Gene: C6orf58

352999
LEG1
chromosome 6 open reading frame 58
protein-coding
6q22.33
Ensembl:ENSG00000184530 Vega:OTTHUMG00000015530 UniprotKB:Q6P5S2
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.359e-1 (AD)  4.344e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZG16B0.6
MUC70.594
PIP0.561
BPIFB20.395
PRM20.371
TNP10.367
PRM10.362
STATH0.334
BOD1L20.328
SPIN40.32

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBC1D3B-0.253
PPIAL4G-0.215
CCDC103-0.205
INSL3-0.2
KRTAP10-4-0.2
OR1J1-0.199
SLC7A9-0.195
PAGE2-0.191
KRTAP4-9-0.188
FITM1-0.187

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of C6ORF58 gene27153756
D000447AldehydesAldehydes results in increased expression of C6ORF58 mRNA25014914
D001151ArsenicArsenic results in increased methylation of C6ORF58 promoter21291286
D001280AtrazineAtrazine results in decreased expression of C6ORF58 mRNA25929836
C018475butyraldehydebutyraldehyde results in increased expression of C6ORF58 mRNA26079696
D003703DemecolcineDemecolcine results in increased expression of C6ORF58 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of C6ORF58 mRNA23649840
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of C6ORF58 mRNA23649840
C046012pentanalpentanal results in increased expression of C6ORF58 mRNA26079696
C005556propionaldehydepropionaldehyde results in increased expression of C6ORF58 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of C6ORF58 mRNA23806026
D014750VincristineVincristine results in increased expression of C6ORF58 mRNA23649840
C088658zoledronic acidzoledronic acid results in increased expression of C6ORF58 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA25645918  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26306861Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects. (2015 Oct 14)Titz BJ Proteomics