Gene: IL5RA

3568
CD125|CDw125|HSIL5R3|IL5R
interleukin 5 receptor subunit alpha
protein-coding
3p26.2
Ensembl:ENSG00000091181 MIM:147851 Vega:OTTHUMG00000090245 UniprotKB:Q01344
NG_029547.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.743e-1 (AD)  9.126e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4K30.811
OR10A70.806
OR14J10.801
APOBEC40.8
PCAT40.797
OR2J20.792
OR1I10.785
POTEC0.782
TRIM600.776
CD1B0.769

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFTPD-0.334
SPAG8-0.302
SPDEF-0.289
HDDC3-0.285
ACY3-0.277
SMKR1-0.276
CLDND2-0.269
ZNF575-0.266
CHST8-0.262
C11orf80-0.261

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB12023BenralizumabBiotechDrug1044511-01-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4754702,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline"2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline inhibits the reaction [IL5 protein binds to IL5RA protein]"15790522
C4754702,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline"2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline binds to and results in decreased activity of IL5RA protein"15790522
C4754702,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline"2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline binds to and results in decreased activity of IL5RA protein"15182727
C4754702,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline"2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo(7,8)indolizino (2,3-b)quinoxaline inhibits the reaction [IL5 protein binds to IL5RA protein]"15182727
D000109AcetylcholineIL5RA protein affects the susceptibility to Acetylcholine10487780
D000109AcetylcholineIL5RA protein results in increased susceptibility to Acetylcholine11897983
D000109AcetylcholineIL5RA protein affects the susceptibility to Acetylcholine10848907
D000305Adrenal Cortex HormonesAdrenal Cortex Hormones inhibits the reaction [IL3 protein results in increased expression of IL5RA protein]10224351
D000305Adrenal Cortex HormonesAdrenal Cortex Hormones inhibits the reaction [IL5 protein results in increased expression of IL5RA protein]10224351
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL5RA mRNA16483693
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of IL5RA mRNA18585445
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of IL5RA mRNA18585445
C080985batimastatbatimastat results in decreased cleavage of IL5RA protein12444155
C006780bisphenol Abisphenol A results in decreased expression of IL5RA mRNA25181051
C000488cladosporincladosporin results in increased expression of IL5RA mRNA19818335
C038459curdlancurdlan affects the expression of IL5RA mRNA19904525
D003907DexamethasoneDexamethasone results in increased expression of IL5RA mRNA11758170
D003907DexamethasoneDexamethasone inhibits the reaction [IL5 protein results in decreased expression of IL5RA protein]14739603
D004041Dietary FatsDietary Fats results in decreased expression of IL5RA mRNA25016146
D004229DithiothreitolDithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]]7957178
D007545IsoproterenolIL5RA protein affects the susceptibility to Isoproterenol10487780
D009151Mustard GasMustard Gas results in increased expression of IL5RA mRNA15674843
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of IL5RA mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of IL5RA mRNA19818335
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide results in decreased cleavage of IL5RA protein12444155
C015380neoechinulinneoechinulin results in increased expression of IL5RA mRNA19818335
C490266neoechinulin Aneoechinulin A results in increased expression of IL5RA mRNA19818335
D059808PolyphenolsPolyphenols results in decreased expression of IL5RA mRNA16293270
C009166retinol acetateIL5RA protein affects the susceptibility to retinol acetate11444878
C017947sodium arsenitesodium arsenite results in increased expression of IL5RA mRNA12760830
D013241SterigmatocystinSterigmatocystin results in increased expression of IL5RA mRNA19818335
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IL5RA gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IL5RA promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL5RA mRNA11804338|2081990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL5RA protein11804338
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of IL5RA mRNA28973375
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of IL5RA mRNA8049355
D013844ThiazolesDithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]]7957178
D013844ThiazolesThiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]7957178
C402696TMC 120ATMC 120A results in decreased expression of IL5RA mRNA19818335
C402696TMC 120ATMC 120A results in increased expression of IL5RA mRNA19818335
D014212TretinoinTretinoin inhibits the reaction [IL3 protein results in increased expression of IL5RA protein]10224351
D014212TretinoinTretinoin inhibits the reaction [IL5 protein results in increased expression of IL5RA protein]10224351
D014212TretinoinTretinoin results in decreased expression of IL5RA mRNA7579340
D014212TretinoinTretinoin results in decreased expression of IL5RA protein11884474
D014212TretinoinTretinoin results in decreased expression of IL5RA protein alternative form11306982
D014212TretinoinTretinoin results in increased expression of IL5RA protein alternative form11306982
D014212TretinoinIL5RA protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein]11171635

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS-  
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004914interleukin-5 receptor activity-TAS1495999  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI1495999  9516124  
GO:0019955cytokine binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0002437inflammatory response to antigenic stimulus-IEA-  
GO:0007165signal transduction-TAS1732409  
GO:0008283cell proliferation-TAS1732409  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032674regulation of interleukin-5 production-IEA-  
GO:0038043interleukin-5-mediated signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS1495999  
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392451G beta:gamma signalling through PI3KgammaTAS
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-912526Interleukin receptor SHC signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15372320Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. (2004)Park BLJ Hum Genet
25523412IL5RA polymorphisms, smoking and eczema in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2015 Feb)Miyake YInt J Immunogenet
24332579Case-control study of rhinoconjunctivitis associated with IL5RA polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2014 Feb)Miyake YCytokine