Gene: IKBKB

3551
IKK-beta|IKK2|IKKB|IMD15|NFKBIKB
inhibitor of nuclear factor kappa B kinase subunit beta
protein-coding
8p11.21
Ensembl:ENSG00000104365 MIM:603258 Vega:OTTHUMG00000164092 UniprotKB:O14920
NG_041793.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.097e-1 (AD)  9.730e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EGFL80.829
TLN10.819
MYO1C0.8
TTC310.8
CDK5RAP20.798
PPP4R10.797
LAMB20.797
ARHGAP170.793
NEK90.792
CFLAR0.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.544
OR4F5-0.512
CRH-0.337
PPP1R17-0.261
PPEF1-0.243
ADRA1D-0.242
ST8SIA2-0.241
GSG1-0.24
DRD5-0.226
NMU-0.226

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00244MesalazineSmall Molecule89-57-6ApprovedTarget
DB00795SulfasalazineSmall Molecule599-79-1ApprovedTarget
DB00945Acetylsalicylic acidSmall Molecule50-78-2ApprovedTarget
DB00995AuranofinSmall Molecule34031-32-8Approved|InvestigationalTarget
DB01169Arsenic trioxideSmall Molecule1327-53-3Approved|InvestigationalTarget
DB05183MLN0415Small Molecule-InvestigationalTarget
DB06151AcetylcysteineSmall Molecule616-91-1Approved|InvestigationalTarget
DB06521ErtiprotafibSmall Molecule251303-04-5InvestigationalTarget
ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole binds to and results in decreased activity of IKBKB protein"21361338
C0407561,2-naphthoquinone"1,2-naphthoquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of IKBKB protein]"21139339
C05499215-keto-5,8,11,13-eicosatetraenoic acid"15-keto-5,8,11,13-eicosatetraenoic acid results in decreased activity of IKBKB protein"25450232
C05499215-keto-5,8,11,13-eicosatetraenoic acid"[15-keto-5,8,11,13-eicosatetraenoic acid results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein"25450232
C0479481'-acetoxychavicol acetate1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of IKBKB protein]15905586
C0479481'-acetoxychavicol acetate1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of IKBKB protein]15905586
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]18789402
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]18789402
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of IKBKB mRNA"21346803
C5012802-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile results in decreased activity of IKBKB protein15756023
C4993262-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide promotes the reaction [resiquimod results in increased phosphorylation of IKBKB protein]28924041
C4993262-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [Cisplatin results in increased phosphorylation of IKBKB protein]28119452
C4993262-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide results in decreased activity of IKBKB protein21296074
C0038982-anisidine2-anisidine affects the expression of IKBKB mRNA28089782
C0188552-tert-butylhydroquinone"2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IKBKB protein modified form]"28844481
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]"20584749
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in decreased activity of IKBKB protein"20584749
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in increased metabolism of IKBKB protein"20584749
C0415253,3',4,5'-tetrahydroxystilbene"Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]"20584749
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Dextran Sulfate results in increased activity of IKBKB protein]"20155626
C0415253,3',4,5'-tetrahydroxystilbene"IKBKB protein mutant form inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]]"20584749
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of IKBKB protein]21135123
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased activity of IKBKB protein21135123
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of IKBKB protein15564333
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]16474181
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]"23452621
C1132764',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein"4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein"10967126
C1132764',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein"arsenite inhibits the reaction [4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein]"10967126
C1132764',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein"Dimercaprol inhibits the reaction [arsenite inhibits the reaction [4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein]]"10967126
C1132764',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein"Unithiol inhibits the reaction [arsenite inhibits the reaction [4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein]]"10967126
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased phosphorylation of IKBKB protein"24161432
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of IKBKB mRNA20829426
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in increased phosphorylation of IKBKB protein"22745752
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"MAP3K14 mutant form inhibits the reaction [5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in increased phosphorylation of IKBKB protein]"22745752
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"MAP3K14 protein promotes the reaction [5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in increased phosphorylation of IKBKB protein]"22745752
C5029727-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one"7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IKBKB protein]"20190013
C5029727-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one"7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one results in decreased activity of IKBKB protein"20190013
C512352abexinostatabexinostat results in decreased expression of IKBKB mRNA19417023
C512352abexinostatBortezomib promotes the reaction [abexinostat results in decreased expression of IKBKB mRNA]19417023
D000082AcetaminophenAcetaminophen results in decreased expression of IKBKB mRNA21420995
D000111AcetylcysteineAcetylcysteine results in decreased activity of IKBKB protein17395010
D000171AcroleinAcrolein affects the metabolism of IKBKB protein15650393
D000255Adenosine TriphosphateAspirin inhibits the reaction [Adenosine Triphosphate binds to IKBKB protein]15861417
C522924afatinibafatinib results in decreased expression of IKBKB protein22242139
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IKBKB gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IKBKB mRNA19770486
D000393Air PollutantsAir Pollutants results in increased expression of IKBKB mRNA28389379
D000393Air PollutantsAir Pollutants results in increased expression of IKBKB protein28389379
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]24491314
D000602Amino Acids, Peptides, and Proteins"Amino Acids, Peptides, and Proteins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]"22003094
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IKBKB mRNA16483693
C006578anetholeanethole results in decreased activity of IKBKB protein10871845
C023650anilineaniline results in increased expression of IKBKB protein18420242
C023650anilineaniline results in increased phosphorylation of IKBKB protein18420242
D000872AnthocyaninsAnthocyanins inhibits the reaction [Dietary Fats results in increased phosphorylation of IKBKB protein]24795233
D047310ApigeninApigenin inhibits the reaction [TNF protein results in increased expression of IKBKB protein]24148603
D047310ApigeninApigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of IKBKB protein]24148603
D047310ApigeninApigenin results in decreased expression of and results in decreased activity of IKBKB protein24148603
D047310ApigeninApigenin results in decreased phosphorylation of and results in decreased activity of IKBKB protein24148603
D047310ApigeninApigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein]25935278
D047310ApigeninApigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]25557508
C061640arjunolic acidarjunolic acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of IKBKB protein]21420465
D001151ArsenicArsenic affects the methylation of IKBKB gene25304211
D001151ArsenicArsenic results in decreased expression of IKBKB mRNA19945496
D001151ArsenicIKBKB protein affects the susceptibility to Arsenic20159942
C050510arsenic trichlorideIKBKB affects the reaction [arsenic trichloride results in increased expression of DDIT3 mRNA]16283526
C050510arsenic trichlorideIKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45A protein]16283526
C050510arsenic trichlorideIKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45B mRNA]16283526
C050510arsenic trichlorideIKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45G mRNA]16283526
C006632arsenic trioxidearsenic trioxide results in decreased expression of IKBKB mRNA19763917|2298896
C006632arsenic trioxidearsenic trioxide results in decreased expression of IKBKB protein22988968
C006632arsenic trioxidearsenic trioxide results in increased phosphorylation of and results in increased activity of IKBKB protein23949314
C006632arsenic trioxide[arsenic trioxide results in increased phosphorylation of and results in increased activity of IKBKB protein] which results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of CCND1 protein23949314
C006632arsenic trioxideTNF protein inhibits the reaction [arsenic trioxide results in decreased expression of IKBKB mRNA]22988968
C006632arsenic trioxideTNF protein inhibits the reaction [arsenic trioxide results in decreased expression of IKBKB protein]22988968
C015001arsenite"arsenite inhibits the reaction [4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein]"10967126
C015001arsenitearsenite inhibits the reaction [MAP3K14 protein results in increased activity of IKBKB protein]10967126
C015001arsenitearsenite results in decreased activity of IKBKB protein10967126
C015001arsenite"Dimercaprol inhibits the reaction [arsenite inhibits the reaction [4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein]]"10967126
C015001arsenite"Unithiol inhibits the reaction [arsenite inhibits the reaction [4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein]]"10967126
C031327artemisinineartemisinine inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]18463201
C519899AS602868AS602868 results in decreased activity of IKBKB protein18325031
C519899AS602868[AS602868 results in decreased activity of IKBKB protein] inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]18325031
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Ethanol results in increased activity of IKBKB protein]24239723
D001241AspirinAspirin results in decreased activity of IKBKB protein16199534
D001241AspirinAspirin results in decreased expression of IKBKB protein16880202
D001241AspirinAspirin results in decreased phosphorylation of IKBKB protein16310244
D001241AspirinAspirin binds to and results in decreased activity of IKBKB protein15861417
D001241AspirinAspirin inhibits the reaction [Adenosine Triphosphate binds to IKBKB protein]15861417
D001241AspirinAspirin results in decreased activity of IKBKB protein10480951|1647204
C010329azadirachtinazadirachtin results in decreased expression of IKBKB protein20429769
D001514Bee VenomsBee Venoms inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]17067557
D001514Bee VenomsBee Venoms inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]17067557
D001514Bee VenomsBee Venoms inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]17067557
D001514Bee VenomsBee Venoms inhibits the reaction [TNF protein results in increased activity of IKBKB protein]17067557
D004958EstradiolEstradiol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IKBKB protein]26220752
D001647Bile Acids and SaltsIKBKB protein results in decreased susceptibility to Bile Acids and Salts22022477
C006780bisphenol Abisphenol A results in increased expression of IKBKB mRNA17010207|2518105
D000069286BortezomibBortezomib promotes the reaction [abexinostat results in decreased expression of IKBKB mRNA]19417023
D000069286BortezomibBortezomib results in decreased expression of IKBKB mRNA20471514
D002083Butylated HydroxyanisoleButylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased activity of MAPK8 protein]]18691550
D002083Butylated HydroxyanisoleButylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL1A protein]]18691550
D002083Butylated HydroxyanisoleButylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL6 protein]]18691550
D002101Cacodylic AcidCacodylic Acid results in increased expression of IKBKB protein26617437
D002104Cadmium[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of IKBKB mRNA21481475
D019256Cadmium Chloridearjunolic acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of IKBKB protein]21420465
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of IKBKB protein21420465
D002110CaffeineCaffeine results in increased expression of IKBKB mRNA20864626
C068623carnosolcarnosol inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]20116392
C043211carvedilolcarvedilol inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein]26036690
C026690cerous chloridecerous chloride results in increased expression of IKBKB mRNA21656643
C026690cerous chloridecerous chloride results in increased expression of IKBKB protein21656643
D002738ChloroquineChloroquine results in decreased expression of IKBKB protein26116531
D002857ChromiumIKBKB protein affects the susceptibility to Chromium11726646
C074702chromium hexavalent ionIKBKB protein affects the reaction [chromium hexavalent ion results in increased expression of PTGS2 mRNA]22472290
C074702chromium hexavalent ionIKBKB protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of and results in increased degradation of NFKBIA protein]22472290
C074702chromium hexavalent ionIKBKB protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein]22472290
C012843cinnamic aldehydecinnamic aldehyde results in decreased phosphorylation of IKBKB protein17486422
D003042CocaineCocaine affects the expression of IKBKB mRNA20187946
D003078ColchicineColchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein]17029595
D003078ColchicineColchicine results in increased phosphorylation of IKBKB protein17029595
D003078ColchicineIKBKB protein affects the susceptibility to Colchicine20159942
D005576ColforsinColforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IKBKB mRNA]17407152
D003300Copper"[N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide results in decreased activity of IKBKB protein] which results in decreased susceptibility to Copper"19747488
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]23452621
D003474CurcuminCurcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]16219905
D003474CurcuminCurcumin results in decreased activity of IKBKB protein16023083|1621990
D003474CurcuminIKBKB protein inhibits the reaction [Curcumin results in decreased expression of CTGF mRNA]17965732
D003474CurcuminCurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]20054000
D003474CurcuminCurcumin results in decreased activity of IKBKB protein16678799
C038459curdlancurdlan results in decreased expression of IKBKB mRNA23543010
D015638Cytochalasin DCytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein]17029595
D015638Cytochalasin DCytochalasin D results in increased phosphorylation of IKBKB protein17029595
C014347decitabinedecitabine results in increased expression of IKBKB mRNA27915011
C044919deferipronedeferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]17172471
C044919deferipronedeferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]17172471
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of IKBKB mRNA]27941970
D016264Dextran Sulfate"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Dextran Sulfate results in increased activity of IKBKB protein]"20155626
D016264Dextran SulfateDextran Sulfate results in increased activity of IKBKB protein20155626
D016264Dextran SulfateDextran Sulfate results in increased expression of IKBKB protein modified form25472953
D016264Dextran Sulfatenotoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IKBKB protein modified form]25472953
D016264Dextran Sulfateresveratrol inhibits the reaction [Dextran Sulfate results in increased activity of IKBKB protein]20155626
D002945CisplatinCisplatin results in increased expression of IKBKB mRNA27392435
D002945CisplatinIKBKB protein affects the susceptibility to Cisplatin21720550
D002945CisplatinIKBKB protein affects the susceptibility to Cisplatin20159942
D002945Cisplatin2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide inhibits the reaction [Cisplatin results in increased phosphorylation of IKBKB protein]28119452
D002945CisplatinCisplatin results in increased phosphorylation of IKBKB protein28119452
D004008DiclofenacDiclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein]25935278
D004041Dietary FatsAnthocyanins inhibits the reaction [Dietary Fats results in increased phosphorylation of IKBKB protein]24795233
D004041Dietary FatsDietary Fats results in increased phosphorylation of IKBKB protein24795233
D004052DiethylnitrosamineButylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased activity of MAPK8 protein]]18691550
D004052DiethylnitrosamineButylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL1A protein]]18691550
D004052DiethylnitrosamineButylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL6 protein]]18691550
D004052DiethylnitrosamineIKBKB gene affects the susceptibility to Diethylnitrosamine15989949
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of BAG3 mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN2B mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of CYP4A12A mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DNAJB1 mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DUSP4 mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of IKBKG mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of PLA2G16 mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRIB1 mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased abundance of Reactive Oxygen Species]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased activity of MAPK8 protein]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of AGT mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of CARD10 mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP7A1 mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of FMO3 mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of GADD45B mRNA]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL1A protein]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL6 protein]18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of JUN protein]18691550
D004052DiethylnitrosamineIKBKB protein results in decreased susceptibility to Diethylnitrosamine18691550|1917112
D004112Dimercaprol"Dimercaprol inhibits the reaction [arsenite inhibits the reaction [4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein]]"10967126
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of IKBKB protein"22044346
D0151279,10-Dimethyl-1,2-benzanthracene"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IKBKB protein]"22044346
D000069462Dimethyl FumarateDimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]26683377
D000069462Dimethyl FumarateDimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA]26683377
D004176DipyridamoleDipyridamole inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]16765938
D004229Dithiothreitol"Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]"20584749
D004229DithiothreitolDithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]17067557
D004229DithiothreitolDithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]17067557
D004317DoxorubicinDoxorubicin results in increased phosphorylation of IKBKB protein18463201
D004317DoxorubicinIKBKB gene mutant form inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]15899819
D004317DoxorubicinSimvastatin promotes the reaction [Doxorubicin results in increased phosphorylation of IKBKB protein]18463201
D004317Doxorubicincarvedilol inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein]26036690
D004317DoxorubicinDoxorubicin results in increased expression of IKBKB protein26036690
D004317DoxorubicinFebuxostat inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein]26036690
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased activity of IKBKB protein"15894585
C413879EKB 569EKB 569 results in decreased expression of IKBKB protein22242139
C530049ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate"ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate inhibits the reaction [Lipopolysaccharides results in increased degradation of IKBKB protein]"17541474
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of IKBKB protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IKBKB mRNA22079256
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of IKBKB protein modified form27659729
C553039epimuqubilin Aepimuqubilin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]22180763
D000431EthanolAscorbic Acid inhibits the reaction [Ethanol results in increased activity of IKBKB protein]24239723
D000431EthanolEthanol results in increased activity of IKBKB protein24239723
D000431EthanolSilymarin inhibits the reaction [Ethanol results in increased activity of IKBKB protein]24239723
D005047EtoposideIKBKB protein affects the susceptibility to Etoposide20159942
D005054EugenolEugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IKBKB protein]19851710
C049639evodiamineevodiamine inhibits the reaction [TNF protein results in increased activity of IKBKB protein]15710601
D000069465FebuxostatFebuxostat inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein]26036690
C020748ferrous sulfatedeferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]17172471
C020748ferrous sulfateferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]17172471
C020748ferrous sulfateFilipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]17172471
C020748ferrous sulfate"N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]"17172471
D005372FilipinFilipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]17172471
D005372FilipinFilipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]17172471
D005419FlavonoidsFlavonoids results in increased expression of IKBKB mRNA18035473
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased activity of IKBKB protein11960367
D016650Fluorescein-5-isothiocyanateFluorescein-5-isothiocyanate binds to IKBKB protein27129696
D005620Freund's AdjuvantApigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein]25935278
D005620Freund's AdjuvantDiclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein]25935278
D005620Freund's AdjuvantFreund's Adjuvant results in increased phosphorylation of IKBKB protein25935278
D005632FructoseAllopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]24491314
D005632FructoseFructose results in increased phosphorylation of IKBKB protein24491314
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]24491314
D037741FullerenesFullerenes analog results in increased expression of IKBKB mRNA22342292
C070081fulvestrantfulvestrant promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IKBKB protein]26220752
D005688GalactosamineGalactosamine results in increased phosphorylation of IKBKB protein22310181
D005688Galactosaminemangiferin inhibits the reaction [Galactosamine results in increased phosphorylation of IKBKB protein]22310181
D005707Gallic AcidGallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]21420233
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]23452621
D019833GenisteinGenistein results in increased expression of IKBKB mRNA17010207
D005839GentamicinsGentamicins results in increased expression of IKBKB mRNA22061828
C049864ginsenoside Reginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]22849695
D005944GlucosamineGlucosamine analog inhibits the reaction [Lipopolysaccharides results in increased expression of IKBKB protein]18786831
C046905glucosamine 6-O-sulfateglucosamine 6-O-sulfate inhibits the reaction [Lipopolysaccharides results in increased expression of IKBKB protein]21877189
D005947GlucoseIKBKB affects the reaction [IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]22558381
D005947Glucose"IKBKB affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]"22558381
C475739glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt"glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of IKBKB protein]"21276822
D005978GlutathioneGCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]20159942
D005978GlutathioneGCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]20159942
D005978GlutathioneGlutathione inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]17067557
D005978GlutathioneGlutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]17067557
D005978GlutathioneIKBKB protein affects the abundance of Glutathione20159942
D006052Gold Sodium ThiomalateGold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]10820281
D006861Hydrogen PeroxideIKBKB protein affects the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA]26514923
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]17067557
D006861Hydrogen PeroxideIKBKB protein affects the susceptibility to Hydrogen Peroxide20159942
C031927hydroquinonehydroquinone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]20054000
C016517indole-3-carbinolindole-3-carbinol inhibits the reaction [TNF protein results in increased activity of IKBKB protein]15811958
D007213IndomethacinIndomethacin results in increased expression of IKBKB mRNA23892052
D007213IndomethacinIndomethacin results in increased expression of IKBKB protein23892052
D007501Irondeferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]17172471
D007501IronFilipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]17172471
D007501IronIron results in increased activity of [CHUK protein binds to IKBKB protein]17172471
D007501Iron"N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]"17172471
C432307isorhapontigeninisorhapontigenin affects the activity of IKBKB protein15607907
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [PCI 32765 results in decreased activity of IKBKB protein]25049379
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased phosphorylation of and results in decreased activity of IKBKB protein25049379
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased phosphorylation of IKBKB protein26324948
C561695(+)-JQ1 compoundPCI 32765 promotes the reaction [(+)-JQ1 compound results in decreased activity of IKBKB protein]25049379
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of [CHUK protein binds to IKBKB protein]"22542583
C433788lipopolysaccharide, E. coli O26-B6"paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of [CHUK protein binds to IKBKB protein]]"22542583
C482199lipopolysaccharide, E coli O55-B5"1,2-naphthoquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of IKBKB protein]"21139339
C482199lipopolysaccharide, E coli O55-B5"IKBKB gene mutant form inhibits the reaction [KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]"23906629
C482199lipopolysaccharide, E coli O55-B5"IKBKB gene mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 protein affects the reaction [lipopolysaccharide, E coli O55-B5 affects the expression of IKBKB protein]"23906629
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the expression of IKBKB protein"23906629
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased activity of IKBKB protein"21139339
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of IKBKB protein"17439952
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of IKBKB protein"28499610
C440499lipopolysaccharide, Escherichia coli O111 B4"Selenium inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of IKBKB protein]"17439952
C440499lipopolysaccharide, Escherichia coli O111 B4"7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IKBKB protein]"20190013
C440499lipopolysaccharide, Escherichia coli O111 B4"IKBKB affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]"22558381
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of IKBKB protein"20190013
C442865lipopolysaccharide, Helicobacter pylori"IKBKB protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CXCL8 mRNA]"21220698
D008070Lipopolysaccharides2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]18789402
D008070Lipopolysaccharides3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of IKBKB protein]21135123
D008070Lipopolysaccharides"Amino Acids, Peptides, and Proteins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]"22003094
D008070Lipopolysaccharidesglucosamine 6-O-sulfate inhibits the reaction [Lipopolysaccharides results in increased expression of IKBKB protein]21877189
D008070LipopolysaccharidesHNRNPD protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of IKBKB protein]21135123
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IKBKB protein21877189
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of and results in increased activity of IKBKB protein21135123
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of IKBKB protein18789402|2200309
D008070Lipopolysaccharides2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]18789402
D008070LipopolysaccharidesBee Venoms inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]17067557
D008070LipopolysaccharidesCurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]20054000
D008070LipopolysaccharidesDipyridamole inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]16765938
D008070Lipopolysaccharides"ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate inhibits the reaction [Lipopolysaccharides results in increased degradation of IKBKB protein]"17541474
D008070Lipopolysaccharidesepimuqubilin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]22180763
D008070Lipopolysaccharidesginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]22849695
D008070LipopolysaccharidesGlucosamine analog inhibits the reaction [Lipopolysaccharides results in increased expression of IKBKB protein]18786831
D008070Lipopolysaccharides"glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of IKBKB protein]"21276822
D008070LipopolysaccharidesGold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]10820281
D008070Lipopolysaccharideshydroquinone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]20054000
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of IKBKB protein16765938|1706755
D008070Lipopolysaccharides[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of IKBKB protein21276822
D008070LipopolysaccharidesLipopolysaccharides results in increased degradation of IKBKB protein17541474
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IKBKB protein18786831
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of IKBKB protein18789402|2005400
D008070LipopolysaccharidesMelitten inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]17067557
D008070Lipopolysaccharidesmonotropein inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]23261679
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]16171798
D008070LipopolysaccharidesSB 203580 inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]16765938
D008070LipopolysaccharidesApigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]25557508
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IKBKB mRNA17594812
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IKBKB protein17594812|2807010
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of IKBKB protein21893401|2555750
D008070Lipopolysaccharidesrosiglitazone inhibits the reaction [Lipopolysaccharides results in increased expression of IKBKB mRNA]17594812
D008070Lipopolysaccharidesrosiglitazone inhibits the reaction [Lipopolysaccharides results in increased expression of IKBKB protein]17594812
D008070Lipopolysaccharideswuzi yanzong analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]21893401
C501277Mangifera indica extractMangifera indica extract inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]21420233
C013592mangiferinmangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]21420233
C013592mangiferinmangiferin inhibits the reaction [Galactosamine results in increased phosphorylation of IKBKB protein]22310181
D008555MelittenMelitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]17067557
D008555MelittenDithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]17067557
D008555MelittenDithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]17067557
D008555MelittenGlutathione inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]17067557
D008555MelittenGlutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]17067557
D008555MelittenHydrogen Peroxide inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]17067557
D008555MelittenMelitten binds to IKBKB protein17067557
D008555MelittenMelitten inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]17067557
D008555MelittenMelitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]17067557
D008555MelittenMelitten inhibits the reaction [TNF protein results in increased activity of IKBKB protein]17067557
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of IKBKB mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IKBKB mRNA20864626
D008769MethylnitronitrosoguanidineEugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IKBKB protein]19851710
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of IKBKB protein19851710
C028577monobutyl phthalatemonobutyl phthalate results in increased phosphorylation of IKBKB protein26745512
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of IKBKB mRNA20864626
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of IKBKB mRNA20024957
C507582monotropeinmonotropein inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]23261679
D009151Mustard GasMustard Gas results in increased phosphorylation of and results in increased activity of IKBKB protein18200059
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IKBKB mRNA]17407152
C492919N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide"[N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide results in decreased activity of IKBKB protein] which results in decreased susceptibility to Copper"19747488
C492919N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide"N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide results in decreased activity of IKBKB protein"19747488
C487932N-(4-(3-chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamideN-(4-(3-chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide results in decreased expression of IKBKB protein22242139
C000621033napabucasinnapabucasin results in decreased expression of IKBKB mRNA25605917
C022838nickel chlorideIKBKB gene mutant form inhibits the reaction [nickel chloride results in decreased expression of TP63 mRNA alternative form]21466819
C022838nickel chlorideIKBKB affects the reaction [nickel chloride results in increased activity of PTGS2 promoter]16982623
C022838nickel chlorideIKBKB affects the susceptibility to nickel chloride16982623
C017558nickel sulfideIKBKB affects the reaction [nickel sulfide results in increased activity of PTGS2 promoter]16982623
C017558nickel sulfideIKBKB affects the susceptibility to nickel sulfide16982623
D009534NiclosamideNiclosamide affects the localization of IKBKB protein26116531
C042198nimbolidenimbolide results in decreased expression of IKBKB protein20429769
D009599NitroprussideBee Venoms inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]17067557
D009599NitroprussideMelitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]17067557
D009599NitroprussideNitroprusside results in increased activity of IKBKB protein17067557
D009599NitroprussideBee Venoms inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]17067557
D009599NitroprussideDithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]17067557
D009599NitroprussideGlutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]17067557
D009599NitroprussideHydrogen Peroxide inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]17067557
D009599NitroprussideMelitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]17067557
D009599NitroprussideNitroprusside results in increased activity of IKBKB protein17067557
C037740N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid"N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]"17172471
C037740N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid"N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]"17172471
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased phosphorylation of IKBKB protein]"16818790
C025256nonylphenolnonylphenol results in increased expression of IKBKB mRNA17010207
C072936notoginsenoside R1notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IKBKB protein modified form]25472953
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of IKBKB mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]23452621
D017239PaclitaxelIKBKB protein affects the susceptibility to Paclitaxel20159942
C013638paeonolpaeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]22542583
C013638paeonol[paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of NFKB1 protein22542583
C013638paeonol[paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of RELA protein22542583
C013638paeonol"paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of [CHUK protein binds to IKBKB protein]]"22542583
D010168PalmitatesPalmitates results in increased phosphorylation of IKBKB protein23504962
D010168Palmitatesquercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]23504962
D010168PalmitatesQuercetin inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]23504962
D010168PalmitatesSodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]23504962
C002669parthenolideparthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]18463201
D052638Particulate MatterParticulate Matter results in increased methylation of IKBKB gene28495853
C551803PCI 32765(+)-JQ1 compound promotes the reaction [PCI 32765 results in decreased activity of IKBKB protein]25049379
C551803PCI 32765PCI 32765 promotes the reaction [(+)-JQ1 compound results in decreased activity of IKBKB protein]25049379
C551803PCI 32765PCI 32765 results in decreased activity of IKBKB protein25049379
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of IKBKB mRNA28973697
D010634PhenobarbitalPhenobarbital affects the expression of IKBKB mRNA23091169
D010656PhenylephrineIKBKB protein promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]11381115
D010656PhenylephrinePhenylephrine results in increased activity of IKBKB protein11381115
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]23452621
D010936Plant ExtractsPlant Extracts results in increased expression of IKBKB mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in decreased phosphorylation of and results in decreased expression of IKBKB protein24960055
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in increased phosphorylation of IKBKB protein24960055
D011134PolysaccharidesPolysaccharides results in increased activity of IKBKB protein15894585
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IKBKB mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IKBKB mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of IKBKB mRNA21549006
D047428Protein Kinase Inhibitors[Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased phosphorylation of IKBKB protein]28924041
C456319PS1145PS1145 inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]19616567
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]19616567
D011753PyronesPyrones results in decreased activity of IKBKB protein21296074
D011794QuercetinQuercetin inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]23504962
D011794Quercetin"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IKBKB protein]"22044346
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]16171798
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein]24491314
C443401quercetin 3-O-glucuronidequercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]23504962
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of IKBKB mRNA25800948
D017382Reactive Oxygen SpeciesIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased abundance of Reactive Oxygen Species]18691550
C402365resiquimod2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide promotes the reaction [resiquimod results in increased phosphorylation of IKBKB protein]28924041
C402365resiquimod[Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased phosphorylation of IKBKB protein]28924041
C402365resiquimodresiquimod results in increased phosphorylation of IKBKB protein28924041
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]23452621
C059514resveratrolresveratrol results in decreased phosphorylation of IKBKB protein25692777
C059514resveratrolresveratrol inhibits the reaction [Dextran Sulfate results in increased activity of IKBKB protein]20155626
C059514resveratrolresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]16474181
C059514resveratrolresveratrol results in decreased expression of IKBKB mRNA19819963
C059514resveratrolresveratrol affects the expression of IKBKB protein17112897
C089730rosiglitazonerosiglitazone inhibits the reaction [Lipopolysaccharides results in increased expression of IKBKB mRNA]17594812
C089730rosiglitazonerosiglitazone inhibits the reaction [Lipopolysaccharides results in increased expression of IKBKB protein]17594812
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of IKBKB mRNA21427059
C093642SB 203580SB 203580 inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]16765938
C093642SB 203580SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]19616567
C477523SC 514SC 514 results in increased expression of IKBKB mRNA17407152
C477523SC 514SC 514 results in decreased activity of IKBKB protein22363678
D012643Selenium[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of IKBKB mRNA21481475
D012643Selenium"Selenium inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of IKBKB protein]"17439952
D012645SelenomethionineSelenomethionine affects the expression of IKBKB mRNA17222674
C040115shogaolshogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of IKBKB protein]23899529
D012838SilymarinSilymarin inhibits the reaction [Ethanol results in increased activity of IKBKB protein]24239723
D019821Simvastatinartemisinine inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]18463201
D019821Simvastatinparthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]18463201
D019821SimvastatinSimvastatin promotes the reaction [Doxorubicin results in increased phosphorylation of IKBKB protein]18463201
D019821SimvastatinSimvastatin results in decreased expression of IKBKB mRNA17277159
D019821SimvastatinSimvastatin results in increased phosphorylation of IKBKB protein18463201
C017947sodium arseniteIKBKB affects the susceptibility to sodium arsenite20810208
C017947sodium arsenitesodium arsenite results in increased activity of IKBKB protein23069812
C017947sodium arsenitePS1145 inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]19616567
C017947sodium arsenitepyrazolanthrone inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]19616567
C017947sodium arseniteSB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]19616567
C017947sodium arsenitesodium arsenite results in increased phosphorylation of IKBKB protein19616567
C017947sodium arseniteTaurine inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]19616567
D017673Sodium Chloride, Dietary"2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IKBKB protein modified form]"28844481
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased expression of IKBKB protein modified form"28844481
D012980Sodium SalicylateSodium Salicylate inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]23504962
D012980Sodium SalicylateSodium Salicylate results in decreased expression of IKBKB protein modified form21303813
D012980Sodium SalicylateSodium Salicylate results in decreased activity of IKBKB protein10480951
D012460SulfasalazineSulfasalazine results in decreased expression of IKBKB protein15564333
D013467SulindacSulindac results in decreased activity of IKBKB protein19526344
C025462sulindac sulfidesulindac sulfide results in decreased activity of IKBKB protein11912124
D013654TaurineTaurine inhibits the reaction [sodium arsenite results in increased phosphorylation of IKBKB protein]19616567
D013749TetrachlorodibenzodioxinColforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IKBKB mRNA]17407152
D013749TetrachlorodibenzodioxinN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IKBKB mRNA]17407152
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IKBKB mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IKBKB mRNA17407152
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of and results in increased phosphorylation of IKBKB protein12361703
D013755Tetradecanoylphorbol Acetate"3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]"20584749
D013755Tetradecanoylphorbol Acetate"Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]"20584749
D013755Tetradecanoylphorbol AcetateEstradiol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IKBKB protein]26220752
D013755Tetradecanoylphorbol Acetatefulvestrant promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IKBKB protein]26220752
D013755Tetradecanoylphorbol Acetateshogaol analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of IKBKB protein]23899529
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of IKBKB protein20584749
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased expression of IKBKB protein23899529
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of IKBKB protein26220752
D013755Tetradecanoylphorbol Acetate3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]16474181
D013755Tetradecanoylphorbol Acetateresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]16474181
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of IKBKB protein16474181
D013755Tetradecanoylphorbol Acetate"IKBKB protein mutant form inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]]"20584749
D013876ThiophenesThiophenes results in decreased activity of IKBKB protein23906629
C009495titanium dioxidetitanium dioxide results in increased expression of IKBKB mRNA22342292
C009495titanium dioxidetitanium dioxide results in increased expression of IKBKB mRNA29128614
C009495titanium dioxidetitanium dioxide results in increased expression of IKBKB protein28646487
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IKBKB mRNA28065790
D014212TretinoinTretinoin results in decreased expression of IKBKB mRNA23724009
D014494Unithiol"Unithiol inhibits the reaction [arsenite inhibits the reaction [4',5'-bis(1,3,2-dithioarsolan-2-yl)fluorescein binds to IKBKB protein]]"10967126
D014635Valproic AcidValproic Acid results in decreased expression of IKBKB mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of IKBKB mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of IKBKB gene28495853
D014747VinblastineVinblastine results in decreased localization of [IKBKB protein binds to NFKBIA protein]17029595
D014747VinblastineVinblastine results in increased phosphorylation of IKBKB protein17029595
C111237vorinostat[vorinostat co-treated with TNFSF10 protein] results in decreased expression of IKBKB protein16450389
C111237vorinostatvorinostat results in decreased phosphorylation of IKBKB protein17681667
C051122wedelolactonewedelolactone results in decreased activity of IKBKB protein25450232
C051122wedelolactone[wedelolactone results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein25450232
C528421wuzi yanzongwuzi yanzong analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]21893401
C403304zerumbonezerumbone inhibits the reaction [TNF protein results in increased activity of IKBKB protein]16007145
D015032ZincZinc affects the expression of IKBKB mRNA16979875
D015032ZincZinc results in increased localization of [IKBKB protein binds to NFKBIA protein]17029595
D015032Zinc[Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of BCL2 protein17029595
D015032Zinc[Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of NFKB1 protein17029595
C016837zinc chloridezinc chloride results in decreased expression of IKBKB mRNA21540303
C031238zinc sulfide[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of IKBKB mRNA21481475

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA20434986  
GO:0004674protein serine/threonine kinase activity-EXP18692471  23613522  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA15084260  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI9520446  9751060  10521409  10733566  11297557  11971985  
12482991  12486103  12842894  14743216  15084260  15389287  
15601829  15749833  16126728  16129692  16286467  16319058  
16365431  16938294  17568778  17693255  17939994  18198944  
18266467  18462684  18930133  19196987  19345327  19365808  
19666608  19675099  19706536  19883646  20098747  20368414  
20434986  20600852  21399639  21423167  21474709  21765415  
21903422  22037600  22810585  22904686  23091055  23104095  
24618592  25036637  25241761  25759022  25852190  26212789  
26334375  26496610  27426725  
GO:0005524ATP binding-IEA-  
GO:0008384IkappaB kinase activityCONTRIBUTES_TOIBA21873635  
GO:0008384IkappaB kinase activity-TAS18626576  
GO:0019901protein kinase binding-IPI12492477  
GO:0042802identical protein binding-IPI14743216  16319058  21423167  23776406  
GO:0042803protein homodimerization activity-IDA23091055  
GO:0046982protein heterodimerization activity-IDA23091055  
GO:0097110scaffold protein binding-IDA23776175  
GO ID GO Term Qualifier Evidence PubMed
GO:0002223stimulatory C-type lectin receptor signaling pathway-TAS-  
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-TAS-  
GO:0002756MyD88-independent toll-like receptor signaling pathway-TAS-  
GO:0006468protein phosphorylation-IDA15084260  20434986  
GO:0006468protein phosphorylation-NAS9346484  
GO:0006954inflammatory response-TAS18626576  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IMP15383541  25816133  
GO:0007249I-kappaB kinase/NF-kappaB signaling-TAS18626576  
GO:0007252I-kappaB phosphorylation-IEA-  
GO:0009615response to virus-TAS18626576  
GO:0009653anatomical structure morphogenesis-IBA21873635  
GO:0010803regulation of tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-IDA21399639  
GO:0030866cortical actin cytoskeleton organization-IMP25816133  
GO:0033209tumor necrosis factor-mediated signaling pathway-IBA21873635  
GO:0033209tumor necrosis factor-mediated signaling pathway-IMP15084260  25816133  
GO:0035509negative regulation of myosin-light-chain-phosphatase activity-IMP25816133  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-TAS-  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0042325regulation of phosphorylation-IDA26212789  
GO:0043066negative regulation of apoptotic process-TAS-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-TAS-  
GO:0045087innate immune response-TAS18626576  
GO:0045893positive regulation of transcription, DNA-templated-NAS9346484  9346485  9813230  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA23091055  23453807  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IBA21873635  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA15790681  
GO:0051092positive regulation of NF-kappaB transcription factor activity-TAS18626576  
GO:0051403stress-activated MAPK cascade-TAS-  
GO:0070498interleukin-1-mediated signaling pathway-IMP25816133  
GO:0070498interleukin-1-mediated signaling pathway-TAS-  
GO:0071356cellular response to tumor necrosis factor-IDA23091055  
GO:0072659protein localization to plasma membrane-IMP25816133  
GO:1903140regulation of establishment of endothelial barrier-IMP25816133  
GO:1903347negative regulation of bicellular tight junction assembly-IMP25816133  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0008385IkappaB kinase complex-IBA21873635  
GO:0008385IkappaB kinase complex-TAS18626576  
GO:0009898cytoplasmic side of plasma membrane-ISS-  
GO:0035631CD40 receptor complex-ISS-  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04062Chemokine signaling pathway
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)TAS
R-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)IEA
R-HSA-1169091Activation of NF-kappaB in B cellsTAS
R-HSA-1169091Activation of NF-kappaB in B cellsIEA
R-HSA-1236974ER-Phagosome pathwayTAS
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1606322ZBP1(DAI) mediated induction of type I IFNsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168638NOD1/2 Signaling PathwayTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment TAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-1810476RIP-mediated NFkB activation via ZBP1TAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-193639p75NTR signals via NF-kBTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-209543p75NTR recruits signalling complexesTAS
R-HSA-209560NF-kB is activated and signals survivalTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2871837FCERI mediated NF-kB activationTAS
R-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complexTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-5260271Diseases of Immune SystemTAS
R-HSA-5357905Regulation of TNFR1 signalingTAS
R-HSA-5357956TNFR1-induced NFkappaB signaling pathwayTAS
R-HSA-5602358Diseases associated with the TLR signaling cascadeTAS
R-HSA-5602636IKBKB deficiency causes SCIDTAS
R-HSA-5603027IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)TAS
R-HSA-5603029IkBA variant leads to EDA-IDTAS
R-HSA-5607764CLEC7A (Dectin-1) signalingTAS
R-HSA-5621481C-type lectin receptors (CLRs)TAS
R-HSA-5684264MAP3K8 (TPL2)-dependent MAPK1/3 activationTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-75893TNF signalingTAS
R-HSA-9020702Interleukin-1 signalingTAS
R-HSA-933542TRAF6 mediated NF-kB activationTAS
R-HSA-933543NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10TAS
R-HSA-937039IRAK1 recruits IKK complexTAS
R-HSA-937041IKK complex recruitment mediated by RIP1TAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975144IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25894374K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation. (2015 Sep)Cheng DTumour Biol
22986747SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. (2012 Nov 15)Beane JCancer Res
26833871A weighted U statistic for association analyses considering genetic heterogeneity. (2016 Jul 20)Wei CStat Med