Gene: IL11

3589
AGIF|IL-11
interleukin 11
protein-coding
19q13.42
Ensembl:ENSG00000095752 MIM:147681 Vega:OTTHUMG00000180789 UniprotKB:P20809
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.515e-1 (AD)  8.586e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QPCTL0.672
INO80C0.667
EBP0.666
ZFR20.662
MRPL550.66
ANKRD540.66
B3GALT60.656
ZNF8210.656
PSMG30.656
MRTO40.656

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.355
YES1-0.352
MTRNR2L9-0.351
REST-0.348
GJB2-0.341
CXCR2-0.334
CARD8-0.333
NEDD4-0.332
OR4F5-0.331
PABPC4L-0.328

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Formaldehyde results in increased secretion of IL11 protein]22138297
C0127962-butenal2-butenal results in increased expression of IL11 mRNA20471460
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of IL11 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [INHBA protein results in increased secretion of IL11 protein]"20074812
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL11 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of IL11 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL11 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of IL11 mRNA"26238291
D000082AcetaminophenAcetaminophen results in increased expression of IL11 mRNA11826401|1270590
D000082AcetaminophenIL10 protein inhibits the reaction [Acetaminophen results in increased expression of IL11 mRNA]11826401
D000082AcetaminophenIL11 protein inhibits the reaction [Acetaminophen results in increased expression of TNF protein]11421492
D000082AcetaminophenIL6 protein affects the reaction [Acetaminophen results in increased expression of IL11 mRNA]12705907
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IL11 mRNA21641981
D000393Air PollutantsAir Pollutants analog results in increased expression of IL11 mRNA21757418
D000447AldehydesAldehydes results in increased expression of IL11 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL11 mRNA16483693
D001151Arsenic[Arsenic co-treated with Fluorides] results in increased expression of IL11 mRNA19962721
D001151ArsenicArsenic results in decreased expression of IL11 mRNA19962721
C006632arsenic trioxidearsenic trioxide results in increased expression of IL11 mRNA22535156
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of IL11 mRNA"18687144
D001205Ascorbic Acid[Ascorbic Acid co-treated with IL11 protein] results in increased expression of BGLAP mRNA17956465
D001205Ascorbic Acid[Ascorbic Acid co-treated with IL11 protein] results in increased expression of IBSP mRNA17956465
D001205Ascorbic Acid[Ascorbic Acid co-treated with IL11 protein] results in increased expression of RUNX2 mRNA17956465
D001379AzathioprineAzathioprine results in increased expression of IL11 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL11 mRNA16002475|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased secretion of IL11 protein16002475
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IL11 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IL11 mRNA"26238291
D004958EstradiolEstradiol affects the expression of IL11 mRNA14699072
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased secretion of IL11 protein20074812
D004958EstradiolIL11 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of PRL protein]20074812
D004958EstradiolIL11 protein promotes the reaction [INHBA protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of PRL protein]]20074812
D004958EstradiolINHBA protein promotes the reaction [IL11 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of PRL protein]]20074812
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL11 mRNA]22138297
C006780bisphenol Abisphenol A results in decreased expression of IL11 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of IL11 mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of IL11 mRNA19818335
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of IL11 mRNA23410634
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of IL11 mRNA15336504|1729509
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of IL11 protein17295091
C018475butyraldehydebutyraldehyde results in increased expression of IL11 mRNA26079696
D002104CadmiumCadmium results in increased expression of IL11 mRNA22562489
D002118CalciumFlurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Calcium]12110441
D002118CalciumIL11 protein results in increased abundance of Calcium12110441
D002118CalciumIL13 protein inhibits the reaction [IL11 protein results in increased abundance of Calcium]12110441
D002118CalciumIL4 protein inhibits the reaction [IL11 protein results in increased abundance of Calcium]12110441
D002118CalciumIL6ST protein promotes the reaction [IL11 protein results in increased abundance of Calcium]12110441
D002118CalciumIndomethacin inhibits the reaction [IL11 protein results in increased abundance of Calcium]12110441
D002118CalciumTNFRSF11B protein inhibits the reaction [IL11 protein results in increased abundance of Calcium]12110441
D002220CarbamazepineCarbamazepine affects the expression of IL11 mRNA25979313
D002251Carbon TetrachlorideIL11 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]16964402
D002251Carbon TetrachlorideIL11 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]16964402
D002251Carbon TetrachlorideIL11 protein promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]16964402
D002251Carbon Tetrachloridetin mesoporphyrin inhibits the reaction [IL11 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]]16964402
D002251Carbon Tetrachloridetin mesoporphyrin inhibits the reaction [IL11 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]]16964402
D005576ColforsinColforsin results in increased expression of IL11 mRNA22138297
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of IL11 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of IL11 mRNA19549813
D003436Croton OilCroton Oil results in increased expression of IL11 mRNA19647056
D016572CyclosporineCyclosporine results in increased expression of IL11 mRNA20106945|2163298
C017160cypermethrincypermethrin results in increased expression of IL11 mRNA22528246
D003609DactinomycinDactinomycin inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
C515055darinaparsindarinaparsin results in increased expression of IL11 mRNA22535156
C515055darinaparsinOxygen deficiency promotes the reaction [darinaparsin results in increased expression of IL11 mRNA]22535156
C007262deoxynivalenoldeoxynivalenol results in increased expression of IL11 mRNA15371230|1568116
C007262deoxynivalenol"Fatty Acids, Omega-3 inhibits the reaction [deoxynivalenol results in increased expression of IL11 mRNA]"15681167
D003907DexamethasoneDexamethasone results in decreased expression of IL11 mRNA25047013
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of IL11 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of IL11 mRNA27392435
D002945CisplatinCisplatin results in increased expression of IL11 mRNA19561079
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of IL11 mRNA]27392435
D002945Cisplatin[Cisplatin co-treated with TNF protein] results in increased expression of IL11 mRNA23103562
D002945CisplatinCisplatin results in increased expression of IL11 mRNA19833167
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IL11 mRNA19647056
C118739entinostatentinostat results in increased expression of IL11 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL11 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IL11 mRNA22079256
D000431EthanolEthanol results in increased expression of IL11 mRNA17295091
D000431EthanolEthanol results in increased expression of IL11 protein17295091
D005459Fluorides[Arsenic co-treated with Fluorides] results in increased expression of IL11 mRNA19962721
D005459FluoridesFluorides results in decreased expression of IL11 mRNA19962721
D005480FlurbiprofenFlurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Calcium]12110441
D005480FlurbiprofenFlurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone]12110441
D005492Folic Acid[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL11 mRNA22975265
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of IL11 mRNA24657277
D005557Formaldehyde2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
D005557Formaldehyde2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Formaldehyde results in increased secretion of IL11 protein]22138297
D005557Formaldehydebisindolylmaleimide I inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
D005557FormaldehydeCREB1 mutant form inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
D005557FormaldehydeDactinomycin inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
D005557FormaldehydeFormaldehyde results in decreased expression of IL11 mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of IL11 mRNA22138297
D005557FormaldehydeFormaldehyde results in increased secretion of IL11 protein22138297
D005557FormaldehydeRo 31-8220 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
D005557FormaldehydeSB 203580 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
D005557FormaldehydeSB 203580 inhibits the reaction [Formaldehyde results in increased secretion of IL11 protein]22138297
D005557FormaldehydeU 0126 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
D005557FormaldehydeU 0126 inhibits the reaction [Formaldehyde results in increased secretion of IL11 protein]22138297
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of IL11 mRNA]17109745
C412815GW 4064GW 4064 results in increased expression of IL11 mRNA26655953
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of IL11 mRNA23410634
C492448ICG 001ICG 001 results in decreased expression of IL11 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of IL11 mRNA16984733
D007213IndomethacinIndomethacin inhibits the reaction [IL11 protein results in increased abundance of Calcium]12110441
D007213IndomethacinIndomethacin inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone]12110441
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of IL11 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of IL11 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of IL11 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of IL11 mRNA24796395|2530787
C045463leflunomideleflunomide results in increased expression of IL11 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IL11 protein"23604539
D008070LipopolysaccharidesTriclosan inhibits the reaction [Lipopolysaccharides results in increased expression of IL11 mRNA]20507366
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of IL11 mRNA20843944
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of IL11 mRNA24657277
D008727MethotrexateMethotrexate results in increased expression of IL11 mRNA24657277
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IL11 mRNA28001369
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of IL11 mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of IL11 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IL11 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL11 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of IL11 mRNA18978301
C015380neoechinulinneoechinulin results in increased expression of IL11 mRNA19818335
C029938nickel sulfatenickel sulfate results in decreased expression of IL11 mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of IL11 mRNA20971185
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 inhibits the reaction [deoxynivalenol results in increased expression of IL11 mRNA]"15681167
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of IL11 mRNA24888373
D010081OxazoloneOxazolone results in increased expression of IL11 mRNA19647056
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of IL11 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of IL11 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of IL11 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of IL11 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of IL11 mRNA]17655762
D010100OxygenOxygen deficiency promotes the reaction [darinaparsin results in increased expression of IL11 mRNA]22535156
C084656paricalcitol[Phosphorus co-treated with paricalcitol] affects the expression of IL11 mRNA17715259
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of IL11 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of IL11 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of IL11 mRNA]17655762
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of IL11 mRNA18593933
D000068437Pemetrexed[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL11 mRNA22975265
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of IL11 mRNA26705709
C046012pentanalpentanal results in increased expression of IL11 mRNA26079696
D015232DinoprostoneFlurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone]12110441
D015232DinoprostoneIL11 protein results in increased abundance of Dinoprostone12110441
D015232DinoprostoneIndomethacin inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone]12110441
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL11 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of IL11 mRNA26272509
D010758Phosphorus[Phosphorus co-treated with paricalcitol] affects the expression of IL11 mRNA17715259
D010938Plant OilsPlant Oils results in increased expression of IL11 mRNA23370395
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons results in increased expression of IL11 mRNA16002475
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of IL11 mRNA24888373
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of IL11 protein29175452
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IL11 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IL11 mRNA22714537
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of IL11 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of IL11 mRNA23608068
C009041primycinprimycin results in increased expression of IL11 mRNA28916286
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased secretion of IL11 protein20074812
D011374ProgesteroneIL11 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of PRL protein]20074812
D011374ProgesteroneIL11 protein promotes the reaction [INHBA protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of PRL protein]]20074812
D011374ProgesteroneINHBA protein promotes the reaction [IL11 protein promotes the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of PRL protein]]20074812
C005556propionaldehydepropionaldehyde results in increased expression of IL11 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of IL11 mRNA24780913
D011794QuercetinQuercetin results in increased expression of IL11 mRNA21632981
C013672riddelliineriddelliine results in increased expression of IL11 mRNA18047727
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL11 mRNA]22138297
C093642SB 203580SB 203580 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
C093642SB 203580SB 203580 inhibits the reaction [Formaldehyde results in increased secretion of IL11 protein]22138297
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IL11 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of IL11 mRNA19073995
D012834SilverSilver results in increased expression of IL11 mRNA26014281|2655175
D012834SilverSilver results in decreased expression of IL11 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of IL11 mRNA12760830
C017947sodium arsenitesodium arsenite results in increased expression of IL11 mRNA16014739
D013241SterigmatocystinSterigmatocystin results in increased expression of IL11 mRNA19818335
D013605T-2 ToxinT-2 Toxin results in increased expression of IL11 mRNA29079362
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL11 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL11 mRNA21570461
D013755Tetradecanoylphorbol Acetatebisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL11 mRNA]22138297
D013755Tetradecanoylphorbol AcetateRo 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL11 mRNA]22138297
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of IL11 mRNA22138297
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [IL11 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]]16964402
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [IL11 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]]16964402
C402696TMC 120ATMC 120A results in decreased expression of IL11 mRNA19818335
C402696TMC 120ATMC 120A results in increased expression of IL11 mRNA19818335
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IL11 mRNA28065790
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of IL11 protein24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of IL11 protein]24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IL11 protein27793746
D014118Toxins, Biological"Toxins, Biological affects the expression of IL11 mRNA"19682533
C012589trichostatin Atrichostatin A results in increased expression of IL11 mRNA24935251
D014260TriclosanTriclosan inhibits the reaction [Lipopolysaccharides results in increased expression of IL11 mRNA]20507366
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of IL11 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of IL11 mRNA19140230
C113580U 0126U 0126 inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA]22138297
C113580U 0126U 0126 inhibits the reaction [Formaldehyde results in increased secretion of IL11 protein]22138297
D014520UrethaneUrethane results in decreased expression of IL11 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of IL11 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of IL11 gene29154799
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of IL11 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of IL11 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of IL11 mRNA]17655762
D024483Vitamin K 3Vitamin K 3 affects the expression of IL11 mRNA23410634
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of IL11 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005142interleukin-11 receptor binding-NAS2145578  
GO:0005515protein binding-IPI16189514  25416956  26551460  
GO:0008083growth factor activity-IBA21873635  
GO:0008083growth factor activity-IDA2145578  
GO ID GO Term Qualifier Evidence PubMed
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IDA2145578  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030183B cell differentiation-NAS2145578  
GO:0030219megakaryocyte differentiation-NAS2145578  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA7508917  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IDA7508917  
GO:0045444fat cell differentiation-NAS1828438  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA7508917  
GO:0046888negative regulation of hormone secretion-IDA7867561  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA7508917  
GO:1903659regulation of complement-dependent cytotoxicityNOTIMP16034134  
GO:2000352negative regulation of endothelial cell apoptotic processNOTIMP16034134  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6783589Interleukin-6 family signalingTAS
R-HSA-6788467IL-6-type cytokine receptor ligand interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28631723Pharmacogenetic biomarkers of response in Crohn's disease. (2018 Jan)Linares-Pineda TMPharmacogenomics J