Gene info: ID 3554

Gene: IL1R1

GENE ID: 3554

Synonyms: CD121A|D2S1473|IL-1R-alpha|IL1R|IL1RA|P80

Description: interleukin 1 receptor type 1

Gene type: protein-coding

Location: 2q11.2-q12.1

dbXrefs: Ensembl:ENSG00000115594 MIM:147810 Vega:OTTHUMG00000130783 UniprotKB:P14778

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.562e-1 (AD) 4.667e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OSMR	0.911
ANXA2	0.895
CDK2	0.887
ANO6	0.887
CLIC1	0.885
S1PR3	0.882
IL4R	0.88
YBX3	0.879
PLSCR1	0.874
MPZL2	0.872

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NEUROD6	-0.569
KCNIP3	-0.568
SLC7A4	-0.565
MARCH4	-0.563
WNT7A	-0.556
ABCC12	-0.551
TMEM179	-0.538
DLK2	-0.537
EXTL1	-0.532
RTN4R	-0.525

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00026	Anakinra	BiotechDrug	143090-92-0	Approved	Target
DB05207	SD118	Small Molecule	-	Investigational	Target
DB05303	OMS-103HP	Small Molecule	-	Investigational	Target

ID	Drug Name	Action	PubMed
C025205	1,10-phenanthroline	"1,10-phenanthroline results in decreased expression of IL1R1 mRNA"	19502547
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of IL1R1 mRNA"	28903501
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL1R1 mRNA"	23146750
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IL1R1 mRNA"	19167446
C003898	2-anisidine	2-anisidine results in increased expression of IL1R1 mRNA	28089782
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1R1 mRNA"	20959002
C035419	3,4-dihydroxybenzohydroxamic acid	"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1R1 mRNA]"	25843059
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [sodium arsenite results in increased expression of IL1R1 mRNA]	24570342
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of IL1R1 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL1R1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL1R1 mRNA"	27188386
C012358	4-hydroxycyclophosphamide	[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL1R1 mRNA	25833159
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL1R1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL1R1 mRNA"	27188386
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]	19407222
C053876	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of IL1R1 protein	19407222
D000082	Acetaminophen	Acetaminophen results in decreased expression of IL1R1 mRNA	21420995
D000082	Acetaminophen	Acetaminophen results in increased expression of IL1R1 mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of IL1R1 mRNA	17562736
D000082	Acetaminophen	IL1R1 protein affects the metabolism of Acetaminophen	19002106
D000082	Acetaminophen	IL1R1 protein results in increased susceptibility to Acetaminophen	19002106
D020106	Acrylamide	Acrylamide results in decreased expression of IL1R1 mRNA	28959563
C499366	Active Hexose Correlated Compound	Active Hexose Correlated Compound inhibits the reaction [IL1B protein results in increased expression of IL1R1]	24878381
C499366	Active Hexose Correlated Compound	Active Hexose Correlated Compound inhibits the reaction [IL1B protein results in increased expression of IL1R1 protein]	22076046
C499366	Active Hexose Correlated Compound	Active Hexose Correlated Compound inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA]	17449585
C499366	Active Hexose Correlated Compound	[Active Hexose Correlated Compound results in decreased phosphorylation of AKT1 protein] inhibits the reaction [IL1B protein results in increased expression of IL1R1 protein]	22076046
D000241	Adenosine	Adenosine inhibits the reaction [IL1B protein results in increased expression of IL1R1]	24878381
C016601	afimoxifene	[afimoxifene co-treated with 4-hydroxycyclophosphamide] affects the expression of IL1R1 mRNA	25833159
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of IL1R1 gene	27153756
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]	19407222
C046926	AH 23848	[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of IL1R1 protein	19407222
D015766	Albendazole	[Ivermectin co-treated with Albendazole] results in increased expression of IL1R1 mRNA	16861626
D000452	Aldrin	Aldrin results in decreased expression of IL1R1 mRNA	18579281
C068582	almond oil	[almond oil co-treated with Carbon Tetrachloride] results in decreased expression of IL1R1 mRNA	27623180
D000534	Alum Compounds	IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with Alum Compounds] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of IL1R1 mRNA	21298039
D000536	Aluminum Hydroxide	IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
C068073	Am 580	Am 580 results in decreased expression of IL1R1 mRNA	16982809
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IL1R1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of IL1R1 mRNA	24449571
D001149	Arsenates	[Atrazine co-treated with Arsenates] results in increased expression of IL1R1 mRNA	18585445
D001151	Arsenic	Arsenic affects the methylation of IL1R1 gene	25304211
D001151	Arsenic	Arsenic results in increased expression of IL1R1 mRNA	19945496
D001280	Atrazine	Atrazine affects the expression of IL1R1 mRNA	21549199
D001280	Atrazine	[Chlorpyrifos co-treated with Atrazine] affects the expression of IL1R1 mRNA	21549199
D001280	Atrazine	[Atrazine co-treated with Arsenates] results in increased expression of IL1R1 mRNA	18585445
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of IL1R1 mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IL1R1 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IL1R1 mRNA	27195522
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL1R1 mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of IL1R1 mRNA	16202921\|2118537
D004958	Estradiol	Estradiol results in increased expression of IL1R1 mRNA	19619570
D004958	Estradiol	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of IL1R1 mRNA]	21185374
D004958	Estradiol	Estradiol results in increased expression of IL1R1 mRNA	15171707
C006780	bisphenol A	bisphenol A results in increased expression of IL1R1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of IL1R1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of IL1R1 gene	28505145
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IL1R1 mRNA	28628672
D000069286	Bortezomib	Bortezomib results in increased expression of IL1R1 mRNA	17895889
C006794	brevianamide A	brevianamide A results in increased expression of IL1R1 mRNA	19818335
C018475	butyraldehyde	butyraldehyde results in decreased expression of IL1R1 mRNA	26079696
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of IL1R1 protein	26396915
D002220	Carbamazepine	Carbamazepine affects the expression of IL1R1 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of IL1R1 mRNA	17484886
D002251	Carbon Tetrachloride	[almond oil co-treated with Carbon Tetrachloride] results in decreased expression of IL1R1 mRNA	27623180
D002330	Carmustine	IL1R1 mRNA affects the susceptibility to Carmustine	16365179
D002713	Chlorine	Chlorine results in increased expression of IL1R1 mRNA	22533443
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of IL1R1 mRNA	21549199
D004390	Chlorpyrifos	[Chlorpyrifos co-treated with Atrazine] affects the expression of IL1R1 mRNA	21549199
C043561	chrysin	chrysin results in decreased expression of IL1R1 mRNA	20816778
C039671	ciglitazone	[ciglitazone binds to PPARG protein] which results in increased expression of IL1R1 mRNA	16197558
D002922	Ciguatoxins	Ciguatoxins affects the expression of IL1R1 mRNA	18353800
C000488	cladosporin	cladosporin results in increased expression of IL1R1 mRNA	19818335
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of IL1R1 mRNA	15467011
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of IL1R1 mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of IL1R1 mRNA	18579281
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IL1R1 mRNA"	19167446
C038459	curdlan	curdlan affects the expression of IL1R1 mRNA	19904525
D016572	Cyclosporine	Cyclosporine results in decreased expression of IL1R1 mRNA	25562108\|2798913
D000069439	Dasatinib	Dasatinib results in decreased expression of IL1R1 protein	17962511
D003634	DDT	DDT results in decreased expression of IL1R1 mRNA	11948501
D003634	DDT	DDT results in increased expression of IL1R1 mRNA	11948501
D003703	Demecolcine	Demecolcine results in increased expression of IL1R1 mRNA	23649840
C007262	deoxynivalenol	deoxynivalenol affects the expression of IL1R1 mRNA	25542652
C007262	deoxynivalenol	deoxynivalenol affects the expression of IL1R1 protein	25542652
C007262	deoxynivalenol	deoxynivalenol results in increased expression of IL1R1 mRNA	22968694
C007262	deoxynivalenol	IL1R1 protein affects the susceptibility to [Lipopolysaccharides co-treated with deoxynivalenol]	12773775
D003907	Dexamethasone	Dexamethasone results in increased expression of IL1R1 mRNA	21356098
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IL1R1 mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of IL1R1 mRNA	17361019\|2126653
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of IL1R1 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of IL1R1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of IL1R1 mRNA	27392435
D002945	Cisplatin	IL1R1 protein affects the susceptibility to Cisplatin	16217747
D002945	Cisplatin	Cisplatin results in increased expression of IL1R1 mRNA	26546572
D004008	Diclofenac	Diclofenac affects the expression of IL1R1 mRNA	24752500
D004008	Diclofenac	Diclofenac results in increased expression of IL1R1 mRNA	26934552
D004041	Dietary Fats	Dietary Fats affects the expression of IL1R1 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of IL1R1 mRNA	18042831
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of IL1R1 mRNA	18164116
D002117	Calcitriol	Calcitriol results in increased expression of IL1R1 mRNA	16002434
D004128	Dimethylnitrosamine	CSF3 protein affects the reaction [Dimethylnitrosamine results in increased expression of IL1R1 mRNA]	17869372
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of IL1R1 mRNA	17869372
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in decreased expression of IL1R1 mRNA	21878375
D004317	Doxorubicin	Doxorubicin results in increased expression of IL1R1 mRNA	27181935
D004317	Doxorubicin	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of IL1R1 mRNA]	27181935
D004610	Ellagic Acid	Ellagic Acid results in decreased expression of IL1R1 mRNA	20816778
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IL1R1 mRNA	22079256
D000069347	Erlotinib Hydrochloride	[Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IL1R1 mRNA	27738319
D005419	Flavonoids	Flavonoids results in increased expression of IL1R1 mRNA	18035473
D004397	Fonofos	Fonofos results in decreased methylation of IL1R1 promoter	22847954
D005557	Formaldehyde	Formaldehyde results in decreased expression of IL1R1 mRNA	20655997
D005557	Formaldehyde	Formaldehyde results in increased expression of IL1R1 mRNA	23649840
D037741	Fullerenes	Fullerenes analog results in increased expression of IL1R1 mRNA	22342292
D062610	Fungal Polysaccharides	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of IL1R1 mRNA]	27181935
C039281	furan	furan results in decreased expression of IL1R1 mRNA	25539665
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in increased expression of IL1R1 mRNA	21782745
C071834	glycidamide	glycidamide results in decreased expression of IL1R1 mRNA	17822822
D006861	Hydrogen Peroxide	Hydrogen Peroxide promotes the reaction [TRAF6 protein binds to [IL1R1 protein binds to MYD88 protein]]	16354686
C027185	indirubin	indirubin results in decreased expression of IL1R1 mRNA	15056799
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IL1R1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of IL1R1 mRNA	28628672
D007559	Ivermectin	[Ivermectin co-treated with Albendazole] results in increased expression of IL1R1 mRNA	16861626
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of IL1R1 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of IL1R1 mRNA	26387944
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of IL1R1 protein	26396915
C045463	leflunomide	leflunomide results in increased expression of IL1R1 mRNA	24136188
C467567	lenalidomide	lenalidomide results in decreased expression of IL1R1 mRNA	15618473
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1R1 mRNA"	23090859
D008070	Lipopolysaccharides	HNRNPD protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1R1 mRNA]	21135123
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL1R1 mRNA	21045076\|2113512
D008070	Lipopolysaccharides	"3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1R1 mRNA]"	25843059
D008070	Lipopolysaccharides	IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with Alum Compounds] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D008070	Lipopolysaccharides	IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D008070	Lipopolysaccharides	IL1R1 protein affects the susceptibility to [Lipopolysaccharides co-treated with deoxynivalenol]	12773775
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL1R1 mRNA	15371095\|2584305
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL1R1 mRNA	13679239
C018091	maduramicin	maduramicin results in decreased expression of IL1R1 mRNA	29128925
D008276	Magnesium Hydroxide	IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]	18604214
D008713	Methimazole	Methimazole results in increased expression of IL1R1 mRNA	22504374
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in increased expression of IL1R1 mRNA	21782745
D008731	Methoxychlor	Methoxychlor results in increased expression of IL1R1 mRNA	21782745
C054634	methyllycaconitine	methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]	27180639
C054634	methyllycaconitine	methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein]	27180639
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IL1R1 mRNA"	20188158\|2625132
C500085	muraglitazar	muraglitazar results in decreased expression of IL1R1 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in increased expression of IL1R1 mRNA	18988085
D009173	Mycophenolic Acid	Mycophenolic Acid results in increased expression of IL1R1 mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in increased expression of IL1R1 mRNA	19818335
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of IL1R1 mRNA"	25511174
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of IL1R1 mRNA"	23845593\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of IL1R1 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of IL1R1 mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of IL1R1 mRNA	15913567
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of IL1R1 mRNA	12832660
C490266	neoechinulin A	neoechinulin A results in increased expression of IL1R1 mRNA	19818335
C029938	nickel sulfate	nickel sulfate results in increased expression of IL1R1 mRNA	22714537
D009538	Nicotine	methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]	27180639
D009538	Nicotine	methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein]	27180639
D009538	Nicotine	Nicotine results in increased expression of IL1R1 mRNA	27180639
D009538	Nicotine	Nicotine results in increased expression of IL1R1 protein	27180639
D010126	Ozone	IL1R1 gene mutant form affects the reaction [Ozone results in increased expression of CCL11 protein]	17575079
D010126	Ozone	IL1R1 gene mutant form affects the reaction [Ozone results in increased expression of CXCL2 protein]	17575079
D010126	Ozone	IL1R1 gene mutant form affects the reaction [Ozone results in increased expression of IL6 protein]	17575079
D010126	Ozone	IL1R1 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL10 protein]	17575079
D010126	Ozone	IL1R1 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 mRNA]	17575079
D010126	Ozone	IL1R1 gene mutant form inhibits the reaction [Ozone results in increased expression of TNFRSF1A protein]	17575079
D010126	Ozone	IL1R1 protein results in increased susceptibility to Ozone	17575079
D017239	Paclitaxel	Paclitaxel results in decreased expression of IL1R1 protein	15907983
D000073878	Palm Oil	Palm Oil affects the expression of IL1R1 mRNA	19680557
D000073878	Palm Oil	Palm Oil results in decreased expression of IL1R1 mRNA	18042831
C016030	pantogab	pantogab results in increased expression of IL1R1 mRNA	17379144
D010278	Parathion	Parathion results in decreased methylation of IL1R1 promoter	22847954
D015232	Dinoprostone	Dinoprostone results in increased activity of IL1R1 protein	19407222
D015232	Dinoprostone	Dinoprostone results in increased expression of IL1R1 mRNA	19273625
D010634	Phenobarbital	Phenobarbital affects the expression of IL1R1 mRNA	19159669
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL1R1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of IL1R1 mRNA	26272509
C005435	phenylmethylpyrazolone	phenylmethylpyrazolone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA]	18078833
C005435	phenylmethylpyrazolone	phenylmethylpyrazolone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein]	18078833
C006253	pirinixic acid	pirinixic acid results in increased expression of IL1R1 mRNA	18301758\|1844570
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IL1R1 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of IL1R1 mRNA	22079256\|2271453
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of IL1R1 mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of IL1R1 mRNA	23012394
D011374	Progesterone	Progesterone results in increased expression of IL1R1 mRNA	20864642\|2179573
D011374	Progesterone	Progesterone results in increased expression of IL1R1 mRNA	20726854
D011374	Progesterone	Progesterone results in decreased expression of IL1R1	17510236
D011441	Propylthiouracil	Propylthiouracil results in increased expression of IL1R1 mRNA	22504374
D011794	Quercetin	Quercetin results in increased expression of IL1R1 mRNA	21356098
D011794	Quercetin	Quercetin results in decreased expression of IL1R1 mRNA	15309432\|2163298
D011794	Quercetin	Quercetin results in increased expression of IL1R1 mRNA	23727915
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of IL1R1 mRNA]	21185374
C059514	resveratrol	resveratrol results in increased expression of IL1R1 mRNA	23419489
C089730	rosiglitazone	rosiglitazone results in decreased expression of IL1R1 mRNA	16982809
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of IL1R1 mRNA	25895662
D012822	Silicon Dioxide	IL1R1 protein affects the susceptibility to Silicon Dioxide	18604214
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of IL1R1 mRNA	23221170
D012834	Silver	Silver analog results in decreased expression of IL1R1 mRNA	24462830
D012834	Silver	Silver analog results in increased expression of IL1R1 mRNA	23086748
D012834	Silver	Silver results in decreased expression of IL1R1 mRNA	22342292
D012834	Silver	Silver analog results in increased expression of IL1R1 mRNA	23086748
D012906	Smoke	Smoke results in increased expression of IL1R1 mRNA	21095227
C017947	sodium arsenite	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [sodium arsenite results in increased expression of IL1R1 mRNA]	24570342
C017947	sodium arsenite	LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of IL1R1 mRNA]	24570342
C017947	sodium arsenite	sodium arsenite results in increased expression of IL1R1 mRNA	22714537\|2457034
C017947	sodium arsenite	sodium arsenite results in decreased expression of IL1R1 mRNA	21911445
C017947	sodium arsenite	sodium arsenite results in decreased methylation of IL1R1 gene	24118411
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased expression of IL1R1 protein	26396915
D012999	Soman	IL1R1 protein affects the susceptibility to Soman	28866071
D053260	Soot	Soot results in increased expression of IL1R1 mRNA	26551751
D013241	Sterigmatocystin	Sterigmatocystin results in increased expression of IL1R1 mRNA	19818335
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA]	17449585
C016766	sulforafan	sulforafan results in increased expression of IL1R1 mRNA	26833863
C025462	sulindac sulfide	sulindac sulfide results in increased expression of IL1R1 mRNA	16184548
C446685	systhane	systhane results in increased expression of IL1R1 mRNA	16643972
D015085	2,4,5-Trichlorophenoxyacetic Acid	"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of IL1R1 mRNA"	18579281
C013698	tallow	tallow affects the expression of IL1R1 mRNA	19680557
D013629	Tamoxifen	Tamoxifen affects the expression of IL1R1 mRNA	20937368
C047246	temozolomide	IL1R1 mRNA affects the susceptibility to temozolomide	16365179
C012568	terbufos	terbufos results in decreased methylation of IL1R1 promoter	22847954
C501413	tesaglitazar	tesaglitazar results in decreased expression of IL1R1 mRNA	21515302
D013739	Testosterone	Testosterone results in increased expression of IL1R1 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL1R1 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IL1R1 mRNA	19619570\|2010694
D013749	Tetrachlorodibenzodioxin	IL1R1 gene mutant form results in decreased susceptibility to Tetrachlorodibenzodioxin	24718703
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IL1R1 mRNA	28922406
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IL1R1 mRNA	19465110
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IL1R1 mRNA	15667827\|1977048
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IL1R1 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	SOD2 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1R1 mRNA]	21045076
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of IL1R1 mRNA	21045076
D013792	Thalidomide	Thalidomide results in decreased expression of IL1R1 mRNA	15618473
D013853	Thioacetamide	Thioacetamide results in decreased expression of IL1R1 mRNA	23411599
C402696	TMC 120A	TMC 120A results in increased expression of IL1R1 mRNA	19818335
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of IL1R1 mRNA	25800949
C082097	tocotrienol, delta	"tocotrienol, delta results in increased expression of IL1R1 mRNA"	21356098
D014212	Tretinoin	Tretinoin results in increased expression of IL1R1 mRNA	21934132
C032910	triadimefon	triadimefon results in increased expression of IL1R1 mRNA	16643972
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of IL1R1 mRNA	15363585
C012589	trichostatin A	trichostatin A results in increased expression of IL1R1 mRNA	24935251
C046488	trimethyltin	trimethyltin results in increased expression of IL1R1 mRNA	20833246
D014302	Trinitrobenzenesulfonic Acid	Active Hexose Correlated Compound inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA]	17449585
D014302	Trinitrobenzenesulfonic Acid	Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA]	17449585
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA	17449585
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of IL1R1 mRNA"	26179874
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL1R1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of IL1R1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of IL1R1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of IL1R1 mRNA	23179753\|2438349
D014638	Vanadates	Vanadates results in increased expression of IL1R1 mRNA	22714537
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of IL1R1 mRNA	16217019
C025643	vinclozolin	vinclozolin results in decreased expression of IL1R1 mRNA	23034163
D014750	Vincristine	Vincristine results in increased expression of IL1R1 mRNA	23649840
D014752	Vinyl Chloride	Vinyl Chloride results in decreased expression of IL1R1 mRNA	18579281
D012256	Riboflavin	Riboflavin results in increased expression of IL1R1 mRNA	21356098
D015032	Zinc	Zinc deficiency results in increased expression of IL1R1 mRNA	9649590
C088658	zoledronic acid	zoledronic acid results in increased expression of IL1R1 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IEA	-
GO:0004888	transmembrane signaling receptor activity	-	TAS	2530587
GO:0004908	interleukin-1 receptor activity	-	IDA	10383454
GO:0004909	interleukin-1, type I, activating receptor activity	-	IEA	-
GO:0005161	platelet-derived growth factor receptor binding	-	IPI	16477012
GO:0005515	protein binding	-	IPI	12925853 16286467 16477012
GO:0019966	interleukin-1 binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006955	immune response	-	TAS	9120302
GO:0007166	cell surface receptor signaling pathway	-	TAS	1833184
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0032729	positive regulation of interferon-gamma production	-	IDA	10653850
GO:0050727	regulation of inflammatory response	-	IEA	-
GO:0070498	interleukin-1-mediated signaling pathway	-	IDA	10383454
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-
GO:0070555	response to interleukin-1	-	IDA	10383454
GO:2000391	positive regulation of neutrophil extravasation	-	IEA	-
GO:2000556	positive regulation of T-helper 1 cell cytokine production	-	IDA	10653850
GO:2000661	positive regulation of interleukin-1-mediated signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	2530587
GO:0009897	external side of plasma membrane	-	IEA	-
GO:0016020	membrane	-	IDA	16477012

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04210	Apoptosis
hsa04380	Osteoclast differentiation
hsa04640	Hematopoietic cell lineage
hsa05146	Amoebiasis

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29566963	Analysis of the relationship between interleukin polymorphisms within miRNA-binding regions and alcoholic liver disease. (2018 May)	Novo-Veleiro I	Rev Clin Esp
20465828	Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. (2010 May 13)	Hermsdorff HH	Nutr Metab (Lond)
24818754	Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese. (2014 Jul)	Kamei H	Arch Oral Biol
15797878	Interleukin-1 gene cluster polymorphisms and alcoholism in Spanish men. (2005 May-Jun)	Pastor IJ	Alcohol Alcohol
23981442	Stress-response pathways are altered in the hippocampus of chronic alcoholics. (2013 Nov)	McClintick JN	Alcohol