Gene: IL3

3562
IL-3|MCGF|MULTI-CSF
interleukin 3
protein-coding
5q31.1
Ensembl:ENSG00000164399 MIM:147740 Vega:OTTHUMG00000059640 UniprotKB:P08700
NC_000005.10
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.321e-1 (AD)  2.846e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17983064chr5:131396357IL3Promoter1.819e-4Alcohol use disorders26763658
cg00771722chr5:131396253IL33.100e-12Smoking27651444
cg04704634chr5:131396204IL36.900e-10Smoking27651444
cg16545743chr5:131396250IL38.800e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC170.541
TRIM400.538
NLRP70.531
CNGA20.53
OR5H140.524
FGF190.52
ZIM30.519
MYF50.517
OTOR0.516
OR4C60.515

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WFDC3-0.223
CDH20-0.214
LIFR-0.208
ETNPPL-0.205
LRTOMT-0.204
MYBPC1-0.2
SLC14A1-0.2
GABRG1-0.195
SPATA3-0.195
GSTT1-0.194

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01025AmlexanoxSmall Molecule68302-57-8Approved|InvestigationalTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09221PolaprezincSmall Molecule107667-60-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]23001822
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]23001822
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]23001822
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IL3 mRNA12419474
D000082AcetaminophenAcetaminophen results in increased expression of IL3 mRNA26690555
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL3 protein]26138014
D000171AcroleinAcrolein results in increased expression of IL3 mRNA18515264
D000276Adjuvants, Immunologic"Adjuvants, Immunologic results in increased secretion of IL3 protein"22967010
D000305Adrenal Cortex HormonesAdrenal Cortex Hormones inhibits the reaction [IL3 protein results in increased expression of IL5RA protein]10224351
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IL3 gene27153756
C430898AGN 194204AGN 194204 results in decreased expression of IL3 mRNA16339527
D000393Air PollutantsAir Pollutants results in increased expression of IL3 protein27865893
D000393Air PollutantsGCLM gene mutant form promotes the reaction [Air Pollutants results in increased expression of IL3 protein]27865893
C021137alclometasone dipropionatealclometasone dipropionate results in decreased expression of IL3 protein11407316
D000535AluminumAluminum results in increased secretion of IL3 protein22967010
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL3 mRNA16483693
C054105ammonium trichloro(dioxoethylene-O,O'-)tellurate"ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased secretion of IL3 protein"7498364
D039741Antigens, Dermatophagoides"Antigens, Dermatophagoides results in increased expression of IL3 mRNA"11167953
D039741Antigens, Dermatophagoides"Antigens, Dermatophagoides results in increased secretion of IL3 protein"11167953
D039741Antigens, Dermatophagoides"Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL3 mRNA]"11167953
D039741Antigens, Dermatophagoides"Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of IL3 protein]"11167953
D039741Antigens, Dermatophagoides"[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL3 protein"27315767
D039741Antigens, Dermatophagoides"[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL3 protein"27315767
C102351apicidinapicidin inhibits the reaction [IL3 protein results in increased expression of CISH mRNA]25769527
C102351apicidinapicidin inhibits the reaction [IL3 protein results in increased expression of MYC mRNA]25769527
C102351apicidinapicidin inhibits the reaction [IL3 protein results in increased expression of OSM mRNA]25769527
C102351apicidinapicidin promotes the reaction [IL3 protein results in increased expression of FOS mRNA]25769527
D001397AzoxymethaneAzoxymethane results in increased expression of IL3 protein20431929
D001507Beclomethasone"Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL3 mRNA]"11167953
D001507Beclomethasone"Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of IL3 protein]"11167953
D001554BenzeneBenzene results in decreased secretion of IL3 protein27339418
D001554Benzene[Formaldehyde co-treated with Benzene] results in decreased secretion of IL3 protein27339418
D001624Betamethasone ValerateBetamethasone Valerate results in decreased expression of IL3 protein11407316
C006780bisphenol Abisphenol A results in decreased expression of IL3 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of IL3 mRNA12419474
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL3 protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IL3 protein26138014
D002110Caffeine"Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL3 mRNA]"26852703
D000001CalcimycinCyclosporine inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL3 protein]1376361
D000001CalcimycinSirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein]]1376361
D000001CalcimycinTacrolimus inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL3 protein]1376361
D000001Calcimycin[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein1376361
D000001CalcimycinCalcimycin results in increased expression of IL3 mRNA17950587
D000001CalcimycinLuteolin inhibits the reaction [Calcimycin results in increased expression of IL3 mRNA]17950587
D000001Calcimycinthunberginol B inhibits the reaction [Calcimycin results in increased expression of IL3 mRNA]17950587
D002211CapsaicinCapsaicin affects the expression of IL3 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin affects the expression of IL3 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin affects the expression of IL3 protein]22150557
D002939CiprofloxacinCiprofloxacin results in increased expression of IL3 mRNA11125792
D002939CiprofloxacinCiprofloxacin results in increased expression of IL3 protein11125792
D003436Croton OilCroton Oil results in increased expression of IL3 mRNA18652873
C038459curdlancurdlan affects the expression of IL3 mRNA19904525
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of IL3 mRNA23454832
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of IL3 protein23454832
D016572CyclosporineCyclosporine inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL3 protein]1376361
D003907DexamethasoneDexamethasone results in decreased expression of IL3 mRNA10596698
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IL3 mRNA18652873
C058064dinitrophenyl-human serum albumin conjugatedinitrophenyl-human serum albumin conjugate results in increased secretion of IL3 protein26621445
C058064dinitrophenyl-human serum albumin conjugateresveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased secretion of IL3 protein]26621445
D004391DustDust results in increased expression of IL3 protein17805423
C118739entinostatentinostat inhibits the reaction [IL3 protein results in increased expression of CISH mRNA]25769527
D005557Formaldehyde[Formaldehyde co-treated with Benzene] results in decreased secretion of IL3 protein27339418
D009240N-Formylmethionine Leucyl-PhenylalanineIL3 protein results in increased susceptibility to N-Formylmethionine Leucyl-Phenylalanine11145705
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in decreased expression of IL3 mRNA17183730
D006918HydroxyureaIL3 protein results in increased susceptibility to Hydroxyurea12548847
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL3 mRNA26387944
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IL3 protein promotes the reaction [BRD2 protein binds to CISH promoter]]25769527
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IL3 protein promotes the reaction [BRD2 protein binds to OSM promoter]]25769527
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IL3 protein results in increased expression of CISH mRNA]25769527
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IL3 protein results in increased expression of MYC mRNA]25769527
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IL3 protein results in increased expression of OSM mRNA]25769527
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [IL3 protein results in increased expression of FOS mRNA]25769527
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IL3 protein"23604539
C482199lipopolysaccharide, E coli O55-B5"neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL3 protein]"23604539
C440499lipopolysaccharide, Escherichia coli O111 B4"Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL3 mRNA]"26852703
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL3 mRNA"26852703
D008070Lipopolysaccharides[IL3 protein co-treated with CSF1 protein co-treated with CSF2 protein] promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]8193360
D008070Lipopolysaccharides[IL3 protein co-treated with CSF1 protein] promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]8193360
D008070Lipopolysaccharides[IL3 protein co-treated with CSF2 protein] promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]8193360
D047311LuteolinLuteolin inhibits the reaction [Calcimycin results in increased expression of IL3 mRNA]17950587
D008727MethotrexateMethotrexate results in decreased expression of IL3 mRNA17400583
D009151Mustard GasIL10 protein affects the reaction [Mustard Gas affects the expression of IL3 mRNA]16173061
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of IL3 mRNA19818335
C530779MyelophilMyelophil results in increased expression of IL3 mRNA18416457
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin affects the expression of IL3 protein]22150557
C002701neocuproine"neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL3 protein]"23604539
C015380neoechinulinneoechinulin results in decreased expression of IL3 mRNA19818335
D009569Nitric Oxide[IL3 protein co-treated with CSF1 protein co-treated with CSF2 protein] promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]8193360
D009569Nitric Oxide[IL3 protein co-treated with CSF1 protein] promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]8193360
D009569Nitric Oxide[IL3 protein co-treated with CSF2 protein] promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]8193360
C434926N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride"N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of IL3 protein]"18509044
C018620oleoresinsoleoresins results in decreased expression of IL3 mRNA20008804
D010081OxazoloneOxazolone results in decreased expression of IL3 mRNA11379042
D010081OxazoloneOxazolone results in increased expression of IL3 mRNA18652873
C029341oxophenylarsineoxophenylarsine inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]11544337
D010100OxygenOxygen affects the expression of IL3 mRNA9555576
D010269ParaquatParaquat results in increased expression of IL3 mRNA22938100
D052638Particulate MatterGCLM gene mutant form promotes the reaction [Particulate Matter results in increased expression of IL3 protein]27865893
D052638Particulate Matter"[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL3 protein"27315767
D052638Particulate MatterParticulate Matter results in increased expression of IL3 protein27865893
C008776pelargonic acidpelargonic acid results in increased expression of IL3 mRNA11379042
D010936Plant ExtractsPlant Extracts results in decreased expression of IL3 mRNA23557933
C059514resveratrolresveratrol results in decreased expression of IL3 mRNA23224687
C059514resveratrolresveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased secretion of IL3 protein]26621445
D020123SirolimusSirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein]]1376361
D013241SterigmatocystinSterigmatocystin results in increased expression of IL3 mRNA19818335
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin affects the expression of IL3 protein]22150557
D016559TacrolimusTacrolimus results in decreased expression of IL3 protein11407316
D016559TacrolimusSirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein]]1376361
D016559TacrolimusTacrolimus inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL3 protein]1376361
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL3 mRNA12167310
C117155tetracycline CMT-3tetracycline CMT-3 results in decreased activity of IL3 protein16039551
C117153tetracycline CMT-8tetracycline CMT-8 results in decreased activity of IL3 protein16039551
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL3 mRNA16979875
D013755Tetradecanoylphorbol AcetateCyclosporine inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL3 protein]1376361
D013755Tetradecanoylphorbol AcetateSirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein]]1376361
D013755Tetradecanoylphorbol AcetateTacrolimus inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL3 protein]1376361
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein1376361
D013806TheophyllineTheophylline results in decreased expression of IL3 mRNA10596698
C079056thunberginol Bthunberginol B inhibits the reaction [Calcimycin results in increased expression of IL3 mRNA]17950587
C402696TMC 120ATMC 120A results in decreased expression of IL3 mRNA19818335
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of IL3 mRNA"11379042|1865287
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of IL3 protein"16271432
D014212TretinoinTretinoin inhibits the reaction [IL3 protein results in increased expression of IL5RA protein]10224351
C012589trichostatin Atrichostatin A inhibits the reaction [IL3 protein promotes the reaction [BRD2 protein binds to CISH promoter]]25769527
C012589trichostatin Atrichostatin A inhibits the reaction [IL3 protein results in increased expression of CISH mRNA]25769527
C012589trichostatin Atrichostatin A inhibits the reaction [IL3 protein results in increased expression of MYC mRNA]25769527
C012589trichostatin Atrichostatin A inhibits the reaction [IL3 protein results in increased expression of OSM mRNA]25769527
C012589trichostatin Atrichostatin A promotes the reaction [IL3 protein results in increased expression of FOS mRNA]25769527
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IL3 mRNA19042947
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in decreased expression of IL3 mRNA17183730
D014635Valproic AcidValproic Acid inhibits the reaction [IL3 protein results in increased expression of CISH mRNA]25769527
D014635Valproic AcidValproic Acid inhibits the reaction [IL3 protein results in increased expression of MYC mRNA]25769527
D014635Valproic AcidValproic Acid inhibits the reaction [IL3 protein results in increased expression of OSM mRNA]25769527
D014635Valproic AcidValproic Acid promotes the reaction [IL3 protein results in increased expression of FOS mRNA]25769527
D001335Vehicle EmissionsGCLM gene mutant form promotes the reaction [Vehicle Emissions results in increased expression of IL3 protein]27865893
D001335Vehicle Emissions"[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL3 protein"27315767
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IL3 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of IL3 protein27865893
C009687wortmanninwortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]23001822
C009687wortmanninwortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]23001822
C009687wortmanninwortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]23001822
C009687wortmanninwortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]11544337
D015215Zidovudine[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]12084393
D015215Zidovudine[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]12084393
D015215ZidovudineIL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]7646543
D015215ZidovudineIL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]7646543
D015032ZincZinc binds to IL3 protein1530641
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL3 mRNA16979875
C016837zinc chlorideNCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL3 protein]18509044
C016837zinc chloride"N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of IL3 protein]"18509044
C016837zinc chloridePARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL3 protein]18509044
C016837zinc chloridezinc chloride results in increased expression of IL3 protein18509044

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005135interleukin-3 receptor binding-TAS2544122  
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001959regulation of cytokine-mediated signaling pathway-TAS-  
GO:0006955immune response-IEA-  
GO:0007267cell-cell signaling-TAS3497400  
GO:0007399nervous system development-TAS9736740  
GO:0008284positive regulation of cell proliferation-IDA9722506  
GO:0008284positive regulation of cell proliferation-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0035162embryonic hemopoiesis-IDA21149635  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IDA9722506  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-ISS-  
GO:0005622intracellular-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa04664Fc epsilon RI signaling pathway
hsa05310Asthma
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392451G beta:gamma signalling through PI3KgammaTAS
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939247RUNX1 regulates transcription of genes involved in interleukin signalingTAS
R-HSA-912526Interleukin receptor SHC signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22674296Interleukin genes and associations with colon and rectal cancer risk and overall survival. (2013 Feb 15)Bondurant KLInt J Cancer
28912468Cytokine-based Predictive Models to Estimate the Probability of Chronic Periodontitis: Development of Diagnostic Nomograms. (2017 Sep 14)Tomas ISci Rep
22797725Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. (2012 Jul 15)Dong JNat Genet
23953855IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: the Kyushu Okinawa maternal and child health study. (2013 Oct)Miyake YCytokine
23726808Interleukin 1B rs16944 G>A polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. (2013 Oct)Zheng LClin Biochem
15372320Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. (2004)Park BLJ Hum Genet
24684517IL3 rs40401 polymorphism and interaction with smoking in risk of asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health study. (2014 Jun)Miyake YScand J Immunol