Gene: POLN

353497
POL4P
DNA polymerase nu
protein-coding
4p16.3
Ensembl:ENSG00000130997 MIM:610887 Vega:OTTHUMG00000090081 UniprotKB:Q7Z5Q5
NG_046934.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.702e-1 (AD)  2.723e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STK360.865
HIC20.859
ABCC100.854
CELSR30.853
TRIM170.851
STK11IP0.85
TRIM110.849
ATXN7L20.849
PTCH20.848
CACNA1I0.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXT2-0.454
COPZ2-0.447
YES1-0.431
MBNL3-0.424
C9orf135-0.413
LRRCC1-0.413
REST-0.404
ZNF114-0.401
MYL3-0.399
FAM89A-0.396

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0581182'-deoxyadenosine[erythritol anhydride binds to 2'-deoxyadenosine] which results in decreased activity of POLN protein26098310
C0581182'-deoxyadenosinePOLN protein inhibits the reaction [[erythritol anhydride binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein]26098310
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of POLN mRNA24449571
D001151ArsenicArsenic affects the methylation of POLN gene25304211
C006780bisphenol Abisphenol A affects the expression of POLN mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of POLN mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of POLN mRNA27339419
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of POLN mRNA21878529
C007366erythritol anhydride[erythritol anhydride binds to 2'-deoxyadenosine] which results in decreased activity of POLN protein26098310
C007366erythritol anhydridePOLN protein inhibits the reaction [[erythritol anhydride binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein]26098310
D017313FenretinideFenretinide results in decreased expression of POLN mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of POLN mRNA27432991
C000598755N6-(2-hydroxy-3-buten-1-yl)-2'-deoxyadenosineN6-(2-hydroxy-3-buten-1-yl)-2'-deoxyadenosine results in decreased activity of POLN protein26098310
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of POLN mRNA"25554681
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of POLN mRNA25895662
D012906SmokeSmoke results in increased expression of POLN mRNA21095227
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of POLN gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003887DNA-directed DNA polymerase activity-IBA21873635  
GO:0003887DNA-directed DNA polymerase activity-IDA12794064  17118716  19908865  
GO:0003887DNA-directed DNA polymerase activity-TAS-  
GO:0005515protein binding-IPI19995904  
GO:00084095'-3' exonuclease activity-IBA21873635  
GO:0030332cyclin binding-IPI19995904  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-IMP19995904  
GO:0006261DNA-dependent DNA replication-IBA21873635  
GO:0019985translesion synthesis-IDA20102227  
GO:0019985translesion synthesis-IMP19908865  
GO:0036297interstrand cross-link repair-IMP19908865  19995904  
GO:0036297interstrand cross-link repair-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12794064  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolusNOTIDA12794064  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6783310Fanconi Anemia PathwayTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22382497Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. (2012 May)Kazma RCarcinogenesis