Gene: IGF2R

3482
CD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRI
insulin like growth factor 2 receptor
protein-coding
6q25.3
Ensembl:ENSG00000197081 MIM:147280 Vega:OTTHUMG00000015945 UniprotKB:P11717
NG_011785.3
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.534e-1 (AD)  1.956e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12754982chr6:160409942IGF2R1.560e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDK120.864
NUP980.863
DCAF50.855
GNS0.838
CNOT10.836
BAZ2A0.835
ANKHD10.831
PHF80.829
DHX380.828
HPS30.827

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.47
OR4F29-0.447
HES5-0.261
KLRC2-0.242
NANOGNB-0.236
REN-0.226
RERGL-0.211
SOX3-0.21
DIAPH3-0.208
C20orf85-0.203

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01277MecaserminBiotechDrug68562-41-4Approved|InvestigationalTarget
DB02900alpha-D-mannose 6-phosphateSmall MoleculeExperimentalTarget
DB13173Cerliponase alfaBiotechDrug151662-36-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of IGF2R mRNA"19162173
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of IGF2R mRNA25596134
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IGF2R mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IGF2R mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGF2R mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of IGF2R mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGF2R mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of IGF2R mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of IGF2R mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IGF2R gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IGF2R mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IGF2R mRNA16483693
D001151ArsenicArsenic affects the expression of IGF2R mRNA28793237
D001151ArsenicIGF2R mRNA results in increased susceptibility to Arsenic17976673
C006632arsenic trioxidearsenic trioxide results in decreased expression of IGF2R protein25419056
C015001arsenitearsenite affects the expression of IGF2R mRNA22959463
D001241AspirinAspirin results in increased expression of IGF2R mRNA15928584
D001280AtrazineAtrazine results in decreased expression of IGF2R mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of IGF2R mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IGF2R mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IGF2R mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IGF2R mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of IGF2R mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of IGF2R mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of IGF2R mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of IGF2R gene22131059|2269988
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in decreased methylation of IGF2R gene]22131059
C006780bisphenol Abisphenol A results in decreased expression of IGF2R mRNA20505776
C006780bisphenol Abisphenol A affects the expression of IGF2R mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of IGF2R mRNA25607892
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of IGF2R mRNA26496021
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of IGF2R protein22174045
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of IGF2R mRNA17553608
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of IGF2R mRNA25607892
D002104CadmiumCadmium results in increased expression of IGF2R mRNA17327699
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of IGF2R mRNA19010381
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IGF2R mRNA17327699
D002220CarbamazepineCarbamazepine affects the expression of IGF2R mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IGF2R mRNA15963342
C004656chloroacetaldehydechloroacetaldehyde affects the expression of IGF2R mRNA25596134
D004390ChlorpyrifosChlorpyrifos results in decreased expression of IGF2R mRNA18668222
C059262cidofovircidofovir affects the expression of IGF2R mRNA25596134
C018021cobaltous chloridecobaltous chloride results in increased expression of IGF2R mRNA19320972
D003300Copper[Disulfiram binds to Copper] which results in increased expression of IGF2R mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of IGF2R mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of IGF2R mRNA19549813
D003345Corticosterone[IGF2R protein co-treated with IGF1R protein] affects the reaction [IGF2 protein inhibits the reaction [Corticosterone results in decreased expression of SOD2 protein]]24667322
D016572CyclosporineCyclosporine results in decreased expression of IGF2R mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of IGF2R mRNA20106945|2559613
C028972dan-shen root extractdan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased activity of IGF2R protein]23419388
C028972dan-shen root extractdan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of IGF2R protein]23419388
C028972dan-shen root extractfulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of IGF2R protein]]23419388
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of IGF2R mRNA]27941970
D016190CarboplatinCarboplatin results in decreased expression of IGF2R mRNA18172885
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IGF2R mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IGF2R mRNA25607892
C000944dicrotophosdicrotophos results in increased expression of IGF2R mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of IGF2R mRNA26924002
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate affects the expression of IGF2R mRNA21636974
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IGF2R mRNA25607892
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Gasoline] results in decreased expression of IGF2R protein8824503
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of IGF2R mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of IGF2R protein8824503
D004052DiethylnitrosamineEthinyl Estradiol inhibits the reaction [Diethylnitrosamine results in decreased expression of IGF2R protein]8824503
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of IGF2R mRNA18544905
D004052DiethylnitrosamineDiethylnitrosamine deficiency results in increased mutagenesis of IGF2R gene15057872
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of IGF2R mRNA19542621
D004052DiethylnitrosamineDiethylnitrosamine results in increased mutagenesis of IGF2R gene15057872
D0198131,2-Dimethylhydrazine"[NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of IGF2R mRNA"26388957
C024629dimethyl phthalatedimethyl phthalate results in increased expression of IGF2R mRNA26924002
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of IGF2R mRNA24690739
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of IGF2R mRNA12655031
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of IGF2R mRNA25607892
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of IGF2R protein23301498
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IGF2R mRNA25607892
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of IGF2R mRNA24412560
D004997Ethinyl EstradiolEthinyl Estradiol inhibits the reaction [Diethylnitrosamine results in decreased expression of IGF2R protein]8824503
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGF2R mRNA17942748
D011345FenofibrateFenofibrate results in decreased expression of IGF2R mRNA25596134
D018120FinasterideFinasteride results in increased expression of IGF2R mRNA24136188
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in increased methylation of IGF2R mRNA22959928
D005492Folic AcidFolic Acid results in increased methylation of IGF2R mRNA22959928
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in decreased methylation of IGF2R gene]22131059
C070081fulvestrantfulvestrant inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased expression of IGF2R protein]]23419388
D005742Gasoline[Diethylnitrosamine co-treated with Gasoline] results in decreased expression of IGF2R protein8824503
D019833GenisteinGenistein results in increased expression of IGF2R mRNA22228119
C071834glycidamideglycidamide results in increased expression of IGF2R mRNA17822822
D007052IbuprofenIbuprofen results in increased expression of IGF2R mRNA28201806
D007069IfosfamideIfosfamide results in increased expression of IGF2R mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IGF2R mRNA25613284
C410337K 7174K 7174 results in increased expression of IGF2R mRNA24086573
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of IGF2R mRNA18544905
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IGF2R mRNA25607892
C025340manganese chloridemanganese chloride results in decreased expression of IGF2R mRNA19276553
D008687Metformin[Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA21664031
D008687Metformin[Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA21664031
D008687Metformin[Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA21664031
D008687MetforminMetformin results in increased expression of IGF2R mRNA25596134
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of IGF2R mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of IGF2R mRNA12710931
C517284monomethyl phthalatemonomethyl phthalate affects the expression of IGF2R mRNA26924002
C523799MRK 003IGF2R results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IGF2R mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of IGF2R mRNA25380136
C007350nitrofennitrofen results in decreased expression of IGF2R mRNA20620343|2143327
C007350nitrofennitrofen results in decreased expression of IGF2R protein20620343
C007350nitrofenTretinoin inhibits the reaction [nitrofen results in decreased expression of IGF2R mRNA]21433279
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of IGF2R mRNA20971185
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of IGF2R mRNA25607892
D010269ParaquatParaquat results in increased expression of IGF2R mRNA16328009
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of IGF2R mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of IGF2R protein26178269
D010575PesticidesPesticides results in decreased expression of IGF2R mRNA27406225
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of IGF2R mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of IGF2R mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of IGF2R mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of IGF2R mRNA12807726
D010634PhenobarbitalPhenobarbital results in increased expression of IGF2R mRNA8055622
D010634PhenobarbitalPhenobarbital results in increased expression of IGF2R protein8055622
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGF2R mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of IGF2R mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IGF2R mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of IGF2R mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of IGF2R mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of IGF2R mRNA19162173
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IGF2R mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IGF2R mRNA25607892
C010313pseudocumenepseudocumene results in decreased expression of IGF2R protein17337753
C059514resveratrolresveratrol results in increased expression of IGF2R mRNA12002526
C089730rosiglitazonerosiglitazone results in decreased expression of IGF2R protein20960268
C010327salinomycinsalinomycin results in decreased expression of IGF2R mRNA19682730
D012643SeleniumSelenium results in decreased expression of IGF2R mRNA19244175
C009277sodium arsenatesodium arsenate results in decreased expression of IGF2R mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of IGF2R mRNA21795629
C017947sodium arsenitesodium arsenite affects the expression of IGF2R mRNA20816728
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in increased methylation of IGF2R mRNA22959928
C017947sodium arsenitesodium arsenite results in decreased expression of IGF2R mRNA19822182
C017947sodium arsenitesodium arsenite results in increased expression of IGF2R mRNA17077188|1745185
C004648testosterone enanthatetestosterone enanthate results in increased expression of IGF2R mRNA23085480
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IGF2R mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGF2R mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IGF2R mRNA23142538
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IGF2R mRNA19770486|2314253
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of IGF2R gene23142538
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IGF2R mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IGF2R mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of IGF2R mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IGF2R mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of IGF2R mRNA20133372
D014118Toxins, Biological"Toxins, Biological affects the expression of IGF2R mRNA"19682533
D014212TretinoinTretinoin promotes the reaction [IGF2R binds to and results in increased secretion of IGF2 protein modified form]16680587
D014212TretinoinTretinoin inhibits the reaction [nitrofen results in decreased expression of IGF2R mRNA]21433279
D014212TretinoinTretinoin results in increased expression of IGF2R protein21433279
C012589trichostatin Atrichostatin A affects the expression of IGF2R mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IGF2R mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of IGF2R mRNA17127020
D014415TunicamycinTunicamycin results in increased expression of IGF2R mRNA17127020
D014520UrethaneUrethane results in increased expression of IGF2R mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of IGF2R mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of IGF2R mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of IGF2R mRNA17292431|1796380
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IGF2R gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of IGF2R mRNA25607892
C025643vinclozolinvinclozolin results in decreased expression of IGF2R mRNA23034163
D014800VitalliumVitallium analog results in increased expression of IGF2R mRNA23825117
D014810Vitamin EVitamin E results in decreased expression of IGF2R mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of IGF2R mRNA20044591
D015034Zinc OxideZinc Oxide affects the expression of IGF2R mRNA28648595

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-IBA21873635  
GO:0001965G-protein alpha-subunit binding-IEA-  
GO:0001972retinoic acid binding-IBA21873635  
GO:0001972retinoic acid binding-IEA-  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IEA-  
GO:0005010insulin-like growth factor-activated receptor activity-TAS10799489  
GO:0005515protein binding-IDA10900005  
GO:0005515protein binding-IPI10900005  11387475  11390366  16977309  17850746  18046459  
20676133  
GO:0005520insulin-like growth factor binding-IBA21873635  
GO:0005537mannose binding-IBA21873635  
GO:0005537mannose binding-IEA-  
GO:0019899enzyme binding-IEA-  
GO:0031995insulin-like growth factor II binding-IBA21873635  
GO:0031995insulin-like growth factor II binding-IEA-  
GO:0036143kringle domain binding-IBA21873635  
GO:0038023signaling receptor activity-TAS7753549  
GO:0042802identical protein binding-IPI22681933  
GO:0051219phosphoprotein binding-IBA21873635  
GO:0051219phosphoprotein binding-IDA10900005  
GO ID GO Term Qualifier Evidence PubMed
GO:0001889liver development-IEA-  
GO:0006892post-Golgi vesicle-mediated transport-IBA21873635  
GO:0006898receptor-mediated endocytosis-TAS10799489  
GO:0007041lysosomal transport-IBA21873635  
GO:0007041lysosomal transport-IEA-  
GO:0007165signal transduction-TAS7753549  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0031100animal organ regeneration-IEA-  
GO:0032526response to retinoic acid-IBA21873635  
GO:0032526response to retinoic acid-IEA-  
GO:0043065positive regulation of apoptotic process-IBA21873635  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0048009insulin-like growth factor receptor signaling pathway-IEA-  
GO:0061024membrane organization-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005641nuclear envelope lumen-IBA21873635  
GO:0005641nuclear envelope lumen-IEA-  
GO:0005765lysosomal membrane-IEA-  
GO:0005768endosome-IDA15078902  
GO:0005769early endosome-IBA21873635  
GO:0005769early endosome-IMP17959629  
GO:0005770late endosome-IBA21873635  
GO:0005770late endosome-IDA22456507  
GO:0005794Golgi apparatus-IDA-  
GO:0005802trans-Golgi network-IBA21873635  
GO:0005802trans-Golgi network-IMP17959629  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS10799489  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-IDA10900005  
GO:0016020membrane-HDA19946888  
GO:0030118clathrin coat-IEA-  
GO:0030133transport vesicle-TAS-  
GO:0030136clathrin-coated vesicle-IBA21873635  
GO:0030139endocytic vesicle-IBA21873635  
GO:0030139endocytic vesicle-IDA10900005  
GO:0030140trans-Golgi network transport vesicle-IBA21873635  
GO:0030140trans-Golgi network transport vesicle-IDA15078902  
GO:0030665clathrin-coated vesicle membrane-TAS-  
GO:0030667secretory granule membrane-TAS-  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0048471perinuclear region of cytoplasm-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-432722Golgi Associated Vesicle BiogenesisTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6811440Retrograde transport at the Trans-Golgi-NetworkTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25102259Periconception maternal smoking and low education are associated with methylation of INSIGF in children at the age of 17 months. (2012 Oct)Obermann-Borst SAJ Dev Orig Health Dis
23116464Beckwith Wiedemann imprinting defect found in leucocyte but not buccal DNA in a child born small for gestational age. (2012 Nov 1)Murphy RBMC Med Genet
25402559IGF2R expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC. (2014)Tian ZCell Physiol Biochem
27167200Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts. (2016 Jun 28)Ting WJOncotarget