Gene: IL10RB

3588
CDW210B|CRF2-4|CRFB4|D21S58|D21S66|IL-10R2
interleukin 10 receptor subunit beta
protein-coding
21q22.11
Ensembl:ENSG00000243646 MIM:123889 Vega:OTTHUMG00000065128 UniprotKB:Q08334
NG_012089.1
PubMed
0   ANCO-SNPs
ND
1   
5.992e-1 (AD)  4.349e-1 (ND)   (Frontal_Cortex)
1.207e-1 (AD)  7.757e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MVP0.81
SLC8B10.797
RRBP10.789
HDAC70.788
EDEM20.786
STAT30.782
ASCC20.78
SLC39A10.776
LMNA0.771
PTBP10.766

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.43
OR4F29-0.423
VIP-0.315
CRH-0.314
CYP1A1-0.305
KIT-0.297
ADRA1D-0.291
DLX1-0.283
HAPLN1-0.281
ABCC12-0.278

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in decreased expression of IL10RB mRNA19428942
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of IL10RB mRNA"20406850
D000082AcetaminophenAcetaminophen results in decreased expression of IL10RB mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of IL10RB mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of IL10RB mRNA17562736
D000111AcetylcysteineAcetylcysteine results in decreased expression of IL10RB mRNA16084531
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of IL10RB mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL10RB mRNA24449571
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of IL10RB mRNA19962721
D001151ArsenicArsenic results in decreased expression of IL10RB mRNA19962721
D001280AtrazineAtrazine results in increased expression of IL10RB mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL10RB mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of IL10RB mRNA21179406
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IL10RB mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of IL10RB mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of IL10RB mRNA19818335
C584509C646 compoundC646 compound results in increased expression of IL10RB mRNA26191083
D002110CaffeineCaffeine results in increased expression of IL10RB mRNA20864626
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IL10RB mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL10RB mRNA20938992
C000488cladosporincladosporin results in increased expression of IL10RB mRNA19818335
C018021cobaltous chloridecobaltous chloride results in decreased expression of IL10RB mRNA24386269
C038459curdlancurdlan affects the expression of IL10RB mRNA19904525
D016572CyclosporineCyclosporine results in decreased expression of IL10RB mRNA25562108
C014347decitabinedecitabine affects the expression of IL10RB mRNA23300844
C007262deoxynivalenoldeoxynivalenol results in increased expression of IL10RB mRNA22968694
D003907DexamethasoneDexamethasone results in increased expression of IL10RB mRNA21356098
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IL10RB mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of IL10RB mRNA16054899
D003907DexamethasoneDexamethasone results in increased expression of IL10RB mRNA21041162
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IL10RB mRNA17361019|2126653
D002945CisplatinCisplatin affects the expression of IL10RB mRNA23300844
D002945CisplatinCisplatin results in increased expression of IL10RB mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of IL10RB mRNA28302478
D004026DieldrinDieldrin results in decreased expression of IL10RB mRNA23041725
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of IL10RB mRNA21041162
D004317DoxorubicinDoxorubicin results in increased expression of IL10RB mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of IL10RB mRNA]27181935
C118739entinostatentinostat results in increased expression of IL10RB mRNA27188386
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of IL10RB mRNA16084531
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IL10RB mRNA22079256
C020748ferrous sulfateferrous sulfate results in decreased expression of IL10RB mRNA19428942
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of IL10RB mRNA19962721
D005459FluoridesFluorides results in decreased expression of IL10RB mRNA19962721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL10RB mRNA20938992
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of IL10RB mRNA]27181935
C492448ICG 001ICG 001 results in increased expression of IL10RB mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IL10RB mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IL10RB mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of IL10RB mRNA16054899
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL10RB mRNA20938992
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of IL10RB mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IL10RB mRNA20864626
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of IL10RB mRNA20864626
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of IL10RB mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of IL10RB mRNA19818335
C490266neoechinulin Aneoechinulin A results in increased expression of IL10RB mRNA19818335
D009532NickelNickel results in decreased expression of IL10RB mRNA23195993
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL10RB mRNA"19013360
D052638Particulate MatterParticulate Matter results in increased expression of IL10RB mRNA24769257
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IL10RB mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IL10RB mRNA22079256
C513428pyrachlostrobinpyrachlostrobin results in increased expression of IL10RB mRNA27029645
D011794QuercetinQuercetin results in increased expression of IL10RB mRNA21356098
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of IL10RB mRNA16054899
D018038Sodium SeleniteSodium Selenite results in decreased expression of IL10RB mRNA18175754
D013241SterigmatocystinSterigmatocystin results in increased expression of IL10RB mRNA19818335
C061133tamibarotenetamibarotene results in increased expression of IL10RB mRNA15498508
C004648testosterone enanthatetestosterone enanthate affects the expression of IL10RB mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL10RB mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL10RB mRNA21041162
C402696TMC 120ATMC 120A results in increased expression of IL10RB mRNA19818335
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IL10RB mRNA28111298
C082097tocotrienol, delta"tocotrienol, delta results in increased expression of IL10RB mRNA"21356098
D014118Toxins, Biological"Toxins, Biological affects the expression of IL10RB mRNA"19682533
D014212TretinoinTretinoin results in increased expression of IL10RB mRNA15498508
C012589trichostatin Atrichostatin A results in increased expression of IL10RB mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of IL10RB mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IL10RB gene25560391
D012256RiboflavinRiboflavin results in increased expression of IL10RB mRNA21356098
C016837zinc chloridezinc chloride results in decreased expression of IL10RB mRNA19428942

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004920interleukin-10 receptor activity-IBA21873635  
GO:0004920interleukin-10 receptor activitycontributes_toTAS10954742  
GO:0005515protein binding-IPI12483210  12513909  15120653  20462497  
GO:0038023signaling receptor activity-TAS8314576  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-TAS10954742  
GO:0006955immune response-TAS9463407  
GO:0007165signal transduction-TAS10954742  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0051607defense response to virus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-TAS9312047  
GO:0032002interleukin-28 receptor complex-NAS12483210  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449836Other interleukin signalingTAS
R-HSA-6783783Interleukin-10 signalingTAS
R-HSA-8854691Interleukin-20 family signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24419231Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. (2014 May)Tang HCarcinogenesis