Gene info: ID 3557

Gene: IL1RN

GENE ID: 3557

Description: interleukin 1 receptor antagonist

Gene type: protein-coding

Location: 2q14.1

dbXrefs: Ensembl:ENSG00000136689 MIM:147679 Vega:OTTHUMG00000131341 UniprotKB:P18510

RefSeq: NG_021240.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 14

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.784e-1 (AD) 7.754e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CD80	0.8
RAB42	0.777
IL4I1	0.776
SCIMP	0.726
KRT75	0.725
C15orf48	0.714
CCL20	0.714
CDCP1	0.706
PLEK2	0.699
NOD2	0.693

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SNX22	-0.329
MYBPC1	-0.28
ZNF835	-0.259
ERBB4	-0.258
CABLES1	-0.251
LRTOMT	-0.249
SAPCD2	-0.249
HCN2	-0.246
KCNJ10	-0.243
FBXL22	-0.243

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB06372	Rilonacept	BiotechDrug	501081-76-1	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1RN mRNA"	15751073
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1RN mRNA]"	15751073
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased secretion of IL1RN protein]"	15751073
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of IL1RN mRNA"	21920950
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of IL1RN mRNA"	25710175
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of IL1RN mRNA"	23146750
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in increased expression of IL1RN mRNA"	21703328
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide affects the expression of IL1RN protein	11428619
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in decreased expression of and results in increased secretion of IL1RN protein	11031321
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1RN mRNA"	22262711\|2835176
C023035	3,4,5,3',4'-pentachlorobiphenyl	"alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1RN mRNA]"	22262711
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of IL1RN mRNA"	24172598
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to IL1RN protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to IL1RN protein]	26598702
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of IL1RN mRNA	19191707
C003001	7-ketocholesterol	[resveratrol co-treated with 7-ketocholesterol] results in increased expression of IL1RN protein	24895526
D000109	Acetylcholine	IL1RN protein affects the susceptibility to Acetylcholine	10487780
D000242	Cyclic AMP	Cyclic AMP promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA]	22117073
D000242	Cyclic AMP	Cyclic AMP promotes the reaction [Metformin results in increased expression of IL1RN mRNA]	22117073
D000242	Cyclic AMP	Cyclic AMP results in increased expression of IL1RN mRNA	22117073
D000242	Cyclic AMP	Metformin promotes the reaction [Cyclic AMP results in increased expression of IL1RN mRNA]	22117073
D000242	Cyclic AMP	PPARGC1A mutant form inhibits the reaction [Cyclic AMP results in increased expression of IL1RN mRNA]	22117073
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of IL1RN mRNA	22100608
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of IL1RN mRNA"	23195993
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased secretion of IL1RN protein"	20005085
D019386	Alendronate	Alendronate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA]	17375077
C011512	alpha-naphthoflavone	"alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1RN mRNA]"	22262711
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1RN mRNA]	22262711
C011512	alpha-naphthoflavone	alpha-naphthoflavone results in increased expression of IL1RN mRNA	22262711
D000534	Alum Compounds	Alum Compounds results in increased secretion of IL1RN protein	18390722
D000536	Aluminum Hydroxide	Aluminum Hydroxide results in increased secretion of IL1RN protein	18390722
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IL1RN mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of IL1RN mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of IL1RN mRNA	16835338
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to IL1RN protein]	26598702
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of IL1RN mRNA	19128835
C006632	arsenic trioxide	IL1RN protein results in decreased susceptibility to arsenic trioxide	27174766
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of IL1RN mRNA"	24160326\|2535159
D017638	Asbestos, Crocidolite	"[TNF protein co-treated with Asbestos, Crocidolite] results in increased secretion of IL1RN protein"	23937860
D001241	Aspirin	Aspirin inhibits the reaction [Salmonella Vaccines results in increased expression of IL1RN protein]	12045164
D001379	Azathioprine	Azathioprine results in decreased expression of IL1RN mRNA	19192274
C000609563	AZD8848	AZD8848 results in increased secretion of IL1RN protein	29122671
C547126	AZM551248	AZM551248 results in increased expression of IL1RN mRNA	22323515
D001397	Azoxymethane	[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA	25026504
D001397	Azoxymethane	[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein	25026504
D001397	Azoxymethane	isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA]	25026504
D001397	Azoxymethane	isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein]	25026504
D001507	Beclomethasone	Beclomethasone results in decreased expression of IL1RN protein	11015126
D001554	Benzene	Benzene affects the expression of IL1RN mRNA	21147609
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IL1RN mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IL1RN mRNA	28351761
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IL1RN mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of IL1RN mRNA	22228805
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of IL1RN mRNA	19157767
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IL1RN mRNA	19619570
D004958	Estradiol	Estradiol results in decreased secretion of IL1RN protein	16934544
D004958	Estradiol	Estradiol results in increased expression of IL1RN mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of IL1RN mRNA	12469912
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in decreased expression of IL1RN mRNA	18192240
C006780	bisphenol A	bisphenol A results in increased expression of IL1RN mRNA	27685785
C006780	bisphenol A	bisphenol A results in decreased expression of IL1RN mRNA	25594700\|2691170
C006780	bisphenol A	bisphenol A affects the expression of IL1RN mRNA	25181051
D001966	Bromine	Bromine results in increased expression of IL1RN mRNA	21391292
D002104	Cadmium	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL1RN mRNA	21481475
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of IL1RN mRNA	20061341
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of IL1RN promoter	22457795
D019256	Cadmium Chloride	IL1RN protein inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]	26396915
D002211	Capsaicin	IL1RN protein inhibits the reaction [Nicotine results in increased activity of Capsaicin]	27180639
D002251	Carbon Tetrachloride	PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of IL1RN mRNA]	18038451
C043211	carvedilol	carvedilol results in increased expression of IL1RN protein	20017808
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of IL1RN mRNA	27188386
D002784	Cholesterol	Cholesterol results in increased expression of IL1RN mRNA	26296894
D002793	Cholic Acids	[Methyltestosterone co-treated with Cholic Acids] affects the expression of IL1RN mRNA	27344345
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL1RN mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1RN mRNA	28133511
D002994	Clofibrate	Clofibrate promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA]	16572457
D002994	Clofibrate	[Clofibrate promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA]] which results in increased expression of MMP13 mRNA	16572457
D002994	Clofibrate	[Clofibrate promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA]] which results in increased expression of MMP1 mRNA	16572457
D002994	Clofibrate	[Clofibrate promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA]] which results in increased expression of MMP3 mRNA	16572457
D002994	Clofibrate	Clofibrate promotes the reaction [IL1B protein results in increased expression of IL1RN protein modified form]	16572457
D002994	Clofibrate	PPARA promotes the reaction [Clofibrate promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA]]	16572457
C000593591	coagulin-L	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	27568862
C018021	cobaltous chloride	cobaltous chloride results in increased expression of IL1RN mRNA	23052192
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of IL1RN mRNA	19549813
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of IL1RN mRNA	15331540
D016572	Cyclosporine	Cyclosporine results in decreased expression of IL1RN mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of IL1RN mRNA	23958496
C007262	deoxynivalenol	deoxynivalenol results in increased expression of IL1RN mRNA	22968694
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	27568862
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	16880258\|2218540
D003907	Dexamethasone	Dexamethasone results in increased expression of IL1RN mRNA	22185406\|2273378
D003907	Dexamethasone	DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]]	16880258
D016264	Dextran Sulfate	[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA	25026504
D016264	Dextran Sulfate	[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein	25026504
D016264	Dextran Sulfate	isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA]	25026504
D016264	Dextran Sulfate	isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein]	25026504
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of IL1RN mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of IL1RN mRNA	23625948
D004008	Diclofenac	Diclofenac results in increased expression of IL1RN mRNA	9491209
D004008	Diclofenac	Diclofenac results in increased secretion of IL1RN protein	9491209
D004008	Diclofenac	Lipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein]	9491209
D004008	Diclofenac	Diclofenac results in increased expression of IL1RN mRNA	26934552
C000944	dicrotophos	dicrotophos results in increased expression of IL1RN mRNA	28302478
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in decreased expression of IL1RN protein	12533503
D004041	Dietary Fats	Dietary Fats affects the expression of IL1RN mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of IL1RN mRNA	25016146
D004041	Dietary Fats	Dietary Fats results in increased expression of IL1RN mRNA	22609946
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of IL1RN mRNA	24535843
D002117	Calcitriol	Calcitriol results in decreased expression of IL1RN mRNA	16002434
D004237	Diuron	Diuron metabolite results in increased expression of IL1RN mRNA	24172598
D004317	Doxorubicin	Doxorubicin results in increased expression of IL1RN mRNA	12187937\|2718193
D004317	Doxorubicin	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of IL1RN mRNA]	27181935
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid promotes the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	22169119
C044101	endotoxin, Escherichia coli	"IL1RN protein inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]"	7648339
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of IL1RN mRNA	20064776
D000069347	Erlotinib Hydrochloride	[Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which affects the expression of IL1RN mRNA	27738319
D000069347	Erlotinib Hydrochloride	[Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased expression of IL1RN mRNA	27738319
D000069347	Erlotinib Hydrochloride	[Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in decreased secretion of IL1RN protein	27738319
D000431	Ethanol	IL1RN gene mutant form results in decreased susceptibility to Ethanol	21309947
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of IL1RN mRNA	17557909
C020748	ferrous sulfate	ferrous sulfate results in increased expression of IL1RN mRNA	19428942
D005472	Fluorouracil	IL1RN protein affects the reaction [Fluorouracil results in increased expression of BAX protein]	20844880
D005472	Fluorouracil	IL1RN protein affects the reaction [Fluorouracil results in increased expression of CASP3 protein modified form]	20844880
D005472	Fluorouracil	IL1RN protein inhibits the reaction [Fluorouracil results in decreased expression of BCL2L1 protein]	20844880
D005472	Fluorouracil	IL1RN protein inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]	20844880
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL1RN mRNA	20938992
D062610	Fungal Polysaccharides	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of IL1RN mRNA]	27181935
C106014	gedunin	gedunin results in decreased expression of IL1RN mRNA	17010675
C007834	genipin	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	22687549
D019833	Genistein	Genistein results in increased expression of IL1RN mRNA	22553218
D005897	Glafenine	Glafenine results in increased expression of IL1RN mRNA	24136188
D005947	Glucose	IL1RN protein inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]	19861503
D005947	Glucose	IL1RN protein inhibits the reaction [Glucose results in increased expression of PTGS2 protein]	19861503
C004312	glycidol	glycidol results in decreased expression of IL1RN mRNA	24915197
D006052	Gold Sodium Thiomalate	Gold Sodium Thiomalate results in decreased expression of IL1RN mRNA	19192274
C425931	GW 501516	GW 501516 promotes the reaction [IL1B protein results in increased secretion of IL1RN protein]	15751073
C000625835	HFPO2 compound	HFPO2 compound results in increased expression of IL1RN mRNA	27553808
C000625836	HFPO4 compound	HFPO4 compound results in increased expression of IL1RN mRNA	27553808
D017313	Fenretinide	Fenretinide results in increased expression of IL1RN mRNA	28973697
D007052	Ibuprofen	Ibuprofen results in decreased secretion of IL1RN protein	12169827
D007052	Ibuprofen	Ibuprofen results in increased expression of and results in increased secretion of IL1RN protein	15837124
D007052	Ibuprofen	Ibuprofen results in increased expression of IL1RN mRNA	15837124
D007213	Indomethacin	IL1RN protein inhibits the reaction [Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein]]	8520508
D007213	Indomethacin	Indomethacin results in decreased secretion of IL1RN protein	12169827
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL1RN mRNA	25613284
C040920	isoliquiritigenin	isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA]	25026504
C040920	isoliquiritigenin	isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein]	25026504
D007545	Isoproterenol	IL1RN protein affects the susceptibility to Isoproterenol	10487780
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	25890327\|2658214
C052787	kallidin, des-Arg(10)-	"IL1RN protein inhibits the reaction [IL1B protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]]"	17931716
C020251	kappa-casein glycomacropeptide	kappa-casein glycomacropeptide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA]	15867298
C008261	lead acetate	lead acetate results in increased expression of IL1RN mRNA	25270620
C008261	lead acetate	IL1RN protein inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]	26396915
C045463	leflunomide	leflunomide results in increased expression of IL1RN mRNA	28988120
C467567	lenalidomide	lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]	16510725
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1RN mRNA"	23090859
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of IL1RN mRNA"	24972896
D008070	Lipopolysaccharides	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	27568862
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	27568862
D008070	Lipopolysaccharides	IL4 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	8777273
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein]	9491209
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL1RN mRNA	18192897
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL1RN protein	10072544\|2470711
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased secretion of IL1RN protein	17377406\|1839072
D008070	Lipopolysaccharides	Mercuric Chloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1RN protein]	20049214
D008070	Lipopolysaccharides	NFKBIA protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	10072544
D008070	Lipopolysaccharides	Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	24707119
D008070	Lipopolysaccharides	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	24707119
D008070	Lipopolysaccharides	retinol palmitate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1RN protein]	17377406
D008070	Lipopolysaccharides	Silymarin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	24707119
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	16880258\|2218540
D008070	Lipopolysaccharides	DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]]	16880258
D008070	Lipopolysaccharides	Eicosapentaenoic Acid promotes the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	22169119
D008070	Lipopolysaccharides	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	22687549
D008070	Lipopolysaccharides	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	25890327\|2658214
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL1RN mRNA	16002565\|1688025
D008070	Lipopolysaccharides	PPARA protein affects the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	17321000
D008070	Lipopolysaccharides	Quercetin affects the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	22185406
D008070	Lipopolysaccharides	"tocotrienol, delta promotes the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]"	22185406
D008070	Lipopolysaccharides	IL1RN protein inhibits the reaction [Lipopolysaccharides affects the expression of GHRL protein]	16959954
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IL1RN mRNA	21641980
D008315	Malondialdehyde	IL1RN protein results in decreased abundance of Malondialdehyde	18474811
D015122	Mercaptopurine	Mercaptopurine results in increased expression of IL1RN mRNA	23358152
D008627	Mercuric Chloride	Mercuric Chloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1RN protein]	20049214
D008687	Metformin	Cyclic AMP promotes the reaction [Metformin results in increased expression of IL1RN mRNA]	22117073
D008687	Metformin	[Metformin co-treated with GCG] results in increased expression of IL1RN mRNA	22117073
D008687	Metformin	Metformin promotes the reaction [Cyclic AMP results in increased expression of IL1RN mRNA]	22117073
D008687	Metformin	Metformin results in increased expression of IL1RN mRNA	22117073
D016210	Methacholine Chloride	Methacholine Chloride results in increased expression of IL1RN protein	15801332
D016210	Methacholine Chloride	IL1RN protein results in decreased susceptibility to [Ozone co-treated with Methacholine Chloride]	14754758
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL1RN mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1RN mRNA	28133511
D008727	Methotrexate	Methotrexate results in decreased expression of IL1RN mRNA	19192274
D008727	Methotrexate	Methotrexate results in increased expression of IL1RN mRNA	21678067
D008775	Methylprednisolone	Methylprednisolone results in decreased expression of IL1RN mRNA	19192274
D008777	Methyltestosterone	[Methyltestosterone co-treated with Cholic Acids] affects the expression of IL1RN mRNA	27344345
C089950	MF59 oil emulsion	MF59 oil emulsion results in increased secretion of IL1RN protein	18390722
C054999	mofezolac	mofezolac results in increased expression of IL1RN mRNA	9491209
C054999	mofezolac	mofezolac results in increased secretion of IL1RN protein	9491209
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of IL1RN mRNA	20886546
D009020	Morphine	IL1RN protein affects the susceptibility to Morphine	15317861
D009151	Mustard Gas	Mustard Gas results in increased expression of IL1RN mRNA	25102026
D009151	Mustard Gas	Mustard Gas results in increased expression of IL1RN mRNA	18955075
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of IL1RN mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of IL1RN mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of IL1RN mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of IL1RN mRNA	23195993
C029938	nickel sulfate	nickel sulfate results in increased expression of IL1RN mRNA	16780908
C029938	nickel sulfate	nickel sulfate results in increased expression of IL1RN mRNA	16166746
D009538	Nicotine	IL1RN protein inhibits the reaction [Nicotine results in increased activity of Capsaicin]	27180639
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of IL1RN mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of IL1RN mRNA	24236059
D010126	Ozone	IL1RN protein inhibits the reaction [Ozone results in increased expression of CXCL1 protein]	14754758
D010126	Ozone	IL1RN protein inhibits the reaction [Ozone results in increased expression of CXCL2 protein]	14754758
D010126	Ozone	IL1RN protein inhibits the reaction [Ozone results in increased expression of TNF protein]	14754758
D010126	Ozone	IL1RN protein results in decreased susceptibility to [Ozone co-treated with Methacholine Chloride]	14754758
D010126	Ozone	Ozone results in increased expression of IL1RN mRNA	25658374
D017239	Paclitaxel	IL1RN protein results in decreased susceptibility to Paclitaxel	17174526
D000073878	Palm Oil	Palm Oil affects the expression of IL1RN mRNA	19680557
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in decreased expression of IL1RN mRNA	17715259
D052638	Particulate Matter	Particulate Matter results in decreased expression of IL1RN protein	28189646
D052638	Particulate Matter	Particulate Matter results in increased expression of IL1RN mRNA	28341207
C410127	PCB 180	PCB 180 affects the expression of IL1RN mRNA	21703328
D015232	Dinoprostone	Dinoprostone inhibits the reaction [IL1RN protein results in decreased expression of IL6 protein]	8520508
D015232	Dinoprostone	IL1RN protein inhibits the reaction [Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein]]	8520508
D010693	Phloretin	Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	24707119
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in decreased expression of IL1RN mRNA	17715259
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IL1RN mRNA	19710929
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in increased expression of IL1RN mRNA	20813756
C006253	pirinixic acid	pirinixic acid promotes the reaction [PPARA protein binds to IL1RN protein]	17321000
C006253	pirinixic acid	pirinixic acid promotes the reaction [[PPARA protein co-treated with RXRA protein] results in increased expression of IL1RN mRNA]	17321000
C006253	pirinixic acid	pirinixic acid results in increased expression of IL1RN mRNA	17321000\|1830175
C006253	pirinixic acid	pirinixic acid results in increased expression of IL1RN protein	17321000
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of IL1RN mRNA]	17321000
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of IL1RN protein]	17321000
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of IL1RN mRNA]	20059764
C006253	pirinixic acid	pirinixic acid results in increased expression of IL1RN mRNA	19162173
D010894	Piroxicam	Piroxicam results in decreased expression of IL1RN mRNA	19192274
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of IL1RN protein	29175452
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of IL1RN mRNA	23608068
D011239	Prednisolone	Prednisolone results in decreased expression of IL1RN mRNA	19192274
D011285	Pregnenolone Carbonitrile	NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of IL1RN mRNA]	22698814
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of IL1RN mRNA	22698814
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of IL1RN mRNA	19157767
D011374	Progesterone	Progesterone results in increased expression of IL1RN mRNA	21770760
D011794	Quercetin	Quercetin affects the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]	22185406
D011794	Quercetin	Quercetin results in increased expression of IL1RN mRNA	22185406
C059514	resveratrol	[resveratrol co-treated with 7-ketocholesterol] results in increased expression of IL1RN protein	24895526
C059514	resveratrol	resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	24707119
C059514	resveratrol	resveratrol results in decreased expression of IL1RN mRNA	19228061
C059514	resveratrol	resveratrol results in increased expression of IL1RN mRNA	25905778
C014794	retinol palmitate	retinol palmitate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1RN protein]	17377406
C116926	rofecoxib	rofecoxib results in increased expression of IL1RN mRNA	17070997
C089730	rosiglitazone	rosiglitazone promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA]	15751073
C089730	rosiglitazone	rosiglitazone promotes the reaction [IL1B protein results in increased secretion of IL1RN protein]	15751073
D022562	Salmonella Vaccines	Aspirin inhibits the reaction [Salmonella Vaccines results in increased expression of IL1RN protein]	12045164
D022562	Salmonella Vaccines	Salmonella Vaccines results in increased expression of IL1RN protein	12045164
D012601	Scopolamine Hydrobromide	IL1RN protein inhibits the reaction [CSF2 protein results in decreased susceptibility to Scopolamine Hydrobromide]	8877002
D012643	Selenium	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL1RN mRNA	21481475
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of IL1RN mRNA"	24160326
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased secretion of IL1RN protein"	23017228
D017632	Asbestos, Serpentine	"IL1RN protein inhibits the reaction [[Asbestos, Serpentine results in increased secretion of IL1B protein] which results in increased secretion of IL6 protein]"	23017228
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of IL1RN mRNA	19428942
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of IL1RN mRNA	19073995\|2322117
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of IL1RN mRNA	22431001
D012834	Silver	Silver results in decreased expression of IL1RN mRNA	26014281
D012838	Silymarin	Silymarin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN protein]	24707119
D012906	Smoke	Smoke results in decreased expression of IL1RN mRNA	21095227
C017947	sodium arsenite	sodium arsenite results in decreased expression of IL1RN mRNA	21457566
C017947	sodium arsenite	sodium arsenite results in increased expression of IL1RN mRNA	25270620\|2582526
C017947	sodium arsenite	IL1RN protein inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]	26396915
D012999	Soman	IL1RN protein affects the susceptibility to Soman	28866071
D053260	Soot	Soot results in increased expression of IL1RN mRNA	19428942
D053260	Soot	Soot results in increased expression of IL1RN mRNA	22461453
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IL1RN mRNA	21641980
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA]	15867298
D016559	Tacrolimus	Tacrolimus results in increased expression of IL1RN mRNA	23958496
C013698	tallow	tallow affects the expression of IL1RN mRNA	19680557
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of IL1RN mRNA	25461914
D013749	Tetrachlorodibenzodioxin	alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1RN mRNA]	22262711
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IL1RN mRNA	19619570
D013749	Tetrachlorodibenzodioxin	IL1RN protein inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA]	20511231
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IL1RN mRNA	20106945\|2226271
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IL1RN mRNA	19619570\|2226271
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IL1RN mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IL1RN mRNA	22298810
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of IL1RN mRNA	28973375
D013755	Tetradecanoylphorbol Acetate	NFKBIA protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1RN protein]	10072544
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of IL1RN protein	10072544
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL1RN mRNA	25613284
D013792	Thalidomide	Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]	16510725
D013853	Thioacetamide	Thioacetamide results in decreased expression of IL1RN mRNA	23411599
C009495	titanium dioxide	titanium dioxide affects the expression of IL1RN mRNA	19695317
C009495	titanium dioxide	titanium dioxide results in increased expression of IL1RN mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of IL1RN mRNA	20133372
C082097	tocotrienol, delta	"tocotrienol, delta promotes the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]"	22185406
C082097	tocotrienol, delta	"tocotrienol, delta results in increased expression of IL1RN mRNA"	22185406
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of IL1RN mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of IL1RN mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of IL1RN mRNA	23830798
D014241	Trichloroethylene	Trichloroethylene results in increased expression of IL1RN mRNA	25549359
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of IL1RN mRNA	19042947
C046488	trimethyltin	trimethyltin results in increased expression of IL1RN mRNA	21435392
D014302	Trinitrobenzenesulfonic Acid	Alendronate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA]	17375077
D014302	Trinitrobenzenesulfonic Acid	kappa-casein glycomacropeptide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA]	15867298
D014302	Trinitrobenzenesulfonic Acid	Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA]	15867298
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA	15867298\|1737507
C050414	tripterine	tripterine results in decreased expression of IL1RN mRNA	17010675
D014520	Urethane	Urethane results in decreased expression of IL1RN mRNA	28818685
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of IL1RN protein	28189646
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of IL1RN gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in increased expression of IL1RN mRNA	26682919
C009687	wortmannin	wortmannin results in decreased expression of IL1RN mRNA	26847702
D015032	Zinc	Zinc results in increased expression of IL1RN protein	18842795
C016837	zinc chloride	zinc chloride results in increased expression of IL1RN mRNA	19428942
C031238	zinc sulfide	[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL1RN mRNA	21481475
D015054	Zymosan	NCF1 protein affects the reaction [Zymosan results in increased expression of IL1RN mRNA]	14507659
D015054	Zymosan	Zymosan results in increased expression of IL1RN mRNA	14507659

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005125	cytokine activity	-	IBA	21873635
GO:0005149	interleukin-1 receptor binding	-	IBA	21873635
GO:0005150	interleukin-1, type I receptor binding	-	IBA	21873635
GO:0005150	interleukin-1, type I receptor binding	-	IPI	1828071
GO:0005151	interleukin-1, type II receptor binding	-	IBA	21873635
GO:0005151	interleukin-1, type II receptor binding	-	IPI	1830582
GO:0005152	interleukin-1 receptor antagonist activity	-	IDA	2139180
GO:0005152	interleukin-1 receptor antagonist activity	-	TAS	7629520
GO:0005515	protein binding	-	IPI	21044950
GO:0045352	interleukin-1 type I receptor antagonist activity	-	IBA	21873635
GO:0045352	interleukin-1 type I receptor antagonist activity	-	IDA	1828071
GO:0045353	interleukin-1 type II receptor antagonist activity	-	IBA	21873635
GO:0045353	interleukin-1 type II receptor antagonist activity	-	IDA	1830582

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001660	fever generation	-	IBA	21873635
GO:0002437	inflammatory response to antigenic stimulus	-	IBA	21873635
GO:0002439	chronic inflammatory response to antigenic stimulus	-	IBA	21873635
GO:0006629	lipid metabolic process	-	IBA	21873635
GO:0006629	lipid metabolic process	-	IEA	-
GO:0006955	immune response	-	NAS	7629520
GO:0007565	female pregnancy	-	IBA	21873635
GO:0007613	memory	-	IBA	21873635
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0014050	negative regulation of glutamate secretion	-	IBA	21873635
GO:0014823	response to activity	-	IBA	21873635
GO:0019221	cytokine-mediated signaling pathway	-	IBA	21873635
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0019233	sensory perception of pain	-	IBA	21873635
GO:0019752	carboxylic acid metabolic process	-	IBA	21873635
GO:0030073	insulin secretion	-	IBA	21873635
GO:0030073	insulin secretion	-	IEA	-
GO:0030336	negative regulation of cell migration	-	IBA	21873635
GO:0030593	neutrophil chemotaxis	-	IBA	21873635
GO:0032755	positive regulation of interleukin-6 production	-	IBA	21873635
GO:0034115	negative regulation of heterotypic cell-cell adhesion	-	IBA	21873635
GO:0034115	negative regulation of heterotypic cell-cell adhesion	-	IDA	2139180
GO:0042493	response to drug	-	IBA	21873635
GO:0042594	response to starvation	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IBA	21873635
GO:0043507	positive regulation of JUN kinase activity	-	IBA	21873635
GO:0045837	negative regulation of membrane potential	-	IBA	21873635
GO:0046330	positive regulation of JNK cascade	-	IBA	21873635
GO:0051384	response to glucocorticoid	-	IBA	21873635
GO:0051384	response to glucocorticoid	-	IDA	10443688
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-
GO:0070555	response to interleukin-1	-	IBA	21873635
GO:0070670	response to interleukin-4	-	IBA	21873635
GO:0071222	cellular response to lipopolysaccharide	-	IBA	21873635
GO:0071874	cellular response to norepinephrine stimulus	-	IBA	21873635
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	-	IBA	21873635
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	-	IDA	2137200 2139180

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	10443688 12483741
GO:0005622	intracellular	-	NAS	7629520
GO:0005737	cytoplasm	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21814463	Effect of gene environment interactions on lung function and cardiovascular disease in COPD. (2011)	Hackett TL	Int J Chron Obstruct Pulmon Dis
15270852	Environmental factors and not genotype influence the plasma level of interleukin-1 receptor antagonist in normal individuals. (2004 Aug)	Cullup H	Clin Exp Immunol
21269700	Role of inflammation-related gene polymorphisms in patients with central retinal vein occlusion. (2011 Jun)	Maier R	Ophthalmology
26124566	An in silico analytical study of lung cancer and smokers datasets from gene expression omnibus (GEO) for prediction of differentially expressed genes. (2015)	Hasan AN	Bioinformation
25721048	Genetic variants in TNFalpha, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. (2016)	Yucesoy B	J Immunotoxicol
29744169	Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)	Heikkinen AM	Clin Exp Dent Res
17107994	Interleukin-1R antagonist gene and pre-natal smoke exposure are associated with childhood asthma. (2007 Mar)	Ramadas RA	Eur Respir J
15797878	Interleukin-1 gene cluster polymorphisms and alcoholism in Spanish men. (2005 May-Jun)	Pastor IJ	Alcohol Alcohol
24275344	Role of familiarity versus interleukin-1 genes cluster polymorphisms in chronic periodontitis. (2014 Feb 10)	Zuccarello D	Gene
26722511	Associations of interleukin-1 gene cluster polymorphisms with C-reactive protein concentration and lung function decline in smoking-induced chronic obstructive pulmonary disease. (2015)	Wang Y	Int J Clin Exp Pathol
28915570	IL1 genes polymorphism and the risk of renal cell carcinoma in Chinese Han population. (2017 Aug 22)	Wang F	Oncotarget
11045853	Polymorphism in the interleukin-1 receptor antagonist gene is associated with alcoholism in Spanish men. (2000 Oct)	Pastor IJ	Alcohol Clin Exp Res
24776844	Associations between functional polymorphisms in the NFkappaB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. (2014 Dec)	Bank S	Pharmacogenomics J
11816697	A prospective evaluation of the interleukin-1 receptor antagonist intron 2 gene polymorphism and the risk of myocardial infarction. (2001 Nov)	Zee RY	Thromb Haemost