Gene: IGH

3492
IGD1|IGH.1@|IGH@|IGHD@|IGHDY1|IGHJ|IGHJ@|IGHV|IGHV@
immunoglobulin heavy locus
protein-coding
14q32.33
MIM:147070
NC_000014.9
PubMed
0   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Lipopolysaccharides results in increased expression of IGH mRNA]]"12628580
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IGH mRNA]]"12628580
C0230353,4,5,3',4'-pentachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Lipopolysaccharides results in increased expression of IGH mRNA]]"12628580
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Lipopolysaccharides results in increased expression of IGH mRNA]"12628580
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of IGH gene27153756
D001151ArsenicArsenic results in increased methylation of IGH gene25325195
D004958EstradiolEstradiol results in increased expression of IGH mRNA19484750
D002104CadmiumIGH protein binds to Cadmium23896426
D012721CarbarylCarbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IGH protein]19447539
D003300CopperIGH protein binds to Copper23896426
C029892cupric chloridecupric chloride results in decreased expression of IGH protein22699969
D000069439DasatinibIGH gene mutant form results in decreased susceptibility to Dasatinib18550857
D005047EtoposideEtoposide results in increased mutagenesis of IGH gene28624474
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of IGH mRNA21599461
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole inhibits the reaction [Lipopolysaccharides results in increased expression of IGH protein]"19447539
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to IGH enhancer]21889194
D007854LeadIGH protein binds to Lead23896426
D008070Lipopolysaccharides"2,5,2',5'-tetrachlorobiphenyl inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Lipopolysaccharides results in increased expression of IGH mRNA]]"12628580
D008070Lipopolysaccharides"2,5,2',5'-tetrachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IGH mRNA]]"12628580
D008070Lipopolysaccharides"3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Lipopolysaccharides results in increased expression of IGH mRNA]"12628580
D008070LipopolysaccharidesCarbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of IGH protein]19447539
D008070Lipopolysaccharides"indolo(3,2-b)carbazole inhibits the reaction [Lipopolysaccharides results in increased expression of IGH protein]"19447539
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [RELB protein binds to IGH enhancer]]26377645
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IGH enhancer]]26377645
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [RELA protein binds to IGH enhancer]]26377645
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IGH mRNA12628580|1848319
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IGH protein19447539
D008070LipopolysaccharidesOmeprazole inhibits the reaction [Lipopolysaccharides results in increased expression of IGH protein]19447539
D008070LipopolysaccharidesPrimaquine inhibits the reaction [Lipopolysaccharides results in increased expression of IGH protein]19447539
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IGH mRNA]12628580|1848319
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IGH protein]19447539
D009532NickelIGH protein binds to Nickel23896426
D009853OmeprazoleOmeprazole inhibits the reaction [Lipopolysaccharides results in increased expression of IGH protein]19447539
D026023PermethrinPermethrin results in increased expression of IGH mRNA mutant form28624474
D026023PermethrinPermethrin results in increased mutagenesis of IGH gene28624474
D011192Potassium DichromatePotassium Dichromate results in increased expression of IGH mRNA23608068
D011319PrimaquinePrimaquine inhibits the reaction [Lipopolysaccharides results in increased expression of IGH protein]19447539
D013749Tetrachlorodibenzodioxin"2,5,2',5'-tetrachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IGH mRNA]]"12628580
D013749TetrachlorodibenzodioxinLipopolysaccharides inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [RELB protein binds to IGH enhancer]]26377645
D013749TetrachlorodibenzodioxinLipopolysaccharides promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IGH enhancer]]26377645
D013749TetrachlorodibenzodioxinLipopolysaccharides promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [RELA protein binds to IGH enhancer]]26377645
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IGH mRNA]12628580|1848319
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IGH protein]19447539
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IGH enhancer]26377645
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [RELA protein binds to IGH enhancer]26377645
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [RELB protein binds to IGH enhancer]26377645
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IGH mRNA12628580
C009495titanium dioxidetitanium dioxide results in increased expression of IGH mRNA27760801
D014212TretinoinTretinoin results in decreased expression of IGH mRNA16604517
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IGH mRNA19042947
D014635Valproic AcidValproic Acid results in increased methylation of IGH gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IGH gene25560391
D015032ZincIGH protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20688547Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia. (2010 Oct 15)Wiemels JLBlood Cells Mol Dis
15143340Intravascular bone marrow accumulation in persistent polyclonal lymphocytosis: a misleading feature for B-cell neoplasm. (2004 Sep)Feugier PMod Pathol
15026372Characterization of the t(14;18) BCL2-IGH translocation in farmers occupationally exposed to pesticides. (2004 Mar 15)Roulland SCancer Res
22901769Histological and immunohistochemical features of the spleen in persistent polyclonal B-cell lymphocytosis closely mimic splenic B-cell lymphoma. (2012 Aug 19)Sun PDiagn Pathol
11920254No BCL-2 protein over expression but BCL-2/IgH rearrangements in B cells of patients with persistent polyclonal B-cell lymphocytosis. (2001)Lancry LHematol J
26924531Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. (2016 Mar 3)Galinsky KJAm J Hum Genet