Gene info: ID 3550

Gene: IK

GENE ID: 3550

Synonyms: CSA2|RED|RER

Description: IK cytokine

Gene type: protein-coding

Location: 5q31.3

dbXrefs: Ensembl:ENSG00000113141 MIM:600549 Vega:OTTHUMG00000163374 UniprotKB:Q13123

RefSeq: NC_000005.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.194e-1 (AD) 3.920e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SNW1	0.949
XRCC6	0.947
PA2G4	0.946
EIF3D	0.945
EWSR1	0.945
PRPF6	0.938
ILF2	0.937
PHB2	0.937
HNRNPD	0.936
SLC25A3	0.935

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.818
OR4F29	-0.813
MTRNR2L6	-0.269
MTRNR2L9	-0.26
MTRNR2L10	-0.225
C8orf74	-0.193
OR4F16	-0.181
MTRNR2L3	-0.178
TTLL10	-0.176
RNF223	-0.166

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of IK mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of IK mRNA"	21346803
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of IK mRNA"	18648102
D000082	Acetaminophen	Acetaminophen results in increased expression of IK mRNA	26690555
C000228	aristolochic acid I	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of IK mRNA	23912714
C042310	aristolochic acid II	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of IK mRNA	23912714
C006632	arsenic trioxide	arsenic trioxide results in increased expression of IK mRNA	20458559
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IK mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IK mRNA"	26238291
C044887	beta-methylcholine	beta-methylcholine affects the expression of IK mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of IK mRNA	21786754
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IK mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of IK mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of IK mRNA	26794494
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IK mRNA	28628672
C013418	bromfenacoum	bromfenacoum results in decreased expression of IK protein	28903499
D002065	Buspirone	Buspirone results in decreased expression of IK mRNA	24136188
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of IK mRNA	18804290
D002220	Carbamazepine	Carbamazepine affects the expression of IK mRNA	25979313
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of IK mRNA	23650126
C031180	chrysene	chrysene results in increased expression of IK mRNA	26377693
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IK mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IK mRNA	28628672
D004237	Diuron	Diuron results in increased expression of IK mRNA	25152437
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of IK protein	23301498
D018120	Finasteride	Finasteride results in increased expression of IK mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of IK mRNA	24136188
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of IK mRNA	20044591
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IK mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IK mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IK mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IK mRNA	28628672
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of IK mRNA	23458150
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of IK mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IK mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of IK promoter"	26251327
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of IK mRNA	29191790
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of IK mRNA"	25620056
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of IK protein	19954255
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of IK mRNA	23892564
C443641	poly(propyleneimine)	poly(propyleneimine) analog results in decreased expression of IK mRNA	16308212
C059514	resveratrol	resveratrol results in decreased expression of IK protein	25505154
D012643	Selenium	Selenium results in increased expression of IK mRNA	19244175
D012715	Sesame Oil	Sesame Oil results in increased expression of IK mRNA	29191790
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IK mRNA	21570461\|2468072
D014501	Uranium	Uranium affects the expression of IK mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of IK mRNA	15672453
D014520	Urethane	Urethane results in increased expression of IK mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of IK mRNA	17292431
C025643	vinclozolin	vinclozolin results in increased expression of IK mRNA	23034163
D014810	Vitamin E	Vitamin E results in increased expression of IK mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	22190034 22351768 22365833 24996188 25416956
GO:0042802	identical protein binding	-	IPI	22365833

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000278	mitotic cell cycle	-	IMP	24252166
GO:0000398	mRNA splicing, via spliceosome	-	IDA	28781166
GO:0007094	mitotic spindle assembly checkpoint	-	IMP	22351768
GO:0016032	viral process	-	IEA	-
GO:0034501	protein localization to kinetochore	-	IMP	22351768

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000228	nuclear chromosome	colocalizes_with	IMP	24252166
GO:0005634	nucleus	-	IDA	28781166
GO:0005654	nucleoplasm	-	IDA	24252166
GO:0005737	cytoplasm	-	IEA	-
GO:0016607	nuclear speck	-	IDA	-
GO:0071005	U2-type precatalytic spliceosome	-	IDA	28781166
GO:0097431	mitotic spindle pole	colocalizes_with	IDA	22351768

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26217968	Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1). (2015)	Christophersen P	Channels (Austin)