Gene: CYR61

3491
CCN1|GIG1|IGFBP10
cysteine rich angiogenic inducer 61
protein-coding
1p22.3
Ensembl:ENSG00000142871 MIM:602369 Vega:OTTHUMG00000010577 UniprotKB:O00622
NC_000001.11
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.855e-1 (AD)  8.701e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOS0.832
CSRNP10.792
JUN0.762
JUNB0.76
ATF30.758
ZC3H12A0.748
BTG20.739
DUSP50.737
SIK10.724
PPP1R15A0.721

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.266
DHRS7C-0.249
KLHL1-0.245
KCNH6-0.242
TMEM182-0.238
OR4F5-0.232
SMIM18-0.232
CNTN6-0.23
HNF1A-0.229
C17orf100-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CYR61 mRNA"26377693
C5580481,7-diphenyl-4,6-heptadien-3-ol"1,7-diphenyl-4,6-heptadien-3-ol results in increased expression of CYR61 mRNA"25575267
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CYR61 mRNA28329830
C0319031-UFT protocolCYR61 protein results in decreased susceptibility to 1-UFT protocol16734730
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CYR61 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of CYR61 mRNA"19095052
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CYR61 protein]21055460
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CYR61 mRNA]15117851
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYR61 mRNA]15117851
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of CYR61 mRNA"20826375
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CYR61 mRNA"19167446
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of CYR61 mRNA"20713471
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CYR61 protein]21055460
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of CYR61 mRNA28522335
C0163923,3'-diindolylmethane"3,3'-diindolylmethane affects the methylation of CYR61 promoter"24466240
C4778983-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of CYR61 protein]25822713
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYR61 mRNA"23196670
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of CYR61 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of CYR61 mRNA"19936915
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of CYR61 mRNA"26238291
D000082AcetaminophenAcetaminophen results in increased expression of CYR61 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of CYR61 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of CYR61 mRNA11264010|2036382
D000111Acetylcysteine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CYR61 protein]21055460
D000111Acetylcysteine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CYR61 protein]21055460
D000111AcetylcysteineAcetylcysteine results in increased expression of CYR61 mRNA21055460
D000111AcetylcysteineAcetylcysteine results in increased expression of CYR61 protein21055460
D000111AcetylcysteineCycloheximide inhibits the reaction [Acetylcysteine results in increased expression of CYR61 protein]21055460
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CYR61 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CYR61 mRNA21632981|2164198
D000452AldrinAldrin results in increased expression of CYR61 mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYR61 mRNA16483693
D000667AmpicillinAmpicillin results in increased expression of CYR61 mRNA21632981
C519728archazolid Barchazolid B results in decreased expression of CYR61 mRNA25218289
D001151ArsenicArsenic results in increased expression of CYR61 mRNA23942117
C006632arsenic trioxidearsenic trioxide results in decreased expression of CYR61 mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CYR61 mRNA"18687144|2535159
D001379AzathioprineAzathioprine results in increased expression of CYR61 mRNA19192274
D001414BacitracinBacitracin affects the expression of CYR61 mRNA18289764
C447119bazedoxifenebazedoxifene results in increased expression of CYR61 mRNA19914376
D001507BeclomethasoneBeclomethasone results in increased expression of CYR61 mRNA23656298
C487081belinostatbelinostat results in increased expression of CYR61 mRNA23671600
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CYR61 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYR61 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYR61 mRNA19181443|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CYR61 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYR61 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYR61 mRNA20713471|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CYR61 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CYR61 mRNA"26238291
D004958EstradiolEstradiol affects the expression of CYR61 mRNA22574217
D004958EstradiolEstradiol results in decreased expression of CYR61 mRNA19167446
D004958EstradiolEstradiol results in increased expression of CYR61 mRNA19153601
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of CYR61 mRNA]20667977
D004958EstradiolEstradiol affects the expression of CYR61 mRNA15598610
D004958EstradiolEstradiol results in increased expression of CYR61 mRNA19484750|2066797
C044887beta-methylcholinebeta-methylcholine affects the expression of CYR61 mRNA21179406
C095105bexarotenebexarotene results in decreased expression of CYR61 mRNA17178900
C006780bisphenol Abisphenol A results in decreased expression of CYR61 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of CYR61 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of CYR61 mRNA20826375
C006780bisphenol Abisphenol A results in increased expression of CYR61 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CYR61 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CYR61 mRNA12414654|1533650
D019256Cadmium ChlorideCadmium Chloride affects the expression of CYR61 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CYR61 mRNA25993096
C037123cadmium sulfatecadmium sulfate results in decreased expression of CYR61 mRNA21783983
C058819calphostin Ccalphostin C inhibits the reaction [Phenylephrine results in increased expression of CYR61 mRNA]15117851
D000069287CapecitabineCYR61 protein results in decreased susceptibility to Capecitabine16734730
D002220CarbamazepineCarbamazepine affects the expression of CYR61 mRNA24752500|2597931
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of CYR61 mRNA19395590
C054133casticincasticin results in increased expression of CYR61 mRNA28444820
C016299chelerythrinechelerythrine inhibits the reaction [Phenylephrine results in increased expression of CYR61 mRNA]15117851
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
D002737ChloropreneChloroprene results in decreased expression of CYR61 mRNA23125180
D002738ChloroquineChloroquine results in increased expression of CYR61 mRNA19393257
C023676chloroquine diphosphatechloroquine diphosphate results in increased expression of CYR61 mRNA19192274
D004390Chlorpyrifos[nickel chloride co-treated with Chlorpyrifos] affects the expression of CYR61 mRNA21496282
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CYR61 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of CYR61 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of CYR61 mRNA19320972
D003300CopperCopper results in increased expression of CYR61 mRNA24403277
D003300CopperCopper results in increased expression of CYR61 mRNA19747488
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CYR61 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of CYR61 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CYR61 mRNA"19167446
C402665CP 31398CP 31398 results in increased expression of CYR61 mRNA15155752
C015763cumene[cumene co-treated with KRAS gene mutant form] results in decreased expression of CYR61 mRNA18648096
C029892cupric chloridecupric chloride results in increased expression of CYR61 mRNA17211630
D003513CycloheximideCycloheximide inhibits the reaction [Acetylcysteine results in increased expression of CYR61 protein]21055460
D016572CyclosporineCyclosporine affects the expression of CYR61 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of CYR61 mRNA22147139
D016572CyclosporineCyclosporine results in increased expression of CYR61 mRNA21632981|2556210
D016572CyclosporineCyclosporine results in increased expression of CYR61 mRNA19770486
C089595cylindrospermopsincylindrospermopsin results in increased expression of CYR61 mRNA24921660
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CYR61 mRNA24317228
C007262deoxynivalenoldeoxynivalenol results in increased expression of CYR61 mRNA15371230
D003907DexamethasoneDexamethasone results in increased expression of CYR61 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CYR61 mRNA17361019|2126653
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of CYR61 mRNA]27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of CYR61 mRNA]27392435
D002945CisplatinCisplatin results in increased expression of CYR61 mRNA21151649
D002945CisplatinCisplatin results in decreased expression of CYR61 mRNA18289764
D004008DiclofenacDiclofenac affects the expression of CYR61 mRNA24752500
D004008DiclofenacDiclofenac results in increased expression of CYR61 mRNA19192274
D004041Dietary FatsDietary Fats results in decreased expression of CYR61 mRNA18042831|2501614
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYR61 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CYR61 mRNA21658437
D002117CalcitriolCalcitriol results in decreased expression of CYR61 mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYR61 mRNA"22485181
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of CYR61 mRNA"27840820
D004237DiuronDiuron metabolite results in decreased expression of CYR61 mRNA24172598
C025034doxifluridineCYR61 protein results in decreased susceptibility to doxifluridine16734730
D004317DoxorubicinDoxorubicin results in increased expression of CYR61 mRNA25896364
D004391DustDust results in increased expression of CYR61 mRNA15735009
D004964EstriolEstriol results in increased expression of CYR61 mRNA25575267
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CYR61 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CYR61 mRNA14976129|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYR61 mRNA17942748
C540355fenamidonefenamidone results in increased expression of CYR61 mRNA27029645
D011345FenofibrateFenofibrate results in decreased expression of CYR61 mRNA25572481
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of CYR61 mRNA28329830
D005472FluorouracilCYR61 affects the susceptibility to Fluorouracil15067352
D005472FluorouracilFluorouracil results in increased expression of CYR61 mRNA17699798
D005472FluorouracilFluorouracil results in increased expression of CYR61 protein17699798
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CYR61 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of CYR61 mRNA23416264|2364984
C069837fullerene C60fullerene C60 results in increased expression of CYR61 mRNA19167457
C039281furanfuran results in decreased methylation of CYR61 gene27387713
D019833GenisteinGenistein results in decreased expression of CYR61 mRNA20884965|2222811
D005839GentamicinsGentamicins affects the expression of CYR61 mRNA18289764
C017338geranylgeraniolgeranylgeraniol inhibits the reaction [zoledronic acid results in decreased expression of CYR61 protein]19530242
D005947GlucoseGlucose results in increased expression of CYR61 mRNA17178593
C004312glycidolglycidol results in decreased expression of CYR61 mRNA24915197
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of CYR61 mRNA19192274
D017313FenretinideFenretinide results in increased expression of CYR61 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CYR61 mRNA26846883
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CYR61 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CYR61 mRNA12414654
C031927hydroquinonehydroquinone affects the expression of CYR61 mRNA15452088
C475919hydroxytamoxifenGPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of CYR61 mRNA]19153601
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of CYR61 mRNA19153601
C492448ICG 001ICG 001 results in increased expression of CYR61 mRNA26191083
C027185indirubinindirubin results in increased expression of CYR61 mRNA15056799
C016517indole-3-carbinolindole-3-carbinol affects the expression of CYR61 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CYR61 mRNA25613284
C051890irinotecanCYR61 protein results in decreased susceptibility to irinotecan16734730
C057531jasplakinolidejasplakinolide results in increased expression of and results in increased secretion of CYR61 protein24040060
C057531jasplakinolidejasplakinolide results in increased expression of CYR61 mRNA24040060
C057531jasplakinolideYAP1 protein affects the reaction [jasplakinolide results in increased expression of CYR61 protein]24040060
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of CYR61 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of CYR61 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of CYR61 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of CYR61 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CYR61 mRNA24796395
C008261lead acetatelead acetate affects the expression of CYR61 mRNA22641619
C045463leflunomideleflunomide results in increased expression of CYR61 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides affects the expression of CYR61 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of CYR61 mRNA]28070326
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CYR61 mRNA27339419
C032881lysophosphatidic acid3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of CYR61 protein]25822713
C032881lysophosphatidic acidlysophosphatidic acid results in increased expression of CYR61 protein25822713
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CYR61 mRNA26378955
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CYR61 mRNA26378955
C042720mercuric bromidemercuric bromide results in increased expression of CYR61 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of CYR61 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of CYR61 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CYR61 gene20938992
D008727MethotrexateMethotrexate results in increased expression of CYR61 mRNA19192274
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CYR61 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CYR61 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CYR61 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CYR61 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CYR61 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CYR61 mRNA"20188158
D008775MethylprednisoloneMethylprednisolone results in increased expression of CYR61 mRNA19192274
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of CYR61 mRNA24128854
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of CYR61 mRNA16809437
D009151Mustard GasMustard Gas results in increased expression of CYR61 mRNA27617619
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CYR61 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CYR61 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CYR61 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYR61 mRNA"25620056
C031721naphthalenenaphthalene results in increased expression of CYR61 mRNA18978301
D009281NaphthalenesNaphthalenes results in increased expression of CYR61 protein17337753
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CYR61 mRNA19812364
D009532NickelNickel results in increased expression of CYR61 mRNA24768652|2558310
D009532NickelNickel results in increased expression of CYR61 mRNA12540486
C022838nickel chloride[nickel chloride co-treated with Chlorpyrifos] affects the expression of CYR61 mRNA21496282
C028007nickel monoxidenickel monoxide results in increased expression of CYR61 mRNA19167457
D009538NicotineNicotine results in increased expression of CYR61 mRNA17456735
D009638NorepinephrineNorepinephrine results in increased expression of CYR61 mRNA15117851
C570897NSC668394NSC668394 results in increased expression of CYR61 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CYR61 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of CYR61 mRNA20971185
C024713n-tetradecanen-tetradecane results in increased expression of CYR61 protein17337753
D009966OrphenadrineOrphenadrine affects the expression of CYR61 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CYR61 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of CYR61 mRNA23999411
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of CYR61 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of CYR61 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of CYR61 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of CYR61 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of CYR61 mRNA]17655762
D010100OxygenOxygen deficiency results in increased expression of CYR61 mRNA24236059
D017239PaclitaxelCYR61 protein results in increased susceptibility to Paclitaxel16734730
C500026palbociclibpalbociclib results in increased expression of CYR61 mRNA22869556
D000073878Palm OilPalm Oil results in decreased expression of CYR61 mRNA18042831
C016030pantogabpantogab results in decreased expression of CYR61 mRNA17379144
D010269ParaquatParaquat results in increased expression of CYR61 mRNA12595580
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of CYR61 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of CYR61 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of CYR61 mRNA]17655762
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of CYR61 mRNA19095052
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CYR61 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CYR61 protein26879310
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of CYR61 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of CYR61 mRNA19084549
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CYR61 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of CYR61 mRNA25270620
D010634PhenobarbitalPhenobarbital results in increased expression of CYR61 mRNA19482888
D010656Phenylephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of CYR61 mRNA]15117851
D010656Phenylephrinecalphostin C inhibits the reaction [Phenylephrine results in increased expression of CYR61 mRNA]15117851
D010656Phenylephrinechelerythrine inhibits the reaction [Phenylephrine results in increased expression of CYR61 mRNA]15117851
D010656PhenylephrinePhenylephrine results in increased expression of CYR61 mRNA15117851
D010656PhenylephrinePhenylephrine results in increased expression of CYR61 protein15117851
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CYR61 mRNA26272509
D010705PhosgenePhosgene affects the expression of CYR61 mRNA16300373
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CYR61 mRNA19710929
D010894PiroxicamPiroxicam results in increased expression of CYR61 mRNA19192274
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of CYR61 mRNA]28070326
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CYR61 protein23718831
D011239PrednisolonePrednisolone results in increased expression of CYR61 mRNA19192274
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CYR61 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of CYR61 mRNA20631399
C045950propiconazolepropiconazole results in decreased expression of CYR61 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of CYR61 mRNA24780913
C010313pseudocumenepseudocumene results in increased expression of CYR61 protein17337753
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CYR61 mRNA27029645
D011794QuercetinQuercetin results in increased expression of CYR61 mRNA21632981
C502851quinocetonequinocetone results in decreased expression of CYR61 mRNA27046791
D015125OxyquinolineOxyquinoline results in increased expression of CYR61 mRNA21632981
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of CYR61 mRNA21127053
D012312RitodrineRitodrine results in increased expression of CYR61 mRNA23370008
C079198S 1 (combination)CYR61 protein results in decreased susceptibility to S 1 (combination)16734730
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of CYR61 mRNA19564919
C078903seocalcitolseocalcitol results in decreased expression of CYR61 mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CYR61 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of CYR61 mRNA25351596
D012834SilverSilver results in increased expression of CYR61 mRNA26014281|2895954
D019821SimvastatinSimvastatin inhibits the reaction [CYR61 results in increased expression of IL1B]20191585
D019821SimvastatinSimvastatin inhibits the reaction [CYR61 results in increased expression of OSM]20191585
D019821SimvastatinSimvastatin inhibits the reaction [CYR61 results in increased expression of TNF]20191585
D019821SimvastatinSimvastatin inhibits the reaction [OSM results in increased expression of CYR61 mRNA]20191585
D019821SimvastatinSimvastatin results in decreased expression of CYR61 mRNA17428261
C009277sodium arsenatesodium arsenate results in decreased expression of CYR61 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of CYR61 gene28589171
C017947sodium arsenitesodium arsenite affects the expression of CYR61 mRNA16507464
C017947sodium arsenitesodium arsenite results in decreased expression of CYR61 mRNA18812580
C017947sodium arsenitesodium arsenite results in increased expression of CYR61 mRNA25270620
D012999SomanSoman results in increased expression of CYR61 mRNA19281266
D053260SootSoot results in increased expression of CYR61 mRNA26551751
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CYR61 mRNA26378955
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CYR61 mRNA26378955
D013629TamoxifenTamoxifen affects the expression of CYR61 mRNA17555576|2093736
D013629TamoxifenTamoxifen results in increased expression of CYR61 mRNA25123088
D013739TestosteroneTestosterone results in increased expression of CYR61 mRNA15788153
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYR61 mRNA18495758
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYR61 mRNA15056799|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYR61 mRNA16611356|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [AHR protein binds to CYR61 promoter]19654925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYR61 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYR61 mRNA19770486|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYR61 mRNA21496263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYR61 mRNA22298810
D013755Tetradecanoylphorbol Acetate2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYR61 mRNA]15117851
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CYR61 mRNA15117851
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CYR61 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of CYR61 mRNA16870260
D013853ThioacetamideThioacetamide results in increased expression of CYR61 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of CYR61 mRNA23557971|2776080
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CYR61 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CYR61 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of CYR61 mRNA19164467|2322803
D014212TretinoinTretinoin results in increased expression of CYR61 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CYR61 mRNA25549359
C012589trichostatin Atrichostatin A results in increased expression of CYR61 mRNA26705709
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CYR61 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CYR61 mRNA19140230|2557248
C022884undecaneundecane results in increased expression of CYR61 protein17337753
D014520UrethaneUrethane results in decreased expression of CYR61 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYR61 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CYR61 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CYR61 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of CYR61 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of CYR61 mRNA24896083
D014639VanadiumVanadium results in decreased expression of CYR61 mRNA19000753
D014640VancomycinVancomycin results in decreased expression of CYR61 mRNA18289764
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of CYR61 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of CYR61 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of CYR61 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CYR61 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CYR61 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of CYR61 mRNA23555832
D014800VitalliumVitallium analog results in decreased expression of CYR61 mRNA23825117
D002762CholecalciferolCholecalciferol results in decreased expression of CYR61 mRNA16508948
D002762CholecalciferolCholecalciferol results in increased expression of CYR61 mRNA17170073
D024483Vitamin K 3Vitamin K 3 results in increased expression of CYR61 mRNA12414654
C088658zoledronic acidCYR61 protein affects the reaction [zoledronic acid results in decreased phosphorylation of and results in decreased activity of AKT1 protein]19530242
C088658zoledronic acidCYR61 protein affects the reaction [zoledronic acid results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]19530242
C088658zoledronic acidCYR61 protein affects the reaction [zoledronic acid results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]19530242
C088658zoledronic acidCYR61 protein affects the reaction [zoledronic acid results in increased expression of CDKN1A protein]19530242
C088658zoledronic acidgeranylgeraniol inhibits the reaction [zoledronic acid results in decreased expression of CYR61 protein]19530242
C088658zoledronic acidzoledronic acid promotes the reaction [CYR61 protein affects the expression of CDKN1B protein]19530242
C088658zoledronic acidzoledronic acid results in decreased expression of CYR61 mRNA19530242
C088658zoledronic acidzoledronic acid results in decreased expression of CYR61 protein19530242

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IBA21873635  
GO:0005520insulin-like growth factor binding-IEA-  
GO:0008201heparin binding-IBA21873635  
GO:0050840extracellular matrix binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-IEA-  
GO:0001649osteoblast differentiation-IEA-  
GO:0001934positive regulation of protein phosphorylation-IDA20675382  
GO:0002041intussusceptive angiogenesis-IEA-  
GO:0003181atrioventricular valve morphogenesis-IEA-  
GO:0003278apoptotic process involved in heart morphogenesis-IEA-  
GO:0003281ventricular septum development-IEA-  
GO:0006935chemotaxis-IEA-  
GO:0007155cell adhesion-IBA21873635  
GO:0007165signal transduction-IBA21873635  
GO:0008283cell proliferation-TAS9135077  
GO:0009653anatomical structure morphogenesis-TAS9135077  
GO:0010518positive regulation of phospholipase activity-IEA-  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO:0030198extracellular matrix organization-IEA-  
GO:0030335positive regulation of cell migration-IDA20675382  
GO:0030513positive regulation of BMP signaling pathway-IGI20675382  
GO:0033690positive regulation of osteoblast proliferation-IDA20675382  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0044319wound healing, spreading of cells-IDA20675382  
GO:0045669positive regulation of osteoblast differentiation-IDA20675382  
GO:0045860positive regulation of protein kinase activity-IDA20675382  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA20675382  
GO:0060413atrial septum morphogenesis-IEA-  
GO:0060548negative regulation of cell death-IBA21873635  
GO:0060591chondroblast differentiation-IEA-  
GO:0060710chorio-allantoic fusion-IEA-  
GO:0060716labyrinthine layer blood vessel development-IEA-  
GO:0061036positive regulation of cartilage development-IEA-  
GO:0070372regulation of ERK1 and ERK2 cascade-IDA20675382  
GO:0072593reactive oxygen species metabolic process-IEA-  
GO:2000304positive regulation of ceramide biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0031012extracellular matrix-HDA23658023  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17579708Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer. (2007 Jun 20)Chen PPPLoS One
21995436Cigarette smoke-induced early growth response-1 regulates the expression of the cysteine-rich 61 in human skin dermal fibroblasts. (2011 Dec)Kim JNExp Dermatol
21159247[Expressions of Cyr61 and WISP-3 in non-small cell lung cancer and its clinical significance]. (2010 Dec)LV JZhongguo Fei Ai Za Zhi
28426731Effect of genetic variation in microRNA binding site in WNT1-inducible signaling pathway protein 1 gene on oral squamous cell carcinoma susceptibility. (2017)Lau HKPLoS One
24780075Association of BTG2, CYR61, ZFP36, and SCD gene polymorphisms with Graves' disease and ophthalmopathy. (2014 Jul)Planck TThyroid