Gene info: ID 3577

Gene: CXCR1

GENE ID: 3577

Description: C-X-C motif chemokine receptor 1

Gene type: protein-coding

Location: 2q35

dbXrefs: Ensembl:ENSG00000163464 MIM:146929 Vega:OTTHUMG00000133108 UniprotKB:P25024

RefSeq: NG_011814.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.040e-1 (AD) 6.279e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CXCR2	0.926
FCGR3B	0.898
KCNJ15	0.875
IL18RAP	0.854
VNN2	0.84
CST7	0.812
MMP25	0.809
FFAR2	0.799
NFE2	0.796
PROK2	0.793

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CORT	-0.562
MAGIX	-0.541
NNAT	-0.535
SVOP	-0.525
LRTM2	-0.524
BCL11A	-0.515
SLC32A1	-0.512
CDK5R2	-0.512
NEUROD6	-0.51
LRRC73	-0.509

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01009	Ketoprofen	Small Molecule	22071-15-4	Approved	Target

ID	Drug Name	Action	PubMed
C490707	2-(4-isobutylphenyl)propionylmethanesulfonamide	2-(4-isobutylphenyl)propionylmethanesulfonamide binds to and results in decreased activity of CXCR1 protein	15282370\|1565223
C490707	2-(4-isobutylphenyl)propionylmethanesulfonamide	2-(4-isobutylphenyl)propionylmethanesulfonamide binds to and results in decreased activity of CXCR1 protein	16164828
C490707	2-(4-isobutylphenyl)propionylmethanesulfonamide	2-(4-isobutylphenyl)propionylmethanesulfonamide binds to CXCR1 protein	15974585
C072876	A 771726	A 771726 results in decreased expression of CXCR1 mRNA	10076546
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CXCR1 mRNA	18316174
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CXCR1 mRNA	18316174
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of CXCR1 mRNA"	23195993
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CXCR1 mRNA	16483693
C118980	antileukinate	antileukinate results in decreased activity of CXCR1 protein	12842759
C037689	benzamide	benzamide analog binds to and results in decreased activity of CXCR1 protein	17181143
C037689	benzamide	benzamide analog binds to and results in decreased activity of CXCR1 protein	17181143
D004958	Estradiol	Estradiol affects the expression of CXCR1 mRNA	19401270
D004958	Estradiol	Estradiol affects the expression of CXCR1 protein	19401270
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CXCR1 protein	16517565
D004958	Estradiol	Estradiol results in decreased expression of CXCR1 protein	16517565
C452139	BIRB 796	BIRB 796 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR1 protein]	14997032
C006780	bisphenol A	bisphenol A results in decreased methylation of CXCR1 gene	28505145
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CXCR1 mRNA	12160620
D002118	Calcium	[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased abundance of and results in increased activity of Calcium	11298490
D002118	Calcium	CXCR1 protein affects the abundance of Calcium	12055238
D000068579	Celecoxib	Celecoxib results in decreased expression of CXCR1 mRNA	12902868
D002858	Chromium Alloys	Chromium Alloys results in decreased expression of CXCR1 protein	16563497
D003471	Cuprizone	Cuprizone results in decreased expression of CXCR1 mRNA	26577399
D003474	Curcumin	Curcumin results in increased expression of CXCR1 protein	12216086
D015638	Cytochalasin D	Cytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR1 protein]	11145710
C060209	deltorphin II, Ala(2)-	"deltorphin II, Ala(2)- results in decreased expression of CXCR1 mRNA"	18977430
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CXCR1 mRNA	22968694
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of CXCR1 mRNA	28962523
D019900	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer	"3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in decreased expression of CXCR1 mRNA"	18977430
D004041	Dietary Fats	Dietary Fats results in decreased expression of CXCR1 mRNA	25016146
D004317	Doxorubicin	Doxorubicin results in increased expression of CXCR1 mRNA	27181935
D004317	Doxorubicin	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CXCR1 mRNA]	27181935
C105294	endomorphin 2	endomorphin 2 results in decreased expression of CXCR1 mRNA	18977430
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CXCR1 mRNA	23550701
D005472	Fluorouracil	CXCR1 gene SNP affects the susceptibility to [oxaliplatin co-treated with Fluorouracil]	16098254
D062610	Fungal Polysaccharides	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CXCR1 mRNA]	27181935
C112772	ginsenoside M1	ginsenoside M1 inhibits the reaction [TNF protein results in increased expression of CXCR1 protein]	21875580
D006918	Hydroxyurea	Hydroxyurea results in increased mutagenesis of CXCR1 gene	16868089
C027185	indirubin	indirubin results in increased expression of CXCR1 protein	16115123
D007476	Ionophores	[Ionophores co-treated with Tetradecanoylphorbol Acetate] results in decreased localization of CXCR1 protein	15265017
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CXCR1 mRNA	26752646
D007660	Ketoprofen	Ketoprofen binds to CXCR1 protein	15974585
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in decreased expression of CXCR1 mRNA"	23090859
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CXCR1 mRNA	12880637\|1855795
D008070	Lipopolysaccharides	Morphine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCR1 mRNA]	18760300
D008070	Lipopolysaccharides	BIRB 796 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR1 protein]	14997032
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CXCR1 mRNA	19428942
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CXCR1 protein	10950785\|1153194
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CXCR1 mRNA	14716737
C032881	lysophosphatidic acid	lysophosphatidic acid inhibits the reaction [CXCR1 protein binds to LPAR1 protein]	16224106
C032881	lysophosphatidic acid	lysophosphatidic acid results in decreased expression of CXCR1 mRNA	16224106
C032881	lysophosphatidic acid	lysophosphatidic acid results in decreased expression of [CXCR1 protein binds to LPAR1 protein]	16224106
D008770	Methylnitrosourea	Methylnitrosourea results in increased mutagenesis of CXCR1 gene	16868089
C406082	monomethylarsonous acid	monomethylarsonous acid affects the localization of CXCR1 protein	22015448
D009020	Morphine	Morphine affects the reaction [Zymosan results in increased expression of CXCR1 mRNA]	18760300
D009020	Morphine	Morphine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCR1 mRNA]	18760300
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CXCR1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CXCR1 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of CXCR1 mRNA	23195993
C028007	nickel monoxide	nickel monoxide results in increased expression of CXCR1 mRNA	19167457
C021065	oleandrin	oleandrin results in increased expression of CXCR1 mRNA	24172227
C021065	oleandrin	oleandrin results in increased expression of CXCR1 protein	24172227
C030110	oxaliplatin	CXCR1 gene SNP affects the susceptibility to [oxaliplatin co-treated with Fluorouracil]	16098254
D010710	Phosphates	CXCR1 protein promotes the reaction [CXCL8 protein promotes the reaction [SLC20A1 protein results in increased uptake of Phosphates]]	15641067
C006253	pirinixic acid	pirinixic acid results in decreased expression of CXCR1 mRNA	19162173
C013672	riddelliine	riddelliine results in increased expression of CXCR1 mRNA	18047727
D012999	Soman	Soman results in decreased expression of CXCR1 mRNA	19281266
D053260	Soot	Soot results in decreased expression of CXCR1 mRNA	19428942
D053260	Soot	Soot results in increased expression of CXCR1 mRNA	26551751
C060506	sphingosine 1-phosphate	sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA	16224106
D019311	Staurosporine	Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of and affects the localization of CCR5 protein]	12594210
D019311	Staurosporine	Staurosporine inhibits the reaction [[CXCL8 protein binds to and results in increased activity of CXCR1 protein] which results in increased phosphorylation of CXCR4 protein]	12594210
D013261	Sterols	Sterols analog inhibits the reaction [CXCL8 protein binds to CXCR1 protein]	10843593
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CXCR1 protein	16517565
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CXCR1 protein	16517565
D013755	Tetradecanoylphorbol Acetate	[Ionophores co-treated with Tetradecanoylphorbol Acetate] results in decreased localization of CXCR1 protein	15265017
D013755	Tetradecanoylphorbol Acetate	SOD2 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCR1 mRNA]	21045076
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CXCR1 mRNA	21045076
D013792	Thalidomide	Thalidomide results in decreased expression of CXCR1 protein	16344495
C009495	titanium dioxide	titanium dioxide results in increased expression of CXCR1 mRNA	23409001
C056583	tolmetin glucuronide	tolmetin glucuronide results in increased expression of CXCR1 mRNA	26528891
D014212	Tretinoin	Tretinoin results in increased expression of CXCR1 mRNA	16322068
C005855	trimethyloxamine	trimethyloxamine promotes the reaction [CXCL8 protein binds to CXCR1 protein]	16185062
C005855	trimethyloxamine	trimethyloxamine results in increased folding of CXCR1 protein	16185062
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CXCR1 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of CXCR1 mRNA	18629315
D014810	Vitamin E	Vitamin E results in increased expression of CXCR1 mRNA	19244175
C027368	zomepirac glucuronide	zomepirac glucuronide results in increased expression of CXCR1 mRNA	26528891
D015054	Zymosan	Morphine affects the reaction [Zymosan results in increased expression of CXCR1 mRNA]	18760300
D015054	Zymosan	Zymosan results in increased expression of CXCR1 mRNA	17988736\|1876030

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004918	interleukin-8 receptor activity	-	IDA	10734056
GO:0004930	G-protein coupled receptor activity	-	TAS	8381837
GO:0004950	chemokine receptor activity	-	TAS	1840701
GO:0016493	C-C chemokine receptor activity	-	IBA	21873635
GO:0019956	chemokine binding	-	IBA	21873635
GO:0019957	C-C chemokine binding	-	IBA	21873635
GO:0019959	interleukin-8 binding	-	IPI	11564821

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002407	dendritic cell chemotaxis	-	TAS	16621978
GO:0006935	chemotaxis	-	IBA	21873635
GO:0006955	immune response	-	IBA	21873635
GO:0007166	cell surface receptor signaling pathway	-	IDA	10734056
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IBA	21873635
GO:0019722	calcium-mediated signaling	-	IBA	21873635
GO:0030593	neutrophil chemotaxis	-	IBA	21873635
GO:0031623	receptor internalization	-	IDA	10734056
GO:0038112	interleukin-8-mediated signaling pathway	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0060326	cell chemotaxis	-	IBA	21873635
GO:0070098	chemokine-mediated signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0009897	external side of plasma membrane	-	IBA	21873635
GO:0016021	integral component of membrane	-	IEA	-
GO:0030667	secretory granule membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway
hsa04144	Endocytosis
hsa05120	Epithelial cell signaling in Helicobacter pylori infection

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-380108	Chemokine receptors bind chemokines	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17573488	Overexpression of CD-11b and CXCR1 on circulating neutrophils: its possible role in COPD. (2007 Sep)	Yamagata T	Chest
22674296	Interleukin genes and associations with colon and rectal cancer risk and overall survival. (2013 Feb 15)	Bondurant KL	Int J Cancer
24946112	IL-8 gene variants are associated with lung function decline and multidimensional BODE index in COPD patients but not with disease susceptibility: a validation study. (2015 Feb)	Cordoba-Lanus E	COPD
28956832	Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival. (2017 Sep 28)	Sharafeldin N	Int J Environ Res Public Health
22561413	LPS challenge in healthy subjects: an investigation of neutrophil chemotaxis mechanisms involving CXCR1 and CXCR2. (2012 Jul)	Aul R	Int Immunopharmacol
21257786	Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease. (2011 May 1)	Sapey E	Am J Respir Crit Care Med
15155777	Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2. (2004 Aug)	Traves SL	J Leukoc Biol