Gene info: ID 3488

Gene: IGFBP5

GENE ID: 3488

Synonyms: IBP5

Description: insulin like growth factor binding protein 5

Gene type: protein-coding

Location: 2q35

dbXrefs: Ensembl:ENSG00000115461 MIM:146734 Vega:OTTHUMG00000133058 UniprotKB:P24593

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.371e-1 (AD) 4.339e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DPYSL3	0.704
ENTPD1	0.663
ANGPT1	0.659
CA5B	0.639
SETD7	0.635
SFRP2	0.624
FNDC3A	0.62
MIPOL1	0.618
SMARCE1	0.611
HNMT	0.608

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.38
OR4F29	-0.363
PLA2G5	-0.219
CRYBA2	-0.202
GRHL2	-0.2
KRTAP5-8	-0.178
C12orf54	-0.176
TBC1D21	-0.168
RHO	-0.167
VPREB3	-0.167

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C025205	1,10-phenanthroline	"1,10-phenanthroline results in decreased degradation of IGFBP5 protein"	8894652
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of IGFBP5 mRNA"	26377693
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of IGFBP5 mRNA"	21354444
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in decreased expression of IGFBP5 mRNA"	22101062
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of IGFBP5 mRNA"	11509743
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of IGFBP5 mRNA"	11509743
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of IGFBP5 mRNA"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of IGFBP5 mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of IGFBP5 mRNA]"	19414516
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IGFBP5 mRNA"	19167446
C013186	2,3-pentanedione	"2,3-pentanedione results in decreased expression of IGFBP5 mRNA"	25710175
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IGFBP5 mRNA"	23196670
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of IGFBP5 mRNA	18544908
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP5 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP5 mRNA"	27188386
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of IGFBP5 mRNA	20829426
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP5 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP5 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of IGFBP5 mRNA	18544908
C109238	acyline	acyline results in decreased expression of IGFBP5 mRNA	17510436
D000242	Cyclic AMP	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of IGFBP5 mRNA]"	19414516
D024502	alpha-Tocopherol	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA	23859036
C032311	aluminum fluoride	aluminum fluoride results in increased expression of IGFBP5 mRNA	11996908
C032311	aluminum fluoride	aluminum fluoride results in increased expression of IGFBP5 protein	11996908
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IGFBP5 mRNA	16483693
D000666	Amphotericin B	Amphotericin B results in decreased expression of IGFBP5 mRNA	20849824
D000728	Androgens	Androgens results in decreased expression of IGFBP5 mRNA	17823924
D000728	Androgens	Androgens results in decreased expression of IGFBP5 protein	17823924
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of IGFBP5 mRNA	24449571
D001152	Arsenicals	Arsenicals results in increased methylation of IGFBP5 promoter	26039340
C006632	arsenic trioxide	[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP5 protein	27430728
C006632	arsenic trioxide	arsenic trioxide results in increased expression of IGFBP5 protein	27430728
D001205	Ascorbic Acid	[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of IGFBP5 mRNA	16443354
D001205	Ascorbic Acid	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA	23859036
D001280	Atrazine	Atrazine results in increased expression of IGFBP5 mRNA	22378314
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of IGFBP5 mRNA	26377693
C032157	benzamidine	benzamidine results in decreased degradation of IGFBP5 protein	8894652
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IGFBP5 mRNA	22610609
D019207	beta Carotene	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA	23859036
D004958	Estradiol	Estradiol affects the expression of IGFBP5 mRNA	14699072\|2182616
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of IGFBP5 mRNA	20660070
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IGFBP5 mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of IGFBP5 mRNA	15159206\|2118537
D004958	Estradiol	Estradiol results in increased expression of IGFBP5 mRNA	17555868\|1961957
D004958	Estradiol	"[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of IGFBP5 mRNA"	11509743
D004958	Estradiol	[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of IGFBP5 mRNA	11509743
D004958	Estradiol	Estradiol results in decreased expression of IGFBP5 mRNA	11509743
C044887	beta-methylcholine	beta-methylcholine affects the expression of IGFBP5 mRNA	21179406
C053541	bicalutamide	bicalutamide results in increased expression of IGFBP5 mRNA	10604720
C006780	bisphenol A	bisphenol A affects the expression of IGFBP5 mRNA	21826169
C006780	bisphenol A	bisphenol A results in decreased expression of IGFBP5 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of IGFBP5 mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP5 mRNA	20147733\|2207961
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of IGFBP5 mRNA	12414654
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of IGFBP5 mRNA	15454312
D002118	Calcium	Calcium affects the expression of IGFBP5 mRNA	15913539
D002118	Calcium	Calcium results in decreased degradation of IGFBP5 protein	8894652
D002220	Carbamazepine	Carbamazepine affects the expression of IGFBP5 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IGFBP5 mRNA	17032414
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of IGFBP5 mRNA	24763279
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP5 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of IGFBP5 mRNA	26272509
D002737	Chloroprene	Chloroprene results in increased expression of IGFBP5 mRNA	23125180
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of IGFBP5 mRNA	18668222
D060729	Coal Ash	Coal Ash results in increased expression of IGFBP5 mRNA	19000753
D003345	Corticosterone	Corticosterone results in decreased expression of IGFBP5 mRNA	15755911
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IGFBP5 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of IGFBP5 mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of IGFBP5 mRNA	19167446
C029892	cupric chloride	cupric chloride results in increased expression of IGFBP5 mRNA	24650576
C029892	cupric chloride	cupric chloride results in decreased expression of IGFBP5 protein	22699969
C029892	cupric chloride	IGFBP5 protein binds to cupric chloride	22699969
D003471	Cuprizone	Cuprizone results in increased expression of IGFBP5 mRNA	26577399
D003474	Curcumin	[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP5 protein	27430728
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP5 mRNA]	18200517
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of IGFBP5 mRNA	20849824
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of IGFBP5 mRNA	15331540
D016572	Cyclosporine	Cyclosporine results in increased expression of IGFBP5 mRNA	21865292
D003561	Cytarabine	Cytarabine results in decreased expression of IGFBP5 mRNA	21198554
D000069439	Dasatinib	Dasatinib results in increased expression of IGFBP5 mRNA	20579391
C014347	decitabine	decitabine inhibits the reaction [monomethylarsonous acid results in decreased expression of IGFBP5 mRNA]	16507463
D013759	Dronabinol	Dronabinol results in decreased expression of IGFBP5 mRNA	18454173
D013759	Dronabinol	Dronabinol results in decreased expression of IGFBP5 mRNA	17578508
D003907	Dexamethasone	Dexamethasone results in increased expression of IGFBP5 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGFBP5 mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA	16054899
D003907	Dexamethasone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA]	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA]	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of IGFBP5 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of IGFBP5 mRNA]	20032058
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of IGFBP5 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of IGFBP5 mRNA	15829613
D002945	Cisplatin	Cisplatin results in decreased expression of IGFBP5 mRNA	20849824
D002945	Cisplatin	IGFBP5 protein affects the susceptibility to Cisplatin	16217747
D002945	Cisplatin	Cisplatin results in decreased expression of IGFBP5 mRNA	21151649
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of IGFBP5 mRNA	26924002
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in decreased expression of IGFBP5 mRNA	17490981
D004041	Dietary Fats	Dietary Fats results in increased expression of IGFBP5 mRNA	19030233
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of IGFBP5 mRNA]	19030233
D004041	Dietary Fats	[Dietary Fats co-treated with resveratrol] results in decreased expression of IGFBP5 mRNA	21852083
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of IGFBP5 mRNA	27614199
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of IGFBP5 mRNA	21527772
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of IGFBP5 mRNA	24535843
D002117	Calcitriol	IGFBP5 protein inhibits the reaction [Calcitriol results in increased expression of COL1A1 protein]	17595320
C472511	dimethylarsinous acid	dimethylarsinous acid results in decreased expression of IGFBP5 mRNA	16507463
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of IGFBP5 mRNA	17032414
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of IGFBP5 mRNA	26924002
D004237	Diuron	Diuron results in decreased expression of IGFBP5 mRNA	25152437
D004492	Edetic Acid	Edetic Acid results in decreased degradation of IGFBP5 protein	8894652
C118739	entinostat	entinostat results in decreased expression of IGFBP5 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP5 mRNA"	27188386
D004964	Estriol	Estriol results in decreased expression of IGFBP5 mRNA	15159206
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of IGFBP5 mRNA	18936297
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of IGFBP5 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGFBP5 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of IGFBP5 mRNA	17557909
D005419	Flavonoids	Flavonoids results in decreased expression of IGFBP5 mRNA	18035473
C053629	fluoroaluminum	fluoroaluminum results in increased expression of IGFBP5 mRNA	11996908
C053629	fluoroaluminum	fluoroaluminum results in increased expression of IGFBP5 protein	11996908
D005472	Fluorouracil	Fluorouracil results in decreased expression of IGFBP5 mRNA	16557594
C065180	fluvastatin	[zoledronic acid co-treated with fluvastatin] results in increased expression of IGFBP5 mRNA	16996129
D005492	Folic Acid	Folic Acid affects the expression of IGFBP5 mRNA	17320366
D005492	Folic Acid	Folic Acid results in decreased expression of IGFBP5 mRNA	8594875
D005557	Formaldehyde	Formaldehyde results in increased expression of IGFBP5 mRNA	28937961
C069837	fullerene C60	fullerene C60 results in decreased expression of IGFBP5 mRNA	19167457
D019833	Genistein	Genistein results in decreased expression of IGFBP5 mRNA	22504913
D005839	Gentamicins	Gentamicins results in decreased expression of IGFBP5 mRNA	20849824
D005839	Gentamicins	Gentamicins results in decreased expression of IGFBP5 mRNA	22061828
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of IGFBP5 mRNA]	17109745
D005944	Glucosamine	Glucosamine results in increased expression of IGFBP5 mRNA	17109745
C071834	glycidamide	glycidamide results in decreased expression of IGFBP5 mRNA	17822822
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of IGFBP5 mRNA	24763279
D017313	Fenretinide	Fenretinide results in decreased expression of IGFBP5 mRNA	16671099
D017313	Fenretinide	Fenretinide results in decreased expression of IGFBP5 mRNA	28973697
D006834	Hydrazines	Hydrazines results in decreased expression of IGFBP5 mRNA	21647536
D006854	Hydrocortisone	Hydrocortisone results in decreased expression of IGFBP5 mRNA	21267416
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of IGFBP5 mRNA	12414654
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of IGFBP5 mRNA"	26377693
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGFBP5 mRNA	28628672
C051890	irinotecan	irinotecan results in increased expression of IGFBP5 mRNA	20097248
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of IGFBP5 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA]	16054899
D007529	Isoflavones	Isoflavones affects the expression of IGFBP5 mRNA	16365062
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of IGFBP5 mRNA	24796395\|2675264
C008261	lead acetate	lead acetate results in decreased expression of IGFBP5 mRNA	11578147
D008044	Linuron	Linuron results in decreased expression of IGFBP5 mRNA	12730624
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of IGFBP5 mRNA"	11578593
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of IGFBP5 mRNA	26378955
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in decreased expression of IGFBP5 mRNA	20843944
C042720	mercuric bromide	mercuric bromide results in decreased expression of IGFBP5 mRNA	26272509
D008694	Methamphetamine	IGFBP5 mutant form inhibits the reaction [Methamphetamine results in increased activity of CASP3 protein]	25127757
D008694	Methamphetamine	IGFBP5 mutant form inhibits the reaction [Methamphetamine results in increased activity of PARP1 protein]	25127757
D008694	Methamphetamine	Methamphetamine results in increased expression of IGFBP5 mRNA	25127757
D008694	Methamphetamine	Methamphetamine results in increased expression of IGFBP5 protein	25127757
D008727	Methotrexate	Methotrexate results in increased expression of IGFBP5 mRNA	15120968
D008731	Methoxychlor	[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of IGFBP5 mRNA	11509743
D008731	Methoxychlor	Methoxychlor metabolite results in decreased expression of IGFBP5 mRNA	11509743
D008731	Methoxychlor	Methoxychlor results in decreased expression of IGFBP5 mRNA	23303685
D008746	Methylazoxymethanol Acetate	Methylazoxymethanol Acetate results in increased expression of IGFBP5 mRNA	28349193
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of IGFBP5 mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of IGFBP5 mRNA"	20188158
D015735	Mifepristone	Mifepristone results in decreased expression of IGFBP5 mRNA	17584828
C406082	monomethylarsonous acid	decitabine inhibits the reaction [monomethylarsonous acid results in decreased expression of IGFBP5 mRNA]	16507463
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of IGFBP5 mRNA	16507463
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of IGFBP5 mRNA	22108045
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of IGFBP5 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in decreased expression of IGFBP5 mRNA	15674843
D009151	Mustard Gas	Mustard Gas results in decreased expression of IGFBP5 mRNA	18988085
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of IGFBP5 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of IGFBP5 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of IGFBP5 mRNA"	25554681
C007350	nitrofen	nitrofen results in decreased expression of IGFBP5 mRNA	19844724
C007350	nitrofen	nitrofen results in decreased expression of IGFBP5 protein	19844724
C025256	nonylphenol	nonylphenol results in decreased expression of IGFBP5 mRNA	15159206
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of IGFBP5 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of IGFBP5 mRNA	25729387
D010269	Paraquat	Paraquat results in increased expression of IGFBP5 mRNA	18198484
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of IGFBP5 mRNA	23602845
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of IGFBP5 mRNA	27614199
D010634	Phenobarbital	Phenobarbital affects the expression of IGFBP5 mRNA	23091169
D010656	Phenylephrine	Phenylephrine results in decreased expression of IGFBP5 mRNA	18158353
D010664	Phenylmethylsulfonyl Fluoride	Phenylmethylsulfonyl Fluoride results in decreased degradation of IGFBP5 protein	8894652
C006253	pirinixic acid	pirinixic acid results in decreased expression of IGFBP5 mRNA	20059764\|2381119
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of IGFBP5 mRNA]	20059764
C006253	pirinixic acid	pirinixic acid results in increased expression of IGFBP5 mRNA	12832660
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of IGFBP5 mRNA	23608068
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of IGFBP5 mRNA	20660070
D011374	Progesterone	Progesterone results in decreased expression of IGFBP5 mRNA	18070364\|2086464
C045950	propiconazole	propiconazole results in decreased expression of IGFBP5 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in increased expression of IGFBP5 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of IGFBP5 mRNA	27029645
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of IGFBP5 mRNA	19167446
C059514	resveratrol	resveratrol results in decreased expression of IGFBP5 mRNA	15280659
C059514	resveratrol	resveratrol results in decreased expression of IGFBP5 mRNA	19228061
C059514	resveratrol	[Dietary Fats co-treated with resveratrol] results in decreased expression of IGFBP5 mRNA	21852083
D015474	Isotretinoin	Isotretinoin results in increased expression of IGFBP5 mRNA	20436886
C089032	rimonabant	rimonabant affects the expression of IGFBP5 mRNA	19030233
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of IGFBP5 mRNA]	19030233
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA	16054899
C089730	rosiglitazone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA]	16054899
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA]	16054899
D012402	Rotenone	Rotenone results in decreased expression of IGFBP5 mRNA	27979718
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of IGFBP5 mRNA	25895662
D012834	Silver	Silver results in decreased expression of IGFBP5 mRNA	27131904
D020123	Sirolimus	Sirolimus results in decreased expression of IGFBP5 mRNA	21865292
C017947	sodium arsenite	sodium arsenite results in decreased expression of IGFBP5 mRNA	16507463\|2457034
C017947	sodium arsenite	sodium arsenite results in increased methylation of IGFBP5 gene	24570342
C017947	sodium arsenite	sodium arsenite affects the expression of IGFBP5 mRNA	16507464
C017947	sodium arsenite	sodium arsenite results in decreased expression of IGFBP5 mRNA	17451858
C017947	sodium arsenite	sodium arsenite results in increased expression of IGFBP5 mRNA	17077188
D018038	Sodium Selenite	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA	23859036
D012999	Soman	Soman results in increased expression of IGFBP5 mRNA	19281266
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of IGFBP5 mRNA	26378955
D016559	Tacrolimus	Tacrolimus results in increased expression of IGFBP5 mRNA	21865292
D013629	Tamoxifen	IGFBP5 protein results in increased susceptibility to Tamoxifen	20354179
D013629	Tamoxifen	Tamoxifen affects the expression of IGFBP5 mRNA	14699072
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of IGFBP5 mRNA]	20032058
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of IGFBP5 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IGFBP5 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGFBP5 mRNA	17555868\|1961957
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IGFBP5 mRNA	17555868\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of IGFBP5 mRNA	16054899
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IGFBP5 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP5 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IGFBP5 mRNA	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IGFBP5 mRNA	26139165
D013755	Tetradecanoylphorbol Acetate	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IGFBP5 mRNA	16979875
D019284	Thapsigargin	Thapsigargin results in increased expression of IGFBP5 mRNA	22378314
D013806	Theophylline	Theophylline results in decreased expression of IGFBP5 mRNA	16083514
D013849	Thimerosal	Thimerosal results in decreased expression of IGFBP5 mRNA	27188386
D015244	Thiorphan	Thiorphan affects the expression of IGFBP5 protein	16405511
D013893	Thiram	Thiram results in decreased expression of IGFBP5 mRNA	20530235
C009495	titanium dioxide	titanium dioxide affects the expression of IGFBP5 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of IGFBP5 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of IGFBP5 mRNA	25729387
D014212	Tretinoin	[Tretinoin co-treated with Ascorbic Acid] results in decreased expression of IGFBP5 mRNA	16443354
D014212	Tretinoin	Tretinoin results in decreased expression of IGFBP5 mRNA	21934132\|2372400
D014212	Tretinoin	Tretinoin results in increased expression of IGFBP5 mRNA	16604517
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of IGFBP5 gene	27618143
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IGFBP5 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of IGFBP5 mRNA	26272509
C012589	trichostatin A	trichostatin A results in increased expression of IGFBP5 mRNA	24935251
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of IGFBP5 mRNA	19042947
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP5 mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of IGFBP5 mRNA	17982090\|1820051
C057693	troglitazone	troglitazone results in increased expression of IGFBP5 mRNA	19140230
C057693	troglitazone	troglitazone results in decreased expression of IGFBP5 mRNA	28973697
D014415	Tunicamycin	Tunicamycin results in increased expression of IGFBP5 mRNA	22378314
D014635	Valproic Acid	Valproic Acid affects the expression of IGFBP5 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of IGFBP5 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in decreased methylation of IGFBP5 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of IGFBP5 mRNA	24935251
D014639	Vanadium	Vanadium results in increased expression of IGFBP5 mRNA	19000753
D014640	Vancomycin	Vancomycin results in increased expression of IGFBP5 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of IGFBP5 gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of IGFBP5 mRNA	18042343
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of IGFBP5 mRNA	12414654
C111237	vorinostat	vorinostat results in decreased expression of IGFBP5 mRNA	27188386
D015032	Zinc	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IGFBP5 mRNA	16979875
D015032	Zinc	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA	23859036
D015032	Zinc	Zinc deficiency results in decreased expression of IGFBP5 mRNA	20128680
D015032	Zinc	Zinc results in decreased degradation of IGFBP5 protein	8894652
C088658	zoledronic acid	[zoledronic acid co-treated with fluvastatin] results in increased expression of IGFBP5 mRNA	16996129

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001968	fibronectin binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	15700281 25910212
GO:0031994	insulin-like growth factor I binding	-	IBA	21873635
GO:0031994	insulin-like growth factor I binding	-	IPI	10766744
GO:0031995	insulin-like growth factor II binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001558	regulation of cell growth	-	IEA	-
GO:0001649	osteoblast differentiation	-	IEA	-
GO:0006006	glucose metabolic process	-	IEA	-
GO:0007165	signal transduction	-	NAS	7525452
GO:0007565	female pregnancy	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0010906	regulation of glucose metabolic process	-	IEA	-
GO:0014912	negative regulation of smooth muscle cell migration	-	IDA	10766744
GO:0017148	negative regulation of translation	-	IDA	15700281
GO:0030336	negative regulation of cell migration	-	IDA	15700281
GO:0031069	hair follicle morphogenesis	-	IEA	-
GO:0035556	intracellular signal transduction	-	IEA	-
GO:0042593	glucose homeostasis	-	IEA	-
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	-	IBA	21873635
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	-	IEA	-
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	-	IDA	10766744
GO:0043687	post-translational protein modification	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0044342	type B pancreatic cell proliferation	-	IEA	-
GO:0045668	negative regulation of osteoblast differentiation	-	IEA	-
GO:0045926	negative regulation of growth	-	IEA	-
GO:0048286	lung alveolus development	-	IEA	-
GO:0048662	negative regulation of smooth muscle cell proliferation	-	IDA	10766744
GO:0051146	striated muscle cell differentiation	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	IEA	-
GO:0060056	mammary gland involution	-	IEA	-
GO:0060416	response to growth hormone	-	ISS	-
GO:0071320	cellular response to cAMP	-	IDA	7559606
GO:0071407	cellular response to organic cyclic compound	-	IDA	7559606
GO:1901862	negative regulation of muscle tissue development	-	IEA	-
GO:1904205	negative regulation of skeletal muscle hypertrophy	-	IEA	-
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	-	IGI	29016699
GO:1904754	positive regulation of vascular associated smooth muscle cell migration	-	IGI	29016699

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0016942	insulin-like growth factor binding protein complex	-	IC	10766744
GO:0042567	insulin-like growth factor ternary complex	-	IDA	9497324

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25888331	A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma. (2015 Mar 27)	Kavalieris L	BMC Urol
21945224	Biomarkers of the insulin-like growth factor pathway predict progression and outcome in lung cancer. (2011 Nov)	Shersher DD	Ann Thorac Surg
27835577	A functional variant rs4442975 modulating FOXA1-binding affinity does not influence the risk or progression of breast cancer in Chinese Han population. (2016 Dec 6)	Zhang Y	Oncotarget