Gene: IL2RA

3559
CD25|IDDM10|IL2R|IMD41|TCGFR|p55
interleukin 2 receptor subunit alpha
protein-coding
10p15.1
Ensembl:ENSG00000134460 MIM:147730 Vega:OTTHUMG00000017616 UniprotKB:P01589
NG_007403.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.009e-1 (AD)  5.551e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4749926chr10:6043349 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARL110.697
FAM20A0.691
PARP150.683
FAM3B0.679
TLR10.671
DAPP10.669
NABP10.668
CSF2RB0.663
TLR70.659
TLR80.658

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf53-0.355
C9orf24-0.33
B3GALT1-0.33
HHATL-0.314
FAM171B-0.314
BGLAP-0.313
NDP-0.303
GABRG1-0.301
OMG-0.3
MOXD1-0.299

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00004Denileukin diftitoxBiotechDrug173146-27-5Approved|InvestigationalTarget
DB00041AldesleukinBiotechDrug110942-02-4ApprovedTarget
DB00074BasiliximabBiotechDrug179045-86-4Approved|InvestigationalTarget
DB00111DaclizumabBiotechDrug152923-56-3Investigational|WithdrawnTarget
ID Drug Name Action PubMed
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in increased expression of IL2RA mRNA"17070881
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of IL2RA mRNA"19162173
C0341821-naphthaleneacetic acid1-naphthaleneacetic acid results in increased expression of IL2RA20728597
C0353141-nitropropane1-nitropropane results in decreased expression of IL2RA mRNA17070881
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of IL2RA mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of IL2RA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of IL2RA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of IL2RA mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of IL2RA mRNA"17070881
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of IL2RA mRNA"25510870
C0252352,6-diaminotoluene"2,6-diaminotoluene results in decreased expression of IL2RA mRNA"17070881
C0038982-anisidine2-anisidine results in decreased expression of IL2RA mRNA28089782
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in decreased expression of IL2RA mRNA17070881
C0166172-nitropropane2-nitropropane results in increased expression of IL2RA mRNA17070881
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in decreased expression of IL2RA mRNA23945499
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in decreased expression of IL2RA protein23945499
C5239344(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester"4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester inhibits the reaction [AGT protein modified form results in increased expression of IL2RA protein]"24456201
C0286764-acetylaminofluorene4-acetylaminofluorene results in increased expression of IL2RA mRNA17070881
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of IL2RA protein"20350561
D000082AcetaminophenAcetaminophen affects the expression of IL2RA mRNA17562736
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
C430898AGN 194204AGN 194204 results in decreased expression of IL2RA mRNA16339527
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Carbon Tetrachloride results in increased expression of IL2RA mRNA]"17299060
D019804MesalamineMesalamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein]7815356
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL2RA mRNA16483693
D039741Antigens, Dermatophagoides"Antigens, Dermatophagoides results in increased expression of IL2RA protein"9344832
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL2RA mRNA24449571
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of IL2RA mRNA19962721
C121153arvanilarvanil results in decreased expression of IL2RA16239036
D001194AsbestosAsbestos results in increased expression of IL2RA protein25162674
D000069059Atorvastatin CalciumAtorvastatin Calcium affects the expression of IL2RA protein16387846
D001280AtrazineAtrazine results in decreased expression of IL2RA protein25433234
C077707B3(Fv)-PE38KDEL recombinant immunotoxinB3(Fv)-PE38KDEL recombinant immunotoxin binds to and results in decreased activity of IL2RA protein15758046
C028559bathocuproine sulfonate"bathocuproine sulfonate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
D001507BeclomethasoneBeclomethasone results in decreased expression of IL2RA protein8111605|9314351
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IL2RA protein21467743
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL2RA mRNA9465272
C006780bisphenol Abisphenol A results in increased expression of IL2RA protein29066408
C006780bisphenol Abisphenol A results in decreased expression of IL2RA mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of IL2RA mRNA10454224|9465272
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of IL2RA protein25446329
C470213capsiatecapsiate analog results in decreased localization of IL2RA protein12115659
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IL2RA mRNA17299060
D002251Carbon Tetrachloride"Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Carbon Tetrachloride results in increased expression of IL2RA mRNA]"17299060
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of IL2RA protein18340409
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2RA protein]18340409
D002392CatechinCatechin results in decreased expression of IL2RA mRNA15465739
D002990ClobetasolClobetasol results in decreased expression of IL2RA protein15086553
D003024ClozapineClozapine results in increased secretion of IL2RA protein8067274
D003042CocaineCocaine results in decreased secretion of IL2RA protein1452400
D005576ColforsinColforsin results in decreased expression of IL2RA protein1709825
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of IL2RA mRNA26033743
D003300CopperCopper deficiency results in increased expression of IL2RA mRNA26033743
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2RA protein]18340409
D016572CyclosporineCyclosporine inhibits the reaction [Ionomycin results in increased secretion of IL2RA protein]8586487
D016572CyclosporineCyclosporine results in decreased expression of IL2RA protein12296857
D016572CyclosporineCyclosporine results in decreased expression of IL2RA mRNA10454224
D0150842,4-Dichlorophenoxyacetic Acid"2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2RA"20728597
D016047ZalcitabineZalcitabine results in decreased expression of IL2RA mRNA7606800
D016047ZalcitabineZalcitabine results in decreased expression of IL2RA protein7606800
D016047ZalcitabineZidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA mRNA]7606800
D016047ZalcitabineZidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA protein]7606800
D003907DexamethasoneDexamethasone results in decreased expression of IL2RA mRNA8206753
D003907DexamethasoneDexamethasone results in decreased expression of IL2RA protein8206753
D003907DexamethasoneIL2 protein inhibits the reaction [Dexamethasone results in decreased expression of IL2RA protein]8206753
D003907DexamethasoneDexamethasone results in increased expression of IL2RA mRNA21041162
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"bathocuproine sulfonate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin co-treated with IL2 protein] results in increased expression of IL2RA protein]"23134680
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA]"23134680
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]"23134680
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"tetrathiomolybdate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
D003994BucladesineBucladesine results in decreased expression of IL2RA protein1709825
D003994BucladesineBucladesine results in decreased expression of IL2RA protein25433234
D003999Dichloroacetic Acid[Dichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein26343699
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of IL2RA mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of IL2RA mRNA26033743
D002117CalcitriolCalcitriol inhibits the reaction [isopentenyl pyrophosphate results in increased expression of IL2RA protein]15879110
D002117CalcitriolCalcitriol results in decreased expression of IL2RA mRNA3093070
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of IL2RA mRNA22302311
D015118Eicosapentaenoic Acid[Eicosapentaenoic Acid co-treated with Lipopolysaccharides] results in increased expression of IL2RA mRNA22169119
D015118Eicosapentaenoic AcidEicosapentaenoic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA]22169119
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased expression of IL2RA protein"24456201
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased expression of IL2RA protein21195724
D000431EthanolEthanol results in increased expression of IL2RA mRNA15513904
D005419FlavonoidsFlavonoids results in increased expression of IL2RA mRNA15465739
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of IL2RA mRNA17070881
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of IL2RA mRNA19962721
D005839GentamicinsGentamicins results in increased expression of IL2RA mRNA22061828
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of IL2RA mRNA9465272
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde affects the expression of IL2RA mRNA22302311
D006854HydrocortisoneHydrocortisone results in decreased expression of IL2RA protein15086553
C030737indoleacetic acidindoleacetic acid results in increased expression of IL2RA20728597
D015759IonomycinCyclosporine inhibits the reaction [Ionomycin results in increased secretion of IL2RA protein]8586487
D015759Ionomycin[Dichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein26343699
D015759Ionomycin[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2RA protein8586487
D015759IonomycinIonomycin results in increased secretion of IL2RA protein8586487
D015759IonomycinSirolimus inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2RA protein]8586487
D015759IonomycinSirolimus inhibits the reaction [Ionomycin results in increased secretion of IL2RA protein]8586487
D015759Ionomycin[Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein26343699
D015759Ionomycin[Trichloroethylene co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein26343699
D015759Ionomycin"Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
D015759Ionomycin"bathocuproine sulfonate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
D015759Ionomycin"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin co-treated with IL2 protein] results in increased expression of IL2RA protein]"23134680
D015759Ionomycin"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA]"23134680
D015759Ionomycin"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]"23134680
D015759Ionomycinlactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA]22398747
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin co-treated with IL2 protein] results in increased expression of IL2RA protein23134680
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA22398747|2313468
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein23134680
D015759Ionomycin"tetrathiomolybdate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
D015759Ionomycin[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2RA protein9766631
D0150561-Methyl-3-isobutylxanthine1-Methyl-3-isobutylxanthine results in decreased expression of IL2RA protein1709825
C004809isopentenyl pyrophosphateCalcitriol inhibits the reaction [isopentenyl pyrophosphate results in increased expression of IL2RA protein]15879110
C004809isopentenyl pyrophosphateisopentenyl pyrophosphate results in increased expression of IL2RA protein15879110
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to IL2RA gene]23086925
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [POLR2A protein modified form binds to IL2RA gene]23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL2RA mRNA23086925
C067713lactacystinlactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA]22398747
D007840LatexLatex analog results in increased expression of IL2RA mRNA24768652
C008290lipophosphonoglycanlipophosphonoglycan results in increased expression of IL2RA protein10496904
D008070Lipopolysaccharides[Eicosapentaenoic Acid co-treated with Lipopolysaccharides] results in increased expression of IL2RA mRNA22169119
D008070LipopolysaccharidesEicosapentaenoic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA]22169119
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL2RA mRNA22169119
D008070Lipopolysaccharidesprocyanidin B3 promotes the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA]22169119
C068562loxoribineloxoribine results in increased expression of IL2RA mRNA8376766
D008627Mercuric ChlorideMercuric Chloride results in increased expression of IL2RA protein7867075
D008727MethotrexateMethotrexate results in decreased expression of IL2RA mRNA24449571
D009151Mustard GasMustard Gas results in increased expression of IL2RA mRNA15674844
C033772N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamideN-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [Pentoxifylline results in decreased expression of IL2RA protein]1709825
C033772N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamideN-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide results in decreased expression of IL2RA protein1709825
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of IL2RA mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IL2RA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL2RA mRNA"25554681
D009532NickelNickel affects the expression of IL2RA mRNA14575637
D009532NickelNickel results in increased expression of IL2RA mRNA24768652|2558310
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of IL2RA mRNA]14575637
C056709N,N-diacetylcystine"N,N-diacetylcystine results in decreased expression of IL2RA protein"17157857
D063086OrganothiophosphatesOrganothiophosphates metabolite results in decreased expression of and results in decreased activity of IL2RA protein20659491
C000605331OTX015OTX015 inhibits the reaction [prostratin results in increased expression of IL2RA protein]27067814
D052638Particulate MatterParticulate Matter results in decreased expression of IL2RA protein25498254
D052638Particulate MatterParticulate Matter results in increased expression of IL2RA mRNA23638009
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of IL2RA mRNA"25510870
C008776pelargonic acidpelargonic acid affects the expression of IL2RA mRNA22302311
D010431PentoxifyllineN-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [Pentoxifylline results in decreased expression of IL2RA protein]1709825
D010431PentoxifyllinePentoxifylline results in decreased expression of IL2RA mRNA1709825
D010431PentoxifyllinePentoxifylline results in decreased expression of IL2RA protein1709825
D010431PentoxifyllinePentoxifylline results in decreased secretion of IL2RA protein1709825
D010431PentoxifyllinePentoxifylline results in decreased expression of IL2RA protein25433234
D010476PerfumePerfume results in increased expression of IL2RA mRNA24768652
D015232DinoprostoneDinoprostone results in decreased expression of IL2RA2948675
D009764o-Phthalaldehydeo-Phthalaldehyde affects the expression of IL2RA mRNA22302311
C117268pimecrolimuspimecrolimus results in decreased expression of IL2RA protein12296857
D010936Plant ExtractsPlant Extracts affects the expression of IL2RA mRNA12878215
D010936Plant ExtractsPlant Extracts results in increased expression of IL2RA mRNA15465739
D010936Plant Extractssodium arsenite affects the reaction [Plant Extracts results in increased expression of IL2RA mRNA]21281968
D059808PolyphenolsPolyphenols results in increased expression of IL2RA mRNA15465739
D059808PolyphenolsPolyphenols results in decreased expression of IL2RA mRNA16293270
C479581procyanidin B3procyanidin B3 promotes the reaction [Lipopolysaccharides results in increased expression of IL2RA mRNA]22169119
D015742PropofolPropofol results in decreased secretion of IL2RA protein16119599
D015237DinoprostDinoprost results in increased expression of IL2RA mRNA11517196
C070999prostratinOTX015 inhibits the reaction [prostratin results in increased expression of IL2RA protein]27067814
C070999prostratinprostratin results in increased expression of IL2RA protein27067814
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL2RA protein]20715097
C059514resveratrolresveratrol results in decreased expression of IL2RA protein22962611
C531092Shuangling Fuzheng anticancer preparationShuangling Fuzheng anticancer preparation results in decreased expression of IL2RA protein18161930
D012834SilverSilver analog results in increased expression of IL2RA protein25172299
D019821SimvastatinSimvastatin affects the expression of IL2RA protein16387846
D019821SimvastatinSimvastatin results in decreased expression of IL2RA mRNA18453621
D020123SirolimusSirolimus inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2RA protein]8586487
D020123SirolimusSirolimus inhibits the reaction [Ionomycin results in increased secretion of IL2RA protein]8586487
D020123SirolimusSirolimus inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2RA protein]8586487
C017947sodium arsenitesodium arsenite affects the reaction [Plant Extracts results in increased expression of IL2RA mRNA]21281968
C017947sodium arsenitesodium arsenite results in decreased expression of IL2RA protein16275621
C017947sodium arsenitesodium arsenite results in increased expression of IL2RA mRNA12760830|2128196
D053260SootSoot results in increased expression of IL2RA mRNA26551751
D010042OuabainOuabain results in decreased expression of IL2RA mRNA7593202
D012460SulfasalazineSulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein]7815356
D016559TacrolimusTacrolimus results in decreased expression of IL2RA protein1701765
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IL2RA protein]20350561
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL2RA protein]20715097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL2RA protein14718643|1597263
D013755Tetradecanoylphorbol Acetate[Dichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein26343699
D013755Tetradecanoylphorbol Acetate[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2RA protein8586487
D013755Tetradecanoylphorbol AcetateMesalamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein]7815356
D013755Tetradecanoylphorbol AcetateSirolimus inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2RA protein]8586487
D013755Tetradecanoylphorbol AcetateSirolimus inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2RA protein]8586487
D013755Tetradecanoylphorbol AcetateSulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein]7815356
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of IL2RA protein12421932|1274990
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased secretion of IL2RA protein8586487
D013755Tetradecanoylphorbol Acetate[Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein26343699
D013755Tetradecanoylphorbol Acetate[Trichloroethylene co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein26343699
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL2RA mRNA16979875
D013755Tetradecanoylphorbol Acetate"Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
D013755Tetradecanoylphorbol Acetate"bathocuproine sulfonate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
D013755Tetradecanoylphorbol Acetate"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin co-treated with IL2 protein] results in increased expression of IL2RA protein]"23134680
D013755Tetradecanoylphorbol Acetate"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA]"23134680
D013755Tetradecanoylphorbol Acetate"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]"23134680
D013755Tetradecanoylphorbol Acetatelactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA]22398747
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin co-treated with IL2 protein] results in increased expression of IL2RA protein23134680
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA22398747|2313468
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein23134680
D013755Tetradecanoylphorbol Acetate"tetrathiomolybdate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
D013755Tetradecanoylphorbol Acetate[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2RA protein9766631
C020809tetrathiomolybdatetetrathiomolybdate analog results in decreased expression of IL2RA mRNA19323979
C020809tetrathiomolybdate"tetrathiomolybdate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]"23134680
D013806TheophyllineTheophylline results in decreased expression of IL2RA protein1709825
D013874ThiopentalThiopental results in decreased secretion of IL2RA protein16119599
D001371trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of IL2RA protein"9756745
D014238Trichloroacetic Acid[Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein26343699
D014241Trichloroethylene[Trichloroethylene co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein26343699
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of IL2RA mRNA]14575637
C015559trimellitic anhydridetrimellitic anhydride affects the expression of IL2RA mRNA22302311
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IL2RA mRNA19042947
D014635Valproic AcidValproic Acid results in decreased methylation of IL2RA gene29154799
D014635Valproic AcidValproic Acid affects the expression of IL2RA mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of IL2RA protein25498254
C020174WR 1065WR 1065 results in increased expression of IL2RA mRNA12007958
D015215ZidovudineZidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA mRNA]7606800
D015215ZidovudineZidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA protein]7606800
D015215ZidovudineZidovudine results in decreased expression of IL2RA mRNA7606800
D015215ZidovudineZidovudine results in decreased expression of IL2RA protein7606800
D015032ZincZinc affects the expression of IL2RA mRNA16930873
D015032ZincZinc affects the expression of IL2RA protein16930873
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL2RA mRNA16979875
D015032ZincZinc results in increased expression of IL2RA mRNA17162254

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004911interleukin-2 receptor activity-IBA21873635  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI16477002  17032757  
GO:0008144drug binding-IEA-  
GO:0019976interleukin-2 binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0002437inflammatory response to antigenic stimulus-IEA-  
GO:0002664regulation of T cell tolerance induction-IMP23416241  
GO:0006915apoptotic process-TAS9096364  
GO:0006924activation-induced cell death of T cells-IEA-  
GO:0006954inflammatory response-IBA21873635  
GO:0006955immune response-TAS9096364  
GO:0007166cell surface receptor signaling pathway-TAS2983318  
GO:0007219Notch signaling pathway-IEA-  
GO:0008283cell proliferation-TAS2983318  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0038110interleukin-2-mediated signaling pathway-TAS-  
GO:0042104positive regulation of activated T cell proliferation-IEA-  
GO:0042130negative regulation of T cell proliferation-IEA-  
GO:0045582positive regulation of T cell differentiation-IEA-  
GO:0045589regulation of regulatory T cell differentiation-TAS-  
GO:0046013regulation of T cell homeostatic proliferation-IEA-  
GO:0050687negative regulation of defense response to virus-IEA-  
GO:0050728negative regulation of inflammatory response-IEA-  
GO:0050777negative regulation of immune response-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04144Endocytosis
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392451G beta:gamma signalling through PI3KgammaTAS
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8877330RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-9020558Interleukin-2 signalingTAS
R-HSA-912526Interleukin receptor SHC signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26293465Plasma Levels of Soluble Interleukin-2 Receptor alpha: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan. (2015 Oct)Durda PArterioscler Thromb Vasc Biol
25231450Thyroid autoimmunity. (2014)Wiersinga WMEndocr Dev
26718593Epidemiology of multiple sclerosis. (2016 Jan)Leray ERev Neurol (Paris)
19968631Gene-gene and gene-environment interactions on IgE production in prenatal stage. (2010 Jun 1)Yang KDAllergy