Gene: IL7

3574
IL-7
interleukin 7
protein-coding
8q21.13
Ensembl:ENSG00000104432 MIM:146660 Vega:OTTHUMG00000164620 UniprotKB:P13232
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
2.605e-1 (AD)  4.607e-1 (ND)   (Frontal_Cortex)
2.091e-1 (AD)  9.874e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25062539chr8:79718482IL71.000e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBD0.686
CXorf380.667
CD2740.64
SLC30A70.634
STAT10.631
SEC24A0.625
CD800.619
SRFBP10.614
KRT750.612
L3HYPDH0.611

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HIGD1B-0.302
ARSE-0.268
FAM166B-0.256
ARSF-0.25
OLIG1-0.244
TEX29-0.244
SNX22-0.233
TMEM253-0.223
ADRA2C-0.223
PTGDR2-0.221

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IL7 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IL7 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IL7 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IL7 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IL7 mRNA"25510870
C0127962-butenal2-butenal results in increased expression of IL7 mRNA20471460
C0299552-nitrotoluene2-nitrotoluene results in increased expression of IL7 mRNA15612046
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IL7 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of IL7 gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of IL7 mRNA15953861
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL7 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL7 mRNA24449571
D001151ArsenicArsenic results in decreased expression of IL7 protein19167470
D001379AzathioprineAzathioprine results in decreased expression of IL7 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IL7 mRNA20064835|2010694
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of IL7 mRNA]22228805
C006780bisphenol Abisphenol A results in increased expression of IL7 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of IL7 mRNA21297351
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IL7 mRNA25993096
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of IL7 mRNA]16221973
D002211CapsaicinCapsaicin results in decreased expression of IL7 mRNA16278290
C000593591coagulin-Lcoagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL7 protein]27568862
D019327Copper SulfateCopper Sulfate results in decreased expression of IL7 mRNA19549813
D003436Croton OilCroton Oil results in decreased expression of IL7 mRNA18242016
D016572CyclosporineCyclosporine results in decreased expression of IL7 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of IL7 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased expression of IL7 protein24971338
D003703DemecolcineDemecolcine results in increased expression of IL7 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in decreased expression of IL7 mRNA22968694
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL7 protein]27568862
D003907DexamethasoneDexamethasone results in increased expression of IL7 mRNA21041162
D002945CisplatinCisplatin results in increased expression of IL7 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with vinorelbine] results in increased expression of IL7 protein21544650
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of IL7 mRNA18242016
D004317Doxorubicin[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of IL7 mRNA27181935
D004391DustDust results in increased expression of IL7 protein17805423
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IL7 mRNA22079256
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of IL7 exon17151827|1717909
D005472FluorouracilFluorouracil affects the expression of IL7 mRNA18344199
D062610Fungal Polysaccharides[Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of IL7 mRNA27181935
C039281furanfuran results in decreased expression of IL7 mRNA25539665
C579046GDC-0152GDC-0152 results in increased expression of IL7 protein22956632
D005839GentamicinsGentamicins results in increased expression of IL7 mRNA22061828
D007213IndomethacinIndomethacin results in decreased expression of IL7 mRNA16984733
D007545IsoproterenolIsoproterenol results in increased expression of IL7 protein24286936
D007545IsoproterenolIsoproterenol results in increased expression of IL7 protein24286936
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL7 mRNA23872705
D007840LatexLatex analog results in increased expression of IL7 mRNA24768652
C008261lead acetatelead acetate results in increased expression of IL7 mRNA20542052|2260969
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IL7 protein"23604539
D008070Lipopolysaccharidescoagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL7 protein]27568862
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL7 protein]27568862
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL7 protein27568862
D008345ManganeseManganese results in increased expression of IL7 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of IL7 mRNA17175027
D008558MelphalanMelphalan results in decreased expression of IL7 mRNA22363485
C036868methyl carbamatemethyl carbamate results in increased expression of IL7 mRNA15612046
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IL7 mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of IL7 mRNA22108045
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [IL7 protein results in increased phosphorylation of JAK1 protein]26921788
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [IL7 protein results in increased phosphorylation of JAK3 protein]26921788
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [IL7 protein results in increased phosphorylation of STAT5A protein]26518055
D009532NickelNickel results in increased expression of IL7 mRNA24768652
D009538NicotineNicotine results in increased expression of and results in increased secretion of IL7 protein18082304
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of IL7 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of IL7 mRNA25729387
D010081OxazoloneOxazolone results in decreased expression of IL7 mRNA18242016
D010081OxazoloneOxazolone results in increased expression of IL7 mRNA11379042
D010100OxygenOxygen deficiency results in increased expression of IL7 mRNA17175027
D010110OxymetholoneOxymetholone results in increased expression of IL7 mRNA15953861
D010269ParaquatParaquat results in increased expression of IL7 mRNA18198484
D052638Particulate MatterParticulate Matter analog results in increased secretion of IL7 protein20026096
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of IL7 mRNA"25510870
C008776pelargonic acidpelargonic acid results in increased expression of IL7 mRNA11379042
D010476PerfumePerfume results in decreased expression of IL7 mRNA24768652
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IL7 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of IL7 mRNA21297082
D059808PolyphenolsPolyphenols results in decreased expression of IL7 mRNA16293270
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IL7 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IL7 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of IL7 mRNA21632981
C013672riddelliineriddelliine results in decreased expression of IL7 mRNA18047727
D019438RitonavirRitonavir results in decreased expression of IL726626330
D012402RotenoneRotenone results in increased secretion of IL7 protein28903492
C017947sodium arsenitesodium arsenite results in increased expression of IL7 mRNA12760830
C017947sodium arsenitesodium arsenite inhibits the reaction [IL7 protein results in increased phosphorylation of JAK3 protein]26921788
D053260SootSoot analog results in increased expression of IL7 mRNA25451823
C061133tamibarotenetamibarotene results in decreased expression of IL7 mRNA20861477
D013629TamoxifenTamoxifen results in decreased expression of IL7 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL7 mRNA12167310|2104116
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of IL7 protein24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of IL7 protein]24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IL7 protein27793746
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in decreased expression of IL7 mRNA"18242016
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of IL7 mRNA25729387
D019772TopotecanTopotecan results in increased expression of IL7 mRNA25729387
D014635Valproic AcidValproic Acid results in decreased methylation of IL7 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of IL7 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased expression of IL7 mRNA19465080
D014750VincristineVincristine results in increased expression of IL7 mRNA23649840
C030852vinorelbine[Cisplatin co-treated with vinorelbine] results in increased expression of IL7 protein21544650
D019345Zinc AcetateZinc Acetate results in increased secretion of IL7 protein21974847
C088658zoledronic acidzoledronic acid results in decreased expression of IL7 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IDA11418668  
GO:0005139interleukin-7 receptor binding-IEA-  
GO:0005515protein binding-IPI8266077  19141282  
GO:0008083growth factor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001961positive regulation of cytokine-mediated signaling pathway-IDA11418668  
GO:0002360T cell lineage commitment-IEA-  
GO:0006959humoral immune response-TAS2643102  
GO:0007267cell-cell signaling-TAS2643102  
GO:0008284positive regulation of cell proliferation-TAS2643102  
GO:0009887animal organ morphogenesis-TAS2643102  
GO:0010468regulation of gene expression-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-IDA11418668  
GO:0030890positive regulation of B cell proliferation-ISS-  
GO:0032722positive regulation of chemokine production-IDA11418668  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:0045453bone resorption-ISS-  
GO:0045582positive regulation of T cell differentiation-ISS-  
GO:0046622positive regulation of organ growth-IEA-  
GO:0048873homeostasis of number of cells within a tissue-IEA-  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA11418668  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1266695Interleukin-7 signalingIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21291536The impact of maternal HIV infection on cord blood lymphocyte subsets and cytokine profile in exposed non-infected newborns. (2011 Feb 3)Borges-Almeida EBMC Infect Dis