Gene: IL7R

3575
CD127|CDW127|IL-7R-alpha|IL7RA|ILRA
interleukin 7 receptor
protein-coding
5p13.2
Ensembl:ENSG00000168685 MIM:146661 Vega:OTTHUMG00000090791 UniprotKB:P16871
NG_009567.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.906e-1 (AD)  4.914e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD20.734
CD3E0.716
CD960.687
CD3G0.683
TBX210.68
LCK0.679
IL2RB0.676
CTSW0.675
PRF10.669
PYHIN10.668

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCNO-0.453
WIPF3-0.404
RGS14-0.387
TMEM221-0.386
DAPK1-0.376
CA7-0.375
CUX2-0.367
CARTPT-0.365
NEUROD1-0.365
CTXN3-0.363

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IL7R mRNA"25380136
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IL7R mRNA12419474
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of IL7R mRNA19191707
D000082AcetaminophenAcetaminophen results in increased expression of IL7R mRNA26690555
C016601afimoxifeneafimoxifene results in increased expression of IL7R mRNA12154049
C430898AGN 194204AGN 194204 results in decreased expression of IL7R mRNA16339527
D000447AldehydesAldehydes results in increased expression of IL7R mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL7R mRNA24449571
D001151ArsenicArsenic affects the expression of IL7R protein24675094
C015001arsenitearsenite results in decreased expression of IL7R mRNA18191166
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of IL7R mRNA"24160326
D001241AspirinAspirin results in increased expression of IL7R mRNA15928584
D016589AstemizoleAstemizole results in decreased expression of IL7R mRNA20221588
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of IL7R mRNA26377693
D001548Benzalkonium CompoundsBenzalkonium Compounds results in increased expression of IL7R mRNA20713136
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of IL7R mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL7R mRNA22228805
D004958EstradiolEstradiol affects the expression of IL7R mRNA14699072
D004958EstradiolEstradiol results in increased expression of IL7R mRNA12154049
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in decreased expression of IL7R mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of IL7R mRNA25210133
C006780bisphenol Abisphenol A results in decreased expression of IL7R mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of IL7R mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of IL7R mRNA26911702
C006780bisphenol Abisphenol A results in decreased expression of IL7R mRNA25181051
D000069286BortezomibBortezomib results in increased expression of IL7R mRNA20471514
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of IL7R mRNA25522274
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL7R mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of IL7R mRNA26079696
D002104CadmiumCadmium results in increased expression of IL7R mRNA21120746
C037123cadmium sulfatecadmium sulfate results in increased expression of IL7R mRNA12064557
C459604candoxincandoxin results in increased expression of IL7R mRNA16309724
C005563captaxcaptax results in increased expression of IL7R mRNA20713136
D002220CarbamazepineCarbamazepine affects the expression of IL7R mRNA25979313
D002737ChloropreneChloroprene results in increased expression of IL7R mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL7R mRNA20938992
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of IL7R mRNA20713136
C026305cobalt sulfatecobalt sulfate results in increased expression of IL7R mRNA20713136
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of IL7R mRNA20971185
D003471CuprizoneCuprizone results in increased expression of IL7R mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of IL7R mRNA22147139
C014347decitabinedecitabine affects the methylation of IL7R promoter17442928
C014347decitabine[decitabine affects the methylation of IL7R promoter] which affects the expression of IL7R mRNA17442928|1744292
C014347decitabinedecitabine results in decreased expression of IL7R protein19545742
D003703DemecolcineDemecolcine results in increased expression of IL7R mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of IL7R mRNA12782123
D003907DexamethasoneDexamethasone results in increased expression of IL7R mRNA21041162
D004041Dietary FatsDietary Fats results in increased expression of IL7R mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of IL7R mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of IL7R mRNA21041162
D002117CalcitriolCalcitriol results in decreased expression of IL7R mRNA16002434|2648566
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of IL7R mRNA25380136
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IL7R mRNA20713136
D004731EndotoxinsEndotoxins results in increased expression of IL7R mRNA12217210
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IL7R mRNA22079256
C004912ethylbenzeneethylbenzene results in decreased expression of IL7R mRNA20955722
D005054EugenolEugenol results in increased expression of IL7R mRNA20713136
D005492Folic Acid[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL7R mRNA22975265
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL7R mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of IL7R mRNA23649840
C007836geraniolgeraniol results in increased expression of IL7R mRNA20713136
D005938GlucocorticoidsGlucocorticoids results in decreased expression of IL7R protein15748212
D006418HemeHeme metabolite results in increased expression of IL7R mRNA19191707
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL7R mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to IL7R promoter]22904298
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL7R mRNA22904298|2312962
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL7R protein22904298
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of IL7R mRNA24231268
D007840LatexLatex analog results in increased expression of IL7R mRNA24768652
C008261lead acetatelead acetate results in increased expression of IL7R mRNA20542052|2260969
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 affects the expression of IL7R mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of IL7R mRNA12057914
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL7R mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of IL7R mRNA25339124
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL7R mRNA"25926378
D008748MethylcholanthreneMethylcholanthrene results in increased expression of IL7R mRNA25926378
D008752Methylene ChlorideMethylene Chloride results in decreased expression of IL7R mRNA20955722
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of IL7R protein26518055|2692178
D009151Mustard GasTNF protein affects the reaction [Mustard Gas affects the expression of IL7R mRNA]16173061
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IL7R mRNA"25102311
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL7R mRNA"25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IL7R mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL7R mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of IL7R mRNA25380136
D009532NickelNickel results in increased expression of IL7R mRNA24768652|2558310
C017557nickel subsulfidenickel subsulfide affects the expression of IL7R mRNA24952340
C029938nickel sulfatenickel sulfate results in increased expression of IL7R mRNA16780908|2271453
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of IL7R mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of IL7R mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of IL7R mRNA25729387
D000068437Pemetrexed[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL7R mRNA22975265
C046012pentanalpentanal results in increased expression of IL7R mRNA26079696
D010476PerfumePerfume results in increased expression of IL7R mRNA24768652
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IL7R mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IL7R mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of IL7R mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of IL7R mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of IL7R mRNA21770760
C005556propionaldehydepropionaldehyde results in increased expression of IL7R mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of IL7R mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of IL7R mRNA14699072
C059514resveratrolresveratrol results in increased expression of IL7R mRNA12154049
C078903seocalcitolseocalcitol results in decreased expression of IL7R mRNA12040012
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of IL7R mRNA"24160326
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of IL7R mRNA"16251409
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IL7R mRNA23806026
D012834SilverSilver affects the expression of IL7R mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of IL7R mRNA23922661
C017947sodium arsenitesodium arsenite affects the methylation of IL7R gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of IL7R protein26921788
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of IL7R mRNA20713136
D053260SootSoot results in increased expression of IL7R mRNA22461453|2655175
C061133tamibarotenetamibarotene results in decreased expression of IL7R mRNA20861477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL7R mRNA20159946
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL7R mRNA28213091
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL7R mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of IL7R mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of IL7R mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of IL7R mRNA25729387
D019772TopotecanTopotecan results in increased expression of IL7R mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of IL7R mRNA"19682533
C032910triadimefontriadimefon results in decreased expression of IL7R mRNA26705709
D014241TrichloroethyleneTrichloroethylene results in decreased expression of IL7R mRNA20955722
C012589trichostatin Atrichostatin A results in increased expression of IL7R mRNA26705709
C012589trichostatin Atrichostatin A results in decreased expression of IL7R protein19545742
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IL7R gene25560391
C025643vinclozolinvinclozolin results in increased expression of IL7R mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003823antigen binding-TAS9495344  
GO:0004896cytokine receptor activity-IDA11418668  
GO:0004917interleukin-7 receptor activity-TAS8266077  
GO:0005515protein binding-IPI8266077  
GO ID GO Term Qualifier Evidence PubMed
GO:0000018regulation of DNA recombination-TAS9495344  
GO:0000902cell morphogenesis-IEA-  
GO:0001915negative regulation of T cell mediated cytotoxicity-IEA-  
GO:0002377immunoglobulin production-IEA-  
GO:0006955immune response-TAS9843216  
GO:0007165signal transduction-TAS2317865  
GO:0007166cell surface receptor signaling pathway-TAS9843216  
GO:0008284positive regulation of cell proliferation-IDA11418668  
GO:0008361regulation of cell size-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0030217T cell differentiation-IEA-  
GO:0033089positive regulation of T cell differentiation in thymus-IEA-  
GO:0038111interleukin-7-mediated signaling pathway-TAS-  
GO:0042100B cell proliferation-IEA-  
GO:0048535lymph node development-IEA-  
GO:0048872homeostasis of number of cells-IEA-  
GO:0061024membrane organization-TAS-  
GO:0070233negative regulation of T cell apoptotic process-IEA-  
GO:1904894positive regulation of STAT cascade-IDA11418668  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030665clathrin-coated vesicle membrane-TAS-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1266695Interleukin-7 signalingIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19505916Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. (2009 Jun)Van Dyke ALCancer Epidemiol Biomarkers Prev