Gene: IL4R

3566
CD124|IL-4RA|IL4RA
interleukin 4 receptor
protein-coding
16p12.1
Ensembl:ENSG00000077238 MIM:147781 Vega:OTTHUMG00000097015 UniprotKB:P24394
NG_012086.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.950e-1 (AD)  4.856e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26937798chr16:27326054IL4R5.500e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACSL50.932
CDK20.91
OSMR0.897
CHSY10.883
PXN0.881
TGM20.88
IL1R10.88
YBX30.874
TNFRSF10B0.867
SLCO4A10.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.561
NEUROD6-0.553
WNT7A-0.547
MARCH4-0.539
KCNIP3-0.539
ABCC12-0.538
CPLX3-0.533
KIT-0.527
VWC2-0.517
PRLHR-0.512

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05078AER001Small Molecule-InvestigationalTarget
DB12159DupilumabBiotechDrug1190264-60-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL4R mRNA"25614096
D000082AcetaminophenAcetaminophen results in increased expression of IL4R mRNA26690555
C099681allergovitallergovit results in decreased expression of IL4R protein12239597
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL4R mRNA24449571
D001151ArsenicArsenic affects the methylation of IL4R gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of IL4R mRNA22521957
C006632arsenic trioxidearsenic trioxide results in decreased expression of IL4R mRNA12243866
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of IL4R mRNA"25757056
C487081belinostatbelinostat results in decreased expression of IL4R mRNA27188386
D001554BenzeneBenzene results in increased expression of IL4R mRNA15929907|1916216
D001554BenzeneBenzene results in increased expression of IL4R protein14673790
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL4R mRNA21632981|2623829
D004958EstradiolEstradiol affects the expression of IL4R mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of IL4R mRNA20660070
D004958EstradiolEstradiol results in increased expression of IL4R mRNA23019147
D004958EstradiolEstradiol results in increased expression of IL4R mRNA12469912
C006780bisphenol Abisphenol A affects the expression of IL4R mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL4R mRNA20147733
D019819BudesonideBudesonide results in decreased expression of IL4R protein15679716
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of IL4R mRNA15336504
D002220CarbamazepineCarbamazepine affects the expression of IL4R mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IL4R mRNA16644059
C018021cobaltous chloridecobaltous chloride results in decreased expression of IL4R mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of IL4R mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of IL4R mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of IL4R mRNA24317228
C014347decitabinedecitabine affects the expression of IL4R mRNA17145863
D003907DexamethasoneDexamethasone results in decreased expression of IL4R mRNA25047013
D002945CisplatinCisplatin promotes the reaction [[TP73 protein binds to IL4R intron] which results in increased expression of IL4R mRNA]14678968|1467896
D002945CisplatinCisplatin results in increased expression of IL4R mRNA14678968|2759478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of IL4R mRNA12807726
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of IL4R mRNA19371625
D002117CalcitriolCalcitriol results in increased expression of IL4R mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of IL4R mRNA21592394
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of IL4R mRNA23649840
D015025ZearalenoneZearalenone results in increased expression of IL4R mRNA19371625
D005557FormaldehydeFormaldehyde results in increased expression of IL4R mRNA23649840
D019833GenisteinGenistein results in decreased expression of IL4R mRNA16705744
D019833GenisteinGenistein results in increased expression of IL4R mRNA23019147
D005839GentamicinsGentamicins results in increased expression of IL4R mRNA22061828
D017313FenretinideFenretinide results in decreased expression of IL4R mRNA16570282
D017313FenretinideFenretinide results in increased expression of IL4R mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of IL4R mRNA20044591
D000068877Imatinib MesylateImatinib Mesylate results in increased expression of IL4R mRNA21935477
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL4R mRNA23086925
D008727MethotrexateMethotrexate results in increased expression of IL4R mRNA21678067
D008775MethylprednisoloneMethylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]11997017
D008775MethylprednisoloneMethylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]11997017
D008775MethylprednisoloneMethylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein]11997017
D009151Mustard GasMustard Gas results in decreased expression of IL4R mRNA16173061
D009151Mustard GasMustard Gas results in decreased expression of IL4R mRNA18988085
D009532NickelNickel results in increased expression of IL4R mRNA24768652|2558310
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IL4R mRNA"12756304
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL4R mRNA"19013360
D052638Particulate MatterParticulate Matter results in increased expression of IL4R mRNA17450221
D010406PenicillinsIL4R gene polymorphism results in increased susceptibility to Penicillins15969687
D010862PilocarpinePilocarpine results in increased expression of IL4R mRNA17971868
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of IL4R mRNA20660070
D011794QuercetinQuercetin results in decreased expression of IL4R mRNA15309432
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of IL4R mRNA14699072
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of IL4R mRNA19244175
D012643SeleniumSelenium results in increased expression of IL4R mRNA19244175
D019821SimvastatinSimvastatin results in decreased expression of IL4R mRNA18453621
D020123Sirolimus[Sirolimus binds to FKBP1A protein] which results in decreased expression of IL4R mRNA12531798
D020123Sirolimus[Sirolimus binds to FKBP1A protein] which results in decreased expression of IL4R protein12531798
C016766sulforafansulforafan results in increased expression of IL4R mRNA26833863
D013629TamoxifenTamoxifen affects the expression of IL4R mRNA14699072
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of IL4R mRNA21592394
D013739TestosteroneTestosterone results in increased expression of IL4R mRNA21592394
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IL4R protein15922011
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IL4R mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of IL4R mRNA29024780
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of IL4R mRNA19244175
D014810Vitamin EVitamin E results in increased expression of IL4R mRNA19244175
D015032ZincZinc deficiency results in increased expression of IL4R mRNA22171008
D019287Zinc SulfateZinc Sulfate results in increased expression of IL4R mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004913interleukin-4 receptor activity-TAS2307934  
GO:0005515protein binding-IPI8266078  8816495  9392697  9651359  10219247  18243101  
23597562  
GO ID GO Term Qualifier Evidence PubMed
GO:0002532production of molecular mediator involved in inflammatory response-IEA-  
GO:0002639positive regulation of immunoglobulin production-IEA-  
GO:0006955immune response-TAS2307934  
GO:0007165signal transduction-TAS2307934  
GO:0016064immunoglobulin mediated immune response-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030728ovulation-IEA-  
GO:0035771interleukin-4-mediated signaling pathway-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0042832defense response to protozoan-IEA-  
GO:0043032positive regulation of macrophage activation-IEA-  
GO:0043306positive regulation of mast cell degranulation-IEA-  
GO:0043627response to estrogen-IEA-  
GO:0045626negative regulation of T-helper 1 cell differentiation-IEA-  
GO:0045630positive regulation of T-helper 2 cell differentiation-IEA-  
GO:0090197positive regulation of chemokine secretion-IEA-  
GO:1901741positive regulation of myoblast fusion-IEA-  
GO:1990834response to odorant-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS2307934  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21169531Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility. (2011 Mar)Spencer KLInvest Ophthalmol Vis Sci
29674199The impact of female fetal sex on preeclampsia and the maternal immune milieu. (2018 Apr)Taylor BDPregnancy Hypertens
26955776Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls. (2016 Jan)Taylor BDPregnancy Hypertens