Gene: IL10RA

3587
CD210|CD210a|CDW210A|HIL-10R|IL-10R1|IL10R
interleukin 10 receptor subunit alpha
protein-coding
11q23.3
Ensembl:ENSG00000110324 MIM:146933 Vega:OTTHUMG00000166523 UniprotKB:Q13651
NG_016275.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.162e-1 (AD)  2.969e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFAM10.915
BMF0.914
WAS0.901
NCKAP1L0.899
PARVG0.897
DOCK20.897
CD370.896
CMTM70.895
TBXAS10.895
MS4A70.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WFDC1-0.349
NEUROD6-0.339
ATOH7-0.331
ASPDH-0.33
KCNIP3-0.33
CPLX3-0.328
C9orf24-0.321
MAGIX-0.321
BDH1-0.314
KRTAP5-7-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of IL10RA mRNA23792671
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of IL10RA mRNA19191707
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of IL10RA mRNA15982314
C072876A 771726A 771726 results in increased expression of IL10RA mRNA10076546
C072876A 771726A 771726 results in increased expression of IL10RA protein10076546
D000082AcetaminophenAcetaminophen results in increased expression of IL10RA mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of IL10RA mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of IL10RA mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IL10RA mRNA]17585979
C103303alitretinoinalitretinoin results in decreased expression of IL10RA mRNA15982314
C103303alitretinoinalitretinoin results in decreased expression of IL10RA mRNA28689802
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of IL10RA mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of IL10RA mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL10RA mRNA16483693
D000967Antimony Sodium GluconateIFNG protein affects the reaction [IL10RA protein affects the susceptibility to Antimony Sodium Gluconate]12870129
D000967Antimony Sodium GluconateIL10RA protein affects the susceptibility to Antimony Sodium Gluconate12379707|1287012
D001151ArsenicArsenic affects the methylation of IL10RA gene25304211
D001554BenzeneBenzene results in increased expression of IL10RA mRNA15929907
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of IL10RA gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IL10RA mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL10RA mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of IL10RA mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of IL10RA mRNA19818335
C018475butyraldehydebutyraldehyde results in increased expression of IL10RA mRNA26079696
D000074262Canola OilCanola Oil metabolite results in decreased expression of IL10RA mRNA27363782
D002737ChloropreneChloroprene results in decreased expression of IL10RA mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IL10RA gene20938992
C000488cladosporincladosporin results in increased expression of IL10RA mRNA19818335
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of IL10RA mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IL10RA mRNA]17585979
C055162clopidogrelclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL10RA mRNA]19172522
D019327Copper SulfateCopper Sulfate results in increased expression of IL10RA mRNA19549813
D003436Croton OilCroton Oil results in increased expression of IL10RA mRNA19647056
C038459curdlancurdlan affects the expression of IL10RA mRNA19904525
D003703DemecolcineDemecolcine results in increased expression of IL10RA mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of IL10RA mRNA21041162
D002945CisplatinCisplatin results in increased expression of IL10RA mRNA27594783
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of IL10RA mRNA17490981
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IL10RA mRNA19647056
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of IL10RA mRNA23649840
C000499ferric oxideferric oxide analog results in decreased expression of IL10RA mRNA25086211
C065180fluvastatin[zoledronic acid co-treated with fluvastatin] results in increased expression of IL10RA mRNA16996129
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IL10RA gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of IL10RA mRNA23649840
C004312glycidolglycidol results in increased expression of IL10RA mRNA24915197
D017313FenretinideFenretinide results in decreased expression of IL10RA mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL10RA mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL10RA mRNA]26582142
C008261lead acetatelead acetate results in increased expression of IL10RA mRNA21829687
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of IL10RA mRNA"23090859
D008070Lipopolysaccharidesclopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL10RA mRNA]19172522
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL10RA mRNA]26582142
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL10RA mRNA26582142
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IL10RA gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IL10RA mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of IL10RA mRNA"26251327
C059539midostaurinmidostaurin results in increased expression of IL10RA mRNA20980353
D009151Mustard GasMustard Gas results in decreased expression of IL10RA mRNA16173061
D009151Mustard GasMustard Gas results in increased expression of IL10RA mRNA15674843
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of IL10RA mRNA19818335
D009183MycotoxinsMycotoxins results in decreased expression of IL10RA mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of IL10RA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IL10RA mRNA"25554681
D009532NickelNickel results in increased expression of IL10RA mRNA25583101
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL10RA mRNA"19013360
D010081OxazoloneOxazolone results in increased expression of IL10RA mRNA19647056
C046012pentanalpentanal results in increased expression of IL10RA mRNA26079696
D010938Plant OilsPlant Oils results in increased expression of IL10RA mRNA23370395
D059808PolyphenolsPolyphenols results in decreased expression of IL10RA mRNA16293270
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of IL10RA mRNA16497877
D015474IsotretinoinIsotretinoin results in decreased expression of IL10RA mRNA15982314
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IL10RA mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL10RA mRNA17337447
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL10RA mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of IL10RA mRNA27760801
D014212TretinoinTretinoin metabolite results in decreased expression of IL10RA mRNA15982314
D014212TretinoinTretinoin results in decreased expression of IL10RA mRNA28689802
C012589trichostatin Atrichostatin A results in increased expression of IL10RA mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of IL10RA mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of IL10RA mRNA17292431
D014750VincristineVincristine results in increased expression of IL10RA mRNA23649840
C088658zoledronic acid[zoledronic acid co-treated with fluvastatin] results in increased expression of IL10RA mRNA16996129

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004920interleukin-10 receptor activity-IBA21873635  
GO:0005515protein binding-IPI11485736  12093920  12513909  15837194  18395809  20462497  
24008843  
GO:0019969interleukin-10 binding-IEA-  
GO:0038023signaling receptor activity-TAS8407942  
GO ID GO Term Qualifier Evidence PubMed
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0050807regulation of synapse organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6783783Interleukin-10 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17331973Polymorphisms of interleukin-10 and its receptor and lung function in COPD. (2007 Jun)He JQEur Respir J