenedione]]22872763
D000735AndrostenedioneFGF9 protein inhibits the reaction [[LHB protein co-treated with IGF1 protein] results in increased abundance of Androstenedione]22872763
D000735AndrostenedioneIGF1 protein promotes the reaction [Bucladesine results in increased abundance of Androstenedione]22872763
D000735AndrostenedioneIGF1 protein promotes the reaction [Colforsin results in increased abundance of Androstenedione]22872763
D000735AndrostenedioneIGF1 protein results in increased abundance of Androstenedione21315524|2287276
D000735Androstenedione[LHB protein co-treated with IGF1 protein] results in increased abundance of Androstenedione22872763
D000841AnisomycinAnisomycin promotes the reaction [IGF1 protein results in increased phosphorylation of JUN protein]11278392
C032739aroclor 1221aroclor 1221 results in increased expression of IGF1 mRNA21277884
D001151ArsenicArsenic affects the methylation of IGF1 gene25304211
D001151Arsenic[[Arsenic results in decreased expression of IGF1 mRNA] co-treated with [Arsenic affects the localization of and results in increased expression of EZH2 protein]] results in decreased expression of MYOG22426358
D001152ArsenicalsArsenicals results in increased expression of IGF1 mRNA28237603
C006632arsenic trioxidearsenic trioxide inhibits the reaction [IGF1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]23041229
C006632arsenic trioxidearsenic trioxide inhibits the reaction [IGF1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]23041229
C006632arsenic trioxidearsenic trioxide results in decreased expression of IGF1 mRNA20458559
C006632arsenic trioxidearsenic trioxide results in increased expression of IGF1 mRNA18414637|2391187
C006632arsenic trioxideIGF1 mRNA affects the susceptibility to arsenic trioxide23911876
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of IGF1 mRNA15894712
C015001arsenitearsenite results in decreased expression of IGF1 mRNA15894712|1819116
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of IGF1 mRNA"17331233
C011669ascorbate-2-phosphate2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ascorbate-2-phosphate results in increased secretion of IGF1 protein]19416266
C011669ascorbate-2-phosphate2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of ascorbate-2-phosphate results in increased expression of IGF1 mRNA19416266
C011669ascorbate-2-phosphateascorbate-2-phosphate results in increased expression of IGF1 mRNA19416266
C011669ascorbate-2-phosphateascorbate-2-phosphate results in increased expression of IGF1 protein19416266
C011669ascorbate-2-phosphateascorbate-2-phosphate results in increased secretion of IGF1 protein19416266
D001205Ascorbic AcidAscorbic Acid affects the expression of IGF1 mRNA21281732
D016589AstemizoleAstemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]17520698
D001379AzathioprineAzathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]23958494
D001379AzathioprineAzathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of FOXO1 protein]23958494
D001379AzathioprineAzathioprine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]23958494
D001379Azathioprine3-methyladenine inhibits the reaction [Azathioprine results in decreased activity of IGF1 protein]23958494
D001379AzathioprineAzathioprine results in decreased activity of IGF1 protein23958494
D001397Azoxymethane[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IGF1 protein19931517
D001397Azoxymethane[Plant Extracts co-treated with Azoxymethane] results in decreased expression of IGF1 mRNA23996930
D001397Azoxymethane[Plant Extracts co-treated with Azoxymethane] results in decreased expression of IGF1 protein23996930
C006680baicaleinbaicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]17458902
C487081belinostatbelinostat results in increased expression of IGF1 mRNA23671600
D001553BenzbromaroneBenzbromarone affects the expression of IGF1 mRNA19483382
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of IGF1 mRNA17690111
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of IGF1 mRNA16269432
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IGF1 mRNA18164116
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of IGF1 mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGF1 mRNA17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of IGF1 mRNA17690111
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of IGF1 mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of IGF1 mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IGF1 mRNA17879257
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of IGF1 mRNA]15034205
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of IGF1 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of IGF1 mRNA15037607
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IGF1 mRNA15034205|1977048
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IGF1 mRNA15894712|2261060
D001585Benzoyl Peroxide"IGF1 protein results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide]"10365914
D004958EstradiolEstradiol results in decreased expression of IGF1 mRNA20467862
D004958Estradiol[Estradiol co-treated with IGF1 protein] results in increased expression of IHH mRNA22811575
D004958Estradiol[Estradiol co-treated with IGF1 protein] results in increased expression of PTCH1 mRNA22811575
D004958Estradiol[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol21315524
D004958EstradiolIGF1 protein results in increased abundance of Estradiol21239528|2131552
D004958EstradiolRETN protein inhibits the reaction [IGF1 protein results in increased abundance of Estradiol]21315524
D004958EstradiolRETN protein promotes the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol]21315524
D004958EstradiolValproic Acid inhibits the reaction [IGF1 protein results in increased abundance of Estradiol]23152920
D004958EstradiolFSHB protein affects the reaction [IGF1 protein affects the abundance of Estradiol]21885231
D004958EstradiolIGF1 protein affects the abundance of Estradiol21885231
D004958EstradiolIGF1 protein affects the reaction [FSHB protein affects the abundance of Estradiol]21885231
D004958Estradiol"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]"17458902
D004958Estradiol"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]"17458902
D004958Estradiol"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]"17458902
D004958Estradiol"1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]"17458902
D004958Estradiol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]17458902
D004958Estradiol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]17458902
D004958Estradiol3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]17458902
D004958Estradiol3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]17458902
D004958Estradiol3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]17458902
D004958Estradiol3-hydroxyflavone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]17458902
D004958EstradiolAcetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]17458902
D004958EstradiolAcetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]17458902
D004958EstradiolAcetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]17458902
D004958EstradiolAcetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]17458902
D004958EstradiolADIPOQ protein promotes the reaction [IGF1 protein results in increased abundance of Estradiol]19081562
D004958Estradiolbaicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]17458902
D004958EstradiolBucladesine promotes the reaction [IGF1 protein results in increased abundance of Estradiol]22798350
D004958EstradiolColforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]22798350
D004958EstradiolCurcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]17458902
D004958EstradiolEstradiol affects the expression of IGF1 mRNA21826169
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein15809018
D004958EstradiolEstradiol inhibits the reaction [NCOR1 protein binds to IGF1 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [CREBBP protein binds to IGF1 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to IGF1 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [ESR2 protein binds to IGF1 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [NCOA1 protein binds to IGF1 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [NCOA2 protein binds to IGF1 promoter]17872375
D004958EstradiolEstradiol promotes the reaction [NCOA3 protein binds to IGF1 promoter]17872375
D004958EstradiolEstradiol results in decreased expression of IGF1 mRNA17872375
D004958EstradiolEstradiol results in decreased expression of IGF1 protein15855258|1748451
D004958EstradiolEstradiol results in increased expression of and affects the localization of IGF1 protein23094148
D004958EstradiolEstradiol results in increased expression of IGF1 mRNA15762036|1596924
D004958EstradiolEstradiol results in increased expression of IGF1 protein27271280
D004958EstradiolEstradiol results in increased secretion of IGF1 protein15809018
D004958EstradiolFGF9 protein inhibits the reaction [Bucladesine promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]22798350
D004958EstradiolFGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]22798350
D004958EstradiolFGF9 protein inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased abundance of Estradiol]22798350
D004958EstradiolFGF9 protein inhibits the reaction [IGF1 protein results in increased abundance of Estradiol]22798350
D004958Estradiol[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein17458902
D004958Estradiol[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of ESR1 protein17458902
D004958Estradiol[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein17458902
D004958Estradiol[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein17458902
D004958Estradiol[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein17458902
D004958Estradiol[IGF1 protein co-treated with FSHB protein] results in increased abundance of Estradiol22798350
D004958EstradiolIGF1 protein results in increased abundance of Estradiol19081562|2279835
D004958EstradiolMifepristone inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]15809018
D004958EstradiolNAMPT protein promotes the reaction [IGF1 protein results in increased abundance of Estradiol]23315983
D004958Estradiolpyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]17458902
D004958Estradiolpyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]17458902
D004958EstradiolQuercetin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]17458902
D004958EstradiolTamoxifen inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]15809018
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased secretion of IGF1 protein]15809018
D004958Estradiol[Tetrachlorodibenzodioxin co-treated with Estradiol] inhibits the reaction [IGF1 protein results in increased uptake of Thymidine]1332906
D004958Estradiol[Dieldrin co-treated with Estradiol] results in decreased expression of IGF1 mRNA23041725
D004958EstradiolEstradiol results in decreased expression of IGF1 mRNA21276474
D004958EstradiolDronabinol affects the reaction [Estradiol results in increased expression of IGF1 mRNA]8390853
D004958EstradiolESR1 protein mutant form inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]19920132
D004958EstradiolEstradiol affects the reaction [CYP19A1 affects the expression of IGF1 mRNA]11985600
D004958Estradiol"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of IGF1 mRNA"11509743
D004958Estradiol[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of IGF1 mRNA11509743
D004958Estradiol[Estradiol co-treated with Progesterone] promotes the reaction [Cuprizone results in increased expression of IGF1 mRNA]19031445
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to IGF1 promoter]19920132
D004958EstradiolEstradiol promotes the reaction [Progesterone results in increased expression of IGF1 mRNA]8390853
D004958EstradiolEstradiol results in decreased expression of IGF1 mRNA11509743|2246701
D004958EstradiolEstradiol results in increased expression of IGF1 mRNA14664709|1934133
D004958EstradiolProgesterone promotes the reaction [Estradiol results in increased expression of IGF1 mRNA]8390853
D004958EstradiolEstradiol results in decreased expression of IGF1 mRNA21703268
D004958EstradiolEstradiol results in decreased expression of IGF1 mRNA19101654
D004958EstradiolEstradiol results in decreased expression of IGF1 protein19101654
D004958EstradiolBMP15 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]22067323
D004958EstradiolBMP2 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]22067323
D004958EstradiolBMP4 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]22067323
D004958EstradiolBMP6 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]22067323
D004958EstradiolBMP7 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]22067323
D004958EstradiolEstradiol inhibits the reaction [Triiodothyronine results in increased expression of IGF1 mRNA]7684602
D004958EstradiolEstradiol inhibits the reaction [Triiodothyronine results in increased secretion of IGF1 protein]7684602
D004958EstradiolEstradiol results in decreased expression of IGF1 protein11408345
D004958EstradiolEstradiol results in increased expression of IGF1 mRNA15979666|1641417
D004958EstradiolIGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]22067323
D004958EstradiolIGF1 protein results in increased abundance of Estradiol21239528
D004958Estradiolpentabromodiphenyl ether inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]16414171
D004958Estradioldeoxynivalenol affects the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol]17656051
D004958Estradioldeoxynivalenol affects the reaction [IGF1 protein results in increased abundance of Estradiol]17656051
D004958Estradiol[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol17656051
D004958EstradiolIGF1 protein results in increased abundance of Estradiol17656051
D004958EstradiolZearalenone affects the reaction [IGF1 protein results in increased abundance of Estradiol]17656051
D004958EstradiolESR1 protein mutant form results in decreased susceptibility to [IGF1 protein co-treated with Estradiol]19920132
D004958EstradiolIGF1 protein results in increased secretion of Estradiol23548939
D004958EstradiolRETN protein inhibits the reaction [IGF1 protein results in increased secretion of Estradiol]23548939
C095105bexarotenebexarotene results in decreased expression of IGF1 protein15591091
D001629BezafibrateBezafibrate results in decreased expression of IGF1 protein10716467
C053541bicalutamide[bicalutamide co-treated with Tamoxifen] results in decreased expression of IGF1 protein16847815
C053541bicalutamidebicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1 mRNA]16368782
C053541bicalutamidebicalutamide results in increased expression of IGF1 mRNA16368782
C053541bicalutamidebicalutamide results in increased expression of IGF1 protein16847815
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone affects the expression of IGF1 mRNA25470364
C006780bisphenol Abisphenol A results in decreased expression of IGF1 mRNA20467862
C006780bisphenol Abisphenol A results in decreased expression of IGF1 mRNA12927593
C006780bisphenol Abisphenol A affects the expression of IGF1 mRNA21826169
C006780bisphenol Abisphenol A inhibits the reaction [FSHB results in increased expression of IGF1 mRNA]20064783
C006780bisphenol Abisphenol A results in decreased expression of IGF1 mRNA27271280|2768578
C006780bisphenol Abisphenol A results in decreased expression of IGF1 protein27271280
C006780bisphenol Abisphenol A results in increased expression of IGF1 mRNA18007998|2479392
C006780bisphenol AIGF1 protein affects the reaction [bisphenol A results in decreased expression of IGF1 protein]27271280
C006780bisphenol AIGF1 protein affects the reaction [bisphenol A results in decreased expression of NES protein]27271280
C006780bisphenol AIGF1 protein affects the reaction [bisphenol A results in increased expression of AFP mRNA]27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of MSI1 mRNA]27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of NES mRNA]27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of SOX1 mRNA]27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TH mRNA]27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TH protein]27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA]27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of TUBB3 protein]27271280
C006780bisphenol Abisphenol A affects the reaction [CYP19A1 affects the expression of IGF1 mRNA]11985600
C006780bisphenol Abisphenol A results in decreased expression of IGF1 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of IGF1 mRNA10965916|2674610
C006780bisphenol Abisphenol A results in decreased expression of IGF1 mRNA20505776
C006780bisphenol Abisphenol A results in increased expression of IGF1 mRNA27104808
C006780bisphenol Abisphenol A affects the expression of IGF1 mRNA25181051|2710353
C006780bisphenol Abisphenol A results in increased expression of IGF1 mRNA12075121
C006780bisphenol Abisphenol A results in increased expression of IGF1 protein22842222
C006780bisphenol Abisphenol A results in increased methylation of IGF1 gene28505145
D001966BromineBromine results in increased expression of IGF1 mRNA21391292
C032036bromobenzenebromobenzene results in decreased expression of IGF1 mRNA12628495
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGF1 mRNA20147733
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of IGF1 mRNA16460773
D002065BuspironeBuspirone results in decreased expression of IGF1 mRNA24136188
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of IGF1 mRNA26472102
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of IGF1 mRNA22659508
D002104CadmiumCadmium results in decreased expression of IGF1 mRNA15316864
D002104CadmiumCadmium promotes the reaction [IGF1 protein binds to IGF1R protein]9648927
D002104CadmiumCadmium results in decreased expression of IGF1 mRNA22666406
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IGF1 mRNA25456234
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IGF1 protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IGF1 protein26138014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IGF1 mRNA24794047
D002110CaffeineCaffeine results in decreased secretion of IGF1 protein1995187
D002110CaffeineCaffeine results in decreased activity of IGF1 protein24239806
D002110CaffeineCaffeine results in decreased expression of IGF1 mRNA22583948
D002110CaffeineCaffeine results in decreased expression of IGF1 protein22583948
D002118CalciumCobalt inhibits the reaction [IGF1 protein results in increased import of Calcium]1550224|2460452|
D002118CalciumIGF1 protein results in increased import of Calcium1550224|2460452|
D002118Calciumtetramethrin inhibits the reaction [IGF1 protein results in increased import of Calcium]1550224|2460452|
D002118CalciumCalcium affects the expression of IGF1 mRNA15913539
C031293calcium silicate[Zinc binds to calcium silicate] which results in increased expression of IGF1 mRNA23483914
C077793candesartan cilexetilcandesartan cilexetil inhibits the reaction [Isoproterenol results in increased expression of IGF1 mRNA]10547078
C077793candesartan cilexetilcandesartan cilexetil inhibits the reaction [Isoproterenol results in increased expression of IGF1 protein]10547078
D002211Capsaicin[Capsaicin co-treated with Isoflavones] results in increased expression of IGF1 protein19502719
D002211CapsaicinCapsaicin results in increased expression of IGF1 mRNA21310942
D002211CapsaicinCapsaicin results in increased expression of IGF1 protein21310942
D002211CapsaicinTRPV1 affects the reaction [Capsaicin results in increased expression of IGF1 mRNA]21310942
D002211CapsaicinCALCA protein affects the reaction [Capsaicin results in increased expression of IGF1 mRNA]17569567
D002211CapsaicinCALCA protein affects the reaction [Capsaicin results in increased expression of IGF1 protein]17569567
D002211CapsaicinCALCA protein promotes the reaction [Capsaicin results in increased expression of IGF1 mRNA]17360009
D002211CapsaicinCALCA protein promotes the reaction [Capsaicin results in increased expression of IGF1 protein]17360009
D002211CapsaicinCapsaicin results in increased expression of IGF1 mRNA17360009|1756956
D002211CapsaicinCapsaicin results in increased expression of IGF1 protein17307377|1736000
D002211CapsaicinIsoflavones promotes the reaction [Capsaicin results in increased expression of IGF1 protein]17569567
D002211CapsaicinCapsaicin results in increased expression of IGF1 protein17693108
D002211Capsaicincapsazepine inhibits the reaction [Capsaicin results in increased expression of IGF1 protein]17693108
C071423capsazepinecapsazepine inhibits the reaction [Capsaicin results in increased expression of IGF1 protein]17693108
C470213capsiatecapsiate results in increased expression of IGF1 protein17307377
D002220CarbamazepineCarbamazepine results in decreased expression of IGF1 mRNA17381134
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IGF1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IGF1 mRNA16239168
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IGF1 mRNA15070850
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IGF1 protein12800242
D002251Carbon TetrachlorideIGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Copper]15745444
D002251Carbon TetrachlorideIGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Iron]15745444
D002251Carbon TetrachlorideIGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of MPO protein]15745444
D002251Carbon TetrachlorideIGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]15745444
D002251Carbon TetrachlorideIGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TF protein]15745444
D002251Carbon TetrachlorideIL10 protein affects the reaction [Carbon Tetrachloride results in increased expression of IGF1 protein]12800242
D002330CarmustineCarmustine results in decreased expression of IGF1 protein18443378
D002330CarmustineCarmustine results in increased expression of IGF1 protein15286697
D002518CeramidesCeramides promotes the reaction [IGF1 protein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]20696185
D002518CeramidesCeramides promotes the reaction [IGF1 protein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]20696185
D002518CeramidesCeramides promotes the reaction [IGF1 protein results in decreased phosphorylation of and results in increased activity of GSK3B protein]20696185
D002518CeramidesIGF1 protein results in decreased susceptibility to Ceramides20696185
C062876cetrorelixcetrorelix results in decreased expression of IGF1 mRNA21062912
C016299chelerythrinechelerythrine affects the activity of IGF1 protein11548882
D002712ChloridesIGF1 protein affects the transport of [Sodium co-treated with Chlorides]18388193
D002716ChlormequatChlormequat affects the expression of IGF1 protein28214531
D002734Chlorophyll"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in decreased expression of IGF1 mRNA]"22079312
D002737ChloropreneChloroprene results in decreased expression of IGF1 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of IGF1 mRNA20350560
D004390ChlorpyrifosChlorpyrifos affects the expression of IGF1 mRNA18691654
D004390ChlorpyrifosChlorpyrifos results in decreased expression of IGF1 mRNA15178118
D004390ChlorpyrifosChlorpyrifos results in increased expression of IGF1 mRNA15178118
D002784Cholesterol"[1,2-dioleoyloxy-3-(trimethylammonium)propane co-treated with Cholesterol] results in increased expression of IGF1 protein"16034455
D002791Cholesterol, Dietary"Cholesterol, Dietary results in decreased expression of IGF1 protein"18775495
C022990chromic chloridechromic chloride results in increased expression of IGF1 mRNA12153762
C022990chromic chloridechromic chloride promotes the reaction [INS1 protein results in increased expression of IGF1 mRNA]20013160
D002857ChromiumChromium deficiency results in decreased expression of IGF1 protein9868179
C013883chrysarobin"IGF1 protein results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with chrysarobin]"10365914
C043561chrysinchrysin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA]29247772
D002922CiguatoxinsCiguatoxins affects the expression of IGF1 mRNA18353800
C475575Cimicifuga extract BNO 1055Cimicifuga extract BNO 1055 affects the expression of IGF1 mRNA19350480
D002994ClofibrateClofibrate results in decreased expression of IGF1 mRNA16081524
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of IGF1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of IGF1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IGF1 mRNA]17585979
D002994ClofibrateClofibrate affects the expression of IGF1 mRNA19483382
D002994ClofibrateClofibrate results in decreased expression of IGF1 mRNA12851107
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of IGF1 mRNA17602206
D003024ClozapineClozapine results in decreased expression of IGF1 protein11769361
D003035CobaltCobalt inhibits the reaction [IGF1 protein results in increased import of Calcium]1550224|2460452|
C007095cobaltiprotoporphyrin[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in increased expression of IGF1 protein18200630
C018021cobaltous chloride[cobaltous chloride co-treated with IGF1 protein] results in increased secretion of VEGFA protein16499871
C018021cobaltous chlorideIGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]16499871
C018021cobaltous chloride[wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]16499871
C018021cobaltous chloridecobaltous chloride results in increased expression of IGF1 mRNA16990490
C018021cobaltous chloridecobaltous chloride results in increased expression of IGF1 protein16990490
C018021cobaltous chloridecobaltous chloride results in decreased expression of IGF1 mRNA21167956
C018021cobaltous chloridecobaltous chloride results in increased expression of IGF1 mRNA23694759
C026305cobalt sulfatecobalt sulfate results in increased secretion of IGF1 protein25310813
D005576ColforsinIGF1 protein promotes the reaction [Colforsin results in increased abundance of Androstenedione]22872763
D005576ColforsinIGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]22872763
D005576ColforsinColforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]22798350
D005576ColforsinFGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]22798350
D005576ColforsinFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]]22798350
D005576ColforsinIGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]22798350
D003300CopperCopper affects the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D003300CopperCopper deficiency results in decreased activity of IGF1 protein17339407
D003300CopperCopper deficiency results in decreased expression of IGF1 protein15734878
D003300CopperIGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Copper]15745444
D003300CopperCopper results in increased expression of IGF1 mRNA22367704
D019327Copper SulfateCopper Sulfate results in increased secretion of IGF1 protein24521407
D003345CorticosteroneCorticosterone results in decreased expression of IGF1 protein12807724
D003345CorticosteroneCorticosterone results in increased expression of IGF1 mRNA15755911
C013453cresidineIGF1 protein results in increased susceptibility to cresidine19415693
C029892cupric chloridecupric chloride affects the expression of IGF1 mRNA19406218
C029892cupric chloridecupric chloride results in increased expression of IGF1 mRNA17211630
C029892cupric chlorideIGF1 protein binds to cupric chloride22699969
D003471CuprizoneCuprizone results in increased expression of IGF1 mRNA19031445
D003471Cuprizone[Estradiol co-treated with Progesterone] promotes the reaction [Cuprizone results in increased expression of IGF1 mRNA]19031445
D003474CurcuminCurcumin analog results in decreased expression of IGF1 mRNA26409325
D003474CurcuminCurcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]17458902
D003474CurcuminCurcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]17499312
D003474CurcuminCurcumin results in decreased activity of IGF1 protein17499312
D003474CurcuminCurcumin results in decreased secretion of IGF1 protein17499312
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 mRNA]18200517
C109140CVT 313CVT 313 inhibits the reaction [IGF1 protein results in increased phosphorylation of CDK2 protein]21880723
C109140CVT 313CVT 313 inhibits the reaction [IGF1 protein results in increased phosphorylation of RB1 protein]21880723
D003513CycloheximideIGF1 protein inhibits the reaction [Cycloheximide results in decreased expression of CDKN1A protein]26687534
D003513Cycloheximide"Cycloheximide inhibits the reaction [IGF1 protein affects the metabolism of 1,2-diacylglycerol]"2120207
D016572CyclosporineCyclosporine inhibits the reaction [IGF1 protein results in increased activity of HIF1A protein]16682453
D016572CyclosporineCyclosporine inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]16682453
D016572CyclosporineCyclosporine results in decreased expression of IGF1 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased secretion of IGF1 protein16882103
D016572CyclosporineCyclosporine results in decreased expression of IGF1 mRNA19770486
D016572CyclosporineCyclosporine affects the activity of IGF1 protein11548882
D016572CyclosporineCyclosporine inhibits the reaction [IGF1 protein results in increased expression of NPPA mRNA]11548882
C017160cypermethrincypermethrin results in decreased expression of IGF1 mRNA22528246
C093628cyproconazolecyproconazole results in decreased expression of IGF1 mRNA22334560
D017373Cyproterone Acetate[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of IGF1 protein16002536
D003609DactinomycinIGF1 protein results in decreased susceptibility to Dactinomycin9525472
D003620DantroleneDantrolene results in decreased susceptibility to IGF1 protein16485066
D003630DaunorubicinDaunorubicin results in increased expression of IGF1 protein10215105
D003634DDTDDT affects the reaction [Metribolone results in increased expression of IGF1 mRNA]25682698
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in decreased expression of IGF1 mRNA25222814|2689491
D003671DEET[fipronil co-treated with DEET] results in decreased expression of IGF1 mRNA27091632
C107676deguelindeguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]17764071
C107676deguelindeguelin inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA]17764071
D013759DronabinolDronabinol affects the reaction [Estradiol results in increased expression of IGF1 mRNA]8390853
D013759DronabinolDronabinol results in decreased expression of IGF1 mRNA16616335
C007262deoxynivalenoldeoxynivalenol promotes the reaction [Glutathione results in increased expression of IGF1 mRNA]19805407
C007262deoxynivalenoldeoxynivalenol results in decreased expression of IGF1 protein19805407
C007262deoxynivalenoldeoxynivalenol affects the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Estradiol]17656051
C007262deoxynivalenoldeoxynivalenol affects the reaction [IGF1 protein results in increased abundance of Estradiol]17656051
C007262deoxynivalenoldeoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone]17656051
C007262deoxynivalenoldeoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP11A1 mRNA]17656051
C007262deoxynivalenoldeoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP19A1 mRNA]17656051
D064791Desoxycorticosterone Acetate"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of IGF1 mRNA"22228705
D003907DexamethasoneDexamethasone results in increased expression of IGF1 mRNA12670838
D003907DexamethasoneDexamethasone results in increased expression of IGF1 protein12670838
D003907Dexamethasone[Dexamethasone co-treated with Sirolimus] inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]15070696
D003907Dexamethasone[Dexamethasone co-treated with Sirolimus] results in decreased activity of IGF1 protein15070696
D003907DexamethasoneDexamethasone results in decreased expression of IGF1 mRNA19681914
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGF1 mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with IGF1 protein] results in decreased expression of CKM protein22936724
D003907Dexamethasone[Dexamethasone co-treated with IGF1 protein] results in increased expression of MYOG mRNA22936724
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGF1 mRNA16054899
D003907DexamethasoneDexamethasone promotes the reaction [IGF1 protein results in increased expression of CKM mRNA]22936724
D003907DexamethasoneDexamethasone promotes the reaction [IGF1 protein results in increased expression of MYH4 mRNA]22936724
D003907DexamethasoneDexamethasone promotes the reaction [IGF1 protein results in increased expression of MYH8 mRNA]22936724
D003907DexamethasoneDexamethasone results in decreased expression of IGF1 mRNA22733784
D003907DexamethasoneDexamethasone results in increased expression of IGF1 mRNA23935943
D003907DexamethasoneIGF1 protein promotes the reaction [Dexamethasone results in increased expression of MYH4 mRNA]22936724
D003907DexamethasoneIGF1 protein promotes the reaction [Dexamethasone results in increased expression of MYH8 mRNA]22936724
D003907DexamethasoneDexamethasone inhibits the reaction [nitrofen results in increased expression of IGF1 mRNA]10370016
D003907DexamethasoneDexamethasone inhibits the reaction [nitrofen results in increased expression of IGF1 protein]10370016
D003907DexamethasoneDexamethasone results in decreased expression of IGF1 mRNA14618091|1985364
D016264Dextran Sulfate[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IGF1 protein19931517
C053316di-(2-ethylhexyl) terephthalatedi-(2-ethylhexyl) terephthalate results in decreased expression of IGF1 mRNA26472102
D003976DiazinonDiazinon affects the expression of IGF1 mRNA22546817
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of IGF1 mRNA"17690111
C041517dibenzo(a,l)pyrene"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in decreased expression of IGF1 mRNA]"22079312
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of IGF1 mRNA"22079312
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of IGF1 mRNA21266533|2647210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IGF1 mRNA15829613
D003994BucladesineFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Androstenedione]]22872763
D003994BucladesineFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]]22872763
D003994BucladesineIGF1 protein promotes the reaction [Bucladesine results in increased abundance of Androstenedione]22872763
D003994BucladesineIGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]22872763
D003994BucladesineBucladesine promotes the reaction [IGF1 protein results in increased abundance of Estradiol]22798350
D003994BucladesineFGF9 protein inhibits the reaction [Bucladesine promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]22798350
D003994BucladesineFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]]22798350
D003994BucladesineIGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]22798350
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of IGF1 mRNA]25682698
D001728DicumarolDicumarol inhibits the reaction [IGF1 protein results in increased phosphorylation of JUN protein]11278392
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of IGF1 mRNA26924002
D004026Dieldrin[Dieldrin co-treated with Estradiol] results in decreased expression of IGF1 mRNA23041725
D004026DieldrinDieldrin affects the expression of IGF1 mRNA22546817
C023635dienogest[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of IGF1 protein11172797
D004041Dietary FatsDietary Fats results in decreased expression of IGF1 mRNA15238619|1804283
D004041Dietary FatsDietary Fats results in increased expression of IGF1 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of IGF1 mRNA]19030233
D004041Dietary Fats[Dietary Fats co-treated with Ethanol] results in increased expression of IGF1 mRNA24275070
D004041Dietary Fats[Dietary Fats co-treated with Ethanol] results in increased expression of IGF1 protein24275070
D019422Dietary SucroseDietary Sucrose results in increased expression of IGF1 mRNA19116878
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of IGF1 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of IGF1 mRNA]19850644
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of IGF1 mRNA22610992|2647210
C058705diethyl malatediethyl malate affects the expression of IGF1 mRNA24814887
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of IGF1 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of IGF1 mRNA]17942915
D004052DiethylnitrosamineDiethylnitrosamine affects the expression of IGF1 mRNA20387270
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IGF1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of IGF1 mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of IGF1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of IGF1 mRNA19638242
C007379diethyl phthalatediethyl phthalate results in decreased expression of IGF1 mRNA26472102
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of IGF1 mRNA10965916
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of IGF1 mRNA17011747|2710353
C012906dihydrocapsaicindihydrocapsaicin results in increased expression of IGF1 protein17307377
D002117CalcitriolCalcitriol affects the expression of IGF1 mRNA19918113
D0151279,10-Dimethyl-1,2-benzanthracene"IGF1 protein results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Benzoyl Peroxide]"10365914
D0151279,10-Dimethyl-1,2-benzanthracene"IGF1 protein results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with chrysarobin]"10365914
D0151279,10-Dimethyl-1,2-benzanthracene"IGF1 protein results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Okadaic Acid]"10365914
D0151279,10-Dimethyl-1,2-benzanthracene"IGF1 protein results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"10365914
D004126DimethylformamideDimethylformamide results in increased expression of IGF1 mRNA22169935
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of IGF1 mRNA"27840820
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of IGF1 mRNA26472102
C024629dimethyl phthalatedimethyl phthalate affects the expression of IGF1 mRNA26924002
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of IGF1 mRNA26472102
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein]20733350
D004237DiuronDiuron results in decreased expression of IGF1 mRNA25152437
D004280DobutamineIGF1 protein results in increased susceptibility to Dobutamine17184500
D004317DoxorubicinDoxorubicin promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]]16740780
D004317DoxorubicinDoxorubicin results in decreased expression of IGF1 mRNA25896364
D004317DoxorubicinIGF1 protein results in decreased susceptibility to Doxorubicin9525472
D004317DoxorubicinDoxorubicin affects the expression of IGF1 protein8792405
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of IGF1 protein"16548355
D004533Egtazic AcidEgtazic Acid results in decreased susceptibility to IGF1 protein16485066
D004656EnalaprilEnalapril affects the expression of IGF1 protein12883983
D004656EnalaprilEnalapril results in decreased expression of IGF1 mRNA12883983
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of IGF1 mRNA12655031
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of IGF1 mRNA20346928|2070667
C109476epoxiconazoleepoxiconazole results in decreased expression of IGF1 mRNA22334560
C010452estradiol-17 beta-benzoateestradiol-17 beta-benzoate affects the expression of IGF1 mRNA15059950
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of IGF1 protein21323755
C074283estradiol 3-benzoateestradiol 3-benzoate affects the expression of IGF1 mRNA15925091|1935048
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased expression of IGF1 mRNA21190954
C015854estradiol valerateestradiol valerate results in decreased expression of IGF1 protein10843175
D004964EstriolEstriol results in increased expression of IGF1 mRNA15969240
D004967EstrogensIGF1 protein affects the susceptibility to [Progesterone co-treated with Estrogens]18562952
D004967EstrogensIGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of IGFBP3 mRNA]18562952
D004967EstrogensIGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of RBP1 mRNA]18562952
D004967EstrogensIGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of TGFB1 mRNA]18562952
D004967EstrogensIGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of TRP53 mRNA]18562952
D004966Estrogens, Conjugated (USP)"Estrogens, Conjugated (USP) results in decreased expression of IGF1 protein"10843175
D000431EthanolEthanol results in decreased expression of IGF1 mRNA23907025
D000431Ethanol[Ethanol co-treated with sodium arsenite] results in increased expression of IGF1 mRNA18182400
D000431EthanolEthanol inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D000431Ethanol[Dietary Fats co-treated with Ethanol] results in increased expression of IGF1 mRNA24275070
D000431Ethanol[Dietary Fats co-treated with Ethanol] results in increased expression of IGF1 protein24275070
D000431EthanolEthanol affects the secretion of IGF1 protein26188107
D000431EthanolEthanol inhibits the reaction [IGF1 protein results in increased phosphorylation of PTEN protein]12700235
D000431EthanolEthanol results in decreased expression of IGF1 mRNA24275070
D000431EthanolEthanol results in decreased expression of IGF1 protein26220516
D000431EthanolEthanol results in increased expression of IGF1 mRNA15353170|2427507
D000431EthanolEthanol results in increased expression of IGF1 protein24275070
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of IGF1 protein16002536
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of IGF1 protein11172797
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of IGF1 protein11172797
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IGF1 protein10843175|1581791
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of IGF1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IGF1 mRNA14976129
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IGF1 mRNA16174780|1646718
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGF1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IGF1 mRNA18000313
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IGF1 protein18000313
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IGF1 mRNA17222921
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of IGF1 mRNA16551644
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IGF1 mRNA12075121|1617478
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IGF1 mRNA18660547
D005001EthionineEthionine affects the expression of IGF1 mRNA19483382
C024565ethylene dichlorideethylene dichloride results in decreased expression of IGF1 mRNA28189721
D015025ZearalenoneZearalenone results in decreased expression of IGF1 mRNA28965971
D015025ZearalenoneZearalenone results in increased expression of IGF1 mRNA27757495
D015025ZearalenoneZearalenone affects the reaction [IGF1 protein results in increased abundance of Estradiol]17656051
D015025ZearalenoneZearalenone inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP11A1 mRNA]17656051
D015025ZearalenoneZearalenone inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP19A1 mRNA]17656051
D015025ZearalenoneZearalenone promotes the reaction [IGF1 protein results in increased abundance of Progesterone]17656051
C047360felbamatefelbamate results in decreased expression of IGF1 mRNA17381134
C033789fenarimolfenarimol results in decreased expression of IGF1 mRNA15590119
C017690fenvaleratefenvalerate results in decreased expression of IGF1 mRNA22210404
C017690fenvaleratefenvalerate results in decreased secretion of IGF1 protein22210404
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of IGF1 mRNA27091632
C082360fipronilfipronil results in decreased expression of IGF1 mRNA27091632
D005419FlavonoidsFlavonoids results in decreased expression of IGF1 mRNA15922007
D005419FlavonoidsFlavonoids results in decreased expression of IGF1 protein15922007
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of IGF1 mRNA17690111
D005472FluorouracilFluorouracil results in increased expression of IGF1 mRNA16888818
D005485FlutamideFlutamide inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1 mRNA]16368782
D005485FlutamideFlutamide results in decreased expression of IGF1 mRNA17222921
D005485FlutamideFlutamide results in decreased expression of IGF1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of IGF1 mRNA24793618
C065180fluvastatin[zoledronic acid co-treated with fluvastatin] results in increased expression of IGF1 mRNA16996129
D005492Folic AcidFolic Acid results in decreased expression of IGF1 mRNA8594875
D005620Freund's AdjuvantFreund's Adjuvant promotes the reaction [Urethane results in increased expression of IGF1 mRNA]12810352
D005620Freund's Adjuvant[Urethane co-treated with Freund's Adjuvant] results in increased expression of IGF1 mRNA12400877
C069837fullerene C60fullerene C60 results in decreased expression of IGF1 mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [naringin results in increased expression of IGF1 mRNA]23596885
C056933fumonisin B1fumonisin B1 results in decreased expression of IGF1 mRNA16221962
C039281furanfuran results in decreased expression of IGF1 mRNA15120968|2553966
D005664FurazolidoneIGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]26687534
D005665FurosemideFurosemide results in increased expression of IGF1 mRNA16526316
C040029gabapentingabapentin results in increased expression of IGF1 mRNA17381134
C038958gadolinium chloridegadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGF1 protein]16522730
D019833GenisteinGenistein results in decreased expression of IGF1 mRNA20706672
D019833GenisteinGenistein results in decreased expression of IGF1 mRNA11880592
D019833GenisteinGenistein results in increased expression of IGF1 mRNA10965916
D019833GenisteinGenistein affects the activity of IGF1 protein11548882
D019833GenisteinGenistein results in decreased expression of IGF1 mRNA20381596
D019833GenisteinGenistein results in increased expression of IGF1 mRNA12075121
C442759ginsenoside Rb1ginsenoside Rb1 inhibits the reaction [aluminum chloride results in decreased expression of IGF1 mRNA]27470910
C442759ginsenoside Rb1ginsenoside Rb1 results in increased expression of IGF1 mRNA27470910
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of IGF1 mRNA22634610
D005978Glutathionedeoxynivalenol promotes the reaction [Glutathione results in increased expression of IGF1 mRNA]19805407
D005978GlutathioneGlutathione results in increased expression of IGF1 mRNA19805407
D017261GlycosylphosphatidylinositolsIGF1 protein results in increased degradation of Glycosylphosphatidylinositols2120207
D006046GoldGold inhibits the reaction [IGF1 protein binds to IGF1R protein]9648927
D006118GriseofulvinGriseofulvin results in decreased expression of IGF1 mRNA12735108
C411572H 1356H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1 mRNA]]25309793
D006533HeptachlorHeptachlor results in increased expression of IGF1 mRNA19101654
D006533HeptachlorHeptachlor results in increased expression of IGF1 protein19101654
D006533HeptachlorHeptachlor results in decreased expression of IGF1 mRNA23153324
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of IGF1 mRNA20200218|2689491
D006581HexachlorobenzeneHexachlorobenzene affects the expression of IGF1 mRNA28923513
D006581HexachlorobenzeneHexachlorobenzene affects the reaction [AHR protein affects the expression of IGF1 mRNA]28923513
D017313FenretinideFenretinide inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]25246272
D017313FenretinideFenretinide results in decreased activity of IGF1 protein15735044
D017313FenretinideFenretinide results in decreased expression of IGF1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of IGF1 mRNA26339600
D006861Hydrogen PeroxideIGF1 protein results in decreased abundance of Hydrogen Peroxide22843358
D002112CalcifediolCalcifediol deficiency results in increased expression of IGF1 mRNA17293106
D007052IbuprofenIbuprofen results in increased expression of IGF1 protein16799050
C056599icariinicariin results in increased expression of IGF1 mRNA18236786
D000068877Imatinib MesylateImatinib Mesylate promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]]16740780
D000068877Imatinib MesylateImatinib Mesylate promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of MTOR protein]]16740780
C011582IMOL S-140IMOL S-140 results in decreased expression of IGF1 mRNA26894911
C011582IMOL S-140IMOL S-140 results in decreased expression of IGF1 mRNA26894911
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGF1 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of IGF1 mRNA23142791
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IGF1 mRNA25613284
C051890irinotecanirinotecan metabolite results in increased expression of IGF1 mRNA15956246
C051890irinotecanirinotecan results in increased expression of IGF1 mRNA15956246
D007501IronIGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Iron]15745444
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGF1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGF1 mRNA16054899
D007529Isoflavones[Capsaicin co-treated with Isoflavones] results in increased expression of IGF1 protein19502719
D007529IsoflavonesIsoflavones promotes the reaction [Capsaicin results in increased expression of IGF1 protein]17569567
D007529IsoflavonesIsoflavones affects the expression of IGF1 mRNA18522411
D007530Isoflurane2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]25597859
D007530Isoflurane[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]25597859
D007530IsofluraneIGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein]25597859
D007530IsofluraneIGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]25597859
D007530IsofluraneIGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of RPS6 protein]25597859
D007530IsofluraneIGF1 protein inhibits the reaction [Isoflurane results in increased cleavage of CASP3 protein]25597859
D007530IsofluraneIsoflurane results in decreased expression of IGF1 protein25597859
D007530IsofluraneMK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]25597859
D007530IsofluraneSirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]25597859
D007530IsofluraneSirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]25597859
D007530IsofluraneU 0126 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]25597859
D007545IsoproterenolIsoproterenol results in decreased expression of IGF1 mRNA20003209
D007545Isoproterenolcandesartan cilexetil inhibits the reaction [Isoproterenol results in increased expression of IGF1 mRNA]10547078
D007545Isoproterenolcandesartan cilexetil inhibits the reaction [Isoproterenol results in increased expression of IGF1 protein]10547078
D007545IsoproterenolIsoproterenol results in increased expression of IGF1 mRNA10547078
D007545IsoproterenolIsoproterenol results in increased expression of IGF1 protein10547078
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of IGF1 mRNA15182950
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of IGF1 protein17337753
C561695(+)-JQ1 compoundIGF1 protein inhibits the reaction [(+)-JQ1 compound results in decreased phosphorylation of AKT1 protein]27259270
C561695(+)-JQ1 compoundIGF1 protein inhibits the reaction [(+)-JQ1 compound results in decreased phosphorylation of IGF1R protein]27259270
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IGF1 mRNA25961927|2725927
D048628KetolidesKetolides analog results in increased expression of IGF1 mRNA24967691
D007854LeadLead inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D007854LeadLead results in decreased expression of IGF1 protein23632160
D007854LeadLead results in increased secretion of IGF1 protein20390873
C008261lead acetatelead acetate results in decreased expression of IGF1 protein24200854
C045463leflunomideleflunomide results in increased expression of IGF1 mRNA19751817
D016729LeuprolideLeuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]17143537
D016729LeuprolideLeuprolide inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]17143537
D001556LindaneLindane results in decreased expression of IGF1 mRNA17785943
D008044LinuronLinuron results in increased expression of IGF1 mRNA12730624
D008055LipidsIGF1 protein affects the abundance of Lipids18755261
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of IGF1 mRNA"11578593
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of IGF1 protein"19474210
C482199lipopolysaccharide, E coli O55-B5"rosiglitazone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of IGF1 protein]"19474210
D008070Lipopolysaccharides[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IGF1 protein18437699
D008070Lipopolysaccharides[IGF1 protein co-treated with Lipopolysaccharides] results in decreased expression of TLR4 mRNA21371294
D008070LipopolysaccharidesIGF1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]21371294
D008070LipopolysaccharidesIGF1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]21371294
D008070LipopolysaccharidesIGF1 protein inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]21371294
D008070Lipopolysaccharides[picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL1B mRNA]21371294
D008070Lipopolysaccharides[picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL6 mRNA]21371294
D008070Lipopolysaccharides[picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]21371294
D008070Lipopolysaccharides[picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TNF mRNA]21371294
D008070Lipopolysaccharidesgadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGF1 protein]16522730
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Rutin] results in decreased expression of IGF1 mRNA28693884
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of IGF1 protein16522730
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IGF1 mRNA16448778
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IGF1 protein16448778
D008070LipopolysaccharidesTretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IGF1 mRNA]16448778
D008070LipopolysaccharidesTretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IGF1 protein]16448778
D018021Lithium ChlorideLithium Chloride promotes the reaction [IGF1 protein results in increased expression of MYH4 mRNA]19657059
C059451lornoxicamlornoxicam results in decreased expression of IGF1 mRNA23142791
D008148LovastatinIGF1 protein results in decreased susceptibility to Lovastatin9525472
C115121LY 353381LY 353381 results in increased expression of IGF1 mRNA10965916
C015329lycopenelycopene inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]16565789
C015329lycopenelycopene inhibits the reaction [IGF1 protein results in increased expression of CDKN1A protein]16565789
C015329lycopenelycopene inhibits the reaction [IGF1 protein results in increased phosphorylation of RB1 protein]16565789
C015329lycopenelycopene results in decreased expression of IGF1 mRNA16886892
C015329lycopenelycopene results in increased expression of IGF1 mRNA16886892
C015329lycopenelycopene results in decreased expression of IGF1 mRNA15084515
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of IGF1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IGF1 mRNA26378955
C030272maleic acidmaleic acid results in increased expression of IGF1 mRNA28392987
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA23963992
D008344ManebMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]23963992
D008344ManebSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]23963992
C025340manganese chloridemanganese chloride results in increased expression of IGF1 mRNA21402727
D008353MannitolIGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein]10567913
D009637MasoprocolMasoprocol inhibits the reaction [IGF1 protein promotes the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of IGF1R protein]]18491370
D009637MasoprocolMasoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of ERBB2 protein]18645000
D009637MasoprocolMasoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]18645000
D008550MelatoninMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]23963992
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of IGF1 mRNA7540432|8538927
D008628MercuryMercury inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D008687Metformin[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA21664031
D008687Metformin[Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA21664031
D008687Metformin[Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA21664031
D008687Metformin[Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein21664031
D008687MetforminMetformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]26497364
D008687MetforminMetformin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]23927877
D008687MetforminMetformin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA]26492952
D008715MethionineMethionine deficiency results in decreased expression of IGF1 protein15924568
D008731MethoxychlorMethoxychlor results in increased expression of IGF1 mRNA21276474
D008731Methoxychlor[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of IGF1 mRNA11509743
D008731MethoxychlorMethoxychlor metabolite results in decreased expression of IGF1 mRNA11509743
D008731MethoxychlorMethoxychlor results in decreased expression of IGF1 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of IGF1 mRNA27103539
D008731MethoxychlorMethoxychlor results in increased methylation of IGF1 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of IGF1 mRNA15316864
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of IGF1 mRNA19465457
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IGF1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IGF1 mRNA23649840
D008770MethylnitrosoureaIGF1 protein results in increased susceptibility to Methylnitrosourea15528971
D0156551-Methyl-4-phenylpyridinium2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK1 protein]]20064577
D0156551-Methyl-4-phenylpyridinium2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK3 protein]]20064577
D0156551-Methyl-4-phenylpyridinium2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]]20064577
D0156551-Methyl-4-phenylpyridinium2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium]20064577
D0156551-Methyl-4-phenylpyridiniumIGF1 protein inhibits the reaction [SNCA protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]15888489
D0156551-Methyl-4-phenylpyridiniumIGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]20064577
D0156551-Methyl-4-phenylpyridiniumIGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK1 protein]20064577
D0156551-Methyl-4-phenylpyridiniumIGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK3 protein]20064577
D0156551-Methyl-4-phenylpyridiniumIGF1 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium20064577
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein26254549
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 mRNA26254549|2826821
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 protein28268219
D0156551-Methyl-4-phenylpyridinium2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]26254549
D0156551-Methyl-4-phenylpyridiniumSB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]26254549
D0156551-Methyl-4-phenylpyridiniumTGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]26254549
D0156551-Methyl-4-phenylpyridiniumTGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 mRNA]26254549
D0156551-Methyl-4-phenylpyridiniumTGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 protein]]26254549
C008493methylselenic acidmethylselenic acid results in increased expression of IGF1 mRNA11830524
D015741MetriboloneDDT affects the reaction [Metribolone results in increased expression of IGF1 mRNA]25682698
D015741MetriboloneDichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of IGF1 mRNA]25682698
D015741Metribolone"[Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] results in decreased expression of IGF1 mRNA"26709203
D015741MetriboloneMetribolone results in increased expression of IGF1 mRNA25682698
D015735MifepristoneMifepristone inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]15809018
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased secretion of IGF1 protein]15809018
D015735MifepristoneMifepristone results in decreased expression of IGF1 mRNA25972201
C548887MK 2206MK 2206 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]25597859
C008542monodansylcadaverinemonodansylcadaverine inhibits the reaction [IGF1 protein results in increased abundance of Reactive Oxygen Species]20733350
C008542monodansylcadaverinemonodansylcadaverine inhibits the reaction [[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein]20733350
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of IGF1 mRNA26924002
D009151Mustard GasMustard Gas results in decreased expression of IGF1 mRNA15674843
D009151Mustard GasMustard Gas results in increased expression of IGF1 mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of IGF1 mRNA"23845593|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IGF1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IGF1 mRNA"25554681|2710602
C031721naphthalenenaphthalene results in increased expression of IGF1 mRNA18978301
C005274naringinfulvestrant inhibits the reaction [naringin results in increased expression of IGF1 mRNA]23596885
C005274naringinnaringin affects the expression of IGF1 mRNA24880026
C005274naringinnaringin results in increased expression of IGF1 mRNA23596885
C051752nefazodonenefazodone results in decreased expression of IGF1 mRNA24136188
D009532NickelNickel results in decreased expression of IGF1 mRNA24768652|2558310
D009532NickelNickel results in decreased susceptibility to IGF1 protein16485066
C022838nickel chloridenickel chloride results in decreased expression of IGF123955483
C022838nickel chloride[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IGF1 protein18437699
C028007nickel monoxidenickel monoxide results in increased expression of IGF1 mRNA19167457
D009538NicotineNicotine results in decreased expression of IGF1 mRNA22265867
D009538NicotineNicotine results in decreased expression of IGF1 protein20960268
D009538Nicotinerosiglitazone inhibits the reaction [Nicotine results in decreased expression of IGF1 protein]20960268
D009543NifedipineNifedipine results in decreased susceptibility to IGF1 protein16485066
C012655nimesulidenimesulide results in decreased expression of IGF1 mRNA23142791|2413618
C007350nitrofenDexamethasone inhibits the reaction [nitrofen results in increased expression of IGF1 mRNA]10370016
C007350nitrofenDexamethasone inhibits the reaction [nitrofen results in increased expression of IGF1 protein]10370016
C007350nitrofennitrofen results in decreased expression of IGF1 mRNA11409163
C007350nitrofennitrofen results in increased expression of IGF1 mRNA10370016
C007350nitrofennitrofen results in increased expression of IGF1 protein10370016
D009599NitroprussideIGF1 protein results in decreased susceptibility to Nitroprusside10203697
D009599NitroprussideIGF1 protein inhibits the reaction [Nitroprusside results in decreased expression of BCL2 protein]10203697
D009599NitroprussideIGF1 protein inhibits the reaction [Nitroprusside results in increased expression of BAX protein]10203697
D009607Nitrosourea CompoundsNitrosourea Compounds results in decreased expression of IGF1 protein18443378
C511689(N)-methanocarba-2MeSADPIGF1 protein affects the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of PTK2B protein]16236484
C090577N,N'-bis(salicylideneamino)ethane-manganese(II)"N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [SOD2 gene mutant form results in decreased expression of IGF1 protein]"21195081
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]"14644152
C040937nonivamidenonivamide results in increased expression of IGF1 protein17307377
C517386nordihydrocapsaicinnordihydrocapsaicin results in increased expression of IGF1 protein17307377
D009638NorepinephrineIGF1 protein results in decreased susceptibility to Norepinephrine17184500
D009638NorepinephrinePrazosin inhibits the reaction [IGF1 protein results in decreased susceptibility to Norepinephrine]17184500
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of IGF1 protein11172797
C024713n-tetradecanen-tetradecane results in decreased expression of IGF1 protein17337753
C502355NVP ADW742Doxorubicin promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]]16740780
C502355NVP ADW742Imatinib Mesylate promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]]16740780
C502355NVP ADW742Imatinib Mesylate promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of MTOR protein]]16740780
C502355NVP ADW742NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]16740780
C502355NVP ADW742NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]16740780
C502355NVP ADW742NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of MTOR protein]16740780
C502355NVP ADW742Vincristine promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]]16740780
C501177NVP-AEW541NVP-AEW541 inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]27734117
C501177NVP-AEW541[Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]27734117
C025589ochratoxin Aochratoxin A results in decreased expression of IGF1 mRNA16251485
D015282OctreotideOctreotide affects the expression of IGF1 protein16449332|2111918
D015282OctreotideOctreotide results in decreased expression of IGF1 protein10806600|1516598
C118580octylmethoxycinnamateoctylmethoxycinnamate results in increased expression of IGF1 mRNA15979666
D019319Okadaic Acid"IGF1 protein results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Okadaic Acid]"10365914
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in increased expression of IGF1 protein"22464816
D009853OmeprazoleOmeprazole affects the expression of IGF1 mRNA19483382
C016340o,p'-DDT"o,p'-DDT results in increased expression of IGF1 mRNA"24096037
C016340o,p'-DDT"o,p'-DDT affects the expression of IGF1 mRNA"17984292
C016340o,p'-DDT"o,p'-DDT results in increased expression of IGF1 mRNA"24096037
C485800osajinosajin results in decreased expression of IGF1 mRNA20706672
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of IGF1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of IGF1 mRNA25729387
C029341oxophenylarsineoxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]1928324
C029341oxophenylarsineoxophenylarsine results in decreased localization of IGF1 protein9145794
D010100Oxygen[Oxygen deficiency results in increased expression of CA9 mRNA] which results in increased expression of IGF1 mRNA26305601
D010100OxygenOxygen deficiency affects the methylation of IGF1 promoter24205000
D010100OxygenOxygen deficiency results in decreased expression of IGF1 mRNA24205000
D010100OxygenOxygen results in increased expression of IGF1 mRNA22911455
D000073878Palm OilPalm Oil results in decreased expression of IGF1 mRNA18042831
D010269ParaquatIGF1 gene mutant form inhibits the reaction [Paraquat results in decreased expression of SLC8A1 protein]17979500
D010269ParaquatIGF1 gene mutant form inhibits the reaction [Paraquat results in increased expression of ATP2A2 protein]17979500
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA23963992
D010269ParaquatMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]23963992
D010269ParaquatParaquat results in increased expression of IGF1 protein23898955
D010269ParaquatSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]23963992
D010269ParaquatParaquat results in increased expression of IGF1 mRNA20498031
D052638Particulate MatterParticulate Matter results in increased expression of IGF1 mRNA21708214
D052638Particulate MatterParticulate Matter results in increased expression of IGF1 mRNA19699283
C410127PCB 180"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of IGF1 protein"19327374
C410127PCB 180"[2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IGF1 mRNA"21190954
C030856pendimethalinpendimethalin results in decreased expression of IGF1 mRNA19897005
D010396PenicillaminePenicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of IGF1 mRNA26705709
C086401pentabromodiphenyl etherpentabromodiphenyl ether inhibits the reaction [Estradiol results in increased expression of IGF1 mRNA]16414171
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of IGF1 mRNA16414171
D004369Pentetic AcidPentetic Acid inhibits the reaction [Zinc Sulfate results in decreased expression of IGF1 mRNA]9685221
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of IGF1 mRNA19397962
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of IGF1 mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IGF1 mRNA18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IGF1 protein20118188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of IGF1 mRNA19162173
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [sodium arsenite results in increased expression of IGF1 mRNA]19349368
C560873PF 5168899PF 5168899 inhibits the reaction [IGF1 protein affects the localization of PDPK1 protein]21402045
C560873PF 5168899PF 5168899 inhibits the reaction [IGF1 protein affects the localization of FOXO3 protein]21402045
C560873PF 5168899PF 5168899 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]21402045
D010615PhenacetinPhenacetin results in decreased expression of IGF1 mRNA23142791
D010634PhenobarbitalPhenobarbital affects the expression of IGF1 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of IGF1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of IGF1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of IGF1 mRNA19482888
D010634PhenobarbitalPhenobarbital affects the expression of IGF1 mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of IGF1 mRNA17381134
D010634PhenobarbitalPhenobarbital results in increased expression of IGF1 mRNA12082028
D010656PhenylephrineIGF1 protein affects the susceptibility to Phenylephrine11159833
D010672PhenytoinPhenytoin results in decreased expression of IGF1 mRNA17381134
D010713PhosphatidylcholinesIGF1 protein results in increased degradation of Phosphatidylcholines2120207
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the expression of IGF1 mRNA"16311027
C030614picolinic acidpicolinic acid promotes the reaction [INS1 protein results in increased expression of IGF1 mRNA]20013160
C415032picropodophyllin[picropodophyllin co-treated with IGF1 protein] results in increased expression of TNF mRNA21371294
C415032picropodophyllin[picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL1B mRNA]21371294
C415032picropodophyllin[picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL6 mRNA]21371294
C415032picropodophyllin[picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]21371294
C415032picropodophyllin[picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TNF mRNA]21371294
C415032picropodophyllinpicropodophyllin inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]21371294
C415032picropodophyllinpicropodophyllin inhibits the reaction [IGF1 protein results in increased expression of IL1B mRNA]21371294
C415032picropodophyllinpicropodophyllin promotes the reaction [IGF1 protein results in increased expression of IL6 mRNA]21371294
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of IGF1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of IGF1 mRNA12727805|1622196
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of IGF1 mRNA]16221962
C006253pirinixic acidpirinixic acid affects the expression of IGF1 mRNA19483382
D010936Plant Extracts[Plant Extracts co-treated with Azoxymethane] results in decreased expression of IGF1 mRNA23996930
D010936Plant Extracts[Plant Extracts co-treated with Azoxymethane] results in decreased expression of IGF1 protein23996930
D028321Plant PreparationsPlant Preparations affects the expression of IGF1 mRNA18522411
C061957polaprezincpolaprezinc results in increased expression of IGF1 mRNA10423164
D011070Poly I-CIL6 protein affects the reaction [Poly I-C results in decreased expression of IGF1 protein]21195166
D011070Poly I-CPoly I-C results in decreased expression of IGF1 protein21195166
C474837pomiferinpomiferin results in decreased expression of IGF1 mRNA20706672
D011188PotassiumIGF1 protein affects the transport of Potassium18388193
D011189Potassium Chloride"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of IGF1 mRNA"22228705
D011189Potassium ChlorideIGF1 protein results in increased susceptibility to Potassium Chloride11159833
D011224PrazosinPrazosin inhibits the reaction [IGF1 protein results in decreased susceptibility to Norepinephrine]17184500
D011239PrednisolonePrednisolone results in decreased susceptibility to IGF1 protein16079165
D011239PrednisolonePrednisolone results in increased expression of IGF1 protein16079165
D011284PregnenoloneFGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone]22798350
D011284Pregnenolone[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone22798350
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of IGF1 mRNA19162173
C045362prochlorazprochloraz results in decreased susceptibility to IGF1 protein11408079
C045362prochlorazprochloraz results in increased expression of IGF1 mRNA20805220
C045362prochlorazprochloraz results in decreased expression of IGF1 mRNA16375936
D011374ProgesteroneFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]]22872763
D011374ProgesteroneFGF9 protein inhibits the reaction [IGF1 protein results in increased abundance of Progesterone]22872763
D011374ProgesteroneFGF9 protein inhibits the reaction [[LHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone]22872763
D011374ProgesteroneIGF1 protein inhibits the reaction [LHB protein results in increased abundance of Progesterone]17154301
D011374ProgesteroneIGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]22872763
D011374ProgesteroneIGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]22872763
D011374ProgesteroneIGF1 protein results in increased abundance of Progesterone21239528|2131552
D011374Progesterone[LEP protein co-treated with IGF1 protein] results in increased abundance of Progesterone17154301
D011374Progesterone[LHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone22872763
D011374ProgesteroneRETN protein inhibits the reaction [IGF1 protein results in increased abundance of Progesterone]21315524
D011374ProgesteroneIGF1 protein results in increased abundance of Progesterone21885231
D011374ProgesteroneAICA ribonucleotide affects the reaction [IGF1 protein results in increased secretion of Progesterone]17478073
D011374ProgesteroneIGF1 protein results in increased secretion of Progesterone17478073
D011374ProgesteronePRKAA2 protein promotes the reaction [AICA ribonucleotide affects the reaction [IGF1 protein results in increased secretion of Progesterone]]17478073
D011374ProgesteroneADIPOQ protein promotes the reaction [IGF1 protein results in increased abundance of Progesterone]19081562
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein15809018
D011374ProgesteroneFGF9 protein inhibits the reaction [[IGF1 protein co-treated with FSHB protein] results in increased abundance of Progesterone]22798350
D011374ProgesteroneFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]]22798350
D011374ProgesteroneFGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]]22798350
D011374ProgesteroneFGF9 protein inhibits the reaction [IGF1 protein results in increased abundance of Progesterone]22798350
D011374Progesterone[IGF1 protein co-treated with FSHB protein] results in increased abundance of Progesterone22798350
D011374ProgesteroneIGF1 protein promotes the reaction [Bucladesine results in increased abundance of Progesterone]22798350
D011374ProgesteroneIGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]22798350
D011374ProgesteroneIGF1 protein results in increased abundance of Progesterone19081562|2279835
D011374ProgesteroneMifepristone inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]15809018
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased secretion of IGF1 protein]15809018
D011374ProgesteroneNAMPT protein promotes the reaction [IGF1 protein results in increased abundance of Progesterone]23315983
D011374ProgesteroneProgesterone results in increased expression of IGF1 mRNA20864642
D011374ProgesteroneProgesterone results in increased secretion of IGF1 protein15809018
D011374ProgesteroneTamoxifen inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]15809018
D011374Progesterone[Estradiol co-treated with Progesterone] promotes the reaction [Cuprizone results in increased expression of IGF1 mRNA]19031445
D011374ProgesteroneEstradiol promotes the reaction [Progesterone results in increased expression of IGF1 mRNA]8390853
D011374ProgesteroneIGF1 protein affects the susceptibility to [Progesterone co-treated with Estrogens]18562952
D011374ProgesteroneIGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of IGFBP3 mRNA]18562952
D011374ProgesteroneIGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of RBP1 mRNA]18562952
D011374ProgesteroneIGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of TGFB1 mRNA]18562952
D011374ProgesteroneIGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of TRP53 mRNA]18562952
D011374ProgesteroneProgesterone affects the expression of IGF1 mRNA17251523
D011374ProgesteroneProgesterone promotes the reaction [Estradiol results in increased expression of IGF1 mRNA]8390853
D011374ProgesteroneProgesterone results in increased expression of IGF1 mRNA8390853
D011374ProgesteroneIGF1 protein inhibits the reaction [BMP15 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneIGF1 protein inhibits the reaction [BMP2 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneIGF1 protein inhibits the reaction [BMP4 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneIGF1 protein inhibits the reaction [BMP6 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneIGF1 protein inhibits the reaction [BMP7 protein inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]22067323
D011374ProgesteroneIGF1 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]22067323
D011374ProgesteroneIGF1 protein promotes the reaction [[FSHB protein results in increased expression of CYP11A1 mRNA] which results in increased abundance of Progesterone]22067323
D011374ProgesteroneIGF1 protein promotes the reaction [[FSHB protein results in increased expression of CYP19A1 mRNA] which results in increased abundance of Progesterone]22067323
D011374ProgesteroneIGF1 protein promotes the reaction [[FSHB protein results in increased expression of HSD3B2 mRNA] which results in increased abundance of Progesterone]22067323
D011374ProgesteroneIGF1 protein promotes the reaction [[FSHB protein results in increased expression of STAR mRNA] which results in increased abundance of Progesterone]22067323
D011374ProgesteroneIGF1 protein results in increased abundance of Progesterone21239528
D011374ProgesteroneProgesterone results in increased expression of IGF1 mRNA19853640|2072685
D011374ProgesteroneRETN protein promotes the reaction [IGF1 protein results in increased abundance of Progesterone]21239528
D011374Progesteronedeoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone]17656051
D011374Progesterone[FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone17656051
D011374ProgesteroneIGF1 protein results in increased abundance of Progesterone17656051
D011374ProgesteroneZearalenone promotes the reaction [IGF1 protein results in increased abundance of Progesterone]17656051
D011374ProgesteroneIGF1 protein results in increased secretion of Progesterone23548939
D011374ProgesteroneRETN protein inhibits the reaction [IGF1 protein results in increased secretion of Progesterone]23548939
C045950propiconazolepropiconazole results in decreased expression of IGF1 mRNA21278054|2233456
D011429PropolisPropolis results in decreased expression of IGF1 mRNA20706672
D011441PropylthiouracilPropylthiouracil results in decreased expression of IGF1 mRNA26894911
D011441PropylthiouracilPropylthiouracil affects the expression of IGF1 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of IGF1 mRNA24780913
D011509ProteoglycansIGF1 protein results in increased metabolism of Proteoglycans16646036
D011509ProteoglycansIL1A protein inhibits the reaction [IGF1 protein results in increased metabolism of Proteoglycans]16646036
D011509ProteoglycansNOS2 protein affects the reaction [Zymosan inhibits the reaction [IGF1 protein results in increased metabolism of Proteoglycans]]16646036
D011509ProteoglycansZymosan inhibits the reaction [IGF1 protein results in increased metabolism of Proteoglycans]16646036
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of IGF1 mRNA23274088
C043680ptaquilosideptaquiloside results in decreased expression of IGF1 mRNA23274088
C033607puerarinpuerarin results in decreased expression of IGF1 mRNA20706672
C033607puerarinpuerarin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]23927877
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]17458902
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]17458902
D011794QuercetinQuercetin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]17458902
D011794QuercetinQuercetin results in decreased expression of IGF1 mRNA20658310
D011794QuercetinQuercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]24353828
D011794QuercetinQuercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]24353828
D011794QuercetinQuercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]24353828
D011794QuercetinQuercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]24353828
D011794QuercetinQuercetin results in decreased expression of IGF1 mRNA24943009
D011802QuinidineQuinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]17520698
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to IGF1 promoter]17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [CREBBP protein binds to IGF1 promoter]17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [ESR1 protein binds to IGF1 promoter]17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [ESR2 protein binds to IGF1 promoter]17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [NCOA1 protein binds to IGF1 promoter]17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to IGF1 promoter]17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to IGF1 promoter]17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of IGF1 mRNA17872375
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of IGF1 protein15978972|1691266
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of IGF1 mRNA15762036|1787237
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of IGF1 mRNA19350480
D017382Reactive Oxygen SpeciesIGF1 protein results in increased abundance of Reactive Oxygen Species20733350
D017382Reactive Oxygen Species[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein20733350
D017382Reactive Oxygen Speciesmonodansylcadaverine inhibits the reaction [IGF1 protein results in increased abundance of Reactive Oxygen Species]20733350
D017382Reactive Oxygen Speciesmonodansylcadaverine inhibits the reaction [[IGF1 protein results in increased abundance of Reactive Oxygen Species] which results in increased expression of ZNF143 protein]20733350
C052785rebamipiderebamipide results in increased expression of IGF1 mRNA15104358
C059514resveratrolresveratrol results in increased expression of IGF1 mRNA25061707
C059514resveratrolresveratrol results in increased expression of IGF1 protein24570423
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein binds to and results in increased phosphorylation of and results in increased activity of IGF1R protein]24782617
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]15297429
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA]15297429
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased expression of VEGFA protein]15297429
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]17513867
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]15297429
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4E protein]15297429
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of FOXO3 protein]17513867
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]15297429
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]15297429
C059514resveratrolresveratrol results in decreased expression of IGF1 mRNA20706672
C059514resveratrolresveratrol results in decreased susceptibility to IGF1 protein15297429
C059514resveratrolresveratrol results in increased expression of IGF1 mRNA12002526
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein binds to and results in increased phosphorylation of and results in increased activity of IGF1R protein]24782617
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased expression of COL1A2 mRNA]24782617
C059514resveratrolresveratrol results in decreased expression of IGF1 mRNA23525482
C059514resveratrolresveratrol results in decreased expression of IGF1 protein17086191|1767533
C059514resveratrolresveratrol results in decreased susceptibility to IGF1 protein24782617
C059514resveratrolresveratrol inhibits the reaction [Dihydrotestosterone results in increased secretion of IGF1 protein]25667201
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased expression of RPS6KB1 protein modified form]25394677
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]16626303
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]16626303
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]16626303
C059514resveratrolresveratrol results in decreased expression of IGF1 mRNA19228061
C059514resveratrolresveratrol results in increased expression of IGF1 mRNA23848300
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased activity of MMP2 protein]18398872
C059514resveratrolresveratrol results in decreased susceptibility to IGF1 protein18398872|2050436
D015474IsotretinoinIsotretinoin results in increased expression of IGF1 mRNA15982314
C021828RevalorRevalor results in increased expression of IGF1 mRNA24987078
C021828RevalorRevalor results in increased expression of IGF1 protein24987078
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of IGF1 mRNA]19030233
C529148rosavinrosavin results in decreased expression of IGF1 mRNA20706672
C089730rosiglitazonerosiglitazone results in decreased secretion of IGF1 protein17122083
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGF1 mRNA16054899
C089730rosiglitazonerosiglitazone results in decreased expression of IGF1 mRNA17122083
C089730rosiglitazonerosiglitazone results in decreased expression of IGF1 protein18948404
C089730rosiglitazonerosiglitazone results in decreased secretion of IGF1 protein17122083
C089730rosiglitazonerosiglitazone inhibits the reaction [Nicotine results in decreased expression of IGF1 protein]20960268
C089730rosiglitazone"rosiglitazone promotes the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of IGF1 protein]"19474210
D012402RotenoneRotenone inhibits the reaction [IGF1 protein results in increased activity of ODC1 protein]9834970
D012430Ruthenium RedRuthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]20539001
D012431Rutin[Lipopolysaccharides co-treated with Rutin] results in decreased expression of IGF1 mRNA28693884
C093642SB 203580SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]26254549
D012765Shikimic AcidShikimic Acid results in increased expression of IGF1 mRNA15265014
D012822Silicon DioxideSilicon Dioxide results in decreased expression of IGF1 mRNA19073995
D012834SilverSilver results in decreased expression of IGF1 mRNA27131904
D012838SilymarinSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]23963992
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin affects the localization of FOXO3 protein]27734117
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]27734117
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]27734117
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of EIF4EBP1 protein]27734117
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]27734117
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6 protein]27734117
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of CASP3 protein]27734117
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]27734117
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]27734117
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]27734117
D019821Simvastatin[Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]27734117
D019821SimvastatinSimvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]27734117
D019821SimvastatinSimvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]27734117
D019821SimvastatinSimvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]27734117
D019821SimvastatinSimvastatin inhibits the reaction [IGF1 results in increased activity of AKT1 protein]17327694
D019821SimvastatinSimvastatin inhibits the reaction [IGF1 results in increased activity of MAPK1 protein]17327694
D019821SimvastatinSimvastatin inhibits the reaction [IGF1 results in increased activity of MAPK3 protein]17327694
D020123Sirolimus[Dexamethasone co-treated with Sirolimus] inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]15070696
D020123Sirolimus[Dexamethasone co-treated with Sirolimus] results in decreased activity of IGF1 protein15070696
D020123Sirolimus[Sirolimus co-treated with IGF1 protein] results in increased expression of ACTA2 protein17908691
D020123Sirolimus[Sirolimus co-treated with IGF1 protein] results in increased expression of CALD1 protein17908691
D020123Sirolimus[Sirolimus co-treated with IGF1 protein] results in increased expression of MYH11 protein17908691
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]15297429|1668245
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]15297429
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]15297429
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein results in increased secretion of IGFBP3 protein]16682453
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]16682453
D020123SirolimusSirolimus results in increased susceptibility to IGF1 protein16227402
D020123SirolimusSirolimus inhibits the reaction [IL2 protein results in increased expression of IGF1 mRNA]11355896
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein affects the localization of CDKN1A protein]19105244
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein affects the localization of CDKN1B protein]19105244
D020123SirolimusSirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]25597859
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]25597859
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]19105244
D012906SmokeSmoke results in decreased nitrosation of IGF1 protein21652289
D012964Sodium[GH1 protein co-treated with IGF1 protein] affects the transport of Sodium18388193
D012964SodiumIGF1 protein affects the transport of [Sodium co-treated with Chlorides]18388193
C009277sodium arsenatesodium arsenate results in decreased expression of IGF1 mRNA16882884|2392266
C009277sodium arsenatesodium arsenate results in increased expression of IGF1 mRNA21795629
C017947sodium arsenite[Ethanol co-treated with sodium arsenite] results in increased expression of IGF1 mRNA18182400
C017947sodium arsenitePertussis Toxin inhibits the reaction [sodium arsenite results in increased expression of IGF1 mRNA]19349368
C017947sodium arseniteS1PR1 protein affects the reaction [sodium arsenite results in increased expression of IGF1 mRNA]19349368
C017947sodium arsenitesodium arsenite results in increased expression of IGF1 mRNA19349368
C017947sodium arsenitesodium arsenite affects the expression of IGF1 mRNA16507464
C017947sodium arsenite[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IGF1 mRNA16368122
C017947sodium arsenitesodium arsenite results in decreased expression of IGF1 mRNA15276417|1745185
C017947sodium arsenitesodium arsenite results in decreased expression of IGF1 protein22426358
C017947sodium arsenitesodium arsenite results in increased expression of IGF1 mRNA17077188
C017947sodium arseniteIGF1 protein inhibits the reaction [sodium arsenite affects the localization of CYCS protein]23219847
C017947sodium arseniteIGF1 protein inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]23219847
C017947sodium arseniteIGF1 protein results in decreased susceptibility to sodium arsenite23219847
C016104sodium bichromatesodium bichromate results in increased expression of IGF1 mRNA22561333
D017673Sodium Chloride, Dietary"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of IGF1 mRNA"22228705
D012969Sodium FluorideSodium Fluoride results in decreased expression of IGF1 protein21461751
D012980Sodium SalicylateSodium Salicylate promotes the reaction [[EGF protein co-treated with IGF1 protein] results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]10993886
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of IGF1 mRNA23274088
D018038Sodium SeleniteSodium Selenite results in decreased expression of IGF1 mRNA23274088
D053260SootSoot results in increased expression of IGF1 mRNA26551751
C471405sorafenibsorafenib inhibits the reaction [IGF1 protein results in increased expression of BIRC5 protein]21601561
C060506sphingosine 1-phosphatesphingosine 1-phosphate results in increased expression of IGF1 mRNA19349368
D019311StaurosporineIGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]19406941
D019311StaurosporineIGF1 protein inhibits the reaction [Staurosporine results in increased activity of CASP7 protein]19406941
D019311StaurosporineStaurosporine affects the activity of IGF1 protein11548882
D013311StreptozocinIGF1 protein inhibits the reaction [Streptozocin results in increased expression of AGT protein]11375343
D013311StreptozocinIGF1 protein inhibits the reaction [Streptozocin results in increased expression of BAX protein]11375343
D013311StreptozocinIGF1 protein inhibits the reaction [Streptozocin results in increased expression of TRP53 protein]11375343
D013311StreptozocinMetformin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]23927877
D013311Streptozocinpuerarin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]23927877
D013311StreptozocinStreptozocin results in decreased expression of IGF1 protein23927877
D013311StreptozocinStreptozocin results in decreased expression of IGF1 mRNA7637645
D013311StreptozocinStreptozocin results in decreased expression of IGF1 protein25617479
D013311StreptozocinStreptozocin results in increased expression of IGF1 protein9868179
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of IGF1 mRNA16214533
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of IGF1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IGF1 mRNA26378955
D013481SuperoxidesIGF1 protein results in decreased abundance of Superoxides22843358
D014284TriiodothyronineEstradiol inhibits the reaction [Triiodothyronine results in increased expression of IGF1 mRNA]7684602
D014284TriiodothyronineEstradiol inhibits the reaction [Triiodothyronine results in increased secretion of IGF1 protein]7684602
D014284TriiodothyronineTriiodothyronine results in increased expression of IGF1 mRNA7684602
D014284TriiodothyronineTriiodothyronine results in increased secretion of IGF1 protein7684602
D016559TacrolimusIGF1 protein results in increased susceptibility to Tacrolimus12826230
D013629TamoxifenTamoxifen results in increased expression of IGF1 mRNA26908177
D013629Tamoxifen[bicalutamide co-treated with Tamoxifen] results in decreased expression of IGF1 protein16847815
D013629TamoxifenTamoxifen inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGF1 protein]15809018
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased secretion of IGF1 protein]15809018
D013629TamoxifenTamoxifen results in decreased expression of IGF1 protein20332317
D013629TamoxifenTamoxifen affects the expression of IGF1 mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of IGF1 mRNA19400957
D013629TamoxifenTamoxifen results in increased expression of IGF1 mRNA19400957
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of IGF1 mRNA15885361
C021754tericsterics results in decreased susceptibility to IGF1 protein11408079
D013739TestosteroneTestosterone results in increased expression of IGF1 mRNA16368782
D013739TestosteroneTestosterone results in increased expression of IGF1 protein16002536
D013739TestosteroneTestosterone results in increased secretion of IGF1 protein16368782
D013739TestosteroneTestosterone affects the expression of IGF1 mRNA20403060
D013739TestosteroneTestosterone deficiency results in decreased expression of IGF1 mRNA21045173
D013739TestosteroneTestosterone inhibits the reaction [Testosterone deficiency results in decreased expression of IGF1 mRNA]21045173
D013739TestosteroneTestosterone results in decreased expression of IGF1 mRNA22138414
D013739TestosteroneTestosterone results in increased expression of IGF1 mRNA21703268
D013739TestosteroneTestosterone results in increased expression of IGF1 protein21703268
D013739Testosteronechrysin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA]29247772
D013739TestosteroneMetformin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA]26492952
D013739TestosteroneTestosterone results in increased expression of IGF1 mRNA15917159|2649295
D013739TestosteroneTestosterone results in increased expression of IGF1 protein10100480
D013739TestosteroneTestosterone results in increased expression of IGF1 protein21084444
C004648testosterone enanthatetestosterone enanthate results in decreased expression of IGF1 mRNA23085480
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of IGF1 mRNA25172293
C020806tetrabromobisphenol Atetrabromobisphenol A affects the expression of IGF1 mRNA26988606
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of IGF1 mRNA28300664
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Estradiol] inhibits the reaction [IGF1 protein results in increased uptake of Thymidine]1332906
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in decreased uptake of Thymidine]1332906
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IGF1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IGF1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of IGF1 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGF1 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with IGF1 protein] results in increased expression of CDKN1B protein20486776
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]20486776
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased activity of IGF1 protein20486776
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IGF1 mRNA19770486|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IGF1 protein24793433
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IGF1 mRNA15034205|1696003
D013749TetrachlorodibenzodioxinIGF1 protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of and results in decreased activity of EIF4EBP1 protein]23639626
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IGF1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]23639626
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]23639626
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]23639626
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IGF1 mRNA16054898|1846511
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IGF1 protein15703265
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of [IGF1 protein results in increased stability of LHB mRNA]15746889
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IGF1 mRNA16960034
C582340tetradecabromodiphenoxybenzenetetradecabromodiphenoxybenzene analog results in decreased expression of IGF1 mRNA25222814|2689491
D013755Tetradecanoylphorbol Acetate"IGF1 protein results in increased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"10365914
D013755Tetradecanoylphorbol Acetate[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IGF1 mRNA16368122
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IGF1 mRNA25613284
C009424tetramethrintetramethrin inhibits the reaction [IGF1 protein results in increased import of Calcium]1550224|2460452|
C020809tetrathiomolybdatetetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]18480265
C020809tetrathiomolybdate[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]18480265
C020809tetrathiomolybdate[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]18480265
D013792ThalidomideThalidomide affects the expression of IGF1 mRNA15939924
D013849ThimerosalThimerosal affects the reaction [IGF1 protein results in increased activity of MTR protein]14745455
D013849ThimerosalIGF1 protein inhibits the reaction [Thimerosal results in decreased expression of BIRC5 protein]23145070
D013849ThimerosalIGF1 protein inhibits the reaction [Thimerosal results in increased cleavage of CASP3 protein]23145070
D013849ThimerosalIGF1 protein inhibits the reaction [Thimerosal results in increased cleavage of CASP9 protein]23145070
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of IGF1 mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of IGF1 mRNA19483382
D013974ThyroxineThyroxine results in increased expression of IGF1 mRNA23935926
D013936ThymidineIGF1 protein results in decreased uptake of Thymidine1332906
D013936Thymidine[Tetrachlorodibenzodioxin co-treated with Estradiol] inhibits the reaction [IGF1 protein results in increased uptake of Thymidine]1332906
D013936ThymidineTetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in decreased uptake of Thymidine]1332906
C009495titanium dioxidetitanium dioxide results in decreased expression of IGF1 mRNA23565150
C009495titanium dioxidetitanium dioxide results in decreased expression of IGF1 protein23565150
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of IGF1 mRNA24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of IGF1 mRNA20133372
C052342topiramatetopiramate results in decreased expression of IGF1 mRNA16979414
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of IGF1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of IGF1 mRNA25729387
D014212TretinoinTretinoin inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]16565789
D014212TretinoinTretinoin inhibits the reaction [IGF1 protein results in increased phosphorylation of RB1 protein]16565789
D014212TretinoinTretinoin metabolite results in increased expression of IGF1 mRNA15982314
D014212TretinoinTretinoin results in increased expression of IGF1 mRNA15982314
D014212TretinoinTretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IGF1 mRNA]16448778
D014212TretinoinTretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IGF1 protein]16448778
C072782tri-(2-chloroisopropyl)phosphatetri-(2-chloroisopropyl)phosphate results in decreased expression of IGF1 mRNA22268003
C011559tributyltintributyltin results in decreased expression of IGF1 mRNA16318860
C012589trichostatin Atrichostatin A results in increased expression of IGF1 mRNA23463510
C009954trilostaneFGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone]22798350
C009954trilostane[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone22798350
C046488trimethyltintrimethyltin results in increased expression of IGF1 mRNA21435392
D014302Trinitrobenzenesulfonic Acid6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 protein]20889569
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTACR1 gene mutant form inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 protein]20889569
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of IGF1 mRNA18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of IGF1 protein20889569
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of IGF1 protein24782617
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of IGF1 mRNA25350880|2689491
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of IGF1 mRNA"26512412|2764616
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of IGF1 mRNA"22268003|2524241
C016805tris(1,3-dichloro-2-propyl)phosphate"[Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] results in decreased expression of IGF1 mRNA"26709203
C541743tris(2,3-dibromopropyl)isocyanurate"tris(2,3-dibromopropyl)isocyanurate results in decreased expression of IGF1 mRNA"24273086
D014317Tritolyl PhosphatesTritolyl Phosphates results in decreased expression of IGF1 mRNA24273086
C057693troglitazonetroglitazone results in increased expression of IGF121937740
D014415TunicamycinTunicamycin inhibits the reaction [IGF1 protein results in increased N-linked glycosylation of IGFBP3 protein]15277511
C113580U 0126U 0126 inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]16499871
C113580U 0126U 0126 inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]16499871
C113580U 0126U 0126 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]16499871
C113580U 0126[wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]16499871
C113580U 0126U 0126 results in decreased susceptibility to IGF1 protein24782617
C113580U 0126[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]25597859
C113580U 0126Sirolimus inhibits the reaction [[IGF1 protein co-treated with U 0126] promotes the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]25597859
C113580U 0126U 0126 inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]25597859
C113580U 0126U 0126 inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]19105244
C113580U 0126U 0126 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]18388193
C113580U 0126U 0126 inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]18388193
C113580U 0126U 0126 inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]18388193
C022884undecaneundecane results in increased expression of IGF1 protein17337753
D014520UrethaneFreund's Adjuvant promotes the reaction [Urethane results in increased expression of IGF1 mRNA]12810352
D014520UrethaneIFNG protein promotes the reaction [Urethane results in increased expression of IGF1 mRNA]12810352
D014520Urethane[Urethane co-treated with Freund's Adjuvant] results in increased expression of IGF1 mRNA12400877
D014635Valproic AcidValproic Acid inhibits the reaction [IGF1 protein results in increased abundance of Estradiol]23152920
D014635Valproic AcidValproic Acid affects the expression of IGF1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of IGF1 mRNA23179753|2915479
D014635Valproic AcidValproic Acid results in decreased methylation of IGF1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of IGF1 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of IGF1 mRNA24896083
D014635Valproic AcidValproic Acid results in increased expression of IGF1 mRNA17381134
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IGF1 gene25560391
C025643vinclozolinvinclozolin affects the expression of IGF1 mRNA19015723
D014750VincristineVincristine promotes the reaction [NVP ADW742 inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]]16740780
D014750VincristineIGF1 protein results in decreased susceptibility to Vincristine9452187
C029297vinylidene chloridevinylidene chloride results in increased expression of IGF1 mRNA26682919
C009687wortmannin[wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]16499871
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]17520698
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]16499871
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]16499871
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein]14745455
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]12569580
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein]20733350
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]16499871|1668245
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]12569580
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]16499871
C009687wortmanninwortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]19657059
C009687wortmanninwortmannin results in decreased susceptibility to IGF1 protein18398872
D015032ZincZinc deficiency results in increased expression of IGF1 mRNA18356318
D015032ZincZinc promotes the reaction [IGF1 protein binds to IGF1R protein]9648927
D015032ZincIGF1 protein results in increased import of Zinc16443356
D015032Zinc[Zinc binds to calcium silicate] which results in increased expression of IGF1 mRNA23483914
D015032ZincZinc deficiency results in decreased expression of IGF1 mRNA10985758|2012868
D015032ZincZinc deficiency results in decreased expression of IGF1 protein21893222|7722689
D015032ZincZinc deficiency results in increased expression of IGF1 mRNA12672911|1599063
D015032ZincZinc deficiency results in increased expression of IGF1 protein20660286
D015032ZincZinc results in increased expression of IGF1 protein15387849
C074508zinc methioninezinc methionine results in increased expression of IGF1 mRNA15810991
D015034Zinc OxideZinc Oxide affects the expression of IGF1 mRNA28648595
D015034Zinc OxideZinc Oxide results in increased expression of IGF1 mRNA7899834
D019287Zinc SulfateZinc Sulfate results in decreased expression of IGF1 mRNA21167956
D019287Zinc SulfatePentetic Acid inhibits the reaction [Zinc Sulfate results in decreased expression of IGF1 mRNA]9685221
D019287Zinc SulfateZinc Sulfate affects the reaction [GH protein results in increased expression of IGF1 mRNA]9685221
D019287Zinc SulfateZinc Sulfate results in decreased expression of IGF1 mRNA9685221
C088658zoledronic acid[zoledronic acid co-treated with fluvastatin] results in increased expression of IGF1 mRNA16996129
D015054ZymosanNOS2 protein affects the reaction [Zymosan inhibits the reaction [IGF1 protein results in increased metabolism of Proteoglycans]]16646036
D015054ZymosanZymosan inhibits the reaction [IGF1 protein results in increased metabolism of Proteoglycans]16646036

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005158insulin receptor binding-IPI8452530  
GO:0005159insulin-like growth factor receptor binding-IDA19578119  
GO:0005159insulin-like growth factor receptor binding-IMP1847964  2967174  
GO:0005159insulin-like growth factor receptor binding-IPI8452530  
GO:0005178integrin binding-IDA19578119  22351760  
GO:0005179hormone activity-IDA7188854  
GO:0005515protein binding-IPI8452530  10766744  15642270  16924115  21645859  22578544  
26027733  
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IMP22351760  
GO:0001501skeletal system development-TAS10448861  
GO:0001775cell activation-IDA22797923  
GO:0002576platelet degranulation-TAS-  
GO:0007165signal transduction-TAS10448861  
GO:0007265Ras protein signal transduction-TAS10848592  
GO:0007517muscle organ development-TAS10448861  
GO:0008283cell proliferation-IMP1847964  9714146  
GO:0008284positive regulation of cell proliferation-IDA7688386  9722506  12746903  
GO:0008284positive regulation of cell proliferation-IMP19578119  
GO:0009408response to heat-IDA11404306  
GO:0009441glycolate metabolic process-TAS10448861  
GO:0010468regulation of gene expression-IMP21543511  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010560positive regulation of glycoprotein biosynthetic process-IMP9564845  
GO:0010613positive regulation of cardiac muscle hypertrophy-IDA19654000  
GO:0010613positive regulation of cardiac muscle hypertrophy-IMP19933931  
GO:0010628positive regulation of gene expression-IGI22635104  
GO:0010629negative regulation of gene expression-IDA29167509  
GO:0014065phosphatidylinositol 3-kinase signaling-IMP24508636  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IDA7688386  
GO:0014834skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration-IDA17531227  
GO:0014896muscle hypertrophy-IMP10191278  
GO:0014904myotube cell development-IDA17531227  
GO:0014911positive regulation of smooth muscle cell migration-IDA10766744  
GO:0030166proteoglycan biosynthetic process-IDA12746903  
GO:0030166proteoglycan biosynthetic process-IMP9564845  
GO:0030335positive regulation of cell migration-IMP24508636  
GO:0032148activation of protein kinase B activity-IMP22351760  
GO:0033160positive regulation of protein import into nucleus, translocation-IDA19654000  
GO:0034392negative regulation of smooth muscle cell apoptotic process-IDA16942485  
GO:0035630bone mineralization involved in bone maturation-IDA16433617  
GO:0040014regulation of multicellular organism growth-IEP8421089  
GO:0042104positive regulation of activated T cell proliferation-IDA15694994  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IDA9722506  
GO:0043066negative regulation of apoptotic process-IMP11949853  
GO:0043388positive regulation of DNA binding-IDA19654000  
GO:0043410positive regulation of MAPK cascade-IDA19654000  
GO:0043491protein kinase B signaling-IMP24508636  
GO:0043568positive regulation of insulin-like growth factor receptor signaling pathway-IDA7688386  10766744  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045445myoblast differentiation-IDA17531227  
GO:0045669positive regulation of osteoblast differentiation-IDA16433617  
GO:0045725positive regulation of glycogen biosynthetic process-IDA21076856  
GO:0045821positive regulation of glycolytic process-IDA7688386  
GO:0045840positive regulation of mitotic nuclear division-IDA7188854  10644978  
GO:0045893positive regulation of transcription, DNA-templated-IDA9722506  19654000  
GO:0045893positive regulation of transcription, DNA-templated-IMP15059951  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16433617  
GO:0046326positive regulation of glucose import-IDA21076856  
GO:0046579positive regulation of Ras protein signal transduction-IDA9722506  
GO:0048009insulin-like growth factor receptor signaling pathway-IMP19578119  22351760  
GO:0048015phosphatidylinositol-mediated signaling-IDA7692086  
GO:0048146positive regulation of fibroblast proliferation-IDA7188854  
GO:0048661positive regulation of smooth muscle cell proliferation-IDA10766744  16942485  
GO:0050679positive regulation of epithelial cell proliferation-IDA7188854  
GO:0050714positive regulation of protein secretion-IMP9564845  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA7782332  22635104  
GO:0050821protein stabilization-IMP9564845  
GO:0051450myoblast proliferation-IDA17531227  
GO:0060283negative regulation of oocyte development-IMP21543511  
GO:0061051positive regulation of cell growth involved in cardiac muscle cell development-IDA24117217  
GO:0061051positive regulation of cell growth involved in cardiac muscle cell development-IGI24117217  
GO:0070371ERK1 and ERK2 cascade-IMP24508636  
GO:0070886positive regulation of calcineurin-NFAT signaling cascade-IDA19654000  
GO:0090201negative regulation of release of cytochrome c from mitochondria-ISS-  
GO:1904075positive regulation of trophectodermal cell proliferation-IMP24508636  
GO:1904646cellular response to amyloid-beta-IGI22635104  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IMP26166810  
GO:1905460negative regulation of vascular associated smooth muscle cell apoptotic process-IMP26166810  
GO:2000679positive regulation of transcription regulatory region DNA binding-IDA15059951  
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IDA16942485  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA7188854  11404306  17119061  25152160  
GO:0016942insulin-like growth factor binding protein complex-IC10766744  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0035867alphav-beta3 integrin-IGF-1-IGF1R complex-IDA19578119  
GO:0042567insulin-like growth factor ternary complex-IDA9497324  
GO:0070382exocytic vesicle-ISS-  
KEGG ID KEGG Term
hsa04114Oocyte meiosis
hsa04115p53 signaling pathway
hsa04150mTOR signaling pathway
hsa04510Focal adhesion
hsa04730Long-term depression
hsa04914Progesterone-mediated oocyte maturation
hsa04960Aldosterone-regulated sodium reabsorption
hsa05200Pathways in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-162582Signal TransductionTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-2428933SHC-related events triggered by IGF1RTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-422085Synthesis, secretion, and deacylation of GhrelinTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24005314Genetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1. (2013 Dec)Aberg NDEur J Endocrinol
21911369Cigarette smoking increases copy number alterations in nonsmall-cell lung cancer. (2011 Sep 27)Huang YTProc Natl Acad Sci U S A
22702433Pregnancy-associated plasma protein-A is related to gender and to adipocytokine levels: results of the Health Survey of Catalonia. (2013 May)Joaquin CClin Endocrinol (Oxf)
21854509Association between insulin-like growth factor-1 polymorphisms and stomach cancer risk in a Japanese population. (2011 Dec)Ennishi DCancer Sci
29713392Fetal growth is associated with the CpG methylation of the P2 promoter of the IGF1 gene. (2018)Le Stunff CClin Epigenetics
28415730A polymorphism at IGF1 locus is associated with anemia. (2017 May 16)Marini MAOncotarget
19019181Factors associated with elevated or blunted PTH response in vitamin D insufficient adults. (2009 Apr)Gunnarsson OJ Intern Med
29765129Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner. (2018 May 15)Dehmel SSci Rep
26346883Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. (2016 Aug)Peregud DICell Mol Neurobiol
19709092Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. (2009 Oct)Melnik BCExp Dermatol
18703768Plasma insulinlike growth factor 1 and binding-protein 3 and risk of myocardial infarction in women: a prospective study. (2008 Oct)Page JHClin Chem
19634593Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men. (2009 Jul)Hoyo CJ Natl Med Assoc
27041823Smoking Functions as a Negative Regulator of IGF1 and Impairs Adipokine Network in Patients with Rheumatoid Arthritis. (2016)Erlandsson MCMediators Inflamm
22113073Associations of IGF1 and its binding proteins with abdominal aortic aneurysm and aortic diameter in older men. (2012 Feb)Yeap BBEur J Endocrinol
29160127The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific. (2017)Meyer KFEpigenetics
22347413Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk. (2012)Lin IHPLoS One
26188228IGF1 deficiency in newly diagnosed Graves' disease patients. (2015 Oct-Dec)Martin SHormones (Athens)
28130259Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring. (2017 Apr 1)Meyer KFAm J Physiol Lung Cell Mol Physiol
23524620Elevated IGF1 in clinical opiate dependence. (2013)Reece ASNeuro Endocrinol Lett
21790896Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women. (2011 Nov)Yoshimoto NCancer Sci
27662841Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study. (2016 Nov)Adachi YTumour Biol
29699830Prevalence and risk factors for low bone mineral density in antiretroviral therapy-naive HIV-infected young men. (2018 Apr 23)Paccou JMed Mal Infect
24586095Polychlorinated dibenzo-p-dioxins, furans, and biphenyls (PCDDs/PCDFs and PCBs) in breast milk and early childhood growth and IGF1. (2014)Wohlfahrt-Veje CReproduction
20490824A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study. (2010 Sep)Kostek MCEur J Appl Physiol
25557790An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. (2015 May)Mahmoudi TTumour Biol
25552916A microsatellite polymorphism in IGF1 gene promoter and timing of natural menopause in Caucasian women. (2015)Kaczmarek MInt J Med Sci
18603571Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects. (2008 Oct)Colao AEur J Endocrinol
21932422Serum IGF1, IGF2 and IGFBP3 and risk of advanced colorectal adenoma. (2012 Jul 15)Gao YInt J Cancer