Gene: HCN1

348980
BCNG-1|BCNG1|EIEE24|HAC-2
hyperpolarization activated cyclic nucleotide gated potassium channel 1
protein-coding
5p12
Ensembl:ENSG00000164588 MIM:602780 Vega:OTTHUMG00000131155 UniprotKB:O60741
NG_042183.1
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.045e-1 (AD)  5.405e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6874279chr5:45393159 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AAK10.977
PRKCE0.977
GABRB20.976
GABRA10.976
KIAA1549L0.973
FRMPD40.973
DLGAP10.972
OLFM30.972
C11orf870.971
ATRNL10.971

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.625
CSAG1-0.624
RNF135-0.623
RAB13-0.623
CMTM3-0.612
WWTR1-0.607
YES1-0.602
REST-0.601
HEY2-0.595
RAI14-0.589

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HCN1 gene27153756
D005680gamma-Aminobutyric AcidHCN1 gene mutant form results in decreased abundance of gamma-Aminobutyric Acid19747469
D000638AmiodaroneAmiodarone results in increased expression of HCN1 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HCN1 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HCN1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HCN1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of HCN1 gene25435355
C006780bisphenol Abisphenol A results in decreased expression of HCN1 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of HCN1 mRNA26577399
D003975Diazepam[Pilocarpine co-treated with Diazepam] results in increased expression of HCN1 mRNA12890777
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of HCN1 mRNA16931933
D019422Dietary SucroseDietary Sucrose results in increased expression of HCN1 mRNA26033743
C001277geldanamycingeldanamycin results in increased expression of HCN1 mRNA26705709
D019469Indinavir[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA16931933
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HCN1 mRNA26752646
D007608Kainic AcidKainic Acid promotes the reaction [REST protein binds to HCN1 intron]21905079
D007608Kainic AcidKainic Acid results in decreased expression of HCN1 mRNA21905079
D007608Kainic AcidKainic Acid results in decreased expression of HCN1 protein21905079
D007608Kainic AcidREST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]21905079
D007608Kainic AcidREST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]21905079
D007608Kainic AcidREST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]21905079
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HCN1 mRNA"24972896
D010100OxygenOxygen deficiency results in increased expression of HCN1 mRNA24236059
D010862Pilocarpine[Pilocarpine co-treated with Diazepam] results in increased expression of HCN1 mRNA12890777
D010862PilocarpinePilocarpine results in decreased expression of HCN1 protein21905079
D059808PolyphenolsPolyphenols results in decreased expression of HCN1 mRNA16293270
D019258Saquinavir[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA16931933
C009277sodium arsenatesodium arsenate results in increased expression of HCN1 mRNA21795629
D013792ThalidomideThalidomide results in decreased expression of HCN1 mRNA26217789
C032910triadimefontriadimefon results in decreased expression of HCN1 mRNA26705709
C012589trichostatin Atrichostatin A results in increased expression of HCN1 mRNA26705709
D014635Valproic AcidValproic Acid results in increased expression of HCN1 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HCN1 gene25487561
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HCN1 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of HCN1 mRNA25423262
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of HCN1 mRNA16931933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005222intracellular cAMP activated cation channel activity-ISS-  
GO:0005248voltage-gated sodium channel activity-IMP22748890  
GO:0005249voltage-gated potassium channel activity-IMP22748890  
GO:0005249voltage-gated potassium channel activity-ISS-  
GO:0005267potassium channel activity-NAS9405696  
GO:0005515protein binding-IPI26966193  
GO:0022843voltage-gated cation channel activity-IDA28086084  
GO:0030552cAMP binding-IDA28086084  
GO:0030552cAMP binding-ISS-  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0035725sodium ion transmembrane transport-IMP22748890  
GO:0042391regulation of membrane potential-IMP22748890  
GO:0045176apical protein localization-IEA-  
GO:0046549retinal cone cell development-IEA-  
GO:0051289protein homotetramerization-IDA28086084  
GO:0071320cellular response to cAMP-IDA22748890  
GO:0071320cellular response to cAMP-IMP28086084  
GO:0071320cellular response to cAMP-ISS-  
GO:0071805potassium ion transmembrane transport-IMP22748890  
GO:0071805potassium ion transmembrane transport-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA22748890  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA28086084  
GO:0005887integral component of plasma membrane-ISS-  
GO:0030424axon-IEA-  
GO:0030425dendrite-IEA-  
GO:0098855HCN channel complex-IDA28086084  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296061HCN channelsTAS
R-HSA-1296071Potassium ChannelsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21507200Similar cation channels mediate protection from cerebellar exitotoxicity by exercise and inheritance. (2012 Mar)Ben-Ari SJ Cell Mol Med