Gene: APRT

353
AMP|APRTD
adenine phosphoribosyltransferase
protein-coding
16q24.3
Ensembl:ENSG00000198931 MIM:102600 Vega:OTTHUMG00000175454 UniprotKB:P07741
NG_008013.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.382e-1 (AD)  9.151e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SF3B50.884
SSR40.877
C19orf700.873
LAMTOR40.872
NDUFAF30.872
NDUFB70.869
EDF10.868
DRAP10.868
C19orf530.867
NME1-NME20.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.733
OR4F29-0.714
MTRNR2L6-0.286
MTRNR2L9-0.267
MTRNR2L10-0.206
RAX2-0.197
P2RY14-0.19
MOGAT2-0.18
TBX4-0.176
HBD-0.171

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00173AdenineSmall Molecule73-24-5Approved|NutraceuticalTarget
DB01632Alpha-Phosphoribosylpyrophosphoric AcidSmall Molecule13270-65-0Approved|Experimental|InvestigationalTarget
DB035069-DeazaadenineSmall MoleculeExperimentalTarget
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
DB00131Adenosine monophosphateSmall Molecule61-19-8Approved|Investigational|NutraceuticalEnzyme
ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of APRT mRNA"20702594
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of APRT mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APRT gene"10692228|7767987
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APRT gene] which affects the susceptibility to 8-azaadenine"10692228
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"SULT1A1 protein promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APRT gene] which affects the susceptibility to 8-azaadenine]"10692228
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"SULT1A3 protein promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APRT gene] which affects the susceptibility to 8-azaadenine]"10692228
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[CYP1A2 protein co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased mutagenesis of APRT gene"2023932
C0292162-amino-3-methylimidazo(4,5-f)quinoline"[NAT2 protein results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline] which results in increased mutagenesis of APRT gene"9150757
C0292162-amino-3-methylimidazo(4,5-f)quinoline"[CYP1A2 protein co-treated with 2-amino-3-methylimidazo(4,5-f)quinoline] results in increased mutagenesis of APRT gene"2023932
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of APRT mRNA"23994337
C0066548-azaadenine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APRT gene] which affects the susceptibility to 8-azaadenine"10692228
C0066548-azaadenineAPRT protein affects the susceptibility to 8-azaadenine10692228
C0066548-azaadenine"SULT1A1 protein promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APRT gene] which affects the susceptibility to 8-azaadenine]"10692228
C0066548-azaadenine"SULT1A3 protein promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of APRT gene] which affects the susceptibility to 8-azaadenine]"10692228
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APRT mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of APRT mRNA24449571
D001241AspirinAspirin results in decreased expression of APRT mRNA15928584
D001280AtrazineAtrazine results in increased expression of APRT mRNA22378314
C547126AZM551248AZM551248 results in increased expression of APRT mRNA22323515
C004456beauvericinbeauvericin results in decreased expression of APRT mRNA29203277
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of APRT mRNA23994337
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of APRT mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of APRT protein24909818
C006780bisphenol Abisphenol A results in increased expression of APRT protein24909818
C006780bisphenol Abisphenol A results in increased expression of APRT mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of APRT mRNA17484886
D002994ClofibrateClofibrate results in decreased expression of APRT mRNA17585979|2381119
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APRT mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of APRT mRNA19376846
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of APRT mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of APRT mRNA19549813
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of APRT mRNA]27941970
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APRT mRNA17602206
D004317DoxorubicinDoxorubicin results in increased oxidation of APRT protein28818578
D000431EthanolEthanol results in decreased expression of APRT protein24646710
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of APRT mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of APRT mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APRT mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of APRT mRNA23649840
D019833GenisteinESR2 promotes the reaction [Genistein results in increased expression of APRT protein]20884965
D019833GenisteinGenistein results in increased expression of APRT protein20884965
D005839GentamicinsGentamicins results in increased expression of APRT mRNA22061828
D005839GentamicinsGentamicins results in increased expression of APRT protein22061828
D005897GlafenineGlafenine results in increased expression of APRT mRNA24136188
D006046GoldGold analog results in decreased expression of APRT protein24780912
D017313FenretinideFenretinide results in increased expression of APRT mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of APRT mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of APRT mRNA23086925
C008261lead acetatelead acetate results in decreased activity of APRT protein19428946
C008261lead acetatelead acetate results in decreased activity of APRT protein19428946
D008094LithiumLithium results in increased expression of APRT protein18296634
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of APRT protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of APRT mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of APRT mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of APRT protein26558463
C568376MT19c compoundMT19c compound results in decreased expression of APRT mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of APRT mRNA"25554681
C012655nimesulidenimesulide results in increased expression of APRT mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of APRT protein19716841
D010269ParaquatParaquat results in decreased expression of APRT mRNA21371552
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of APRT mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of APRT protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of APRT mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of APRT mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of APRT mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of APRT mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of APRT mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of APRT mRNA23018184
C045950propiconazolepropiconazole results in increased expression of APRT mRNA21278054
C059514resveratrolresveratrol results in increased expression of APRT protein25505154
C017947sodium arsenitesodium arsenite results in decreased expression of APRT protein15725613
D018038Sodium SeleniteSodium Selenite results in increased expression of APRT mRNA18175754
D013605T-2 ToxinT-2 Toxin affects the expression of APRT protein26141394
D013629TamoxifenTamoxifen affects the expression of APRT mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APRT mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of APRT mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APRT mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APRT mRNA17942748|1879615
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of APRT mRNA28973375
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of APRT mRNA28065790
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of APRT mRNA19042947
D014520UrethaneUrethane results in decreased expression of APRT mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of APRT mRNA17292431|1796380
C025643vinclozolinvinclozolin results in increased expression of APRT mRNA22570695
C029297vinylidene chloridevinylidene chloride results in increased expression of APRT mRNA26682919
D015215ZidovudineZidovudine results in increased mutagenesis of APRT gene10970446
D015032ZincZinc results in decreased expression of APRT mRNA20932299
D019287Zinc SulfateZinc Sulfate results in decreased expression of APRT mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002055adenine binding-IBA21873635  
GO:0002055adenine binding-IEA-  
GO:0003999adenine phosphoribosyltransferase activity-IBA21873635  
GO:0003999adenine phosphoribosyltransferase activity-TAS-  
GO:0016208AMP binding-IBA21873635  
GO:0016208AMP binding-IDA15196008  
GO ID GO Term Qualifier Evidence PubMed
GO:0006166purine ribonucleoside salvage-IEA-  
GO:0006168adenine salvage-IBA21873635  
GO:0006168adenine salvage-IEA-  
GO:0007595lactation-IEA-  
GO:0007625grooming behavior-IEA-  
GO:0032869cellular response to insulin stimulus-IEA-  
GO:0043101purine-containing compound salvage-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0044209AMP salvage-IBA21873635  
GO:0044209AMP salvage-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS16130169  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0034774secretory granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-74217Purine salvageTAS
R-HSA-8956321Nucleotide salvageTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27838211Chronic alcohol administration affects purine nucleotide catabolism in vivo. (2017 Jan 1)Zhang JDLife Sci
15518579Chromium(VI) enhances (+/-)-anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a ]pyrene-induced cytotoxicity and mutagenicity in mammalian cells through its inhibitory effect on nucleotide excision repair. (2004 Nov 9)Hu WBiochemistry