Gene info: ID 3486

Gene: IGFBP3

GENE ID: 3486

Synonyms: BP-53|IBP3

Description: insulin like growth factor binding protein 3

Gene type: protein-coding

Location: 7p12.3

dbXrefs: Ensembl:ENSG00000146674 MIM:146732 Vega:OTTHUMG00000023769 UniprotKB:P17936

RefSeq: NG_011508.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 19

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.059e-1 (AD) 5.693e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CNOT8	0.642
NEXN	0.632
PRSS23	0.629
RPGR	0.597
IFNGR1	0.593
HSD17B11	0.591
PDCD4	0.59
COL8A1	0.587
HIPK3	0.586
FBLN5	0.585

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
BTBD17	-0.371
HES5	-0.367
HPSE2	-0.359
ADAMTSL5	-0.345
PYGM	-0.341
PIPOX	-0.338
REN	-0.336
MMD2	-0.329
WNT7B	-0.315
ARSF	-0.315

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00523	Alitretinoin	Small Molecule	5300-03-8	Approved\|Investigational	Target
DB01277	Mecasermin	BiotechDrug	68562-41-4	Approved\|Investigational	Target
DB06448	Lonafarnib	Small Molecule	193275-84-2	Investigational	Target

ID	Drug Name	Action	PubMed
C070046	1,2-dioleoyloxy-3-(trimethylammonium)propane	"[1,2-dioleoyloxy-3-(trimethylammonium)propane co-treated with Cholesterol] results in increased expression of IGFBP3 protein"	16034455
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of IGFBP3 mRNA"	19162173
C038625	1-N-methyl-5-thiotetrazole	1-N-methyl-5-thiotetrazole results in increased expression of IGFBP3 mRNA	28465218
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of IGFBP3 mRNA	19933214
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of IGFBP3 mRNA"	21920950
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of IGFBP3 mRNA"	20638727
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of IGFBP3 mRNA"	22262711
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	"2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of IGFBP3 mRNA"	24497940\|2910824
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	"2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of IGFBP3 protein"	29108245
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	"TGFBR2 protein inhibits the reaction [2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of IGFBP3 mRNA]"	29108245
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	"TGFBR2 protein inhibits the reaction [2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of IGFBP3 protein]"	29108245
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of IGFBP3 mRNA]	12710931
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of IGFBP3 protein]	16682453
C011269	2,5-hexanedione	"2,5-hexanedione results in decreased expression of IGFBP3 mRNA"	16141653
C019499	2-nitrofluorene	2-nitrofluorene results in decreased expression of IGFBP3 mRNA	15890375
C029955	2-nitrotoluene	2-nitrotoluene results in increased expression of IGFBP3 mRNA	16460773
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl affects the expression of IGFBP3 mRNA"	20638727
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IGFBP3 mRNA"	22262711
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IGFBP3 protein"	10919282
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of IGFBP3 mRNA"	24172598
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of IGFBP3 mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of IGFBP3 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP3 mRNA"	27188386
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Smoke] affects the expression of IGFBP3 mRNA	17278094
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Smoke] results in increased expression of IGFBP3 protein	17278094
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of IGFBP3 mRNA	15890375
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of IGFBP3 mRNA	15982314
C029370	4-toluidine	4-toluidine results in decreased expression of IGFBP3 mRNA	27638505
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of IGFBP3 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of IGFBP3 mRNA	17562736
C016601	afimoxifene	afimoxifene results in increased expression of IGFBP3 mRNA	12154049
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of IGFBP3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of IGFBP3 mRNA	28943387
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of IGFBP3 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of IGFBP3 mRNA	21641981\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of IGFBP3 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of IGFBP3 mRNA	15890375
C430898	AGN 194204	[AGN 194204 co-treated with IGFBP3 protein] results in increased activity of CASP3 protein	16000583
C430898	AGN 194204	[AGN 194204 co-treated with IGFBP3 protein] results in increased activity of CASP7 protein	16000583
D000447	Aldehydes	Aldehydes results in decreased expression of IGFBP3 mRNA	25014914
C103303	alitretinoin	[alitretinoin binds to RARB protein] which binds to IGFBP3 promoter	16760641
C103303	alitretinoin	alitretinoin results in increased expression of IGFBP3 mRNA	16760641
C103303	alitretinoin	alitretinoin results in increased expression of IGFBP3 protein	15994153
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of IGFBP3 mRNA	28522335
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of IGFBP3 mRNA	16368782
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased secretion of IGFBP3 protein	16368782
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of IGFBP3 mRNA	16825320
C041524	aluminum sulfate	aluminum sulfate results in decreased secretion of IGFBP3 protein	7685579
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IGFBP3 mRNA	16483693
D000667	Ampicillin	Ampicillin results in increased expression of IGFBP3 mRNA	21632981
D000728	Androgens	Androgens affects the expression of IGFBP3 mRNA	17288544
C519728	archazolid B	archazolid B results in increased expression of IGFBP3 mRNA	25218289
D001151	Arsenic	Arsenic affects the methylation of IGFBP3 gene	25304211
C006632	arsenic trioxide	[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP3 protein	27430728
C006632	arsenic trioxide	arsenic trioxide results in increased expression of IGFBP3 protein	27430728
C015001	arsenite	arsenite results in decreased expression of IGFBP3 mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of IGFBP3 mRNA]	18929588
D001379	Azathioprine	Azathioprine results in increased expression of IGFBP3 mRNA	22623647
C010038	azelaic acid	azelaic acid results in decreased expression of IGFBP3 protein	19880116
D001507	Beclomethasone	Beclomethasone results in increased expression of IGFBP3 mRNA	23656298
D001554	Benzene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of IGFBP3 mRNA	17905399
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of IGFBP3 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of IGFBP3 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IGFBP3 mRNA	19152381\|2010694
D001564	Benzo(a)pyrene	chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IGFBP3 mRNA]	19152381
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of IGFBP3 mRNA	20127859\|2234223
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IGFBP3 mRNA	19770486\|2222880
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP3 mRNA	20823114
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of IGFBP3 mRNA	20660070
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased secretion of IGFBP3 protein	15809018
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IGFBP3 mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of IGFBP3 mRNA	23019147\|2532141
D004958	Estradiol	Estradiol results in decreased expression of IGFBP3 protein	15855258
D004958	Estradiol	Estradiol results in decreased secretion of IGFBP3 protein	15809018
D004958	Estradiol	Estradiol results in increased expression of IGFBP3 mRNA	12154049\|1961957
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of IGFBP3 mRNA	17404688
D004958	Estradiol	Estradiol results in decreased expression of IGFBP3 mRNA	19341330\|2521013
C044887	beta-methylcholine	beta-methylcholine affects the expression of IGFBP3 mRNA	21179406
C095105	bexarotene	[bexarotene co-treated with Tamoxifen] results in decreased expression of IGFBP3 mRNA	17630414
C095105	bexarotene	bexarotene results in decreased expression of IGFBP3 mRNA	16648578
C053541	bicalutamide	[bicalutamide co-treated with Tamoxifen] results in increased expression of IGFBP3 protein	16847815
C053541	bicalutamide	bicalutamide results in decreased expression of IGFBP3 mRNA	16368782
C053541	bicalutamide	bicalutamide results in decreased secretion of IGFBP3 protein	16368782
C053541	bicalutamide	bicalutamide results in increased expression of IGFBP3 protein	16847815
C053541	bicalutamide	bicalutamide results in increased expression of IGFBP3 mRNA	10604720
D001663	Bilirubin	Bilirubin results in decreased expression of IGFBP3 mRNA	20196124
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of IGFBP3 mRNA	27685785
C006780	bisphenol A	bisphenol A affects the expression of IGFBP3 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of IGFBP3 mRNA	20170705
C006780	bisphenol A	bisphenol A results in increased expression of IGFBP3 mRNA	25181051
C099813	bromochloroacetic acid	bromochloroacetic acid results in increased expression of IGFBP3 mRNA	16460773
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of IGFBP3 mRNA	15336504
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of IGFBP3 mRNA	15963989
C018475	butyraldehyde	butyraldehyde results in decreased expression of IGFBP3 mRNA	26079696
D002087	Butyrates	Butyrates results in decreased expression of IGFBP3 mRNA	14674679
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of IGFBP3 mRNA	26472689
D002220	Carbamazepine	Carbamazepine affects the expression of IGFBP3 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of IGFBP3 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IGFBP3 mRNA	27339419
D002330	Carmustine	Carmustine results in decreased expression of IGFBP3 mRNA	16005536
D002438	Cefoperazone	Cefoperazone metabolite results in decreased expression of IGFBP3 mRNA	28465218
D002438	Cefoperazone	Cefoperazone results in decreased expression of IGFBP3 mRNA	28465218
D002713	Chlorine	Chlorine results in decreased expression of IGFBP3 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of IGFBP3 mRNA	18636392
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP3 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of IGFBP3 mRNA	26272509
C007020	chlorophyllin	chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IGFBP3 mRNA]	19152381
D002737	Chloroprene	Chloroprene results in decreased expression of IGFBP3 mRNA	23125180
D002784	Cholesterol	"[1,2-dioleoyloxy-3-(trimethylammonium)propane co-treated with Cholesterol] results in increased expression of IGFBP3 protein"	16034455
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of IGFBP3 mRNA	27344345
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of IGFBP3 mRNA	17602206
D060729	Coal Ash	Coal Ash results in increased expression of IGFBP3 mRNA	19000753
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased expression of IGFBP3 protein	18200630
C018021	cobaltous chloride	cobaltous chloride results in increased secretion of IGFBP3 protein	16682453
C018021	cobaltous chloride	Cyclosporine inhibits the reaction [cobaltous chloride results in increased secretion of IGFBP3 protein]	16682453
D003300	Copper	Copper results in decreased expression of IGFBP3 mRNA	26293553
D003300	Copper	Copper results in decreased expression of IGFBP3 mRNA	19747488
D003300	Copper	Copper deficiency results in decreased expression of IGFBP3 protein	15734878
D003300	Copper	Copper deficiency results in increased expression of IGFBP3 mRNA	17418555
C030973	cupric oxide	cupric oxide results in decreased expression of IGFBP3 mRNA	22077320
D003474	Curcumin	[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP3 protein	27430728
D003474	Curcumin	Curcumin results in decreased expression of IGFBP3 mRNA	16101141
D003474	Curcumin	Curcumin results in increased expression of IGFBP3 mRNA	21594647
D003474	Curcumin	Curcumin results in increased secretion of IGFBP3 protein	17499312
D003474	Curcumin	Curcumin results in decreased expression of IGFBP3 mRNA	18299980
D003520	Cyclophosphamide	IGFBP3 protein affects the susceptibility to Cyclophosphamide	16217747
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of IGFBP3 mRNA	16141653
D016572	Cyclosporine	Cyclosporine inhibits the reaction [cobaltous chloride results in increased secretion of IGFBP3 protein]	16682453
D016572	Cyclosporine	Cyclosporine results in decreased expression of IGFBP3 mRNA	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of IGFBP3 mRNA	20106945\|2556210
D003561	Cytarabine	Cytarabine results in decreased expression of IGFBP3 mRNA	21198554
C014347	decitabine	[decitabine affects the acetylation of HIST3H3 promoter] which affects the expression of IGFBP3 mRNA	16505122
C014347	decitabine	decitabine results in increased expression of IGFBP3 mRNA	16367923\|1915171
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in decreased secretion of IGFBP3 protein	16368782
C007262	deoxynivalenol	deoxynivalenol promotes the reaction [Glutathione results in increased expression of IGFBP3 mRNA]	19805407
D003907	Dexamethasone	Dexamethasone results in decreased expression of IGFBP3 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of IGFBP3 mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA	16054899
D003907	Dexamethasone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA]	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA]	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of IGFBP3 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of IGFBP3 mRNA]	20032058
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP3 mRNA	20823114
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of IGFBP3 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of IGFBP3 mRNA	16061661\|2739243
D002945	Cisplatin	Cisplatin results in increased expression of IGFBP3 mRNA	21532991
D004008	Diclofenac	Diclofenac affects the expression of IGFBP3 mRNA	24752500
D004041	Dietary Fats	Dietary Fats results in decreased expression of IGFBP3 mRNA	25016146
D004041	Dietary Fats	Dietary Fats results in increased expression of IGFBP3 mRNA	18457598
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of IGFBP3 mRNA	21527772
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of IGFBP3 mRNA	17602206
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of IGFBP3 mRNA	25374375
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of IGFBP3 promoter	25374375
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of IGFBP3 mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of IGFBP3 mRNA	15171707
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of IGFBP3 mRNA	15890375
D002117	Calcitriol	[Calcitriol co-treated with Genistein] results in increased expression of IGFBP3 mRNA	15955619
D002117	Calcitriol	[Calcitriol co-treated with Metribolone] results in increased expression of IGFBP3 mRNA	16825320
D002117	Calcitriol	Calcitriol results in increased expression of IGFBP3 mRNA	16825320
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of IGFBP3 mRNA	15890375\|2538013
D004237	Diuron	Diuron metabolite results in increased expression of IGFBP3 mRNA	24172598
D004237	Diuron	Diuron results in decreased expression of IGFBP3 mRNA	21551480\|2515243
D004317	Doxorubicin	Doxorubicin results in decreased expression of IGFBP3 mRNA	28940058
D004317	Doxorubicin	Doxorubicin results in increased expression of IGFBP3 mRNA	21040762\|2589636
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of IGFBP3 mRNA	21040762
D004391	Dust	Dust results in increased expression of IGFBP3 mRNA	17805423
C118739	entinostat	entinostat results in decreased expression of IGFBP3 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP3 mRNA"	27188386
C010452	estradiol-17 beta-benzoate	estradiol-17 beta-benzoate results in decreased expression of IGFBP3 mRNA	15972882
C015854	estradiol valerate	estradiol valerate results in decreased expression of IGFBP3 protein	10843175
C015854	estradiol valerate	estradiol valerate results in decreased expression of IGFBP3 mRNA	15972882
D004967	Estrogens	IGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of IGFBP3 mRNA]	18562952
D004967	Estrogens	[Progesterone co-treated with Estrogens] results in increased expression of IGFBP3 mRNA	18562952
D004966	Estrogens, Conjugated (USP)	"Estrogens, Conjugated (USP) results in decreased expression of IGFBP3 protein"	10843175
D000431	Ethanol	Ethanol results in increased expression of IGFBP3 mRNA	15963989
D000431	Ethanol	Ethanol results in increased secretion of IGFBP3 protein	28763032
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of IGFBP3 mRNA	20170705\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of IGFBP3 mRNA	18936297
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of IGFBP3 protein	10843175
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of IGFBP3 mRNA	20170705\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of IGFBP3 mRNA	12655037\|1583489
D015025	Zearalenone	Zearalenone results in decreased expression of IGFBP3 mRNA	28965971
C540355	fenamidone	fenamidone results in increased expression of IGFBP3 mRNA	27029645
D005419	Flavonoids	Flavonoids results in decreased expression of IGFBP3 mRNA	18035473
D005485	Flutamide	Flutamide results in decreased secretion of IGFBP3 protein	16368782
D005485	Flutamide	Flutamide results in decreased expression of IGFBP3 mRNA	21525395
D005492	Folic Acid	Folic Acid results in decreased expression of IGFBP3 mRNA	8594875
D004397	Fonofos	Fonofos results in increased methylation of IGFBP3 promoter	22847954
C069837	fullerene C60	fullerene C60 results in decreased expression of IGFBP3 mRNA	19167457
C038958	gadolinium chloride	gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGFBP3 protein]	16522730
C056507	gemcitabine	gemcitabine affects the expression of IGFBP3 mRNA	20103597
D019833	Genistein	[Calcitriol co-treated with Genistein] results in increased expression of IGFBP3 mRNA	15955619
D019833	Genistein	Genistein results in decreased expression of IGFBP3 mRNA	23019147\|2686566
C063170	Ginkgo biloba extract	Ginkgo biloba extract results in decreased expression of IGFBP3 mRNA	28943387
D005897	Glafenine	Glafenine results in decreased expression of IGFBP3 mRNA	24136188
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of IGFBP3 mRNA]	17109745
D005944	Glucosamine	Glucosamine results in decreased expression of IGFBP3 mRNA	17109745
D005944	Glucosamine	IL1B inhibits the reaction [Glucosamine results in increased expression of IGFBP3 mRNA]	17109745
D005978	Glutathione	deoxynivalenol promotes the reaction [Glutathione results in increased expression of IGFBP3 mRNA]	19805407
D005978	Glutathione	Glutathione results in increased expression of IGFBP3 mRNA	19805407
C004312	glycidol	glycidol results in decreased expression of IGFBP3 mRNA	24915197
C010176	halofuginone	halofuginone inhibits the reaction [Thioacetamide results in increased expression of IGFBP3 mRNA]	14739098
C010176	halofuginone	halofuginone results in increased expression of IGFBP3 mRNA	17180598
D017313	Fenretinide	Fenretinide results in increased expression of IGFBP3 mRNA	28973697
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of IGFBP3 mRNA	28628672
D007501	Iron	Iron deficiency results in increased expression of IGFBP3 mRNA	16629162
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of IGFBP3 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA]	16054899
D007529	Isoflavones	Isoflavones affects the expression of IGFBP3 mRNA	16365062
D007545	Isoproterenol	Isoproterenol results in decreased expression of IGFBP3	12883319
D007545	Isoproterenol	SI 27 inhibits the reaction [Isoproterenol results in decreased expression of IGFBP3]	12883319
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of IGFBP3 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of IGFBP3 mRNA	27392435
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of IGFBP3 mRNA	25119042
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of IGFBP3 mRNA	24796395\|2511904
D007649	Ketamine	Ketamine results in increased expression of IGFBP3 mRNA	20080153
C045463	leflunomide	leflunomide results in increased expression of IGFBP3 mRNA	28988120
C533894	LG 100815	LG 100815 results in increased expression of IGFBP3 mRNA	16951191
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of IGFBP3 mRNA"	11578593
D008070	Lipopolysaccharides	gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGFBP3 protein]	16522730
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of IGFBP3 protein	16522730
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of IGFBP3 mRNA	26378955
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP3 mRNA	20823114
C042720	mercuric bromide	mercuric bromide results in decreased expression of IGFBP3 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP3 mRNA"	27188386
D008701	Methapyrilene	Methapyrilene results in decreased expression of IGFBP3 mRNA	15890375
D008713	Methimazole	Methimazole results in increased expression of IGFBP3 mRNA	22504374
D008727	Methotrexate	Methotrexate results in increased expression of IGFBP3 mRNA	17379860\|2167806
D008727	Methotrexate	Methotrexate results in decreased expression of IGFBP3 mRNA	16005536
C013598	methoxyacetic acid	methoxyacetic acid results in decreased expression of IGFBP3 mRNA	18486176
C005219	methyl cellosolve	methyl cellosolve results in increased expression of IGFBP3 mRNA	16141653
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of IGFBP3 mRNA	26272509
C030957	methylmercury II	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of IGFBP3 mRNA	17905399
D015655	1-Methyl-4-phenylpyridinium	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of IGFBP3 mRNA]	12710931
D015655	1-Methyl-4-phenylpyridinium	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of IGFBP3 mRNA]	12710931
D015741	Metribolone	[Calcitriol co-treated with Metribolone] results in increased expression of IGFBP3 mRNA	16825320
D015741	Metribolone	Metribolone promotes the reaction [AR protein binds to IGFBP3 promoter]	16825320
D015741	Metribolone	Metribolone results in increased expression of IGFBP3 mRNA	16825320
D015735	Mifepristone	Mifepristone results in increased expression of IGFBP3 mRNA	17584828
D008942	Mitoxantrone	IGFBP3 protein affects the susceptibility to Mitoxantrone	16217747
C028577	monobutyl phthalate	monobutyl phthalate affects the expression of IGFBP3 mRNA	19162170
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of IGFBP3 protein	24625837
C500085	muraglitazar	muraglitazar results in increased expression of IGFBP3 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in decreased expression of IGFBP3 mRNA	15674843
C452423	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of IGFBP3 mRNA	16052530
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of IGFBP3 mRNA"	24389112
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of IGFBP3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of IGFBP3 mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of IGFBP3 mRNA	18978301
C031721	naphthalene	naphthalene analog results in increased expression of IGFBP3 mRNA	24976557
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of IGFBP3 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of IGFBP3 mRNA	25380136
C051752	nefazodone	nefazodone results in decreased expression of IGFBP3 mRNA	24136188
D009532	Nickel	Nickel results in increased expression of IGFBP3 mRNA	25583101
C119536	nickel acetate	nickel acetate affects the expression of IGFBP3 mRNA	12915101
C022838	nickel chloride	nickel chloride results in increased expression of IGFBP3 mRNA	21455298
C028007	nickel monoxide	nickel monoxide affects the expression of IGFBP3 mRNA	19167457
C017557	nickel subsulfide	nickel subsulfide results in increased expression of IGFBP3 mRNA	12760830
C012655	nimesulide	nimesulide results in decreased expression of IGFBP3 mRNA	24136188
C007350	nitrofen	nitrofen results in decreased expression of IGFBP3 mRNA	19844724
C007350	nitrofen	nitrofen results in decreased expression of IGFBP3 protein	19844724
D016912	Levonorgestrel	[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of IGFBP3 mRNA	19074003
C558013	NSC 689534	NSC 689534 results in increased expression of IGFBP3 mRNA	20971185
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in increased expression of IGFBP3 mRNA"	16951191
C016340	o,p'-DDT	"o,p'-DDT affects the expression of IGFBP3 mRNA"	17984292
C030110	oxaliplatin	oxaliplatin results in decreased expression of IGFBP3 mRNA	17762391
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of IGFBP3 mRNA	25729387
D010100	Oxygen	HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of IGFBP3 mRNA]	20042640
D010100	Oxygen	Oxygen deficiency results in increased expression of IGFBP3 mRNA	20042640\|2651600
D010100	Oxygen	Tretinoin affects the reaction [Oxygen affects the secretion of IGFBP3 protein]	16055936
D010126	Ozone	Ozone results in decreased expression of IGFBP3 mRNA	25658374
D010126	Ozone	TTPA protein affects the reaction [Ozone results in decreased expression of IGFBP3 mRNA]	19555225
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of IGFBP3 mRNA	18636392
C496932	panobinostat	panobinostat results in decreased expression of IGFBP3 mRNA	26272509
D010278	Parathion	Parathion results in increased methylation of IGFBP3 promoter	22847954
D052638	Particulate Matter	Particulate Matter results in decreased expression of IGFBP3 mRNA	22178795\|2308503
C506614	PD 0325901	[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of IGFBP3 mRNA	25119042
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of IGFBP3 mRNA	26705709
C046012	pentanal	pentanal results in decreased expression of IGFBP3 mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of IGFBP3 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of IGFBP3 mRNA	25868421
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of IGFBP3 mRNA	19162173
D026023	Permethrin	Permethrin results in increased expression of IGFBP3 mRNA	19017407
D010634	Phenobarbital	Phenobarbital affects the expression of IGFBP3 mRNA	19159669
D010634	Phenobarbital	Phenobarbital affects the expression of IGFBP3 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of IGFBP3 mRNA	19270015
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of IGFBP3 mRNA	25374375
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of IGFBP3 promoter	25374375
D016226	Phosphorus, Dietary	"Phosphorus, Dietary affects the expression of IGFBP3 mRNA"	16311027
D010862	Pilocarpine	Pilocarpine results in increased expression of IGFBP3 mRNA	17971868
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in decreased expression of IGFBP3 mRNA	15890375
C006253	pirinixic acid	pirinixic acid results in decreased expression of IGFBP3 mRNA	20813756\|2381119
C006253	pirinixic acid	pirinixic acid results in decreased expression of IGFBP3 mRNA	15890375\|1916217
D028321	Plant Preparations	Plant Preparations affects the expression of IGFBP3 mRNA	16251609
D011070	Poly I-C	IL6 protein affects the reaction [Poly I-C results in decreased expression of IGFBP3 protein]	21195166
D011070	Poly I-C	Poly I-C results in decreased expression of IGFBP3 protein	21195166
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of IGFBP3 mRNA	23608068
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of IGFBP3 mRNA	20660070
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased secretion of IGFBP3 protein	15809018
D011374	Progesterone	[Progesterone affects the activity of PGR protein alternative form] which affects the expression of IGFBP3 mRNA	15866122
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of IGFBP3 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of IGFBP3 mRNA	18070364
D011374	Progesterone	Progesterone results in decreased secretion of IGFBP3 protein	15809018
D011374	Progesterone	IGF1 protein inhibits the reaction [[Progesterone co-treated with Estrogens] results in increased expression of IGFBP3 mRNA]	18562952
D011374	Progesterone	Progesterone affects the expression of IGFBP3	15178747
D011374	Progesterone	Progesterone affects the expression of IGFBP3 mRNA	17251523
D011374	Progesterone	[Progesterone co-treated with Estrogens] results in increased expression of IGFBP3 mRNA	18562952
D011374	Progesterone	Progesterone results in increased expression of IGFBP3 mRNA	19341330\|2223828
D011374	Progesterone	Progesterone results in increased expression of IGFBP3 mRNA	18753603
D011374	Progesterone	Progesterone results in increased expression of IGFBP3 mRNA	20726854
C045950	propiconazole	propiconazole results in decreased expression of IGFBP3 mRNA	21278054
C005556	propionaldehyde	propionaldehyde results in decreased expression of IGFBP3 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of IGFBP3 mRNA	22504374\|2478091
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of IGFBP3 mRNA	27029645
C009131	pyrimidin-2-one beta-ribofuranoside	pyrimidin-2-one beta-ribofuranoside affects the expression of IGFBP3 mRNA	16505122
D011794	Quercetin	Quercetin results in increased expression of IGFBP3 mRNA	20658310\|2163298
D011794	Quercetin	Quercetin results in increased secretion of IGFBP3 protein	16898267
D011794	Quercetin	Quercetin results in increased expression of IGFBP3 mRNA	17103110
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of IGFBP3 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of IGFBP3 protein	15855258\|1691266
C059514	resveratrol	resveratrol results in increased expression of IGFBP3 mRNA	25866375
C059514	resveratrol	resveratrol results in increased expression of IGFBP3 mRNA	12154049
D015474	Isotretinoin	Isotretinoin results in increased expression of IGFBP3 mRNA	18769122
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of IGFBP3 mRNA	21127053
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA	16054899
C089730	rosiglitazone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA]	16054899
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA]	16054899
C089730	rosiglitazone	rosiglitazone results in increased expression of IGFBP3 mRNA	21515302
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of IGFBP3 mRNA	21427059
D012643	Selenium	Selenium results in increased expression of IGFBP3 mRNA	18997278
D012643	Selenium	Selenium results in increased expression of IGFBP3 protein	15318950
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of IGFBP3 mRNA"	21148743
C421267	SI 27	SI 27 inhibits the reaction [Isoproterenol results in decreased expression of IGFBP3]	12883319
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of IGFBP3 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of IGFBP3 mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of IGFBP3 mRNA	23221170
D012834	Silver	Silver results in decreased expression of IGFBP3 mRNA	27131904
D020123	Sirolimus	Sirolimus inhibits the reaction [IGF1 protein results in increased secretion of IGFBP3 protein]	16682453
C439060	sirtinol	sirtinol results in increased expression of IGFBP3 mRNA	22495798
D012906	Smoke	[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Smoke] affects the expression of IGFBP3 mRNA	17278094
D012906	Smoke	[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Smoke] results in increased expression of IGFBP3 protein	17278094
C009277	sodium arsenate	sodium arsenate results in decreased expression of IGFBP3 mRNA	12727804
C017947	sodium arsenite	sodium arsenite results in decreased expression of IGFBP3 mRNA	12727804\|2519968
C017947	sodium arsenite	sodium arsenite affects the expression of IGFBP3 mRNA	16507464
C017947	sodium arsenite	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IGFBP3 mRNA	16368122
D012999	Soman	Soman results in increased expression of IGFBP3 mRNA	19281266
D053260	Soot	Soot results in decreased expression of IGFBP3 mRNA	22461453\|2655175
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in decreased expression of IGFBP3 mRNA	16214533
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of IGFBP3 mRNA	26378955
D012460	Sulfasalazine	Sulfasalazine affects the expression of IGFBP3 mRNA	16141653
C061133	tamibarotene	tamibarotene results in increased expression of IGFBP3 mRNA	10766424
C061133	tamibarotene	tamibarotene results in increased expression of IGFBP3 protein	10766424
D013629	Tamoxifen	[bicalutamide co-treated with Tamoxifen] results in increased expression of IGFBP3 protein	16847815
D013629	Tamoxifen	[bexarotene co-treated with Tamoxifen] results in decreased expression of IGFBP3 mRNA	17630414
D013654	Taurine	Taurine results in decreased expression of IGFBP3 mRNA	16579726
C012568	terbufos	terbufos results in increased methylation of IGFBP3 promoter	22847954
D013739	Testosterone	Testosterone results in decreased expression of IGFBP3 mRNA	16368782
D013739	Testosterone	Testosterone results in decreased secretion of IGFBP3 protein	16368782
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of IGFBP3 mRNA]	20032058
C010792	testosterone undecanoate	[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of IGFBP3 mRNA	19074003
C010792	testosterone undecanoate	testosterone undecanoate results in increased expression of IGFBP3 mRNA	19074003
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of IGFBP3 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IGFBP3 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IGFBP3 mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGFBP3 mRNA	21632981
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGFBP3 mRNA	16480812\|1961957
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IGFBP3 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of IGFBP3 mRNA	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGFBP3 mRNA	16054899\|1869160
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGFBP3 mRNA	16054898\|2121527
D013752	Tetracycline	Tetracycline results in decreased expression of IGFBP3 mRNA	24489787
D013755	Tetradecanoylphorbol Acetate	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IGFBP3 mRNA	16368122
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of IGFBP3 mRNA	19945525
D013792	Thalidomide	Thalidomide affects the expression of IGFBP3 mRNA	15939924
D013792	Thalidomide	Thalidomide results in decreased expression of IGFBP3 mRNA	26217789
D019284	Thapsigargin	Thapsigargin results in increased expression of IGFBP3 mRNA	22378314
D013853	Thioacetamide	halofuginone inhibits the reaction [Thioacetamide results in increased expression of IGFBP3 mRNA]	14739098
D013853	Thioacetamide	Thioacetamide affects the expression of IGFBP3 mRNA	16098781
D013853	Thioacetamide	Thioacetamide results in increased expression of IGFBP3 mRNA	14739098
D013866	Thioguanine	Thioguanine results in decreased expression of IGFBP3 mRNA	16005536
C009495	titanium dioxide	titanium dioxide results in decreased expression of IGFBP3 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of IGFBP3 mRNA	20133372
D019772	Topotecan	IGFBP3 protein affects the susceptibility to Topotecan	16217747
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of IGFBP3 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of IGFBP3 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of IGFBP3 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of IGFBP3 mRNA	15982314\|1601251
D014212	Tretinoin	Tretinoin results in increased expression of IGFBP3 mRNA	16604517
D014212	Tretinoin	Tretinoin affects the reaction [Oxygen affects the secretion of IGFBP3 protein]	16055936
C011559	tributyltin	tributyltin affects the expression of IGFBP3 mRNA	26418422
D014241	Trichloroethylene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of IGFBP3 mRNA	17905399
C012589	trichostatin A	[trichostatin A affects the acetylation of HIST3H3 promoter] which affects the expression of IGFBP3 mRNA	16505122
C012589	trichostatin A	trichostatin A results in decreased expression of IGFBP3 mRNA	26272509
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of IGFBP3 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IGFBP3 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of IGFBP3 mRNA	29024780
C057693	troglitazone	troglitazone results in decreased expression of IGFBP3 mRNA	19140230
D014415	Tunicamycin	Tunicamycin inhibits the reaction [IGF1 protein results in increased N-linked glycosylation of IGFBP3 protein]	15277511
D014415	Tunicamycin	Tunicamycin results in decreased N-linked glycosylation of IGFBP3 protein	15277511
D014415	Tunicamycin	Tunicamycin results in increased expression of IGFBP3 mRNA	22378314
C113580	U 0126	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of IGFBP3 mRNA]	12710931
D014520	Urethane	Urethane results in increased expression of IGFBP3 mRNA	28818685
C406224	valdecoxib	valdecoxib results in decreased expression of IGFBP3 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased expression of IGFBP3 mRNA	24383497\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of IGFBP3 mRNA	23527032
D014635	Valproic Acid	Valproic Acid results in decreased expression of IGFBP3 mRNA	21427059
D014635	Valproic Acid	Valproic Acid results in increased expression of IGFBP3 mRNA	24896083
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of IGFBP3 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of IGFBP3 mRNA	23034163
D002762	Cholecalciferol	Cholecalciferol results in increased expression of IGFBP3 mRNA	17170073
D015032	Zinc	Zinc results in increased expression of IGFBP3 protein	19913001
D015032	Zinc	Zinc deficiency results in decreased expression of IGFBP3 protein	10985758
D015032	Zinc	Zinc deficiency results in increased expression of IGFBP3 mRNA	15990634

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001968	fibronectin binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	9388210 14561895 23178489
GO:0005520	insulin-like growth factor binding	-	NAS	12599210
GO:0008160	protein tyrosine phosphatase activator activity	-	IDA	11940579
GO:0031994	insulin-like growth factor I binding	-	IBA	21873635
GO:0031994	insulin-like growth factor I binding	-	IPI	10766744
GO:0031995	insulin-like growth factor II binding	-	IBA	21873635
GO:0046872	metal ion binding	-	NAS	14576163

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001558	regulation of cell growth	-	IEA	-
GO:0001649	osteoblast differentiation	-	IEA	-
GO:0001933	negative regulation of protein phosphorylation	-	IDA	17591901
GO:0006468	protein phosphorylation	-	IDA	17434920
GO:0006915	apoptotic process	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IGI	19258508
GO:0009968	negative regulation of signal transduction	-	NAS	11940579
GO:0010906	regulation of glucose metabolic process	-	IEA	-
GO:0014912	negative regulation of smooth muscle cell migration	-	IDA	10766744
GO:0042981	regulation of apoptotic process	-	TAS	-
GO:0043065	positive regulation of apoptotic process	-	IMP	11971816
GO:0043410	positive regulation of MAPK cascade	-	IEA	-
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	-	IBA	21873635
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	-	IEA	-
GO:0043666	regulation of phosphoprotein phosphatase activity	-	IEA	-
GO:0043687	post-translational protein modification	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0044342	type B pancreatic cell proliferation	-	IEA	-
GO:0045663	positive regulation of myoblast differentiation	-	IDA	12599210
GO:0048662	negative regulation of smooth muscle cell proliferation	-	IDA	10766744

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	17119061
GO:0005634	nucleus	-	IDA	17434920
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0016942	insulin-like growth factor binding protein complex	-	IC	10766744
GO:0042567	insulin-like growth factor ternary complex	-	IDA	9497324

KEGG ID	KEGG Term
hsa04115	p53 signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6803211	TP53 Regulates Transcription of Death Receptors and Ligands	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22113073	Associations of IGF1 and its binding proteins with abdominal aortic aneurysm and aortic diameter in older men. (2012 Feb)	Yeap BB	Eur J Endocrinol
28386678	Identification of novel potential genetic predictors of urothelial bladder carcinoma susceptibility in Pakistani population. (2017 Oct)	Ali SHB	Fam Cancer
19038836	Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival beyond 100 years of age. (2008 Nov)	Arai Y	J Gerontol A Biol Sci Med Sci
23363376	Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study. (2013 Mar)	Noordam R	Br J Dermatol
21892705	Urinary bladder cancer risk in relation to a single nucleotide polymorphism (rs2854744) in the insulin-like growth factor-binding protein-3 (IGFBP3) gene. (2012 Feb)	Selinski S	Arch Toxicol
22347413	Smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk. (2012)	Lin IH	PLoS One
27662841	Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study. (2016 Nov)	Adachi Y	Tumour Biol
25557790	An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. (2015 May)	Mahmoudi T	Tumour Biol
27035126	Correlation between insulinlike growth factor binding protein 3 and metastasisassociated gene 1 protein in esophageal squamous cell carcinoma. (2016 May)	Yang H	Mol Med Rep
21790896	Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women. (2011 Nov)	Yoshimoto N	Cancer Sci
19634593	Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men. (2009 Jul)	Hoyo C	J Natl Med Assoc
22479380	Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. (2012)	McKay JA	PLoS One
26924531	Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. (2016 Mar 3)	Galinsky KJ	Am J Hum Genet
21932422	Serum IGF1, IGF2 and IGFBP3 and risk of advanced colorectal adenoma. (2012 Jul 15)	Gao Y	Int J Cancer
23405181	Association of serum C-peptide concentrations with cancer mortality risk in pre-diabetes or undiagnosed diabetes. (2013)	Hsu CN	PLoS One
18615538	No association between a polymorphic variant of the IRS-1 gene and prostate cancer risk. (2008 Sep 15)	Fall K	Prostate
21933378	Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: a prospective study. (2011 Sep 20)	Wohlfahrt-Veje C	Environ Health
18703768	Plasma insulinlike growth factor 1 and binding-protein 3 and risk of myocardial infarction in women: a prospective study. (2008 Oct)	Page JH	Clin Chem
16923367	[Effects of L-arginine on the expression of insulin-like growth factors and insulin-like growth factor binding protein 3 in rats with intrauterine growth retardation]. (2006 Aug)	Lu Y	Zhongguo Dang Dai Er Ke Za Zhi