Gene info: ID 3484

Gene: IGFBP1

GENE ID: 3484

Synonyms: AFBP|IBP1|IGF-BP25|PP12|hIGFBP-1

Description: insulin like growth factor binding protein 1

Gene type: protein-coding

Location: 7p12.3

dbXrefs: Ensembl:ENSG00000146678 MIM:146730 Vega:OTTHUMG00000152343 UniprotKB:P08833

RefSeq: NC_000007.14

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.506e-1 (AD) 3.930e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
IGFBP3	0.558
C1RL	0.545
CD1D	0.54
NAT1	0.539
CD300E	0.536
ST14	0.527
CD163	0.524
NABP1	0.523
SULT1B1	0.516
FPR2	0.515

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ARSF	-0.29
HES5	-0.265
SOX1	-0.256
CPLX3	-0.255
PYGM	-0.251
SLC25A48	-0.242
TMEM253	-0.241
DIO2	-0.24
FBN3	-0.24
POU3F4	-0.237

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of IGFBP1 mRNA"	16269432
C026486	1,2,5,6-dibenzanthracene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of IGFBP1 mRNA"	17690111
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of IGFBP1 mRNA"	26377693
C070046	1,2-dioleoyloxy-3-(trimethylammonium)propane	"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IGFBP1 mRNA"	22129739
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of IGFBP1 mRNA"	19162173
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of IGFBP1 mRNA"	28903501
C041507	1-methylphenanthrene	[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGFBP1 mRNA	17690111
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of IGFBP1 mRNA"	27291303
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of IGFBP1 mRNA"	21920950
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of IGFBP1 mRNA	19782052
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of IGFBP1 mRNA	16236254
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of IGFBP1 mRNA]"	19414516
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IGFBP1 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of IGFBP1 mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IGFBP1 mRNA"	15059925
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of IGFBP1 mRNA	25088246
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of IGFBP1 mRNA	15890375
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IGFBP1 mRNA"	19692669\|2095900
C091768	3'-methoxy-4'-nitroflavone	3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IGFBP1 mRNA]	19782052
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of IGFBP1 mRNA"	18289764\|2538013
C525872	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide inhibits the reaction [Progesterone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]]	23275455
C525872	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide results in decreased expression of IGFBP1 mRNA	23264615
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of IGFBP1 mRNA	15890375
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of IGFBP1 mRNA"	26238291
D000082	Acetaminophen	Acetaminophen results in increased expression of IGFBP1 mRNA	11793227\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of IGFBP1 mRNA	15606129\|1756273
D000082	Acetaminophen	Acetaminophen results in increased expression of IGFBP1 mRNA	17585979
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of IGFBP1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IGFBP1 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in increased expression of IGFBP1 mRNA	15120968\|1720276
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IGFBP1 protein]	26138014
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of IGFBP1 mRNA]	22129741
C016601	afimoxifene	afimoxifene results in increased expression of IGFBP1 mRNA	12154049
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of IGFBP1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of IGFBP1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of IGFBP1 mRNA	21632981\|2164198
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of IGFBP1 mRNA	15890375
D000638	Amiodarone	Amiodarone results in increased expression of IGFBP1 mRNA	27089845
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IGFBP1 mRNA	16483693
D000661	Amphetamine	Amphetamine results in increased expression of IGFBP1 mRNA	15183010
C519728	archazolid B	archazolid B results in increased expression of IGFBP1 mRNA	25218289
D034341	Aristolochic Acids	Aristolochic Acids results in increased expression of IGFBP1 mRNA	19717638
C006632	arsenic trioxide	[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP1 protein	27430728
C006632	arsenic trioxide	arsenic trioxide results in increased expression of IGFBP1 mRNA	15073043
D001374	Azacitidine	Azacitidine inhibits the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA]	20823114
D001374	Azacitidine	Azacitidine promotes the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 protein]	20823114
D001374	Azacitidine	Azacitidine results in increased expression of IGFBP1 mRNA	20823114
C087670	azoxystrobin	azoxystrobin results in increased expression of IGFBP1 mRNA	20825990
D001414	Bacitracin	Bacitracin results in increased expression of IGFBP1 mRNA	18289764
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of IGFBP1 mRNA	17690111
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of IGFBP1 mRNA	16269432
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of IGFBP1 mRNA	19737606
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of IGFBP1 mRNA"	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGFBP1 mRNA	17690111
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of IGFBP1 mRNA	17690111
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of IGFBP1 mRNA"	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IGFBP1 mRNA	16269432\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IGFBP1 mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IGFBP1 mRNA"	26238291
D004958	Estradiol	Azacitidine inhibits the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA]	20823114
D004958	Estradiol	Azacitidine promotes the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 protein]	20823114
D004958	Estradiol	BMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IGFBP1 mRNA]	20085912
D004958	Estradiol	BMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGFBP1 protein]	20085912
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA	20823114
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 protein	20823114
D004958	Estradiol	[Estradiol co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1	12093828
D004958	Estradiol	[Estradiol co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA	11756571
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of IGFBP1 mRNA	20085912
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased secretion of IGFBP1 protein	20085912
D004958	Estradiol	[Estradiol deficiency co-treated with Medroxyprogesterone Acetate deficiency] results in decreased expression of IGFBP1 mRNA	11756571
D004958	Estradiol	[Estradiol deficiency co-treated with Medroxyprogesterone Acetate deficiency] results in increased expression of IGFBP1 mRNA	11756571
D004958	Estradiol	Estradiol promotes the reaction [Medroxyprogesterone Acetate results in increased expression of IGFBP1 mRNA]	11756571
D004958	Estradiol	Estradiol results in increased expression of IGFBP1 mRNA	12154049
D004958	Estradiol	Estradiol results in increased expression of IGFBP1 protein	17484513
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of IGFBP1 mRNA	17404688
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased expression of IGFBP1 protein]	17484513
C095105	bexarotene	bexarotene results in increased expression of IGFBP1 mRNA	16648578
C053541	bicalutamide	[bicalutamide co-treated with Tamoxifen] results in increased expression of IGFBP1 protein	16847815
D015082	2,2'-Dipyridyl	"2,2'-Dipyridyl results in increased expression of IGFBP1 mRNA"	19924283
C006780	bisphenol A	bisphenol A results in increased expression of IGFBP1 mRNA	21273127\|2660402
C006780	bisphenol A	bisphenol A results in increased expression of IGFBP1 protein	21273127
C006780	bisphenol A	bisphenol A results in increased secretion of IGFBP1 protein	26604029
C006780	bisphenol A	[Progesterone co-treated with bisphenol A] results in increased expression of IGFBP1 mRNA	26604029
D015124	8-Bromo Cyclic Adenosine Monophosphate	1-Butanol inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]	17065600
D015124	8-Bromo Cyclic Adenosine Monophosphate	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide inhibits the reaction [Progesterone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]]	23275455
D015124	8-Bromo Cyclic Adenosine Monophosphate	[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA	21903722
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of IGFBP1 mRNA	18815356
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of IGFBP1 protein	18815356
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA	17065600\|2014773
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 protein	20147733
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased secretion of IGFBP1 protein	21273127
D015124	8-Bromo Cyclic Adenosine Monophosphate	Dexamethasone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]	23275455
D015124	8-Bromo Cyclic Adenosine Monophosphate	EZH2 mutant form inhibits the reaction [[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA]	21903722
D015124	8-Bromo Cyclic Adenosine Monophosphate	FOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased secretion of IGFBP1 protein]	16709600
D015124	8-Bromo Cyclic Adenosine Monophosphate	Hydrocortisone promotes the reaction [Progesterone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]]	23275455
D015124	8-Bromo Cyclic Adenosine Monophosphate	[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased secretion of IGFBP1 protein	16709600
D015124	8-Bromo Cyclic Adenosine Monophosphate	PLD1 protein affects the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]	17065600
D015124	8-Bromo Cyclic Adenosine Monophosphate	Progesterone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]	23275455
D020001	1-Butanol	1-Butanol inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]	17065600
D000440	Butanols	Butanols results in increased expression of IGFBP1 mRNA	12394292
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [INS1 protein results in decreased expression of IGFBP1 mRNA]	17213664
C018475	butyraldehyde	butyraldehyde results in decreased expression of IGFBP1 mRNA	26079696
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of IGFBP1 mRNA	15345372
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IGFBP1 protein]	26138014
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of IGFBP1 protein	26138014
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of IGFBP1 mRNA	25993096
D002110	Caffeine	Caffeine results in increased expression of IGFBP1 mRNA	11793227
D000074262	Canola Oil	Canola Oil metabolite results in decreased expression of IGFBP1 mRNA	27363782
D000074262	Canola Oil	Starch analog inhibits the reaction [Canola Oil metabolite results in decreased expression of IGFBP1 mRNA]	27363782
D002220	Carbamazepine	Carbamazepine affects the expression of IGFBP1 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IGFBP1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of IGFBP1 mRNA	15963342
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IGFBP1 mRNA	15070850\|1752207
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in decreased expression of IGFBP1 mRNA	19072826
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of IGFBP1 mRNA	18178546
D002746	Chlorpromazine	Chlorpromazine results in increased expression of IGFBP1 mRNA	15924885
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of IGFBP1 mRNA	21356183
D002784	Cholesterol	"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IGFBP1 mRNA"	22129739
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of IGFBP1 mRNA	27344345
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGFBP1 mRNA	20938992
C022990	chromic chloride	chromic chloride results in decreased expression of IGFBP1 mRNA	12153762
D002922	Ciguatoxins	Ciguatoxins affects the expression of IGFBP1 mRNA	18353800
C019304	ciprofibrate	ciprofibrate results in increased expression of IGFBP1 mRNA	12771043
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of IGFBP1 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of IGFBP1 mRNA	17585979\|2381119
D002994	Clofibrate	Clofibrate results in increased expression of IGFBP1 mRNA	11356909
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IGFBP1 mRNA]	17585979
D002994	Clofibrate	Clofibrate results in increased expression of IGFBP1 mRNA	17522070
D003022	Clotrimazole	Clotrimazole results in increased expression of IGFBP1 mRNA	12659874
D003022	Clotrimazole	Clotrimazole results in increased secretion of IGFBP1 protein	12659874
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of IGFBP1 mRNA	21139344
C018021	cobaltous chloride	cobaltous chloride results in increased expression of IGFBP1 mRNA	16990490
C018021	cobaltous chloride	cobaltous chloride results in increased expression of IGFBP1 protein	16990490
C018021	cobaltous chloride	cobaltous chloride results in increased expression of IGFBP1 mRNA	16990490
C018021	cobaltous chloride	cobaltous chloride results in increased expression of IGFBP1 protein	16990490
D005576	Colforsin	Colforsin results in increased expression of IGFBP1	12093828
D019327	Copper Sulfate	Copper Sulfate results in increased expression of IGFBP1 mRNA	19549813
D003314	Corn Oil	Corn Oil affects the expression of IGFBP1 mRNA	16360708
D003474	Curcumin	[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP1 protein	27430728
D003484	Cyanamide	Cyanamide inhibits the reaction [Ethanol results in increased expression of IGFBP1 mRNA]	12394292
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of IGFBP1 mRNA	17654400
D016572	Cyclosporine	Cyclosporine results in increased expression of IGFBP1 mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in decreased expression of IGFBP1 mRNA	21865292
D016572	Cyclosporine	Cyclosporine results in increased expression of IGFBP1 mRNA	21865292
D003840	Deoxycholic Acid	Deoxycholic Acid results in decreased expression of IGFBP1 mRNA	27089845
D003907	Dexamethasone	Dexamethasone results in decreased expression of IGFBP1 protein	12670838
D003907	Dexamethasone	Dexamethasone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]	23275455
D003907	Dexamethasone	[Dexamethasone results in increased phosphorylation of and results in increased activity of NR3C1 protein] which results in increased expression of IGFBP1 mRNA	18483179
D003907	Dexamethasone	Dexamethasone results in increased expression of IGFBP1 mRNA	17522070
C041517	dibenzo(a,l)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of IGFBP1 mRNA"	17690111
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in increased expression of IGFBP1 mRNA"	16269432
D003994	Bucladesine	Azacitidine inhibits the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA]	20823114
D003994	Bucladesine	Azacitidine promotes the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 protein]	20823114
D003994	Bucladesine	Bucladesine results in increased expression of IGFBP1	12093828
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA	20823114
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 protein	20823114
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of IGFBP1 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of IGFBP1 mRNA	27392435
D002945	Cisplatin	Cisplatin affects the expression of IGFBP1 mRNA	18289764
D004008	Diclofenac	Diclofenac affects the expression of IGFBP1 mRNA	24752500
D004008	Diclofenac	Diclofenac results in increased expression of IGFBP1 mRNA	26934552
D018119	Stavudine	Stavudine results in increased expression of IGFBP1 mRNA	18299183
D004041	Dietary Fats	Dietary Fats affects the expression of IGFBP1 mRNA	19680557
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of IGFBP1 mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of IGFBP1 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IGFBP1 mRNA]	19850644
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of IGFBP1 mRNA	21527772
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of IGFBP1 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of IGFBP1 mRNA	12771043\|1794291
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of IGFBP1 mRNA]	17942915
D004052	Diethylnitrosamine	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of IGFBP1 mRNA]	22129741
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of IGFBP1 mRNA	19638242
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of IGFBP1 mRNA	22129741
D004054	Diethylstilbestrol	[Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of IGFBP1 mRNA	19665456
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of IGFBP1 mRNA	15890375
D002117	Calcitriol	Calcitriol results in increased expression of IGFBP1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of IGFBP1 mRNA	21592394
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of IGFBP1 mRNA	17072980
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of IGFBP1 mRNA	15890375\|2538013
D004147	Dioxins	Dioxins affects the expression of IGFBP1 mRNA	20463971
D004656	Enalapril	Enalapril results in increased expression of IGFBP1 mRNA	12883983
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of IGFBP1 mRNA	12655031
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of IGFBP1 mRNA	17522070
D000431	Ethanol	Ethanol results in decreased expression of IGFBP1 mRNA	19167417
D000431	Ethanol	Cyanamide inhibits the reaction [Ethanol results in increased expression of IGFBP1 mRNA]	12394292
D000431	Ethanol	Ethanol results in increased expression of IGFBP1 mRNA	12394292
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of IGFBP1 mRNA	17606305
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of IGFBP1 mRNA	16872691
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of IGFBP1 mRNA	14976129
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGFBP1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of IGFBP1 mRNA	15795090
C000591741	Firemaster 550	Firemaster 550 results in decreased expression of IGFBP1 mRNA	27957850
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGFBP1 mRNA	20938992
D005492	Folic Acid	Folic Acid results in increased expression of IGFBP1 mRNA	8594875
C069837	fullerene C60	fullerene C60 results in decreased expression of IGFBP1 mRNA	19167457
C056933	fumonisin B1	fumonisin B1 results in increased expression of IGFBP1 mRNA	16221962
C039281	furan	furan results in increased expression of IGFBP1 mRNA	24183702
C039281	furan	furan results in decreased expression of IGFBP1 mRNA	26194646
D005688	Galactosamine	Galactosamine results in increased expression of IGFBP1 mRNA	11779202
D019833	Genistein	Genistein results in decreased expression of IGFBP1 mRNA	17049845
D019833	Genistein	Genistein results in increased expression of IGFBP1 mRNA	15795090
D005839	Gentamicins	Gentamicins results in increased expression of IGFBP1 mRNA	18289764
C412815	GW 4064	GW 4064 results in increased expression of IGFBP1 mRNA	26655953
C010176	halofuginone	halofuginone inhibits the reaction [Thioacetamide results in decreased expression of IGFBP1 mRNA]	14739098
C010176	halofuginone	halofuginone results in decreased expression of IGFBP1 mRNA	17180598
C010176	halofuginone	halofuginone results in increased expression of IGFBP1 mRNA	14739098
C010176	halofuginone	halofuginone results in increased expression of IGFBP1 protein	14739098
C070163	homobrassinolide	homobrassinolide results in increased expression of IGFBP1 mRNA	21491949
D017313	Fenretinide	Fenretinide results in increased expression of IGFBP1 mRNA	28973697
D006854	Hydrocortisone	Hydrocortisone promotes the reaction [Progesterone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]]	23275455
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [INS1 protein results in decreased expression of IGFBP1 mRNA]	17213664
C027185	indirubin	indirubin results in increased expression of IGFBP1 mRNA	15056799
C016517	indole-3-carbinol	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of IGFBP1 mRNA]	22129741
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of IGFBP1 mRNA	22129741
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of IGFBP1 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of IGFBP1 mRNA	27392435
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of IGFBP1 protein	27169980
C410337	K 7174	K 7174 results in increased expression of IGFBP1 mRNA	24086573
D007649	Ketamine	Ketamine results in increased expression of IGFBP1 mRNA	20080153
D007654	Ketoconazole	Ketoconazole results in increased expression of IGFBP1 mRNA	18289764
D007657	Ketone Bodies	Ketone Bodies results in increased expression of IGFBP1 mRNA	15469884
C008261	lead acetate	lead acetate results in decreased expression of IGFBP1 mRNA	25270620
C008261	lead acetate	lead acetate results in increased expression of IGFBP1 mRNA	21335049
C045463	leflunomide	leflunomide results in increased expression of IGFBP1 mRNA	28988120
C045463	leflunomide	leflunomide results in increased expression of IGFBP1 mRNA	24136188
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IGFBP1 mRNA"	18930950
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of IGFBP1 mRNA"	11578593
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of IGFBP1 mRNA	27339419
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IGFBP1 mRNA	11779202
D017706	Lisinopril	Lisinopril results in increased expression of IGFBP1 protein	9663927
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IGFBP1 mRNA	26378955
D017258	Medroxyprogesterone Acetate	[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA	21903722
D017258	Medroxyprogesterone Acetate	Azacitidine inhibits the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA]	20823114
D017258	Medroxyprogesterone Acetate	Azacitidine promotes the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 protein]	20823114
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA	20823114
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 protein	20823114
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1	12093828
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA	11756571
D017258	Medroxyprogesterone Acetate	[Estradiol deficiency co-treated with Medroxyprogesterone Acetate deficiency] results in decreased expression of IGFBP1 mRNA	11756571
D017258	Medroxyprogesterone Acetate	[Estradiol deficiency co-treated with Medroxyprogesterone Acetate deficiency] results in increased expression of IGFBP1 mRNA	11756571
D017258	Medroxyprogesterone Acetate	Estradiol promotes the reaction [Medroxyprogesterone Acetate results in increased expression of IGFBP1 mRNA]	11756571
D017258	Medroxyprogesterone Acetate	EZH2 mutant form inhibits the reaction [[8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP1 mRNA]	21903722
D017258	Medroxyprogesterone Acetate	FOXO1 protein affects the reaction [[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased secretion of IGFBP1 protein]	16709600
D017258	Medroxyprogesterone Acetate	[Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased secretion of IGFBP1 protein	16709600
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of IGFBP1 mRNA	11756571\|2068586
C065757	meloxicam	meloxicam results in decreased expression of IGFBP1 mRNA	21270428\|2326461
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of IGFBP1 mRNA	20353558
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of IGFBP1 mRNA	7540432
D008687	Metformin	Metformin results in decreased expression of IGFBP1 mRNA	21316309
D008701	Methapyrilene	Methapyrilene results in increased expression of IGFBP1 mRNA	15120968\|1589037
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IGFBP1 mRNA	20938992
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of IGFBP1 mRNA	20020106
D008767	Methylmercury Compounds	[Polychlorinated Biphenyls co-treated with Methylmercury Compounds] results in increased expression of IGFBP1 mRNA	20020106
C030957	methylmercury II	methylmercury II results in decreased expression of IGFBP1 mRNA	17905399
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in increased secretion of IGFBP1 protein]	26604029
C020300	monomethylarsonic acid	monomethylarsonic acid results in increased expression of IGFBP1 mRNA	15345372
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of IGFBP1 mRNA"	29244179
C452423	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of IGFBP1 mRNA	16052530
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of IGFBP1 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of IGFBP1 mRNA	15913567
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of IGFBP1 mRNA	17522070\|1828976
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of IGFBP1 mRNA	19812364
C022838	nickel chloride	nickel chloride results in increased expression of IGFBP1 mRNA	21455298
C028007	nickel monoxide	nickel monoxide results in decreased expression of IGFBP1 mRNA	19167457
C007350	nitrofen	nitrofen results in increased expression of IGFBP1 mRNA	27592368
C025589	ochratoxin A	ochratoxin A results in decreased expression of IGFBP1 mRNA	19287073
C025589	ochratoxin A	ochratoxin A results in decreased expression of IGFBP1 protein	19287073
C025589	ochratoxin A	ochratoxin A results in increased expression of IGFBP1 mRNA	19717638
C053238	onapristone	onapristone results in decreased expression of IGFBP1 mRNA	17709569
D009966	Orphenadrine	Orphenadrine affects the expression of IGFBP1 mRNA	23665939
D010076	Oxazepam	Oxazepam results in increased expression of IGFBP1 mRNA	12727805\|1561823
D010076	Oxazepam	Oxazepam results in increased expression of IGFBP1 protein	12727805
D010098	Oxycodone	Oxycodone results in increased expression of IGFBP1 mRNA	23439660
D010100	Oxygen	Oxygen deficiency results in increased expression of IGFBP1 mRNA	19924283
D010126	Ozone	Ozone results in decreased expression of IGFBP1 mRNA	16183385
D000073878	Palm Oil	Palm Oil affects the expression of IGFBP1 mRNA	19680557
C016030	pantogab	pantogab results in increased expression of IGFBP1 mRNA	17379144
D010269	Paraquat	Paraquat inhibits the reaction [INS1 protein results in decreased expression of IGFBP1 mRNA]	17213664
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of IGFBP1 mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of IGFBP1 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of IGFBP1 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of IGFBP1 protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of IGFBP1 mRNA	28511854
D010634	Phenobarbital	Phenobarbital affects the expression of IGFBP1 mRNA	19084549\|1915966
D010634	Phenobarbital	Phenobarbital results in increased expression of IGFBP1 mRNA	12659874
D010634	Phenobarbital	Phenobarbital results in increased secretion of IGFBP1 protein	12659874
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of IGFBP1 mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of IGFBP1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of IGFBP1 mRNA	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of IGFBP1 mRNA	19162173
C018637	phorone	phorone affects the expression of IGFBP1 mRNA	18198479
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of IGFBP1 mRNA	15890375
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IGFBP1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of IGFBP1 mRNA	12727805\|1561823
C006253	pirinixic acid	pirinixic acid results in increased expression of IGFBP1 protein	12727805
C006253	pirinixic acid	pirinixic acid results in increased expression of IGFBP1 mRNA	15890375
D010936	Plant Extracts	Plant Extracts results in decreased expression of IGFBP1 mRNA	23557933
D011078	Polychlorinated Biphenyls	[Polychlorinated Biphenyls co-treated with Methylmercury Compounds] results in increased expression of IGFBP1 mRNA	20020106
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in increased expression of IGFBP1 mRNA	20020106
C019536	potassium bromate	potassium bromate results in increased expression of IGFBP1 mRNA	23588252
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of IGFBP1 mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of IGFBP1 mRNA	22698814\|2741311
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of IGFBP1 mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of IGFBP1 mRNA	19162173
D011374	Progesterone	Progesterone results in increased expression of IGFBP1 mRNA	23018184
D011374	Progesterone	4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide inhibits the reaction [Progesterone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]]	23275455
D011374	Progesterone	BMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IGFBP1 mRNA]	20085912
D011374	Progesterone	BMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGFBP1 protein]	20085912
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of IGFBP1 mRNA	20085912
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased secretion of IGFBP1 protein	20085912
D011374	Progesterone	Hydrocortisone promotes the reaction [Progesterone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]]	23275455
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in increased secretion of IGFBP1 protein]	26604029
D011374	Progesterone	Progesterone affects the expression of IGFBP1 mRNA	15501902
D011374	Progesterone	Progesterone affects the expression of IGFBP1 protein	15501902
D011374	Progesterone	[Progesterone co-treated with bisphenol A] results in increased expression of IGFBP1 mRNA	26604029
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of IGFBP1 mRNA	17404688
D011374	Progesterone	[Progesterone co-treated with Triclosan] results in increased expression of IGFBP1 mRNA	26604029
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased expression of IGFBP1 protein]	17484513
D011374	Progesterone	Progesterone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]	23275455
D011374	Progesterone	Progesterone promotes the reaction [Triclosan results in increased secretion of IGFBP1 protein]	26604029
D011374	Progesterone	Progesterone results in increased expression of IGFBP1 mRNA	17404688\|1881535
D011374	Progesterone	Progesterone results in increased secretion of IGFBP1 protein	26604029
D011374	Progesterone	Progesterone results in increased expression of IGFBP1 mRNA	18753603\|1969004
D011374	Progesterone	Progesterone results in decreased expression of IGFBP1	17510236
C005556	propionaldehyde	propionaldehyde results in decreased expression of IGFBP1 mRNA	26079696
D011794	Quercetin	Quercetin results in decreased expression of IGFBP1 mRNA	21632981
D015125	Oxyquinoline	Oxyquinoline results in increased expression of IGFBP1 mRNA	21632981
C059514	resveratrol	resveratrol results in increased expression of IGFBP1 mRNA	12154049
C059514	resveratrol	resveratrol promotes the reaction [FOXO1 protein results in increased expression of IGFBP1 mRNA]	16917544
C059514	resveratrol	FOXO1 protein affects the reaction [resveratrol results in increased expression of IGFBP1 mRNA]	15788402
C059514	resveratrol	resveratrol inhibits the reaction [INS1 protein results in decreased expression of IGFBP1 mRNA]	16626303
C059514	resveratrol	resveratrol results in increased expression of IGFBP1 mRNA	16236254
C013672	riddelliine	riddelliine results in increased expression of IGFBP1 mRNA	18047727
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP1 mRNA	21127053
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of IGFBP1 mRNA	25895662
D020123	Sirolimus	Sirolimus results in increased expression of IGFBP1 mRNA	21865292
C017947	sodium arsenite	[Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of IGFBP1 mRNA	19665456
C017947	sodium arsenite	sodium arsenite affects the expression of IGFBP1 mRNA	16507464
C017947	sodium arsenite	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IGFBP1 mRNA	16368122
C017947	sodium arsenite	sodium arsenite results in decreased expression of IGFBP1 mRNA	17350061\|1745185
C017947	sodium arsenite	sodium arsenite results in increased expression of IGFBP1 mRNA	14691202\|1527641
C016104	sodium bichromate	sodium bichromate results in increased expression of IGFBP1 mRNA	25993096
D013213	Starch	Starch analog inhibits the reaction [Canola Oil metabolite results in decreased expression of IGFBP1 mRNA]	27363782
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IGFBP1 mRNA	26378955
D016559	Tacrolimus	Tacrolimus results in decreased expression of IGFBP1 mRNA	21865292
D016559	Tacrolimus	Tacrolimus results in increased expression of IGFBP1 mRNA	21865292
C013698	tallow	tallow affects the expression of IGFBP1 mRNA	19680557
D013629	Tamoxifen	[bicalutamide co-treated with Tamoxifen] results in increased expression of IGFBP1 protein	16847815
D013629	Tamoxifen	Tamoxifen results in increased expression of IGFBP1 mRNA	27089845
D013629	Tamoxifen	Tamoxifen affects the expression of IGFBP1 mRNA	20937368
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in increased expression of IGFBP1 mRNA	15885361
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of IGFBP1 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of IGFBP1 mRNA	21592394
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of IGFBP1 mRNA	20189893
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IGFBP1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGFBP1 mRNA	15056799\|1549650
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGFBP1 protein	15496506
D013749	Tetrachlorodibenzodioxin	3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IGFBP1 mRNA]	19782052
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IGFBP1 mRNA]	18827440
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IGFBP1 protein]	18827440
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IGFBP1 mRNA	28922406
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGFBP1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of IGFBP1 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IGFBP1 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGFBP1 mRNA	17949056
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGFBP1 mRNA	16960034\|1882744
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGFBP1 protein	18827440
D013749	Tetrachlorodibenzodioxin	AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IGFBP1 mRNA]	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IGFBP1 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGFBP1 mRNA	16054898\|1696003
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of IGFBP1 mRNA	28973375
D013752	Tetracycline	Tetracycline results in increased expression of IGFBP1 mRNA	27089845
D013752	Tetracycline	Tetracycline results in increased expression of IGFBP1 mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IGFBP1 mRNA	16368122
D013853	Thioacetamide	Thioacetamide results in increased expression of IGFBP1 mRNA	11793227
D013853	Thioacetamide	halofuginone inhibits the reaction [Thioacetamide results in decreased expression of IGFBP1 mRNA]	14739098
D013853	Thioacetamide	Thioacetamide results in decreased expression of IGFBP1 mRNA	14739098
D013853	Thioacetamide	Thioacetamide results in increased expression of IGFBP1 mRNA	16297948
C050504	tianeptine	tianeptine results in increased expression of IGFBP1 mRNA	27089845
C009495	titanium dioxide	titanium dioxide results in increased expression of IGFBP1 mRNA	23557971
C066340	tolcapone	tolcapone results in increased expression of IGFBP1 mRNA	24136188
D014212	Tretinoin	Tretinoin results in increased expression of IGFBP1 mRNA	28689802
D014241	Trichloroethylene	Trichloroethylene results in increased expression of IGFBP1 mRNA	25549359
D014260	Triclosan	[Progesterone co-treated with Triclosan] results in increased expression of IGFBP1 mRNA	26604029
D014260	Triclosan	Progesterone promotes the reaction [Triclosan results in increased secretion of IGFBP1 protein]	26604029
D014260	Triclosan	Triclosan results in increased expression of IGFBP1 mRNA	26604029
D014260	Triclosan	Triclosan results in increased secretion of IGFBP1 protein	26604029
C001899	triptolide	triptolide results in decreased expression of IGFBP1 mRNA	23639586
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IGFBP1 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of IGFBP1 mRNA	29024780
C057693	troglitazone	troglitazone results in decreased expression of IGFBP1 mRNA	25572481
C057693	troglitazone	troglitazone results in increased expression of IGFBP1 mRNA	12659874
C057693	troglitazone	troglitazone results in increased secretion of IGFBP1 protein	12659874
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IGFBP1 mRNA"	18930950
D014425	Turpentine	Turpentine results in increased expression of IGFBP1 mRNA	16044259
D014520	Urethane	Urethane results in increased expression of IGFBP1 mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of IGFBP1 mRNA	15885361
D014635	Valproic Acid	Valproic Acid affects the expression of IGFBP1 mRNA	17963808
D014640	Vancomycin	Vancomycin results in increased expression of IGFBP1 mRNA	18930951
D014640	Vancomycin	Vancomycin affects the expression of IGFBP1 mRNA	18289764
C551177	vemurafenib	[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of IGFBP1 protein	27169980
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of IGFBP1 mRNA	26682919
D009536	Niacinamide	Niacinamide inhibits the reaction [FOXO1 protein results in increased expression of IGFBP1 mRNA]	16917544
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of IGFBP1 mRNA"	24525044
D015032	Zinc	Zinc deficiency results in decreased expression of IGFBP1 mRNA	12672911
D015032	Zinc	Zinc deficiency results in decreased expression of IGFBP1 protein	12672911\|2040403

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	TAS	24431302
GO:0005515	protein binding	-	IPI	16924115 22578544 26091039
GO:0005520	insulin-like growth factor binding	-	TAS	2454104
GO:0031994	insulin-like growth factor I binding	-	IBA	21873635
GO:0031994	insulin-like growth factor I binding	-	IDA	21550830
GO:0031995	insulin-like growth factor II binding	-	IBA	21873635
GO:0031995	insulin-like growth factor II binding	-	IDA	21550830

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	TAS	2454104
GO:0007568	aging	-	IEA	-
GO:0008286	insulin receptor signaling pathway	-	IEA	-
GO:0030307	positive regulation of cell growth	-	IEA	-
GO:0036499	PERK-mediated unfolded protein response	-	TAS	-
GO:0042246	tissue regeneration	-	IEA	-
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	-	IBA	21873635
GO:0043687	post-translational protein modification	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	24431302

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005794	Golgi apparatus	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-380994	ATF4 activates genes	TAS
R-HSA-381042	PERK regulates gene expression	TAS
R-HSA-381119	Unfolded Protein Response (UPR)	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22113073	Associations of IGF1 and its binding proteins with abdominal aortic aneurysm and aortic diameter in older men. (2012 Feb)	Yeap BB	Eur J Endocrinol
21945224	Biomarkers of the insulin-like growth factor pathway predict progression and outcome in lung cancer. (2011 Nov)	Shersher DD	Ann Thorac Surg