Gene: IL6R

3570
CD126|IL-6R-1|IL-6RA|IL6Q|IL6RA|IL6RQ|gp80
interleukin 6 receptor
protein-coding
1q21.3
Ensembl:ENSG00000160712 MIM:147880 Vega:OTTHUMG00000036073 UniprotKB:P08887
NG_012087.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.240e-1 (AD)  1.358e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4240872chr1:154463719 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05756780chr1:154380705IL6R3.980e-8Alcohol consumption der day27843151
cg06980173chr1:154376344IL6R1.050e-8Alcohol consumption der day27843151
cg09257526chr1:154379696IL6R1.800e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF2170.879
CHSY10.872
LTBR0.868
PXN0.864
MSN0.864
IL1R10.862
TNFRSF10B0.86
IL4R0.856
STAT30.854
CLIC10.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.485
NEUROD6-0.477
ABCC12-0.474
LYPD8-0.465
SMIM18-0.461
MARCH4-0.46
PPEF1-0.46
DRD5-0.459
CALHM1-0.451
KCNB2-0.449

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06273TocilizumabBiotechDrug375823-41-9ApprovedTarget
DB11767SarilumabBiotechDrug1189541-98-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C46679520,21-epoxyresibufogenin-3-formate"20,21-epoxyresibufogenin-3-formate inhibits the reaction [IL6 protein binds to IL6R protein]"20599324
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of IL6R mRNA"21724226
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of IL6R mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6R mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6R mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6R mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IL6R mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6R mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6R mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6R mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of IL6R mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of IL6R mRNA21420995|2669055
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IL6R protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of IL6R gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of IL6R mRNA"23195993
D015766AlbendazoleAlbendazole results in increased expression of IL6R protein modified form20116850
C001570alexidinealexidine results in decreased expression of IL6R protein modified form20116850
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of IL6R mRNA28522335
D000841AnisomycinAnisomycin results in decreased expression of IL6R protein modified form20116850
D000968Antimycin AAntimycin A results in decreased expression of IL6R protein modified form20116850
D001151ArsenicArsenic results in increased expression of IL6R mRNA11134558
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of IL6R mRNA"25351596
D001374AzacitidineAzacitidine affects the expression of IL6R mRNA18443271
D001374Azacitidine[Azacitidine affects the expression of IL6R protein] which affects the expression of BCL2L1 protein18443271
D001374Azacitidine[Azacitidine affects the expression of IL6R protein] which affects the phosphorylation of STAT3 protein18443271
D001379AzathioprineAzathioprine results in increased expression of IL6R mRNA22623647
D001554BenzeneBenzene results in increased expression of IL6R mRNA15929907
D001558BenzethoniumBenzethonium results in decreased expression of IL6R protein modified form20116850
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of IL6R mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL6R mRNA21632981|2187194
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of IL6R mRNA24758408
C006780bisphenol Abisphenol A results in increased expression of IL6R mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of IL6R mRNA25181051
D002065BuspironeBuspirone results in increased expression of IL6R mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of IL6R mRNA26079696
D002166CamptothecinCamptothecin results in decreased expression of IL6R protein modified form20116850
D000074262Canola OilCanola Oil metabolite results in decreased expression of IL6R mRNA27363782
C005963cephaelincephaelin results in decreased expression of IL6R protein modified form20116850
D002911ChrysenesChrysenes results in decreased expression of IL6R protein modified form20116850
D019327Copper SulfateCopper Sulfate results in increased expression of IL6R mRNA19549813
C000666coralynecoralyne results in decreased expression of IL6R protein modified form20116850
D003471CuprizoneCuprizone results in increased expression of IL6R mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of IL6R mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of IL6R mRNA25562108|2798913
C004742daidzein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA27424125
C013908daidzin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA27424125
D003630DaunorubicinDaunorubicin results in decreased expression of IL6R protein modified form20116850
C014347decitabinedecitabine results in increased expression of IL6R mRNA16367923
D003868DequaliniumDequalinium results in decreased expression of IL6R protein modified form20116850
D003907DexamethasoneDexamethasone results in increased expression of IL6R mRNA1872801
D003907DexamethasoneDexamethasone results in increased expression of IL6R mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of IL6R mRNA]20032058
D016190CarboplatinIL6R protein results in decreased susceptibility to Carboplatin7834629
D002945CisplatinCisplatin results in decreased expression of IL6R mRNA27392435
D002945CisplatinIL6R protein results in decreased susceptibility to Cisplatin7834629
D004073DigitoxigeninDigitoxigenin results in decreased expression of IL6R protein modified form20116850
D004076DigoxigeninDigoxigenin results in decreased expression of IL6R protein modified form20116850
D004077DigoxinDigoxin results in decreased expression of IL6R protein modified form20116850
D004640EmetineEmetine results in decreased expression of IL6R protein modified form20116850
C118739entinostatentinostat results in increased expression of IL6R mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6R mRNA"27188386
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of IL6R mRNA12655031
D015251EpirubicinEpirubicin results in increased expression of IL6R protein19060235
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of IL6R mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IL6R protein11907703
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IL6R mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of IL6R mRNA26865667
D005273FenbendazoleFenbendazole results in increased expression of IL6R protein modified form20116850
D005485FlutamideFlutamide results in decreased expression of IL6R mRNA24136188
C039281furanfuran results in increased expression of IL6R mRNA26194646
D019833Genistein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA27424125
D019833GenisteinGenistein results in increased expression of IL6R mRNA22228119|2686566
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of IL6R mRNA21782745
C040641genistin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA27424125
C004312glycidolglycidol results in increased expression of IL6R mRNA24915197
C086566glycitein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA27424125
C433283glycitin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA27424125
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL6R mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[IL6 protein co-treated with IL6R protein] promotes the reaction [STAT3 protein modified form results in increased expression of SOCS3 mRNA]]24657799
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of IL6R mRNA26752646
C410337K 7174K 7174 results in increased expression of IL6R mRNA24086573
C018548lanatoside Clanatoside C results in decreased expression of IL6R protein modified form20116850
C045463leflunomideleflunomide results in increased expression of IL6R mRNA24136188
D064704LevofloxacinLevofloxacin results in increased expression of IL6R mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL6R mRNA17321000
D008463MebendazoleMebendazole results in increased expression of IL6R protein modified form20116850
C100122meclocyclinemeclocycline results in decreased expression of IL6R protein modified form20116850
D008555MelittenMelitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of APAF1 protein]21354845
D008555MelittenMelitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of BCL2 mRNA]21354845
D008555MelittenMelitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of BCL2 protein]21354845
D008555MelittenMelitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of IL6STP1 mRNA]21354845
D008555MelittenMelitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of STAT3 mRNA]21354845
D008555MelittenMelitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased localization of and results in increased activity of RELA protein]21354845
D008555MelittenMelitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased phosphorylation of and results in increased activity of STAT3 protein]21354845
D008555MelittenMelitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of and results in increased activity of CASP3 protein]21354845
D008555MelittenMelitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP3 mRNA]21354845
D008555MelittenMelitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP9 mRNA]21354845
D008555MelittenMelitten promotes the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of CASP9 protein]21354845
C042720mercuric bromidemercuric bromide results in increased expression of IL6R mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6R mRNA"27188386
D008717Methionine SulfoximineMethionine Sulfoximine results in decreased expression of IL6R protein modified form20116850
D008727MethotrexateMethotrexate results in increased expression of IL6R mRNA24136188
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of IL6R mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of IL6R mRNA21782745
C005106methylbenzethonium chloridemethylbenzethonium chloride results in decreased expression of IL6R protein modified form20116850
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IL6R mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IL6R mRNA23649840
D008911MinocyclineMinocycline results in decreased expression of IL6R protein modified form20116850
D016685MitomycinIL6R protein results in decreased susceptibility to Mitomycin7834629
D009151Mustard GasMustard Gas results in decreased expression of IL6R mRNA16173061
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL6R protein"26589480
D009532NickelNickel results in decreased expression of IL6R mRNA23195993
D009532NickelNickel results in increased expression of IL6R mRNA24768652|2558310
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6R mRNA"19013360
D015739NocodazoleNocodazole results in increased expression of IL6R protein modified form20116850
C464660obeticholic acidobeticholic acid results in decreased expression of IL6R mRNA27939613
C016340o,p'-DDT"o,p'-DDT results in increased expression of IL6R mRNA"22609851
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of IL6R mRNA25729387
D010118OxytetracyclineOxytetracycline results in decreased expression of IL6R protein modified form20116850
C005413palmatinepalmatine results in decreased expression of IL6R protein modified form20116850
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of IL6R mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of IL6R mRNA23948077
C046012pentanalpentanal results in decreased expression of IL6R mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6R mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of IL6R mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of IL6R mRNA17321000
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of IL6R mRNA]17321000
D010938Plant OilsPlant Oils results in increased expression of IL6R mRNA23370395
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of IL6R mRNA24583197
D011374ProgesteroneProgesterone results in increased expression of IL6R mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of IL6R mRNA21768398
D011374ProgesteroneProgesterone results in decreased expression of IL6R protein21768398
D011419PropidiumPropidium results in decreased expression of IL6R protein modified form20116850
D011442ProscillaridinProscillaridin results in decreased expression of IL6R protein modified form20116850
D011691PuromycinPuromycin results in decreased expression of IL6R protein modified form20116850
C024631pyrviniumpyrvinium results in decreased expression of IL6R protein modified form20116850
D012822Silicon DioxideSilicon Dioxide results in increased expression of IL6R mRNA25351596
D013328StrophanthinsStrophanthins results in decreased expression of IL6R protein modified form20116850
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of IL6R mRNA]20032058
C004648testosterone enanthatetestosterone enanthate affects the expression of IL6R mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL6R mRNA21215274|2172422
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL6R mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL6R mRNA25613284
D013806TheophyllineTheophylline results in decreased expression of IL6R mRNA18951874
D013853ThioacetamideThioacetamide results in decreased expression of IL6R mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of IL6R gene26756918
C479163tofacitinibtofacitinib inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased phosphorylation of STAT3 protein]21548952
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of IL6R mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of IL6R mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of IL6R mRNA24935251
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of IL6R mRNA29024780
D014635Valproic AcidValproic Acid results in increased expression of IL6R mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in decreased expression of IL6R mRNA23665938
C025643vinclozolinvinclozolin results in decreased expression of IL6R mRNA23034163
D025101Vitamin B 6Vitamin B 6 affects the expression of IL6R protein16690736
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of IL6R mRNA18593933
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL6R mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004897ciliary neurotrophic factor receptor activitycontributes_toIMP12643274  
GO:0004915interleukin-6 receptor activitycontributes_toIDA2261637  
GO:0005138interleukin-6 receptor bindingcontributes_toIPI12829785  
GO:0005143interleukin-12 receptor binding-IBA21873635  
GO:0005515protein binding-IPI11238858  12829785  16034137  18775332  
GO:0008083growth factor activity-IBA21873635  
GO:0019899enzyme binding-IPI12748171  
GO:0019955cytokine binding-IBA21873635  
GO:0019981interleukin-6 binding-IBA21873635  
GO:0019981interleukin-6 binding-IPI12829785  
GO:0042164interleukin-12 alpha subunit binding-IBA21873635  
GO:0042803protein homodimerization activity-IPI12633863  
GO:0045519interleukin-23 receptor binding-IBA21873635  
GO:0070119ciliary neurotrophic factor binding-IPI12643274  
GO ID GO Term Qualifier Evidence PubMed
GO:0002384hepatic immune response-TAS12832423  
GO:0002548monocyte chemotaxis-IC10510402  
GO:0002690positive regulation of leukocyte chemotaxis-TAS15100312  
GO:0002827positive regulation of T-helper 1 type immune response-IBA21873635  
GO:0006953acute-phase response-TAS12832423  
GO:0008284positive regulation of cell proliferation-IDA2261637  
GO:0008284positive regulation of cell proliferation-IMP18719127  
GO:0010536positive regulation of activation of Janus kinase activity-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-IDA2261637  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0031018endocrine pancreas development-IC18719127  
GO:0031018endocrine pancreas development-IMP18719127  
GO:0032722positive regulation of chemokine production-IDA10510402  
GO:0032729positive regulation of interferon-gamma production-IBA21873635  
GO:0032755positive regulation of interleukin-6 production-IDA10510402  
GO:0032816positive regulation of natural killer cell activation-IBA21873635  
GO:0034097response to cytokine-IDA2261637  
GO:0042104positive regulation of activated T cell proliferation-IBA21873635  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IBA21873635  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IMP12643274  
GO:0045669positive regulation of osteoblast differentiation-TAS12372336  
GO:0048661positive regulation of smooth muscle cell proliferation-IDA10510402  
GO:0050671positive regulation of lymphocyte proliferation-IBA21873635  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA11884403  
GO:0050829defense response to Gram-negative bacterium-TAS16034137  
GO:0051135positive regulation of NK T cell activation-IBA21873635  
GO:0070102interleukin-6-mediated signaling pathwayCONTRIBUTES_TOIBA21873635  
GO:0070102interleukin-6-mediated signaling pathway-IMP12643274  
GO:0070102interleukin-6-mediated signaling pathway-TAS-  
GO:0070120ciliary neurotrophic factor-mediated signaling pathway-IMP12643274  
GO:0097191extrinsic apoptotic signaling pathway-TAS15100312  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA12748171  
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005896interleukin-6 receptor complex-IBA21873635  
GO:0005896interleukin-6 receptor complex-IDA2261637  12829785  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009986cell surface-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-IDA16034137  
GO:0043235receptor complex-IBA21873635  
GO:0043514interleukin-12 complex-IBA21873635  
GO:0070110ciliary neurotrophic factor receptor complex-IDA12643274  
GO:0070743interleukin-23 complex-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-1059683Interleukin-6 signalingTAS
R-HSA-110056MAPK3 (ERK1) activationTAS
R-HSA-112409RAF-independent MAPK1/3 activationTAS
R-HSA-112411MAPK1 (ERK2) activationTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6783589Interleukin-6 family signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26756918Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population. (2016 Jul)Zhu XEnviron Health Perspect
24559495The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women. (2014 Feb 22)Dogan MVBMC Genomics
26846412Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study. (2016 Feb 5)Ramos BRBMC Pregnancy Childbirth
20887155Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. (2010 Dec)Edmiston JSBiomarkers
25524550Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in Japanese individuals. (2015 Apr)Horibe HNephrology (Carlton)
28348007Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome. (2017 May 26)Li JCirc Res
16899024Interleukin-6 receptor gene polymorphisms and periodontitis in a non-smoking Japanese population. (2006 Oct)Galicia JCJ Clin Periodontol
25505548Early life environmental predictors of asthma age-of-onset. (2014 Nov)Ferry ORImmun Inflamm Dis
22674296Interleukin genes and associations with colon and rectal cancer risk and overall survival. (2013 Feb 15)Bondurant KLInt J Cancer
22421339Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. (2012 Mar 31)Sarwar NLancet
17903307Framingham Heart Study genome-wide association: results for pulmonary function measures. (2007 Sep 19)Wilk JBBMC Med Genet