Gene: CXCR2

3579
CD182|CDw128b|CMKAR2|IL8R2|IL8RA|IL8RB
C-X-C motif chemokine receptor 2
protein-coding
2q35
Ensembl:ENSG00000180871 MIM:146928 Vega:OTTHUMG00000133107 UniprotKB:P25025
NG_052975.1
PubMed
0   ANCO-SNPs
OD|ND
13   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.191e-1 (AD)  4.957e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCR10.926
FCGR3B0.89
KCNJ150.854
VNN20.832
IL18RAP0.81
FFAR20.801
PROK20.792
MMP250.761
NFE20.759
MGAM0.747

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SVOP-0.569
CORT-0.568
LRTM2-0.563
BCL11A-0.557
NNAT-0.557
MAGIX-0.555
LRRC73-0.554
ATOH7-0.543
CDK5R2-0.542
KCNK4-0.541

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5495001-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea results in decreased activity of CXCR2 protein27678262
C0326681-nitropyrene1-nitropyrene results in decreased expression of CXCR2 mRNA19428942
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CXCR2 mRNA"19114083
C4907072-(4-isobutylphenyl)propionylmethanesulfonamide2-(4-isobutylphenyl)propionylmethanesulfonamide binds to and results in decreased activity of CXCR2 protein15652230
C4907072-(4-isobutylphenyl)propionylmethanesulfonamide2-(4-isobutylphenyl)propionylmethanesulfonamide results in decreased activity of CXCR2 protein15302676
C4907072-(4-isobutylphenyl)propionylmethanesulfonamide2-(4-isobutylphenyl)propionylmethanesulfonamide binds to and results in decreased activity of CXCR2 protein15282370|1616482
C4907072-(4-isobutylphenyl)propionylmethanesulfonamide2-(4-isobutylphenyl)propionylmethanesulfonamide results in decreased activity of CXCR2 protein15840022|1713895
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [CXCL8 protein results in increased activity of CXCR2 protein]12975484
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CXCR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CXCR2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CXCR2 mRNA17562736
D000082Acetaminophen[Acetaminophen results in increased expression of CXCL10 protein] which results in increased expression of CXCR2 protein11739529
D000082AcetaminophenCXCR2 protein affects the reaction [Acetaminophen results in increased expression of HMOX1 mRNA]16552707
D000082AcetaminophenCXCR2 protein affects the reaction [Acetaminophen results in increased expression of NOS2 mRNA]16552707
D000082AcetaminophenCXCR2 protein affects the susceptibility to Acetaminophen16552707
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CXCR2 mRNA18316174
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CXCR2 mRNA18316174|2163298
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of CXCR2 mRNA"23195993
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of CXCR2 mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CXCR2 mRNA16483693
C118980antileukinateantileukinate results in decreased activity of CXCR2 protein15123771
C118980antileukinateantileukinate results in decreased activity of CXCR2 protein12842759
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CXCR2 mRNA24449571
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of CXCR2 mRNA18585445
C006632arsenic trioxidearsenic trioxide results in increased expression of CXCR2 mRNA15761015
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of CXCR2 mRNA18585445
C037689benzamidebenzamide analog binds to and results in decreased activity of CXCR2 protein17181143
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CXCR2 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of CXCR2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CXCR2 mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CXCR2 mRNA21632981
D004958EstradiolEstradiol affects the expression of CXCR2 mRNA19401270
D004958EstradiolEstradiol affects the expression of CXCR2 protein19401270
D004958Estradiol"Estradiol inhibits the reaction [Cholesterol, Dietary results in increased expression of CXCR2 mRNA]"12852833
D004958Estradiol"Estradiol inhibits the reaction [Cholesterol, Dietary results in increased expression of CXCR2 protein]"12852833
C452139BIRB 796BIRB 796 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein]14997032
C006780bisphenol Abisphenol A results in decreased expression of CXCR2 mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of CXCR2 mRNA19818335
D002118Calcium[CXCL2 protein modified form binds to and results in increased activity of CXCR2 protein] which results in increased uptake of Calcium25833952
D002118Calcium[CXCL5 protein modified form binds to and results in increased activity of CXCR2 protein] which results in increased uptake of Calcium25833952
D002118Calcium[CXCL8 protein binds to and results in increased activity of CXCR2 protein] which results in increased abundance of and results in increased activity of Calcium11298490
D002118CalciumCXCR2 protein affects the transport of Calcium15618463
D002118CalciumExcitatory Amino Acid Agonists inhibits the reaction [CXCR2 protein affects the localization of Calcium]15914698
D002224CarbanilidesCarbanilides analog binds to and results in decreased activity of CXCR2 protein16182534
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CXCR2 mRNA27339419
D000068579CelecoxibCelecoxib results in decreased expression of CXCR2 mRNA12902868
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CXCR2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of CXCR2 mRNA26272509
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of CXCR2 mRNA"12852833
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of CXCR2 protein"12852833
D002791Cholesterol, Dietary"Estradiol inhibits the reaction [Cholesterol, Dietary results in increased expression of CXCR2 mRNA]"12852833
D002791Cholesterol, Dietary"Estradiol inhibits the reaction [Cholesterol, Dietary results in increased expression of CXCR2 protein]"12852833
D002858Chromium AlloysChromium Alloys results in increased expression of CXCR2 protein16563497
C000488cladosporincladosporin results in decreased expression of CXCR2 mRNA19818335
C000488cladosporincladosporin results in increased expression of CXCR2 mRNA19818335
D003300CopperCopper deficiency results in increased expression of CXCR2 mRNA26033743
D003436Croton OilCroton Oil results in increased expression of CXCR2 mRNA19647056
D003474CurcuminCurcumin results in increased expression of CXCR2 protein12216086
D015638Cytochalasin DCytochalasin D promotes the reaction [CXCL8 protein results in decreased expression of CXCR2 protein]11145710
C060209deltorphin II, Ala(2)-"deltorphin II, Ala(2)- results in decreased expression of CXCR2 mRNA"18977430
C007262deoxynivalenoldeoxynivalenol results in increased expression of CXCR2 mRNA22968694
D064791Desoxycorticosterone AcetateCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA]27678262
D064791Desoxycorticosterone AcetateCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA]27678262
D064791Desoxycorticosterone AcetateCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA]27678262
D064791Desoxycorticosterone AcetateCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL1B mRNA]27678262
D064791Desoxycorticosterone AcetateCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL6 mRNA]27678262
D064791Desoxycorticosterone AcetateCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA]27678262
D064791Desoxycorticosterone AcetateCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX4 mRNA]27678262
D064791Desoxycorticosterone AcetateCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of TNF mRNA]27678262
D064791Desoxycorticosterone AcetateCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of VCAM1 mRNA]27678262
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CXCR2 mRNA20426967
D002945CisplatinCisplatin results in increased expression of CXCR2 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of CXCR2 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of CXCR2 mRNA26033743
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CXCR2 mRNA19647056
C046855epostaneepostane promotes the reaction [Dinoprost results in increased expression of CXCR2 mRNA]21505051
C004912ethylbenzeneethylbenzene results in increased expression of CXCR2 mRNA20955722
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CXCR2 mRNA23649840
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists affects the localization of CXCR2 protein15914698
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists inhibits the reaction [CXCR2 protein affects the localization of Calcium]15914698
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists results in increased phosphorylation of CXCR2 protein15914698
C020748ferrous sulfateferrous sulfate results in decreased expression of CXCR2 mRNA19428942
D005557FormaldehydeFormaldehyde results in increased expression of CXCR2 mRNA23649840
C039281furanfuran results in decreased expression of CXCR2 mRNA25539665
D019812Heparan Sulfate ProteoglycansHeparan Sulfate Proteoglycans promotes the reaction [CXCL1 protein binds to CXCR2 protein]12549928
D007476Ionophores[Ionophores co-treated with Tetradecanoylphorbol Acetate] results in decreased localization of CXCR2 protein15265017
D007545IsoproterenolIsoproterenol results in increased activity of CXCR2 protein15477226
C050016lipoarabinomannanlipoarabinomannan results in decreased expression of CXCR2 protein10950785
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of CXCR2 mRNA"23090859
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CXCR2 mRNA12880637
D008070LipopolysaccharidesBIRB 796 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein]14997032
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CXCR2 mRNA26111115
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CXCR2 protein10950785|1153194
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CXCR2 protein26111115
D008070LipopolysaccharidesSB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein]10950785
C009900lipoteichoic acidlipoteichoic acid results in decreased expression of CXCR2 protein10950785
D008466MechlorethamineCXCR2 protein affects the susceptibility to Mechlorethamine12753603
D016210Methacholine ChlorideOzone promotes the reaction [CXCR2 protein affects the susceptibility to Methacholine Chloride]15361358
D008727MethotrexateMethotrexate results in decreased expression of CXCR2 mRNA17400583
D008752Methylene ChlorideMethylene Chloride results in increased expression of CXCR2 mRNA20955722
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CXCR2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CXCR2 mRNA"20188158
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of CXCR2 mRNA29162477
C406082monomethylarsonous acidmonomethylarsonous acid affects the localization of CXCR2 protein22015448
D009020MorphineMorphine affects the reaction [Zymosan results in increased expression of CXCR2 mRNA]18760300
D009151Mustard GasMustard Gas results in increased expression of CXCR2 mRNA15674843
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of CXCR2 mRNA19818335
D009183MycotoxinsMycotoxins results in decreased expression of CXCR2 mRNA19818335
C469668N-(3-(aminosulfonyl)-4-chloro-2-hydroxyphenyl)-N'-(2,3-dichlorophenyl)urea"N-(3-(aminosulfonyl)-4-chloro-2-hydroxyphenyl)-N'-(2,3-dichlorophenyl)urea binds to and results in decreased activity of CXCR2 protein"12444152
C469668N-(3-(aminosulfonyl)-4-chloro-2-hydroxyphenyl)-N'-(2,3-dichlorophenyl)urea"N-(3-(aminosulfonyl)-4-chloro-2-hydroxyphenyl)-N'-(2,3-dichlorophenyl)urea inhibits the reaction [CXCL8 protein binds to and results in increased activity of CXCR2 protein]"12444152
C469668N-(3-(aminosulfonyl)-4-chloro-2-hydroxyphenyl)-N'-(2,3-dichlorophenyl)urea"N-(3-(aminosulfonyl)-4-chloro-2-hydroxyphenyl)-N'-(2,3-dichlorophenyl)urea results in decreased activity of CXCR2 protein"12444152
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of CXCR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CXCR2 mRNA"25554681|2562005
C015380neoechinulinneoechinulin results in decreased expression of CXCR2 mRNA19818335
C015380neoechinulinneoechinulin results in increased expression of CXCR2 mRNA19818335
D009532NickelNickel results in decreased expression of CXCR2 mRNA23195993
D009532NickelNickel results in increased expression of CXCR2 mRNA25583101
C037645nicotinamide N-oxidenicotinamide N-oxide analog binds to and results in decreased activity of CXCR2 protein16182534
D009538NicotineNicotine results in decreased expression of CXCR2 mRNA18247414
D009538NicotineNicotine results in increased expression of CXCR2 mRNA20457658
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CXCR2 mRNA27935865
C021065oleandrinoleandrin results in increased expression of CXCR2 mRNA24172227
C021065oleandrinoleandrin results in increased expression of CXCR2 protein24172227
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CXCR2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of CXCR2 mRNA25729387
D010126OzoneOzone promotes the reaction [CXCR2 protein affects the susceptibility to Methacholine Chloride]15361358
D010634PhenobarbitalPhenobarbital results in decreased expression of CXCR2 mRNA19270015
C004479pimagedine[pimagedine results in decreased activity of NOS2 protein] which results in increased expression of CXCR2 protein17138957
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CXCR2 mRNA23608068
D011239PrednisolonePrednisolone results in decreased expression of CXCR2 protein15804745
D015237DinoprostDinoprost results in increased expression of CXCR2 mRNA21505051
D015237Dinoprostepostane promotes the reaction [Dinoprost results in increased expression of CXCR2 mRNA]21505051
D011810QuinoxalinesQuinoxalines analog binds to and results in decreased activity of CXCR2 protein16182534
C093642SB 203580SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein]10950785
C112019SB 225002SB 225002 binds to and results in decreased activity of CXCR2 protein12628493
C112019SB 225002SB 225002 inhibits the reaction [CXCL8 protein binds to CXCR2 protein]15028780
C112019SB 225002SB 225002 results in decreased activity of CXCR2 protein15795529
C112019SB 225002SB 225002 results in decreased activity of CXCR2 protein15476666
C112019SB 225002SB 225002 binds to and results in decreased activity of CXCR2 protein15477226|2133034
C112019SB 225002SB 225002 results in decreased activity of CXCR2 protein15831558
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CXCR2 mRNA19428942
D012822Silicon DioxideSilicon Dioxide results in increased expression of CXCR2 mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in increased expression of CXCR2 mRNA21602193
D019821SimvastatinSimvastatin results in decreased expression of CXCR2 mRNA16414398
C017947sodium arsenitesodium arsenite affects the methylation of CXCR2 gene28589171
D012965Sodium ChlorideCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CD68 mRNA]27678262
D012965Sodium ChlorideCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA]27678262
D012965Sodium ChlorideCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBB mRNA]27678262
D012965Sodium ChlorideCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL1B mRNA]27678262
D012965Sodium ChlorideCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of IL6 mRNA]27678262
D012965Sodium ChlorideCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX1 mRNA]27678262
D012965Sodium ChlorideCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of NOX4 mRNA]27678262
D012965Sodium ChlorideCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of TNF mRNA]27678262
D012965Sodium ChlorideCXCR2 gene mutant form inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of VCAM1 mRNA]27678262
D053260SootSoot results in decreased expression of CXCR2 mRNA19428942
D053260SootSoot results in increased expression of CXCR2 mRNA22461453|2655175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CXCR2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Ionophores co-treated with Tetradecanoylphorbol Acetate] results in decreased localization of CXCR2 protein15265017
D013792ThalidomideThalidomide results in decreased expression of CXCR2 protein16344495
D013853ThioacetamideThioacetamide results in increased methylation of CXCR2 promoter27914986
C009495titanium dioxidetitanium dioxide results in increased expression of CXCR2 mRNA23409001|2355797
C402696TMC 120ATMC 120A results in decreased expression of CXCR2 mRNA19818335
C402696TMC 120ATMC 120A results in increased expression of CXCR2 mRNA19818335
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CXCR2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CXCR2 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of CXCR2 mRNA20955722
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CXCR2 mRNA15973123
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CXCR2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of CXCR2 mRNA18629315
C009687wortmanninwortmannin inhibits the reaction [CXCL8 protein results in increased activity of CXCR2 protein]12975484
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CXCR2 mRNA27935865
D015054ZymosanMorphine affects the reaction [Zymosan results in increased expression of CXCR2 mRNA]18760300
D015054ZymosanZymosan results in increased expression of CXCR2 mRNA17988736|1876030

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004918interleukin-8 receptor activity-IDA10820279  
GO:0004930G-protein coupled receptor activity-IDA10438939  
GO:0005515protein binding-IPI22904195  23597562  
GO:0016493C-C chemokine receptor activity-IBA21873635  
GO:0016494C-X-C chemokine receptor activity-IDA10878382  
GO:0019956chemokine binding-IBA21873635  
GO:0019957C-C chemokine binding-IBA21873635  
GO:0019959interleukin-8 binding-IPI1840701  
GO ID GO Term Qualifier Evidence PubMed
GO:0002407dendritic cell chemotaxis-TAS16621978  
GO:0002438acute inflammatory response to antigenic stimulus-IEA-  
GO:0006935chemotaxis-IBA21873635  
GO:0006935chemotaxis-IDA10725748  
GO:0006954inflammatory response-TAS9725262  
GO:0006955immune response-IBA21873635  
GO:0006968cellular defense response-IDA10725748  
GO:0007165signal transduction-TAS9079638  
GO:0007166cell surface receptor signaling pathway-IDA10734056  10878382  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IDA10438939  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0008284positive regulation of cell proliferation-IDA10438939  
GO:0010666positive regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0019722calcium-mediated signaling-IBA21873635  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0030593neutrophil chemotaxis-IDA10820279  
GO:0030901midbrain development-IEA-  
GO:0031623receptor internalization-IDA10734056  
GO:0033030negative regulation of neutrophil apoptotic process-IEA-  
GO:0038112interleukin-8-mediated signaling pathway-IDA10820279  
GO:0042119neutrophil activation-IDA10878382  
GO:0043117positive regulation of vascular permeability-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0060326cell chemotaxis-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IEA-  
GO:0072173metanephric tubule morphogenesis-IEA-  
GO:0090023positive regulation of neutrophil chemotaxis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA10878382  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS10438939  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009986cell surface-IDA10878382  
GO:0016020membrane-IDA10725748  
GO:0030667secretory granule membrane-TAS-  
GO:0042629mast cell granule-IDA9725262  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa05120Epithelial cell signaling in Helicobacter pylori infection
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17573488Overexpression of CD-11b and CXCR1 on circulating neutrophils: its possible role in COPD. (2007 Sep)Yamagata TChest
22674296Interleukin genes and associations with colon and rectal cancer risk and overall survival. (2013 Feb 15)Bondurant KLInt J Cancer
26929306Novel approaches to the management of noneosinophilic asthma. (2016 Jun)Thomson NCTher Adv Respir Dis
28790817Emerging pharmaceutical therapies for COPD. (2017)Lakshmi SPInt J Chron Obstruct Pulmon Dis
25888331A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma. (2015 Mar 27)Kavalieris LBMC Urol
20070156Association of haplotypes in the CXCR2 gene with periodontitis in a Brazilian population. (2010 Apr)Viana ACDNA Cell Biol
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