Gene: LCE2C

353140
LEP11
late cornified envelope 2C
protein-coding
1q21.3
Ensembl:ENSG00000187180 MIM:612611 Vega:OTTHUMG00000012389 UniprotKB:Q5TA81
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.167e-1 (AD)  2.313e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12060809chr1:152676474 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM2470.601
MEOX10.589
ZBTB200.568
OR56A40.568
HOXC120.566
PSAPL10.559
PRAMEF170.559
PCDHGA80.558
DUSP130.552
OR10K10.551

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACRV1-0.271
C5orf47-0.249
CYP4A11-0.241
TMEM117-0.234
NME5-0.232
RWDD2B-0.226
C3orf67-0.221
C1orf74-0.22
OSTN-0.218
PTGES3L-0.215

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of LCE2C mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LCE2C gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of LCE2C mRNA21298039
D019327Copper SulfateCopper Sulfate results in increased expression of LCE2C mRNA19549813
D010936Plant ExtractsPlant Extracts results in decreased expression of LCE2C mRNA23557933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0018149peptide cross-linking-IBA21873635  
GO:0030216keratinocyte differentiation-IBA21873635  
GO:0031424keratinization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal