Gene: RBPJ

3516
AOS3|CBF1|IGKJRB|IGKJRB1|KBF2|RBP-J|RBPJK|RBPSUH|SUH|csl
recombination signal binding protein for immunoglobulin kappa J region
protein-coding
4p15.2
Ensembl:ENSG00000168214 MIM:147183 Vega:OTTHUMG00000097793 UniprotKB:Q06330
NG_030343.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.944e-1 (AD)  6.155e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04276669chr4:26319867RBPJ1.800e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF1460.871
PICALM0.863
IST10.862
RNF130.861
AIMP10.858
ADAM100.854
FBXO70.854
LSM14A0.853
FNTA0.852
STXBP30.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.699
OR4F5-0.696
HES5-0.194
GOLGA6L1-0.194
SHISA8-0.192
NPBWR1-0.187
PAX2-0.18
CHRNA2-0.174
PRTN3-0.173
SP8-0.146

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of RBPJ mRNA"20713471
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of RBPJ protein]17513037
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of RBPJ mRNA"18648102
D020106AcrylamideAcrylamide affects the expression of RBPJ mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RBPJ mRNA24449571
D001151ArsenicArsenic affects the methylation of RBPJ gene25304211
D001151ArsenicArsenic results in increased methylation of RBPJ promoter21291286
C015001arsenitearsenite results in increased methylation of RBPJ promoter23974009
D001280AtrazineAtrazine results in increased expression of RBPJ mRNA25929836
D001554BenzeneBenzene results in increased expression of RBPJ mRNA19162166
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RBPJ mRNA"19150397
C006780bisphenol Abisphenol A affects the methylation of RBPJ promoter27334623
C006780bisphenol Abisphenol A results in increased expression of RBPJ mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RBPJ gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of RBPJ mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of RBPJ promoter22457795
C018021cobaltous chloridecobaltous chloride results in increased expression of RBPJ mRNA19376846|2220211
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RBPJ mRNA]22202117
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of RBPJ mRNA23640034
C014347decitabinedecitabine affects the expression of RBPJ mRNA23300844
D002945CisplatinCisplatin affects the expression of RBPJ mRNA23300844
C000944dicrotophosdicrotophos results in decreased expression of RBPJ mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of RBPJ mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of RBPJ mRNA]19030233
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of RBPJ mRNA17374397
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RBPJ protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBPJ mRNA17942748
D005472Fluorouracil[Fluorouracil co-treated with irinotecan] results in decreased expression of RBPJ mRNA16391804
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RBPJ mRNA20044591|2117940
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of RBPJ protein23134680
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RBPJ mRNA25613284
C051890irinotecan[Fluorouracil co-treated with irinotecan] results in decreased expression of RBPJ mRNA16391804
C051890irinotecanirinotecan analog results in decreased expression of RBPJ mRNA18927307
C544151jinfukangjinfukang results in decreased expression of RBPJ mRNA27392435
D008748MethylcholanthreneMethylcholanthrene results in increased expression of RBPJ mRNA20713471
D008777MethyltestosteroneMethyltestosterone results in decreased expression of RBPJ mRNA29191790
C523799MRK 003RBPJ results in increased susceptibility to MRK 00319903844
C029938nickel sulfatenickel sulfate results in decreased expression of RBPJ mRNA17374397|2271453
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RBPJ mRNA]"24223152
C570897NSC668394NSC668394 results in decreased expression of RBPJ mRNA27137931
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RBPJ mRNA25729387
D010081OxazoloneOxazolone results in decreased expression of RBPJ mRNA17374397
D010100OxygenOxygen deficiency results in increased expression of RBPJ protein24223152
D010100Oxygen"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RBPJ mRNA]"24223152
D010100OxygenOxygen deficiency results in increased expression of RBPJ mRNA24223152
D011794QuercetinQuercetin results in increased expression of RBPJ mRNA23117658
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of RBPJ mRNA]19030233
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of RBPJ mRNA21427059
D012715Sesame OilSesame Oil results in increased expression of RBPJ mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in increased expression of RBPJ mRNA18685790
C017947sodium arsenitesodium arsenite affects the expression of RBPJ mRNA29319823
D018038Sodium SeleniteSodium Selenite results in increased expression of RBPJ mRNA18175754
D012999SomanSoman results in increased expression of RBPJ mRNA19281266
D053260SootSoot results in increased expression of RBPJ mRNA26551751
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBPJ mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RBPJ mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of RBPJ protein23134680
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RBPJ mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of RBPJ mRNA24675092
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RBPJ mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of RBPJ mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of RBPJ mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RBPJ mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RBPJ gene25487561
D024483Vitamin K 3Vitamin K 3 results in decreased expression of RBPJ mRNA25270620
C009687wortmanninwortmannin inhibits the reaction [Zinc affects the localization of RBPJ protein]17513037
D015032Zinc2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of RBPJ protein]17513037
D015032Zincwortmannin inhibits the reaction [Zinc affects the localization of RBPJ protein]17513037
D015032ZincZinc affects the localization of RBPJ protein17513037
D015032ZincZinc inhibits the reaction [NOTCH1 protein binds to RBPJ protein]17513037
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RBPJ mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000150recombinase activity-NAS8406481  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA16691198  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA18663143  
GO:0001103RNA polymerase II repressing transcription factor binding-IBA21873635  
GO:0001103RNA polymerase II repressing transcription factor binding-IPI16287852  
GO:0003677DNA binding-TAS9874765  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS9874765  
GO:0005515protein binding-IPI8627785  9874765  10713164  15710417  16510869  16530044  
17284587  21102556  21475249  22810586  23022380  23303788  
25609649  26302407  26496610  
GO:0008134transcription factor binding-IDA23303788  
GO:0008134transcription factor binding-IPI23303788  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IDA23303788  
GO:0047485protein N-terminus binding-IEA-  
GO:0070491repressing transcription factor binding-IBA21873635  
GO:0070491repressing transcription factor binding-IPI16691198  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP18663143  
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001525angiogenesis-ISS-  
GO:0001756somitogenesis-IEA-  
GO:0001837epithelial to mesenchymal transition-ISS-  
GO:0001974blood vessel remodeling-IEA-  
GO:0002437inflammatory response to antigenic stimulus-IEA-  
GO:0003139secondary heart field specification-IEA-  
GO:0003151outflow tract morphogenesis-ISS-  
GO:0003160endocardium morphogenesis-ISS-  
GO:0003176aortic valve development-IEA-  
GO:0003177pulmonary valve development-IEA-  
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation-ISS-  
GO:0003214cardiac left ventricle morphogenesis-ISS-  
GO:0003222ventricular trabecula myocardium morphogenesis-ISS-  
GO:0003256regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation-ISS-  
GO:0006310DNA recombination-NAS8406481  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006959humoral immune response-IEA-  
GO:0007219Notch signaling pathway-IBA21873635  
GO:0007219Notch signaling pathway-IMP18663143  
GO:0007219Notch signaling pathway-TAS-  
GO:0007221positive regulation of transcription of Notch receptor target-IDA21102556  
GO:0007221positive regulation of transcription of Notch receptor target-TAS-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009912auditory receptor cell fate commitment-IEA-  
GO:0009957epidermal cell fate specification-IEA-  
GO:0010628positive regulation of gene expression-ISS-  
GO:0021983pituitary gland development-IEA-  
GO:0030183B cell differentiation-IEA-  
GO:0030216keratinocyte differentiation-IEA-  
GO:0030279negative regulation of ossification-ISS-  
GO:0030513positive regulation of BMP signaling pathway-ISS-  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0035912dorsal aorta morphogenesis-ISS-  
GO:0036302atrioventricular canal development-ISS-  
GO:0042742defense response to bacterium-IEA-  
GO:0043011myeloid dendritic cell differentiation-IEA-  
GO:0045596negative regulation of cell differentiation-IEA-  
GO:0045747positive regulation of Notch signaling pathway-TAS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA10713164  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP18663143  20890042  
GO:0048505regulation of timing of cell differentiation-IEA-  
GO:0048733sebaceous gland development-IEA-  
GO:0048820hair follicle maturation-IEA-  
GO:0060045positive regulation of cardiac muscle cell proliferation-ISS-  
GO:0060412ventricular septum morphogenesis-IEA-  
GO:0060486Clara cell differentiation-IEA-  
GO:0060716labyrinthine layer blood vessel development-ISS-  
GO:0060844arterial endothelial cell fate commitment-IEA-  
GO:0061314Notch signaling involved in heart development-IC21311046  
GO:0061419positive regulation of transcription from RNA polymerase II promoter in response to hypoxia-IDA23303788  
GO:0072554blood vessel lumenization-ISS-  
GO:0072602interleukin-4 secretion-IEA-  
GO:0097101blood vessel endothelial cell fate specification-ISS-  
GO:1901186positive regulation of ERBB signaling pathway-ISS-  
GO:1901189positive regulation of ephrin receptor signaling pathway-ISS-  
GO:1901297positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment-IEA-  
GO:2000138positive regulation of cell proliferation involved in heart morphogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002193MAML1-RBP-Jkappa- ICN1 complex-IBA21873635  
GO:0002193MAML1-RBP-Jkappa- ICN1 complex-IDA16510869  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9874765  21102556  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IBA21873635  
GO:0005667transcription factor complex-IEA-  
GO:0005730nucleolus-IDA9874765  
GO:0005737cytoplasm-IDA21102556  
GO:0017053transcriptional repressor complex-IDA16691198  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-186712Regulation of beta-cell developmentIEA
R-HSA-1912408Pre-NOTCH Transcription and TranslationIEA
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980143Signaling by NOTCH1TAS
R-HSA-1980145Signaling by NOTCH2TAS
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-210744Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2197563NOTCH2 intracellular domain regulates transcriptionTAS
R-HSA-2197563NOTCH2 intracellular domain regulates transcriptionIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-350054Notch-HLH transcription pathwayTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3IEA
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8941856RUNX3 regulates NOTCH signalingIEA
R-HSA-8941856RUNX3 regulates NOTCH signalingTAS
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionTAS
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25144241A functional polymorphism in CSF1R gene is a novel susceptibility marker for lung cancer among never-smoking females. (2014 Nov)Kang HGJ Thorac Oncol