Gene info: ID 3481

Gene: IGF2

GENE ID: 3481

Synonyms: C11orf43|GRDF|IGF-II|PP9974

Description: insulin like growth factor 2

Gene type: protein-coding

Location: 11p15.5

dbXrefs: Ensembl:ENSG00000167244 MIM:147470 Vega:OTTHUMG00000009395 UniprotKB:P01344

RefSeq: NG_008849.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 26

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.895e-2 (AD) 4.039e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TBX18	0.749
ECM2	0.741
FOXC2	0.741
MYL9	0.72
NR2F2-AS1	0.72
PDE5A	0.713
NOTCH3	0.71
CASQ2	0.707
OLFML1	0.697
FRZB	0.695

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GPR150	-0.378
B9D2	-0.372
MARCH11	-0.372
CCDC175	-0.372
GNB1L	-0.361
CHST8	-0.352
MUM1L1	-0.35
FOXD4L6	-0.349
TUBA3D	-0.347
SIRT4	-0.342

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of IGF2 mRNA"	17690111
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IGF2 mRNA"	21394737
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]	24055520
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to IGF2 protein	24055520
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]]	23419388
C021296	2-ethoxyethanol	2-ethoxyethanol results in increased expression of IGF2 mRNA	19643169
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]	24055520
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased susceptibility to IGF2 protein	24055520
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of IGF2 mRNA"	18648102
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in decreased expression of IGF2 mRNA	15982314
C000595015	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of IGF2 mRNA"	28073004
C000601052	(6,7-dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl acetate	"(6,7-dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl acetate results in decreased expression of IGF2 mRNA"	25976766
C000601052	(6,7-dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl acetate	"(6,7-dimethoxyquinolin-4-yl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methyl acetate results in decreased expression of IGF2 protein"	25976766
D000082	Acetaminophen	Acetaminophen results in decreased expression of IGF2 mRNA	26690555
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of IGF2 mRNA	20036727
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of IGF2 protein	20036727
D000447	Aldehydes	Aldehydes results in increased expression of IGF2 mRNA	25014914
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]	29094188
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of IGF2 promoter]	29094188
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IGF2 mRNA]	29094188
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of IGF2 promoter]	29094188
C011512	alpha-naphthoflavone	alpha-naphthoflavone results in decreased acetylation of IGF2 promoter	29094188
C032311	aluminum fluoride	aluminum fluoride results in increased expression of IGF2 mRNA	11996908
C032311	aluminum fluoride	aluminum fluoride results in increased expression of IGF2 protein	11996908
C041524	aluminum sulfate	aluminum sulfate results in increased secretion of IGF2 mRNA	7685579
C041524	aluminum sulfate	aluminum sulfate results in increased secretion of IGF2 protein	7685579
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IGF2 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of IGF2 mRNA	24449571
C006632	arsenic trioxide	[arsenic trioxide co-treated with Curcumin] results in increased expression of IGF2 protein	27430728
C006632	arsenic trioxide	arsenic trioxide results in increased expression of IGF2 mRNA	25258189
C006632	arsenic trioxide	arsenic trioxide results in increased expression of IGF2 protein	27430728
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of IGF2 mRNA"	24160326
D001241	Aspirin	Aspirin results in decreased expression of IGF2 mRNA	9399670
D001280	Atrazine	Atrazine results in decreased expression of IGF2 mRNA	27413107
C547126	AZM551248	AZM551248 results in decreased expression of IGF2 mRNA	22323515
D001562	Benzimidazoles	Benzimidazoles inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]	24055520
D001562	Benzimidazoles	Benzimidazoles results in decreased susceptibility to IGF2 protein	24055520
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of IGF2 mRNA	17690111
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of IGF2 mRNA"	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of IGF2 mRNA	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IGF2 mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IGF2 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IGF2 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IGF2 mRNA	22342234
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IGF2 mRNA	21839799
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IGF2 mRNA"	20382639
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]	24055520
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IGF2 protein results in increased expression of STS protein]	24055520
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased susceptibility to IGF2 protein	24055520
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IGF2 mRNA	19619570
D004958	Estradiol	Estradiol promotes the reaction [resveratrol results in decreased secretion of IGF2 protein]	16037384
D004958	Estradiol	Estradiol results in increased expression of IGF2 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of IGF2 protein	18191855
D004958	Estradiol	Estradiol results in increased secretion of IGF2 protein	16037384
D004958	Estradiol	IGF2 protein results in increased chemical synthesis of Estradiol	24055520
D004958	Estradiol	resveratrol inhibits the reaction [Estradiol results in increased secretion of IGF2 protein]	16037384
D004958	Estradiol	Tamoxifen inhibits the reaction [Estradiol results in increased secretion of IGF2 protein]	16037384
D004958	Estradiol	Estradiol results in decreased expression of IGF2 mRNA	21703268
C095105	bexarotene	bexarotene results in increased expression of IGF2 mRNA	16648578
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of IGF2 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of IGF2 mRNA	27685785
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IGF2 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the methylation of IGF2 promoter	23593014
C006780	bisphenol A	bisphenol A results in decreased methylation of IGF2 promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of IGF2 mRNA	23593014\|2580704
C006780	bisphenol A	bisphenol A results in increased methylation of IGF2 gene	25807043
C006780	bisphenol A	bisphenol A results in decreased expression of IGF2 mRNA	20505776
C006780	bisphenol A	bisphenol A affects the expression of IGF2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of IGF2 mRNA	23653003
D000069286	Bortezomib	Bortezomib inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]	24055520
D000069286	Bortezomib	Bortezomib inhibits the reaction [IGF2 protein results in increased expression of STS protein]	24055520
D000069286	Bortezomib	Bortezomib results in decreased susceptibility to IGF2 protein	24055520
D019819	Budesonide	Budesonide inhibits the reaction [vinyl carbamate results in decreased methylation of IGF2 protein]	15824018
C018475	butyraldehyde	butyraldehyde results in increased expression of IGF2 mRNA	26079696
D002104	Cadmium	Cadmium promotes the reaction [IGF2 protein binds to IGF1R protein]	9648927
D002104	Cadmium	Cadmium results in decreased expression of IGF2 mRNA	24067728
D002110	Caffeine	Caffeine results in decreased expression of IGF2 mRNA	26179615
D002118	Calcium	Cobalt inhibits the reaction [IGF2 protein results in increased import of Calcium]	2442157\|2539779
D002118	Calcium	[IGF2 protein co-treated with EGF protein] results in increased import of Calcium	2442157
D002118	Calcium	IGF2 protein results in increased import of Calcium	2442157\|2460452\|
D002118	Calcium	Lanthanum inhibits the reaction [IGF2 protein results in increased import of Calcium]	2442157
D002118	Calcium	Pertussis Toxin inhibits the reaction [IGF2 protein results in increased import of Calcium]	2442157
D002118	Calcium	tetramethrin inhibits the reaction [IGF2 protein results in increased import of Calcium]	2442157\|2539779
D002211	Capsaicin	Capsaicin results in increased expression of IGF2 mRNA	20349343
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IGF2 mRNA	11566570
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IGF2 mRNA	17032414
C010063	carbonyl sulfide	carbonyl sulfide results in decreased expression of IGF2 mRNA	19395590
D002330	Carmustine	IGF2 mRNA affects the susceptibility to Carmustine	16365179
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGF2 mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IGF2 gene	20938992
D002794	Choline	Choline results in increased expression of IGF2 mRNA	17264169
D002794	Choline	Choline results in increased expression of IGF2 protein	17264169
D002857	Chromium	Chromium deficiency results in decreased expression of IGF2 protein	9868179
D002994	Clofibrate	Clofibrate results in decreased expression of IGF2 mRNA	16081524
D003035	Cobalt	Cobalt inhibits the reaction [IGF2 protein results in increased import of Calcium]	2442157\|2539779
C018021	cobaltous chloride	cobaltous chloride results in increased expression of IGF2 mRNA	25100165
C018021	cobaltous chloride	HIF1A mutant form inhibits the reaction [cobaltous chloride results in increased expression of IGF2 mRNA]	25100165
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of IGF2 mRNA	21167956
D003042	Cocaine	Cocaine results in decreased expression of IGF2 mRNA	16076954
D003345	Corticosterone	IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein]	24667322
D003345	Corticosterone	[IGF2R protein co-treated with IGF1R protein] affects the reaction [IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein]]	24667322
C030973	cupric oxide	cupric oxide results in increased expression of IGF2 mRNA	22077320
D003471	Cuprizone	Cuprizone results in increased expression of IGF2 mRNA	26577399
D003474	Curcumin	[arsenic trioxide co-treated with Curcumin] results in increased expression of IGF2 protein	27430728
D003474	Curcumin	Curcumin analog results in decreased expression of IGF2 mRNA	26409325
C028972	dan-shen root extract	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]]	23419388
C028972	dan-shen root extract	dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in decreased expression of BAD protein modified form]	23419388
C028972	dan-shen root extract	dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased activity of IGF2R protein]	23419388
C028972	dan-shen root extract	dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]	23419388
C028972	dan-shen root extract	dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of BAD protein]	23419388
C028972	dan-shen root extract	dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of BCL2L1 protein]	23419388
C028972	dan-shen root extract	dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of CYCS protein]	23419388
C028972	dan-shen root extract	dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]	23419388
C028972	dan-shen root extract	dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of IGF2R protein]	23419388
C028972	dan-shen root extract	dan-shen root extract results in decreased susceptibility to IGF2 protein mutant form	23419388
C028972	dan-shen root extract	fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in decreased expression of BAD protein modified form]]	23419388
C028972	dan-shen root extract	fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]]	23419388
C028972	dan-shen root extract	fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of BCL2L1 protein]]	23419388
C028972	dan-shen root extract	fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]]	23419388
C028972	dan-shen root extract	fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of IGF2R protein]]	23419388
C028972	dan-shen root extract	fulvestrant inhibits the reaction [dan-shen root extract results in decreased susceptibility to IGF2 protein mutant form]	23419388
D003620	Dantrolene	Dantrolene results in decreased susceptibility to IGF2 protein	16485066
D000069439	Dasatinib	Dasatinib results in increased expression of IGF2 mRNA	20579391
D003634	DDT	DDT results in decreased expression of IGF2 mRNA	19797855
C017180	decamethrin	decamethrin results in decreased expression of IGF2 mRNA	20647053
C014347	decitabine	decitabine inhibits the reaction [tobacco tar results in decreased expression of IGF2 mRNA]	19559774
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of IGF2 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IGF2 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGF2 mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in increased expression of IGF2 mRNA	22733784
D003907	Dexamethasone	Dexamethasone inhibits the reaction [nitrofen results in increased expression of IGF2 mRNA]	10370016
D003907	Dexamethasone	Dexamethasone inhibits the reaction [nitrofen results in increased expression of IGF2 protein]	10370016
D003976	Diazinon	Diazinon affects the expression of IGF2 mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of IGF2 mRNA	15829613\|2126653
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of IGF2 mRNA	28962523
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased methylation of IGF2 gene	15036762
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of IGF2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of IGF2 mRNA	27392435
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased expression of IGF2 mRNA	28867213
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in decreased methylation of IGF2 gene	25187598\|2886721
C000944	dicrotophos	dicrotophos results in increased expression of IGF2 mRNA	28302478
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of IGF2 mRNA	22610992
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of IGF2 mRNA	12127304
D004052	Diethylnitrosamine	Diethylnitrosamine affects the expression of IGF2 mRNA	20387270
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of IGF2 mRNA	19542621
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of IGF2 protein	12532445
D004054	Diethylstilbestrol	[Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of IGF2 mRNA	19665456
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of IGF2 mRNA	21658437
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of IGF2 mRNA"	19480007
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of IGF2 mRNA	17032414
D004533	Egtazic Acid	Egtazic Acid results in decreased susceptibility to IGF2 protein	16485066
C070609	EMD 53998	EMD 53998 analog results in increased expression of IGF2 mRNA	24977338
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of IGF2 mRNA	20346928
C010452	estradiol-17 beta-benzoate	estradiol-17 beta-benzoate affects the expression of IGF2 mRNA	15059950
D004967	Estrogens	Estrogens results in increased expression of IGF2 mRNA	14669216
D004967	Estrogens	Tetrachlorodibenzodioxin inhibits the reaction [Estrogens results in increased expression of IGF2 mRNA]	14669216
D004970	Estrone	IGF2 protein results in increased chemical synthesis of Estrone	24055520
D000431	Ethanol	Ethanol affects the expression of IGF2 mRNA	11772933
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of IGF2 mRNA	16872691
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of IGF2 protein	15817916
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of IGF2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of IGF2 mRNA	15576828\|1583489
C017690	fenvalerate	fenvalerate results in decreased expression of IGF2 mRNA	28369636
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of IGF2 mRNA	22213190
C053629	fluoroaluminum	fluoroaluminum results in increased expression of IGF2 mRNA	11996908
C053629	fluoroaluminum	fluoroaluminum results in increased expression of IGF2 protein	11996908
D005473	Fluoxetine	Fluoxetine results in decreased expression of IGF2 mRNA	17033635
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGF2 mRNA	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IGF2 gene	20938992
D004397	Fonofos	Fonofos results in increased methylation of IGF2 promoter	22847954
D005620	Freund's Adjuvant	Freund's Adjuvant inhibits the reaction [Urethane affects the expression of IGF2 mRNA]	12810352
D005620	Freund's Adjuvant	[Urethane co-treated with Freund's Adjuvant] results in increased expression of IGF2 mRNA	12400877
C070081	fulvestrant	fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in decreased expression of BAD protein modified form]]	23419388
C070081	fulvestrant	fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]]	23419388
C070081	fulvestrant	fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of BCL2L1 protein]]	23419388
C070081	fulvestrant	fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]]	23419388
C070081	fulvestrant	fulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of IGF2R protein]]	23419388
C070081	fulvestrant	fulvestrant inhibits the reaction [dan-shen root extract results in decreased susceptibility to IGF2 protein mutant form]	23419388
C039281	furan	furan results in decreased expression of IGF2 mRNA	25539665
D019833	Genistein	Genistein results in decreased expression of IGF2 mRNA	21048042
D006046	Gold	Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]	9648927
C070163	homobrassinolide	homobrassinolide results in increased expression of IGF2 mRNA	21491949
D017313	Fenretinide	Fenretinide results in decreased expression of IGF2 mRNA	28973697
D006854	Hydrocortisone	IFNB1 protein inhibits the reaction [IGF2 protein results in increased secretion of Hydrocortisone]	23507702
D006854	Hydrocortisone	IGF2 protein results in increased secretion of Hydrocortisone	23507702
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [CTCF protein binds to and results in decreased methylation of and results in decreased expression of IGF2 gene]	24558376
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased methylation of and results in increased expression of IGF2 gene	24558376
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of IGF2 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IGF2 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGF2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of IGF2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IGF2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGF2 mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of IGF2 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of IGF2 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of IGF2 mRNA	26644586
C410337	K 7174	K 7174 results in decreased expression of IGF2 mRNA	24086573
D007811	Lanthanum	Lanthanum inhibits the reaction [IGF2 protein results in increased import of Calcium]	2442157
D007854	Lead	Lead results in decreased methylation of IGF2 gene	26115033
C008261	lead acetate	lead acetate results in decreased expression of IGF2 mRNA	25596546
C008261	lead acetate	lead acetate results in decreased methylation of IGF2 gene	25596546
C008261	lead acetate	lead acetate results in decreased expression of IGF2 protein	24200854
C008261	lead acetate	lead acetate affects the expression of IGF2 mRNA	21864555
C017461	lead nitrate	lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]	11891201
C017461	lead nitrate	lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]	11891201
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of IGF2 mRNA	12057914
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IGF2 mRNA	16448778
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IGF2 protein	16448778
D008070	Lipopolysaccharides	Tretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IGF2 mRNA]	16448778
D008070	Lipopolysaccharides	Tretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IGF2 protein]	16448778
C025340	manganese chloride	manganese chloride results in decreased methylation of IGF2 gene	27913844
D008687	Metformin	[Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA	21664031
D008687	Metformin	[Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA	21664031
D008687	Metformin	[Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA	21664031
D008687	Metformin	[Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein	21664031
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGF2 mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IGF2 gene	20938992
C005219	methyl cellosolve	methyl cellosolve results in increased expression of IGF2 mRNA	19643169
D008748	Methylcholanthrene	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]	29094188
D008748	Methylcholanthrene	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of IGF2 promoter]	29094188
D008748	Methylcholanthrene	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IGF2 mRNA]	29094188
D008748	Methylcholanthrene	alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of IGF2 promoter]	29094188
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]	29094188
D008748	Methylcholanthrene	Methylcholanthrene results in increased acetylation of IGF2 promoter	29094188
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of IGF2 mRNA	29094188
D008748	Methylcholanthrene	Methylcholanthrene results in increased methylation of IGF2 promoter	29094188
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IGF2 mRNA"	20188158
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of IGF2 mRNA"	23634900
D009532	Nickel	Nickel results in decreased susceptibility to IGF2 protein	16485066
C022838	nickel chloride	nickel chloride affects the expression of IGF2 mRNA	22546817
C017557	nickel subsulfide	nickel subsulfide results in increased expression of IGF2 mRNA	21086188
D009543	Nifedipine	Nifedipine results in decreased susceptibility to IGF2 protein	16485066
C007350	nitrofen	Dexamethasone inhibits the reaction [nitrofen results in increased expression of IGF2 mRNA]	10370016
C007350	nitrofen	Dexamethasone inhibits the reaction [nitrofen results in increased expression of IGF2 protein]	10370016
C007350	nitrofen	nitrofen results in decreased expression of IGF2 protein	24352370
C007350	nitrofen	nitrofen results in increased expression of IGF2 mRNA	10370016
C007350	nitrofen	nitrofen results in increased expression of IGF2 protein	10370016
C007350	nitrofen	Tretinoin inhibits the reaction [nitrofen results in decreased expression of IGF2 protein]	24352370
C025589	ochratoxin A	ochratoxin A results in decreased expression of IGF2 mRNA	19287073
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of IGF2 mRNA	25729387
C029341	oxophenylarsine	oxophenylarsine results in decreased localization of IGF2 protein	9145794
D010100	Oxygen	Oxygen deficiency results in increased expression of IGF2 mRNA	20862257
D019308	Palmitic Acid	Palmitic Acid results in increased expression of IGF2 mRNA	17658692
C496932	panobinostat	panobinostat results in increased expression of IGF2 mRNA	26272509
D010269	Paraquat	Paraquat results in increased expression of IGF2 mRNA	21371552
D010278	Parathion	Parathion results in increased methylation of IGF2 promoter	22847954
C046012	pentanal	pentanal results in increased expression of IGF2 mRNA	26079696
D010455	Peptides	Peptides inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]	24055520
D010455	Peptides	Peptides results in decreased susceptibility to IGF2 protein	24055520
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of IGF2 protein	26178269
D037342	Pertussis Toxin	Pertussis Toxin inhibits the reaction [IGF2 protein results in increased import of Calcium]	2442157
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of IGF2 mRNA	26272509
D010672	Phenytoin	Phenytoin results in increased expression of IGF2 mRNA	9988880
D059808	Polyphenols	Polyphenols results in decreased expression of IGF2 mRNA	16293270
C045362	prochloraz	prochloraz results in increased expression of IGF2 mRNA	20805220
D011374	Progesterone	Progesterone affects the localization of IGF2 protein	22085906
D011374	Progesterone	Progesterone results in increased expression of IGF2 mRNA	18497975
C045950	propiconazole	propiconazole results in increased expression of IGF2 mRNA	21278054
C005556	propionaldehyde	propionaldehyde results in increased expression of IGF2 mRNA	26079696
C573121	ProstaCaid	ProstaCaid results in decreased expression of IGF2 mRNA	21468543
D015237	Dinoprost	Dinoprost affects the expression of IGF2 mRNA	20484870
D015237	Dinoprost	Dinoprost results in decreased expression of IGF2 mRNA	20484870
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of IGF2 mRNA	27029645
D011794	Quercetin	Quercetin results in decreased expression of IGF2 mRNA	20658310
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of IGF2 mRNA	15576828
C059514	resveratrol	resveratrol results in increased expression of IGF2 mRNA	25866375
C059514	resveratrol	Estradiol promotes the reaction [resveratrol results in decreased secretion of IGF2 protein]	16037384
C059514	resveratrol	resveratrol affects the expression of IGF2 mRNA	16037384\|1639369
C059514	resveratrol	resveratrol inhibits the reaction [Estradiol results in increased secretion of IGF2 protein]	16037384
C059514	resveratrol	resveratrol results in decreased secretion of IGF2 protein	16037384
C059514	resveratrol	resveratrol results in increased expression of and results in increased secretion of IGF2 protein	16037384
C059514	resveratrol	resveratrol results in increased expression of IGF2 protein	16393696
C059514	resveratrol	[resveratrol results in increased expression of IGF2 protein] which results in increased secretion of CTSD protein	16393696
C059514	resveratrol	Tamoxifen inhibits the reaction [resveratrol results in increased secretion of IGF2 protein]	16037384
D012402	Rotenone	Rotenone results in decreased expression of IGF2 mRNA	27900601
C093642	SB 203580	SB 203580 inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]	24055520
C093642	SB 203580	SB 203580 results in decreased susceptibility to IGF2 protein	24055520
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of IGF2 mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of IGF2 mRNA	25895662
D020123	Sirolimus	Sirolimus results in decreased expression of IGF2 mRNA	20622751
D020123	Sirolimus	Sirolimus results in decreased expression of IGF2 protein	20622751
C017947	sodium arsenite	sodium arsenite results in increased expression of IGF2 mRNA	12016162
C017947	sodium arsenite	[Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of IGF2 mRNA	19665456
C017947	sodium arsenite	sodium arsenite affects the expression of IGF2 mRNA	16507464
C017947	sodium arsenite	sodium arsenite results in decreased expression of IGF2 mRNA	17451858
C017947	sodium arsenite	sodium arsenite results in increased expression of IGF2 mRNA	17077188
C017947	sodium arsenite	sodium arsenite results in decreased expression of IGF2 mRNA	16876216
C017947	sodium arsenite	sodium arsenite results in increased expression of IGF2 mRNA	11241755
D013629	Tamoxifen	Tamoxifen inhibits the reaction [Estradiol results in increased secretion of IGF2 protein]	16037384
D013629	Tamoxifen	Tamoxifen inhibits the reaction [resveratrol results in increased secretion of IGF2 protein]	16037384
D013629	Tamoxifen	Tamoxifen results in decreased secretion of IGF2 protein	16037384
D013629	Tamoxifen	Tamoxifen affects the expression of IGF2 mRNA	17555576
C047246	temozolomide	IGF2 mRNA affects the susceptibility to temozolomide	16365179
C012568	terbufos	terbufos results in increased methylation of IGF2 promoter	22847954
D013739	Testosterone	Testosterone results in decreased expression of IGF2 protein	15817916
D013739	Testosterone	Testosterone results in increased expression of IGF2 mRNA	21703268
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IGF2 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGF2 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGF2 mRNA	15056799
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IGF2 mRNA	21570461\|2728432
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGF2 mRNA	14960483
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased methylation of IGF2 gene	14960483
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the methylation of IGF2 gene	26455773
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estrogens results in increased expression of IGF2 mRNA]	14669216
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [CEBPB protein binds to IGF2 promoter]	21777668
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGF2 mRNA	26455773
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGF2 protein	26455773
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased methylation of IGF2 gene	17407073
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGF2 mRNA	17407073\|2177766
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGF2 protein	17407073\|2177766
C009424	tetramethrin	tetramethrin inhibits the reaction [IGF2 protein results in increased import of Calcium]	2442157\|2539779
D013853	Thioacetamide	Thioacetamide results in increased expression of IGF2 mRNA	17997003
C402769	tipifarnib	tipifarnib results in increased expression of IGF2 mRNA	16403772
C024746	tobacco tar	decitabine inhibits the reaction [tobacco tar results in decreased expression of IGF2 mRNA]	19559774
C024746	tobacco tar	tobacco tar results in decreased expression of IGF2 mRNA	19559774
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of IGF2 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of IGF2 mRNA"	19682533
D014212	Tretinoin	Tretinoin metabolite results in increased expression of IGF2 mRNA	15982314
D014212	Tretinoin	Tretinoin promotes the reaction [IGF2R binds to and results in increased secretion of IGF2 protein modified form]	16680587
D014212	Tretinoin	Tretinoin results in decreased activity of IGF2 protein	16680587
D014212	Tretinoin	Tretinoin results in decreased expression of IGF2 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of IGF2 mRNA	16604517
D014212	Tretinoin	Tretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IGF2 mRNA]	16448778
D014212	Tretinoin	Tretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IGF2 protein]	16448778
D014212	Tretinoin	Tretinoin inhibits the reaction [nitrofen results in decreased expression of IGF2 protein]	24352370
D014212	Tretinoin	Tretinoin results in increased expression of IGF2 mRNA	24977338
D014238	Trichloroacetic Acid	Trichloroacetic Acid results in decreased methylation of IGF2 gene	15036762
C012589	trichostatin A	trichostatin A results in increased expression of IGF2 mRNA	24935251\|2627250
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of IGF2 mRNA	19042947
D014520	Urethane	Freund's Adjuvant inhibits the reaction [Urethane affects the expression of IGF2 mRNA]	12810352
D014520	Urethane	IFNG protein promotes the reaction [Urethane results in increased expression of IGF2 mRNA]	12810352
D014520	Urethane	[Urethane co-treated with Freund's Adjuvant] results in increased expression of IGF2 mRNA	12400877
D014635	Valproic Acid	Valproic Acid results in increased expression of IGF2 mRNA	24935251\|2627250
D014635	Valproic Acid	Valproic Acid results in increased expression of IGF2 mRNA	24896083
C025643	vinclozolin	vinclozolin affects the expression of IGF2 mRNA	19015723
C017963	vinyl carbamate	Budesonide inhibits the reaction [vinyl carbamate results in decreased methylation of IGF2 protein]	15824018
C017963	vinyl carbamate	vinyl carbamate results in decreased expression of IGF2 mRNA	17849452
C017963	vinyl carbamate	vinyl carbamate results in decreased methylation of IGF2 protein	15824018
D002762	Cholecalciferol	Cholecalciferol results in increased expression of IGF2 mRNA	17170073
C111237	vorinostat	vorinostat results in increased expression of IGF2 mRNA	26272509
C009687	wortmannin	wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]	24055520
C009687	wortmannin	wortmannin results in decreased susceptibility to IGF2 protein	24055520
D015032	Zinc	Zinc promotes the reaction [IGF2 protein binds to IGF1R protein]	9648927
D015034	Zinc Oxide	Zinc Oxide affects the expression of IGF2 mRNA	28648595
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of IGF2 mRNA	21167956

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005158	insulin receptor binding	-	IPI	12138094
GO:0005159	insulin-like growth factor receptor binding	-	IMP	2967174
GO:0005178	integrin binding	-	IDA	28873464
GO:0005179	hormone activity	-	IEA	-
GO:0005515	protein binding	-	IPI	10611375 18046459 25416956
GO:0008083	growth factor activity	-	IDA	11500939
GO:0043539	protein serine/threonine kinase activator activity	-	ISS	-
GO:0048018	receptor ligand activity	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0001501	skeletal system development	-	TAS	8298652
GO:0001649	osteoblast differentiation	-	IEA	-
GO:0001701	in utero embryonic development	-	ISS	-
GO:0001892	embryonic placenta development	-	ISS	-
GO:0001934	positive regulation of protein phosphorylation	-	ISS	-
GO:0002576	platelet degranulation	-	TAS	-
GO:0006006	glucose metabolic process	-	IEA	-
GO:0006349	regulation of gene expression by genetic imprinting	-	TAS	8968759
GO:0006355	regulation of transcription, DNA-templated	-	NAS	12881524
GO:0007275	multicellular organism development	-	TAS	6382022
GO:0008284	positive regulation of cell proliferation	-	IC	11500939
GO:0008284	positive regulation of cell proliferation	-	IDA	28873464
GO:0008286	insulin receptor signaling pathway	-	TAS	1845984
GO:0009887	animal organ morphogenesis	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0031017	exocrine pancreas development	-	IEA	-
GO:0031056	regulation of histone modification	-	ISS	-
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase	-	ISS	-
GO:0040018	positive regulation of multicellular organism growth	-	IEA	-
GO:0042104	positive regulation of activated T cell proliferation	-	IDA	15694994
GO:0043085	positive regulation of catalytic activity	-	ISS	-
GO:0043410	positive regulation of MAPK cascade	-	IDA	11500939
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0045725	positive regulation of glycogen biosynthetic process	-	ISS	-
GO:0045840	positive regulation of mitotic nuclear division	-	IDA	11500939
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0046628	positive regulation of insulin receptor signaling pathway	-	IDA	11500939
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	-	ISS	-
GO:0051146	striated muscle cell differentiation	-	IEA	-
GO:0051147	regulation of muscle cell differentiation	-	ISS	-
GO:0051781	positive regulation of cell division	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	IDA	11500939
GO:0060669	embryonic placenta morphogenesis	-	ISS	-
GO:0071902	positive regulation of protein serine/threonine kinase activity	-	IEA	-
GO:2000467	positive regulation of glycogen (starch) synthase activity	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IEA	-
GO:0031093	platelet alpha granule lumen	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114608	Platelet degranulation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-2428933	SHC-related events triggered by IGF1R	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16344718	A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys. (2006 Jan)	Rodriguez S	Pharmacogenet Genomics
23917818	Association of maternal and nutrient supply line factors with DNA methylation at the imprinted IGF2/H19 locus in multiple tissues of newborn twins. (2013 Oct)	Loke YJ	Epigenetics
17044860	Refined association mapping for a quantitative trait: weight in the H19-IGF2-INS-TH region. (2006 Nov)	Zhang W	Ann Hum Genet
22479380	Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. (2012)	McKay JA	PLoS One
27023171	The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood. (2016 Mar 29)	Mansell T	Transl Psychiatry
23724145	Long-term exposure to cigarette smoke extract induces hypomethylation at the RUNX3 and IGF2-H19 loci in immortalized human urothelial cells. (2013)	Chen LM	PLoS One
15057734	Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition. (2004 Apr)	Cruz-Correa M	Gastroenterology
28018293	Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants. (2016)	Piyasena C	Front Endocrinol (Lausanne)
22447362	Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk. (2012 Dec 1)	Yuasa Y	Int J Cancer
23539450	Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas. (2013 May 1)	Burnett-Hartman AN	Cancer Res
21245875	Relationship of folate, vitamin B12 and methylation of insulin-like growth factor-II in maternal and cord blood. (2011 Apr)	Ba Y	Eur J Clin Nutr
22347413	Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk. (2012)	Lin IH	PLoS One
22202639	Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. (2012 Feb 15)	Murphy SK	Gene
22414206	The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring. (2011 Oct 26)	Soubry A	Clin Epigenetics
23609933	Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. (2013 Jul)	Vidal AC	Int J Obes (Lond)
25480659	DNA methylation alterations in response to prenatal exposure of maternal cigarette smoking: A persistent epigenetic impact on health from maternal lifestyle? (2016 Feb)	Nielsen CH	Arch Toxicol
22341586	Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children. (2012 Jul)	Perkins E	J Pediatr
25630355	In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver. (2015 Jan 29)	Drake AJ	BMC Med
25199973	Indoor air pollution from solid fuels and peripheral blood DNA methylation: findings from a population study in Warsaw, Poland. (2014 Oct)	Tao MH	Environ Res
24451080	Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients. (2013)	Szymanowska-Narloch A	Adv Med Sci
22392079	Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight. (2012 Apr)	Hoyo C	Cancer Causes Control
22677950	Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. (2012 Jul)	Liu Y	Epigenetics
25102259	Periconception maternal smoking and low education are associated with methylation of INSIGF in children at the age of 17 months. (2012 Oct)	Obermann-Borst SA	J Dev Orig Health Dis
27708216	Smoking-associated lung cancer prevention by blockade of the beta-adrenergic receptor-mediated insulin-like growth factor receptor activation. (2016 Oct 25)	Min HY	Oncotarget
21932422	Serum IGF1, IGF2 and IGFBP3 and risk of advanced colorectal adenoma. (2012 Jul 15)	Gao Y	Int J Cancer
20930547	DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age. (2011 Feb)	Tobi EW	Epigenetics