Gene: IGFBP2

3485
IBP2|IGF-BP53
insulin like growth factor binding protein 2
protein-coding
2q35
Ensembl:ENSG00000115457 MIM:146731 Vega:OTTHUMG00000155341 UniprotKB:P18065
NC_000002.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.447e-1 (AD)  3.607e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNDIG10.84
CLEC2L0.831
CHGA0.826
HR0.826
SCN1B0.825
SEMA7A0.824
DIRAS10.824
MCOLN10.821
CRTAC10.821
SEZ6L20.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.561
PARD3B-0.529
CDC14A-0.504
MAML2-0.499
PARD3-0.499
YES1-0.496
MBNL3-0.495
GNG12-0.495
STON2-0.493
ABCA1-0.48

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of IGFBP2 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of IGFBP2 mRNA"21354444|2890350
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of IGFBP2 mRNA"27291303
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IGFBP2 mRNA"20056577|2139473
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of IGFBP2 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IGFBP2 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of IGFBP2 mRNA"19167446
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of IGFBP2 mRNA"20638727
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of IGFBP2 mRNA"15215175
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of IGFBP2 mRNA"15215175
C0065932-anthramine2-anthramine results in increased expression of IGFBP2 mRNA23038007
C0299552-nitrotoluene2-nitrotoluene results in increased expression of IGFBP2 mRNA16460773
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of IGFBP2 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IGFBP2 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IGFBP2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGFBP2 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to IGFBP2 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to IGFBP2 protein]26598702
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of IGFBP2 mRNA22484513|2305219
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGFBP2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of IGFBP2 mRNA15606129
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of IGFBP2 protein]26138014
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IGFBP2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IGFBP2 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IGFBP2 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IGFBP2 mRNA23052194
C103303alitretinoinalitretinoin results in increased expression of IGFBP2 mRNA16648578
D013196Dihydrotestosteronebicalutamide promotes the reaction [Dihydrotestosterone results in increased expression of IGFBP2 mRNA]16368782
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of IGFBP2 mRNA16368782
D013196DihydrotestosteroneFlutamide inhibits the reaction [Dihydrotestosterone results in increased expression of IGFBP2 mRNA]16368782
D000638AmiodaroneAmiodarone affects the expression of IGFBP2 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IGFBP2 mRNA16483693
C006632arsenic trioxide[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP2 protein27430728
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to IGFBP2 protein]26598702
C006632arsenic trioxidearsenic trioxide results in decreased expression of IGFBP2 mRNA15070760|1576101
C015001arsenitearsenite results in increased methylation of IGFBP2 promoter23974009
D001280AtrazineAtrazine results in increased expression of IGFBP2 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of IGFBP2 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of IGFBP2 mRNA19483382
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of IGFBP2 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IGFBP2 mRNA18164116
C022921benzo(k)fluoranthenebenzo(k)fluoranthene affects the expression of IGFBP2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of IGFBP2 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IGFBP2 mRNA21632981|2231617
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of IGFBP2 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IGFBP2 mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IGFBP2 mRNA20127859|2261060
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IGFBP2 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IGFBP2 mRNA"20382639
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased secretion of IGFBP2 protein15809018
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IGFBP2 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of IGFBP2 mRNA19619570|2118537
D004958EstradiolEstradiol results in increased expression of IGFBP2 mRNA25878060
D004958EstradiolEstradiol results in increased secretion of IGFBP2 protein15809018
D004958EstradiolEstradiol results in increased expression of IGFBP2 mRNA26945725
C095105bexarotenebexarotene results in increased expression of IGFBP2 mRNA16648578|1763041
C095105bexarotene[Tamoxifen co-treated with bexarotene] results in increased expression of IGFBP2 mRNA17630414
C053541bicalutamidebicalutamide promotes the reaction [Dihydrotestosterone results in increased expression of IGFBP2 mRNA]16368782
C053541bicalutamidebicalutamide results in increased expression of IGFBP2 mRNA16368782
C053541bicalutamidebicalutamide results in increased expression of IGFBP2 mRNA10604720
C006780bisphenol Abisphenol A results in decreased expression of IGFBP2 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of IGFBP2 mRNA26746108
C006780bisphenol Abisphenol A affects the expression of IGFBP2 mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of IGFBP2 protein21296659
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of IGFBP2 mRNA16460773
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of IGFBP2 mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of IGFBP2 mRNA26191083
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of IGFBP2 protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of IGFBP2 protein26138014
D002118CalciumCalcium affects the expression of IGFBP2 mRNA15913539
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of IGFBP2 mRNA27339419
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of IGFBP2 mRNA19395590
C100187chloropicrinchloropicrin results in decreased expression of IGFBP2 mRNA26352163|2847649
C019304ciprofibrateciprofibrate results in increased expression of IGFBP2 mRNA12771043
D002994ClofibrateClofibrate affects the expression of IGFBP2 mRNA19483382
D003033Coal TarCoal Tar results in increased expression of IGFBP2 mRNA27858113
D003042CocaineCocaine results in decreased expression of IGFBP2 mRNA16076954
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of IGFBP2 mRNA"19167446
D003471CuprizoneCuprizone results in increased expression of IGFBP2 mRNA26577399|2752363
D003474Curcumin[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP2 protein27430728
D016572CyclosporineCyclosporine results in decreased expression of IGFBP2 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of IGFBP2 mRNA23640034
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of IGFBP2 mRNA]21095227
D003907DexamethasoneDexamethasone results in decreased expression of IGFBP2 protein12670838
D003907DexamethasoneDexamethasone results in increased expression of IGFBP2 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGFBP2 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of IGFBP2 mRNA19853640
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of IGFBP2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of IGFBP2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of IGFBP2 mRNA27594783
D004008DiclofenacDiclofenac results in decreased expression of IGFBP2 mRNA26934552
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of IGFBP2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of IGFBP2 mRNA22609946
D004041Dietary FatsDietary Fats results in increased expression of IGFBP2 mRNA19467301
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of IGFBP2 mRNA12771043
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IGFBP2 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of IGFBP2 mRNA15766595
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of IGFBP2 mRNA15171707
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of IGFBP2 mRNA17072980
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of IGFBP2 mRNA25380136
D004237DiuronDiuron results in increased expression of IGFBP2 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of IGFBP2 protein8792405
D004610Ellagic AcidEllagic Acid results in increased expression of IGFBP2 mRNA12002526
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of IGFBP2 mRNA24412560
D000431EthanolEthanol affects the expression of IGFBP2 mRNA11772933
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IGFBP2 mRNA16872691
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IGFBP2 protein15817916
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of IGFBP2 mRNA12655037|1607927
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IGFBP2 mRNA29097150
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IGFBP2 mRNA17557909
D005001EthionineEthionine affects the expression of IGFBP2 mRNA19483382
C024565ethylene dichlorideethylene dichloride results in increased expression of IGFBP2 mRNA28189721
D005472FluorouracilFluorouracil results in increased expression of IGFBP2 protein21296659
D005473FluoxetineFluoxetine results in decreased expression of IGFBP2 mRNA17033635
D005485FlutamideFlutamide inhibits the reaction [Dihydrotestosterone results in increased expression of IGFBP2 mRNA]16368782
D005485FlutamideFlutamide results in decreased expression of IGFBP2 mRNA24136188
D005492Folic AcidFolic Acid results in increased expression of IGFBP2 mRNA8594875
C039281furanfuran results in increased expression of IGFBP2 mRNA26194646
C071834glycidamideglycidamide results in decreased expression of IGFBP2 mRNA17822822
D006118GriseofulvinGriseofulvin affects the expression of IGFBP2 mRNA12735108
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of IGFBP2 mRNA26941288
D017313FenretinideFenretinide results in increased expression of IGFBP2 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGFBP2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGFBP2 mRNA28628672
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of IGFBP2 protein27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IGFBP2 mRNA25961927
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IGFBP2 mRNA26941288
C045463leflunomideleflunomide results in increased expression of IGFBP2 mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of IGFBP2 mRNA27339419
C015329lycopenelycopene results in increased expression of IGFBP2 protein17337101
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of IGFBP2 mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IGFBP2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IGFBP2 mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of IGFBP2 mRNA25380136
D009532NickelNickel results in decreased expression of IGFBP2 mRNA25583101
D009538NicotineNicotine results in increased expression of IGFBP2 mRNA23825647
C025589ochratoxin Aochratoxin A results in increased expression of IGFBP2 mRNA14994279
D009853OmeprazoleOmeprazole affects the expression of IGFBP2 mRNA19483382
C016340o,p'-DDT"o,p'-DDT results in increased expression of IGFBP2 mRNA"20686349
D010100OxygenOxygen deficiency results in increased expression of IGFBP2 mRNA24236059
D010100OxygenTretinoin affects the reaction [Oxygen affects the secretion of IGFBP2 protein]16055936
D010126OzoneOzone results in decreased expression of IGFBP2 mRNA16330353
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of IGFBP2 mRNA17560707
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IGFBP2 mRNA19162173|2131816
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of IGFBP2 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of IGFBP2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of IGFBP2 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of IGFBP2 mRNA19162173
D010795Phthalic AcidsPhthalic Acids results in decreased expression of IGFBP2 mRNA15728792|2106145
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IGFBP2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of IGFBP2 mRNA18301758|2081375
C006253pirinixic acidpirinixic acid affects the expression of IGFBP2 mRNA19483382
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of IGFBP2 mRNA27413110
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of IGFBP2 mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of IGFBP2 mRNA19162173|2131816
D011374ProgesteroneProgesterone results in decreased expression of and affects the localization of IGFBP2 protein22085906
D011374ProgesteroneProgesterone results in increased expression of IGFBP2 mRNA22085906
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased secretion of IGFBP2 protein15809018
D011374ProgesteroneProgesterone results in decreased expression of IGFBP2 mRNA18070364
D011374ProgesteroneProgesterone results in increased secretion of IGFBP2 protein15809018
D011374ProgesteroneProgesterone results in increased expression of IGFBP2 mRNA19853640
D011441PropylthiouracilPropylthiouracil affects the expression of IGFBP2 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of IGFBP2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of IGFBP2 mRNA27029645
D011794QuercetinQuercetin results in increased expression of IGFBP2 mRNA21632981
C059514resveratrolresveratrol results in increased expression of IGFBP2 mRNA12002526|1256957
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of IGFBP2 mRNA25905778
C059514resveratrolresveratrol results in decreased expression of IGFBP2 protein23192356
C013672riddelliineriddelliine results in increased expression of IGFBP2 mRNA18047727
C089730rosiglitazonerosiglitazone results in decreased expression of IGFBP2 mRNA25572481
C086511RU 58668RU 58668 affects the expression of IGFBP2 protein15868441
C541923sandostatinLARsandostatinLAR results in decreased expression of IGFBP2 mRNA17210224
D012643SeleniumSelenium results in increased expression of IGFBP2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IGFBP2 mRNA23806026
D012834SilverSilver results in decreased expression of IGFBP2 mRNA27131904
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of IGFBP2 mRNA]21095227
C009277sodium arsenatesodium arsenate results in decreased expression of IGFBP2 mRNA12727804
C017947sodium arsenitesodium arsenite results in decreased expression of IGFBP2 mRNA12727804
C017947sodium arsenitesodium arsenite results in decreased expression of IGFBP2 mRNA17350061|1745185
C025399sodium tungstate(VI)sodium tungstate(VI) affects the expression of IGFBP2 mRNA26164860
D053260SootSoot results in increased expression of IGFBP2 mRNA26551751
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of IGFBP2 mRNA25905778
D014284TriiodothyronineTriiodothyronine results in increased expression of IGFBP2 mRNA15953391
C061133tamibarotenetamibarotene affects the expression of IGFBP2 mRNA15498508
D013629TamoxifenTamoxifen results in increased expression of IGFBP2 mRNA17555576
D013629Tamoxifen[Tamoxifen co-treated with bexarotene] results in increased expression of IGFBP2 mRNA17630414
D013629TamoxifenTamoxifen results in decreased expression of IGFBP2 mRNA17630414
D013739TestosteroneTestosterone results in increased expression of IGFBP2 mRNA16368782
D013739TestosteroneTestosterone results in increased expression of IGFBP2 protein15817916
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IGFBP2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IGFBP2 mRNA19619570|2010694
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IGFBP2 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IGFBP2 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IGFBP2 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IGFBP2 mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IGFBP2 mRNA16267337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IGFBP2 mRNA21215274
D013752TetracyclineTetracycline results in decreased expression of IGFBP2 mRNA24489787
D019284ThapsigarginThapsigargin results in decreased expression of IGFBP2 mRNA22378314
D013849ThimerosalThimerosal results in decreased expression of IGFBP2 mRNA27188386
D013853ThioacetamideThioacetamide affects the expression of IGFBP2 mRNA19483382
D013853ThioacetamideThioacetamide results in increased expression of IGFBP2 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of IGFBP2 mRNA23409001|2356515
C009495titanium dioxidetitanium dioxide results in increased expression of IGFBP2 protein23565150
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IGFBP2 mRNA28065790
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of IGFBP2 mRNA24096154
D014118Toxins, Biological"Toxins, Biological affects the expression of IGFBP2 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of IGFBP2 mRNA15498508|1721838
D014212TretinoinTretinoin affects the reaction [Oxygen affects the secretion of IGFBP2 protein]16055936
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IGFBP2 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of IGFBP2 mRNA25572481
D014415TunicamycinTunicamycin results in decreased expression of IGFBP2 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IGFBP2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of IGFBP2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of IGFBP2 mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of IGFBP2 mRNA17292431|1796380
D014635Valproic AcidValproic Acid results in increased expression of IGFBP2 mRNA21318169
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IGFBP2 gene25560391
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of IGFBP2 protein27169980
D014810Vitamin EVitamin E results in increased expression of IGFBP2 mRNA19244175
D024483Vitamin K 3Vitamin K 3 results in decreased expression of IGFBP2 mRNA25270620
C111237vorinostatvorinostat results in increased expression of IGFBP2 mRNA26941288
D015032ZincZinc deficiency results in decreased expression of IGFBP2 mRNA12672911

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS24431302  
GO:0005515protein binding-IPI19095771  
GO:0031994insulin-like growth factor I binding-IBA21873635  
GO:0031994insulin-like growth factor I binding-IDA19081843  
GO:0031995insulin-like growth factor II binding-IBA21873635  
GO:0031995insulin-like growth factor II binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-IEA-  
GO:0007165signal transduction-IEA-  
GO:0007565female pregnancy-IEA-  
GO:0007568aging-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0009612response to mechanical stimulus-IEA-  
GO:0010226response to lithium ion-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0032526response to retinoic acid-IEA-  
GO:0032870cellular response to hormone stimulus-IEA-  
GO:0042104positive regulation of activated T cell proliferation-IDA15694994  
GO:0042493response to drug-IEA-  
GO:0043567regulation of insulin-like growth factor receptor signaling pathway-IBA21873635  
GO:0043567regulation of insulin-like growth factor receptor signaling pathway-IC19081843  
GO:0043567regulation of insulin-like growth factor receptor signaling pathway-ISS-  
GO:0043627response to estrogen-IEA-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0051384response to glucocorticoid-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-TAS24431302  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-ISS-  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA15694994  
GO:0016324apical plasma membrane-IEA-  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21917606Potential role of HE4 in multimodal screening for epithelial ovarian cancer. (2011 Nov 2)Urban NJ Natl Cancer Inst
24069370Insulin-like growth factor binding protein-2 level is increased in blood of lung cancer patients and associated with poor survival. (2013)Guo CPLoS One
29500455Trichostatin A reverses the chemoresistance of lung cancer with high IGFBP2 expression through enhancing autophagy. (2018 Mar 2)Tang DSci Rep