Gene: LCE3C

353144
LEP15|SPRL3A
late cornified envelope 3C
protein-coding
1q21.3
Ensembl:ENSG00000244057 MIM:612615 Vega:OTTHUMG00000014403 UniprotKB:Q5T5A8
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.329e-1 (AD)  6.132e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTAG20.606
CCDC170.578
SPATA31A10.555
RSPH6A0.544
CHRM50.483
TBX190.48
GRHL30.455
KRTAP12-40.431
MIA0.422
SERPINA50.416

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTC30A-0.322
PDE7B-0.32
FDXACB1-0.289
FAM86C1-0.284
LCMT2-0.266
EXO5-0.265
TIRAP-0.261
SRBD1-0.259
NHLRC1-0.254
HYKK-0.253

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of LCE3C mRNA19933214
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of LCE3C gene27153756
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LCE3C mRNA26377693
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LCE3C mRNA21457566
C031180chrysenechrysene results in increased expression of LCE3C mRNA26377693
D011374ProgesteroneProgesterone results in decreased expression of LCE3C mRNA22238285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LCE3C mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LCE3C mRNA19933214
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LCE3C gene25560391
D014752Vinyl ChlorideVinyl Chloride results in increased expression of LCE3C mRNA18579281

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0018149peptide cross-linking-IBA21873635  
GO:0030216keratinocyte differentiation-IBA21873635  
GO:0031424keratinization-IEA-  
GO:0031640killing of cells of other organism-IDA28634035  
GO:0050829defense response to Gram-negative bacterium-IDA28634035  
GO:0050830defense response to Gram-positive bacterium-IDA28634035  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29623515DNA methylation-based subclassification of psoriasis in the Chinese Han population. (2018 Apr 5)Zhou FFront Med