Gene info: ID 3549

Gene: IHH

GENE ID: 3549

Synonyms: BDA1|HHG2

Description: indian hedgehog

Gene type: protein-coding

Location: 2q35

dbXrefs: Ensembl:ENSG00000163501 MIM:600726 Vega:OTTHUMG00000154631 UniprotKB:Q14623

RefSeq: NG_016741.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.490e-1 (AD) 3.259e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SDR42E2	0.415
TRIM11	0.396
QRICH2	0.392
SLC22A7	0.385
LCN8	0.384
LEFTY1	0.384
GLIS1	0.381
HIC2	0.377
TRIM17	0.376
TMEM74B	0.374

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ADORA3	-0.286
ACOT6	-0.28
APOBR	-0.266
HESX1	-0.261
CD86	-0.26
IL18	-0.259
DPH6	-0.256
C3AR1	-0.255
SH3TC1	-0.254
CXorf58	-0.252

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of IHH mRNA"	28903501
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of IHH mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of IHH mRNA"	21346803
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of IHH mRNA"	17109907
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of IHH mRNA"	21346803
D000082	Acetaminophen	Acetaminophen affects the expression of IHH mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of IHH mRNA	28959563
D000452	Aldrin	Aldrin results in increased expression of IHH mRNA	18579281
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IHH mRNA	16483693
D001151	Arsenic	[Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of IHH protein	23604592
C015001	arsenite	arsenite results in increased methylation of IHH promoter	23974009
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of IHH mRNA	20530736
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of IHH mRNA	26377693
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of IHH mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IHH mRNA	22228805
D004958	Estradiol	[Estradiol co-treated with IGF1 protein] results in increased expression of IHH mRNA	22811575
D004958	Estradiol	Estradiol inhibits the reaction [Progesterone results in increased expression of IHH mRNA]	16794005
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of IHH mRNA	20660070
D004958	Estradiol	ESR1 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IHH mRNA]	25210133
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of IHH mRNA	22958837\|2521013
D004958	Estradiol	Estradiol promotes the reaction [Plant Preparations results in decreased expression of IHH mRNA]	26945725
D004958	Estradiol	Estradiol results in decreased expression of IHH mRNA	26945725
D004958	Estradiol	Estradiol results in increased expression of IHH mRNA	20232216
C006780	bisphenol A	bisphenol A results in decreased expression of IHH mRNA	25181051
D002104	Cadmium	[Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of IHH protein	23604592
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of IHH protein	23604592
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IHH mRNA	20938992
D019327	Copper Sulfate	Copper Sulfate results in increased expression of IHH mRNA	18579281
C107676	deguelin	deguelin results in increased expression of IHH mRNA	19861542
D003907	Dexamethasone	Dexamethasone results in increased expression of IHH mRNA	27608943
C492519	diarylpropionitrile	diarylpropionitrile results in decreased expression of IHH mRNA	17109907
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of IHH mRNA	28962523
D004052	Diethylnitrosamine	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of IHH gene	23968726
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of IHH mRNA	18164116
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of IHH mRNA"	27840820
D004237	Diuron	Diuron results in increased expression of IHH mRNA	25152437
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of IHH mRNA"	23262642
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of IHH mRNA	17109907
D004997	Ethinyl Estradiol	fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of IHH mRNA]	17109907
C082360	fipronil	fipronil results in decreased expression of IHH mRNA	23962444
D005472	Fluorouracil	Fluorouracil results in decreased expression of IHH mRNA	25190613
D005472	Fluorouracil	Fluorouracil results in decreased expression of IHH protein	25190613
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IHH mRNA	20938992
C070081	fulvestrant	fulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of IHH mRNA]	17109907
C070081	fulvestrant	fulvestrant results in decreased expression of IHH mRNA	20232216
D019833	Genistein	Genistein affects the expression of IHH mRNA	21810550
C004312	glycidol	glycidol results in decreased expression of IHH mRNA	24915197
D006025	Glycosaminoglycans	Glycosaminoglycans affects the activity of IHH protein	20807638
D017313	Fenretinide	Fenretinide results in increased expression of IHH mRNA	28973697
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IHH mRNA	25613284
D048628	Ketolides	Ketolides analog results in increased expression of IHH mRNA	24967691
D007854	Lead	[Arsenic co-treated with Cadmium co-treated with Lead] results in decreased expression of IHH protein	23604592
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of IHH protein	23604592
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IHH mRNA	26378955
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IHH mRNA	20938992
D008727	Methotrexate	Methotrexate affects the expression of IHH mRNA	18502557
C028577	monobutyl phthalate	monobutyl phthalate results in increased expression of IHH mRNA	29162477
D009151	Mustard Gas	Mustard Gas results in increased expression of IHH mRNA	15674843
D009538	Nicotine	Nicotine results in increased expression of IHH mRNA	27782041
C025589	ochratoxin A	ochratoxin A results in decreased expression of IHH mRNA	23358140
D009966	Orphenadrine	Orphenadrine affects the expression of IHH mRNA	23665939
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of IHH mRNA]	19482888
D010634	Phenobarbital	NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of IHH mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of IHH mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of IHH mRNA	19482888
D010672	Phenytoin	Phenytoin results in increased expression of IHH mRNA	16141649
D010882	Piperonyl Butoxide	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of IHH gene	23968726
C006253	pirinixic acid	pirinixic acid results in decreased expression of IHH mRNA	17950772
D010936	Plant Extracts	Plant Extracts results in increased expression of IHH mRNA	23262642
D028321	Plant Preparations	Estradiol promotes the reaction [Plant Preparations results in decreased expression of IHH mRNA]	26945725
D028321	Plant Preparations	Plant Preparations results in decreased expression of IHH mRNA	26945725
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of IHH mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of IHH mRNA	28903501
D011374	Progesterone	Progesterone results in decreased expression of IHH mRNA	23018184
D011374	Progesterone	Estradiol inhibits the reaction [Progesterone results in increased expression of IHH mRNA]	16794005
D011374	Progesterone	Progesterone results in increased expression of IHH mRNA	16794005
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of IHH mRNA	20660070
D011374	Progesterone	ESR1 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IHH mRNA]	25210133
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of IHH mRNA	22958837\|2521013
D011374	Progesterone	Progesterone affects the expression of IHH	16794005
D011374	Progesterone	Progesterone results in increased expression of IHH	20232216
D011374	Progesterone	Progesterone results in increased expression of IHH mRNA	22238285
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of IHH mRNA	24780913
C043680	ptaquiloside	ptaquiloside results in decreased expression of IHH mRNA	23274088
D011794	Quercetin	Quercetin results in decreased expression of IHH protein	28431985
C059514	resveratrol	resveratrol results in decreased expression of IHH mRNA	25190613
C059514	resveratrol	resveratrol results in decreased expression of IHH protein	25190613
D012906	Smoke	Smoke results in increased expression of IHH mRNA	23693141
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in decreased expression of IHH protein	23604592
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of IHH mRNA	27862939
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IHH mRNA	26378955
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IHH mRNA"	18579281
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of IHH mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IHH mRNA	25613284
D013806	Theophylline	Theophylline results in increased expression of IHH mRNA	16083514
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of IHH mRNA	18087596
D014118	Toxins, Biological	"Toxins, Biological affects the expression of IHH mRNA"	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of IHH mRNA	16350840
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of IHH mRNA	25549359\|2761814
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of IHH gene	27618143
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of IHH promoter	25549359
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of IHH mRNA	27618143
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of IHH mRNA	21346803
D014520	Urethane	Urethane results in increased expression of IHH mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of IHH mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of IHH gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of IHH mRNA	23034163
D014752	Vinyl Chloride	Vinyl Chloride results in increased expression of IHH mRNA	18579281

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005113	patched binding	-	IPI	21537345
GO:0005509	calcium ion binding	-	IDA	21537345
GO:0008233	peptidase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001501	skeletal system development	-	IMP	21537345
GO:0001569	branching involved in blood vessel morphogenesis	-	IEA	-
GO:0001649	osteoblast differentiation	-	IEA	-
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001708	cell fate specification	-	IEA	-
GO:0001947	heart looping	-	ISS	-
GO:0002053	positive regulation of mesenchymal cell proliferation	-	IEA	-
GO:0003382	epithelial cell morphogenesis	-	IEA	-
GO:0003406	retinal pigment epithelium development	-	IEA	-
GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	-	IEA	-
GO:0006029	proteoglycan metabolic process	-	IEA	-
GO:0007224	smoothened signaling pathway	-	IDA	21537345
GO:0007267	cell-cell signaling	-	IEA	-
GO:0009612	response to mechanical stimulus	-	IEA	-
GO:0009880	embryonic pattern specification	-	IEA	-
GO:0016539	intein-mediated protein splicing	-	IEA	-
GO:0030704	vitelline membrane formation	-	IEA	-
GO:0031016	pancreas development	-	IEA	-
GO:0032355	response to estradiol	-	IEA	-
GO:0032967	positive regulation of collagen biosynthetic process	-	IEA	-
GO:0033085	negative regulation of T cell differentiation in thymus	-	ISS	-
GO:0033088	negative regulation of immature T cell proliferation in thymus	-	ISS	-
GO:0033089	positive regulation of T cell differentiation in thymus	-	ISS	-
GO:0035264	multicellular organism growth	-	IEA	-
GO:0035988	chondrocyte proliferation	-	IEA	-
GO:0040008	regulation of growth	-	IEA	-
GO:0042733	embryonic digit morphogenesis	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0045453	bone resorption	-	IEA	-
GO:0045880	positive regulation of smoothened signaling pathway	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0046638	positive regulation of alpha-beta T cell differentiation	-	ISS	-
GO:0046639	negative regulation of alpha-beta T cell differentiation	-	ISS	-
GO:0048074	negative regulation of eye pigmentation	-	IEA	-
GO:0048469	cell maturation	-	IEA	-
GO:0048557	embryonic digestive tract morphogenesis	-	IEA	-
GO:0048596	embryonic camera-type eye morphogenesis	-	IEA	-
GO:0048666	neuron development	-	IEA	-
GO:0048745	smooth muscle tissue development	-	IEA	-
GO:0050679	positive regulation of epithelial cell proliferation	-	IEA	-
GO:0060135	maternal process involved in female pregnancy	-	IEA	-
GO:0060220	camera-type eye photoreceptor cell fate commitment	-	IEA	-
GO:0060323	head morphogenesis	-	IEA	-
GO:0061053	somite development	-	ISS	-
GO:0072498	embryonic skeletal joint development	-	IEA	-
GO:0090136	epithelial cell-cell adhesion	-	IEA	-
GO:0097421	liver regeneration	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IEA	-
GO:0005886	plasma membrane	-	IDA	21537345

KEGG ID	KEGG Term
hsa04340	Hedgehog signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-373080	Class B/2 (Secretin family receptors)	IEA
R-HSA-500792	GPCR ligand binding	IEA
R-HSA-5358346	Hedgehog ligand biogenesis	IEA
R-HSA-5358346	Hedgehog ligand biogenesis	TAS
R-HSA-5358351	Signaling by Hedgehog	TAS
R-HSA-5358351	Signaling by Hedgehog	IEA
R-HSA-5362798	Release of Hh-Np from the secreting cell	IEA
R-HSA-5362798	Release of Hh-Np from the secreting cell	TAS
R-HSA-5387390	Hh mutants abrogate ligand secretion	TAS
R-HSA-5632681	Ligand-receptor interactions	TAS
R-HSA-5632681	Ligand-receptor interactions	IEA
R-HSA-5632684	Hedgehog 'on' state	TAS
R-HSA-5632684	Hedgehog 'on' state	IEA
R-HSA-5635838	Activation of SMO	TAS
R-HSA-5658034	HHAT G278V abrogates palmitoylation of Hh-Np	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8941284	RUNX2 regulates chondrocyte maturation	IEA
R-HSA-8941326	RUNX2 regulates bone development	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28506824	Hypoxia and nicotine effects on Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the developing piglet brainstem. (2017 Sep)	Huang J	Neurotoxicology
27038133	Changes in orexinergic immunoreactivity of the piglet hypothalamus and pons after exposure to chronic postnatal nicotine and intermittent hypercapnic hypoxia. (2016 Jun)	Hunt NJ	Eur J Neurosci