Gene: IGHMBP2

3508
CATF1|CMT2S|HCSA|HMN6|SMARD1|SMUBP2|ZFAND7
immunoglobulin mu binding protein 2
protein-coding
11q13.3
Ensembl:ENSG00000132740 MIM:600502 Vega:OTTHUMG00000167894 UniprotKB:P38935
NG_007976.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  1.516e-1 (ND)   (Frontal_Cortex)
7.501e-1 (AD)  9.820e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2O0.951
URGCP0.945
GGA30.941
PISD0.94
MYBBP1A0.938
GBF10.938
ABCF30.938
SIN3B0.937
ATP6AP10.935
GGT70.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.524
OR4F29-0.471
YES1-0.425
RAI14-0.419
MTRNR2L10-0.404
MTRNR2L6-0.404
KLRB1-0.403
MTRNR2L9-0.396
SH2D1A-0.396
MYL3-0.395

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of IGHMBP2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of IGHMBP2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IGHMBP2 mRNA"18648102
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IGHMBP2 mRNA16483693
D001280AtrazineAtrazine results in increased expression of IGHMBP2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of IGHMBP2 mRNA22378314
C006780bisphenol Abisphenol A results in increased expression of IGHMBP2 mRNA25181051
C029892cupric chloridecupric chloride results in increased expression of IGHMBP2 mRNA17211630
D016572CyclosporineCyclosporine results in increased expression of IGHMBP2 mRNA25562108
C069837fullerene C60fullerene C60 results in increased expression of IGHMBP2 mRNA19167457
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IGHMBP2 mRNA24297863
D008727MethotrexateMethotrexate results in decreased expression of IGHMBP2 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IGHMBP2 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of IGHMBP2 mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IGHMBP2 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IGHMBP2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of IGHMBP2 mRNA"20188158
D009151Mustard GasMustard Gas results in increased expression of IGHMBP2 mRNA15674843
C005246myristicinmyristicin results in decreased expression of IGHMBP2 mRNA24792648
C028007nickel monoxidenickel monoxide results in increased expression of IGHMBP2 mRNA19167457
D059808PolyphenolsPolyphenols results in decreased expression of IGHMBP2 mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in increased expression of IGHMBP2 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of IGHMBP2 mRNA19690047
D012834SilverSilver results in increased expression of IGHMBP2 mRNA27131904
D012906SmokeSmoke results in increased expression of IGHMBP2 mRNA21095227
D014118Toxins, Biological"Toxins, Biological affects the expression of IGHMBP2 mRNA"19682533
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IGHMBP2 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of IGHMBP2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of IGHMBP2 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IGHMBP2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-IDA19299493  
GO:0003677DNA binding-IDA19158098  
GO:0003678DNA helicase activity-TAS8349627  
GO:0003697single-stranded DNA binding-TAS8349627  8493094  
GO:0003723RNA binding-IDA19158098  
GO:0005515protein binding-IPI19299493  
GO:0005524ATP binding-IDA19158098  
GO:0008094DNA-dependent ATPase activity-IDA19158098  
GO:0008134transcription factor binding-IPI19299493  
GO:0008186RNA-dependent ATPase activity-IDA19158098  
GO:0008270zinc ion binding-IEA-  
GO:0032575ATP-dependent 5'-3' RNA helicase activity-IDA19158098  
GO:0043022ribosome binding-IDA19158098  
GO:0043141ATP-dependent 5'-3' DNA helicase activity-IDA19158098  
GO ID GO Term Qualifier Evidence PubMed
GO:0006260DNA replication-TAS8493094  
GO:0006281DNA repair-TAS8493094  
GO:0006310DNA recombination-TAS8349627  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006412translation-NAS19299493  
GO:0032508DNA duplex unwinding-IEA-  
GO:0051260protein homooligomerization-IDA19299493  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19299493  
GO:0005737cytoplasm-IDA19299493  
GO:0016020membrane-HDA19946888  
GO:0030424axon-ISS-  
GO:0030426growth cone-ISS-  
GO:0032797SMN complexNOT colocalizes_withIDA19299493  
GO:1990904ribonucleoprotein complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16752224IGHMBP2 Thr671Ala polymorphism might be a modifier for the effects of cigarette smoking and PAH-DNA adducts to breast cancer risk. (2006 Sep)Shen JBreast Cancer Res Treat