Gene info: ID 3516

Gene: RBPJ

GENE ID: 3516

Description: recombination signal binding protein for immunoglobulin kappa J region

Gene type: protein-coding

Location: 4p15.2

dbXrefs: Ensembl:ENSG00000168214 MIM:147183 Vega:OTTHUMG00000097793 UniprotKB:Q06330

RefSeq: NG_030343.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.944e-1 (AD) 6.155e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg04276669	chr4:26319867	RBPJ		1.800e-9	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNF146	0.871
PICALM	0.863
IST1	0.862
RNF13	0.861
AIMP1	0.858
ADAM10	0.854
FBXO7	0.854
LSM14A	0.853
FNTA	0.852
STXBP3	0.851

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.699
OR4F5	-0.696
HES5	-0.194
GOLGA6L1	-0.194
SHISA8	-0.192
NPBWR1	-0.187
PAX2	-0.18
CHRNA2	-0.174
PRTN3	-0.173
SP8	-0.146

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of RBPJ mRNA"	20713471
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of RBPJ protein]	17513037
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of RBPJ mRNA"	18648102
D020106	Acrylamide	Acrylamide affects the expression of RBPJ mRNA	28959563
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of RBPJ mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of RBPJ gene	25304211
D001151	Arsenic	Arsenic results in increased methylation of RBPJ promoter	21291286
C015001	arsenite	arsenite results in increased methylation of RBPJ promoter	23974009
D001280	Atrazine	Atrazine results in increased expression of RBPJ mRNA	25929836
D001554	Benzene	Benzene results in increased expression of RBPJ mRNA	19162166
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RBPJ mRNA"	19150397
C006780	bisphenol A	bisphenol A affects the methylation of RBPJ promoter	27334623
C006780	bisphenol A	bisphenol A results in increased expression of RBPJ mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of RBPJ gene	28505145
C018475	butyraldehyde	butyraldehyde results in decreased expression of RBPJ mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of RBPJ promoter	22457795
C018021	cobaltous chloride	cobaltous chloride results in increased expression of RBPJ mRNA	19376846\|2220211
C018021	cobaltous chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RBPJ mRNA]	22202117
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of RBPJ mRNA	23640034
C014347	decitabine	decitabine affects the expression of RBPJ mRNA	23300844
D002945	Cisplatin	Cisplatin affects the expression of RBPJ mRNA	23300844
C000944	dicrotophos	dicrotophos results in decreased expression of RBPJ mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of RBPJ mRNA	19030233
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of RBPJ mRNA]	19030233
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in decreased expression of RBPJ mRNA	17374397
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RBPJ protein	23301498
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBPJ mRNA	17942748
D005472	Fluorouracil	[Fluorouracil co-treated with irinotecan] results in decreased expression of RBPJ mRNA	16391804
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of RBPJ mRNA	20044591\|2117940
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of RBPJ protein	23134680
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RBPJ mRNA	25613284
C051890	irinotecan	[Fluorouracil co-treated with irinotecan] results in decreased expression of RBPJ mRNA	16391804
C051890	irinotecan	irinotecan analog results in decreased expression of RBPJ mRNA	18927307
C544151	jinfukang	jinfukang results in decreased expression of RBPJ mRNA	27392435
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of RBPJ mRNA	20713471
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of RBPJ mRNA	29191790
C523799	MRK 003	RBPJ results in increased susceptibility to MRK 003	19903844
C029938	nickel sulfate	nickel sulfate results in decreased expression of RBPJ mRNA	17374397\|2271453
C419410	N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RBPJ mRNA]"	24223152
C570897	NSC668394	NSC668394 results in decreased expression of RBPJ mRNA	27137931
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of RBPJ mRNA	25729387
D010081	Oxazolone	Oxazolone results in decreased expression of RBPJ mRNA	17374397
D010100	Oxygen	Oxygen deficiency results in increased expression of RBPJ protein	24223152
D010100	Oxygen	"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RBPJ mRNA]"	24223152
D010100	Oxygen	Oxygen deficiency results in increased expression of RBPJ mRNA	24223152
D011794	Quercetin	Quercetin results in increased expression of RBPJ mRNA	23117658
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of RBPJ mRNA]	19030233
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of RBPJ mRNA	21427059
D012715	Sesame Oil	Sesame Oil results in increased expression of RBPJ mRNA	29191790
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of RBPJ mRNA	18685790
C017947	sodium arsenite	sodium arsenite affects the expression of RBPJ mRNA	29319823
D018038	Sodium Selenite	Sodium Selenite results in increased expression of RBPJ mRNA	18175754
D012999	Soman	Soman results in increased expression of RBPJ mRNA	19281266
D053260	Soot	Soot results in increased expression of RBPJ mRNA	26551751
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBPJ mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RBPJ mRNA	19770486
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of RBPJ protein	23134680
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RBPJ mRNA	25613284
D013849	Thimerosal	Thimerosal results in decreased expression of RBPJ mRNA	24675092
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of RBPJ mRNA	25729387
C057693	troglitazone	troglitazone results in decreased expression of RBPJ mRNA	28973697
D014635	Valproic Acid	Valproic Acid affects the expression of RBPJ mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of RBPJ mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of RBPJ gene	25487561
D024483	Vitamin K 3	Vitamin K 3 results in decreased expression of RBPJ mRNA	25270620
C009687	wortmannin	wortmannin inhibits the reaction [Zinc affects the localization of RBPJ protein]	17513037
D015032	Zinc	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of RBPJ protein]	17513037
D015032	Zinc	wortmannin inhibits the reaction [Zinc affects the localization of RBPJ protein]	17513037
D015032	Zinc	Zinc affects the localization of RBPJ protein	17513037
D015032	Zinc	Zinc inhibits the reaction [NOTCH1 protein binds to RBPJ protein]	17513037
C016837	zinc chloride	zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RBPJ mRNA]	22202117

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000150	recombinase activity	-	NAS	8406481
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	16691198
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	18663143
GO:0001103	RNA polymerase II repressing transcription factor binding	-	IBA	21873635
GO:0001103	RNA polymerase II repressing transcription factor binding	-	IPI	16287852
GO:0003677	DNA binding	-	TAS	9874765
GO:0003682	chromatin binding	-	IEA	-
GO:0003700	DNA-binding transcription factor activity	-	TAS	9874765
GO:0005515	protein binding	-	IPI	8627785 9874765 10713164 15710417 16510869 16530044 17284587 21102556 21475249 22810586 23022380 23303788 25609649 26302407 26496610
GO:0008134	transcription factor binding	-	IDA	23303788
GO:0008134	transcription factor binding	-	IPI	23303788
GO:0043565	sequence-specific DNA binding	-	IBA	21873635
GO:0043565	sequence-specific DNA binding	-	IDA	23303788
GO:0047485	protein N-terminus binding	-	IEA	-
GO:0070491	repressing transcription factor binding	-	IBA	21873635
GO:0070491	repressing transcription factor binding	-	IPI	16691198

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	18663143
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0001525	angiogenesis	-	ISS	-
GO:0001756	somitogenesis	-	IEA	-
GO:0001837	epithelial to mesenchymal transition	-	ISS	-
GO:0001974	blood vessel remodeling	-	IEA	-
GO:0002437	inflammatory response to antigenic stimulus	-	IEA	-
GO:0003139	secondary heart field specification	-	IEA	-
GO:0003151	outflow tract morphogenesis	-	ISS	-
GO:0003160	endocardium morphogenesis	-	ISS	-
GO:0003176	aortic valve development	-	IEA	-
GO:0003177	pulmonary valve development	-	IEA	-
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	-	ISS	-
GO:0003214	cardiac left ventricle morphogenesis	-	ISS	-
GO:0003222	ventricular trabecula myocardium morphogenesis	-	ISS	-
GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation	-	ISS	-
GO:0006310	DNA recombination	-	NAS	8406481
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0006959	humoral immune response	-	IEA	-
GO:0007219	Notch signaling pathway	-	IBA	21873635
GO:0007219	Notch signaling pathway	-	IMP	18663143
GO:0007219	Notch signaling pathway	-	TAS	-
GO:0007221	positive regulation of transcription of Notch receptor target	-	IDA	21102556
GO:0007221	positive regulation of transcription of Notch receptor target	-	TAS	-
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0009912	auditory receptor cell fate commitment	-	IEA	-
GO:0009957	epidermal cell fate specification	-	IEA	-
GO:0010628	positive regulation of gene expression	-	ISS	-
GO:0021983	pituitary gland development	-	IEA	-
GO:0030183	B cell differentiation	-	IEA	-
GO:0030216	keratinocyte differentiation	-	IEA	-
GO:0030279	negative regulation of ossification	-	ISS	-
GO:0030513	positive regulation of BMP signaling pathway	-	ISS	-
GO:0035019	somatic stem cell population maintenance	-	IEA	-
GO:0035912	dorsal aorta morphogenesis	-	ISS	-
GO:0036302	atrioventricular canal development	-	ISS	-
GO:0042742	defense response to bacterium	-	IEA	-
GO:0043011	myeloid dendritic cell differentiation	-	IEA	-
GO:0045596	negative regulation of cell differentiation	-	IEA	-
GO:0045747	positive regulation of Notch signaling pathway	-	TAS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	10713164
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	18663143 20890042
GO:0048505	regulation of timing of cell differentiation	-	IEA	-
GO:0048733	sebaceous gland development	-	IEA	-
GO:0048820	hair follicle maturation	-	IEA	-
GO:0060045	positive regulation of cardiac muscle cell proliferation	-	ISS	-
GO:0060412	ventricular septum morphogenesis	-	IEA	-
GO:0060486	Clara cell differentiation	-	IEA	-
GO:0060716	labyrinthine layer blood vessel development	-	ISS	-
GO:0060844	arterial endothelial cell fate commitment	-	IEA	-
GO:0061314	Notch signaling involved in heart development	-	IC	21311046
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	IDA	23303788
GO:0072554	blood vessel lumenization	-	ISS	-
GO:0072602	interleukin-4 secretion	-	IEA	-
GO:0097101	blood vessel endothelial cell fate specification	-	ISS	-
GO:1901186	positive regulation of ERBB signaling pathway	-	ISS	-
GO:1901189	positive regulation of ephrin receptor signaling pathway	-	ISS	-
GO:1901297	positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	-	IEA	-
GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002193	MAML1-RBP-Jkappa- ICN1 complex	-	IBA	21873635
GO:0002193	MAML1-RBP-Jkappa- ICN1 complex	-	IDA	16510869
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	9874765 21102556
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IBA	21873635
GO:0005667	transcription factor complex	-	IEA	-
GO:0005730	nucleolus	-	IDA	9874765
GO:0005737	cytoplasm	-	IDA	21102556
GO:0017053	transcriptional repressor complex	-	IDA	16691198

KEGG ID	KEGG Term
hsa04330	Notch signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-157118	Signaling by NOTCH	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-186712	Regulation of beta-cell development	IEA
R-HSA-1912408	Pre-NOTCH Transcription and Translation	IEA
R-HSA-1912408	Pre-NOTCH Transcription and Translation	TAS
R-HSA-1912422	Pre-NOTCH Expression and Processing	IEA
R-HSA-1912422	Pre-NOTCH Expression and Processing	TAS
R-HSA-1980143	Signaling by NOTCH1	IEA
R-HSA-1980143	Signaling by NOTCH1	TAS
R-HSA-1980145	Signaling by NOTCH2	TAS
R-HSA-1980145	Signaling by NOTCH2	IEA
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	IEA
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	IEA
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	TAS
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	IEA
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	TAS
R-HSA-2644603	Signaling by NOTCH1 in Cancer	TAS
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	TAS
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	TAS
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	TAS
R-HSA-350054	Notch-HLH transcription pathway	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878159	Transcriptional regulation by RUNX3	IEA
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8941856	RUNX3 regulates NOTCH signaling	IEA
R-HSA-8941856	RUNX3 regulates NOTCH signaling	TAS
R-HSA-9012852	Signaling by NOTCH3	TAS
R-HSA-9012852	Signaling by NOTCH3	IEA
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	TAS
R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25144241	A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females. (2014 Nov)	Kang HG	J Thorac Oncol