Gene: IL12A

3592
CLMF|IL-12A|NFSK|NKSF1|P35
interleukin 12A
protein-coding
3q25.33
Ensembl:ENSG00000168811 MIM:161560 Vega:OTTHUMG00000158942 UniprotKB:P29459
NG_033022.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.866e-1 (AD)  8.746e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLSCR10.72
IFI160.704
DTX3L0.702
TANC10.682
PARP90.68
IRAK40.671
FSTL10.669
MYD880.668
PSMB90.665
CDK20.664

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.446
ADRA1D-0.418
ABCC12-0.401
SCRT1-0.399
LRTM2-0.393
CDH22-0.392
KCNQ4-0.387
TMEM179-0.386
CALHM1-0.385
DLK2-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl affects the expression of IL12A mRNA"21703328
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL12A mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of IL12A mRNA"27291303
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]"15894585
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]15894585
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine[2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine co-treated with TNF protein] results in decreased expression of IL12A mRNA22923002
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of IL12A mRNA"21703328
C0038982-anisidine2-anisidine results in increased expression of IL12A mRNA28089782
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]17475839
C0188552-tert-butylhydroquinone"2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]"25680285
C0188552-tert-butylhydroquinone"2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]"25680285
C0188552-tert-butylhydroquinone"NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]"25680285
C0188552-tert-butylhydroquinone"NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]]"25680285
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of [IL12A protein binds to IL12B protein]"29216392
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]"23452621
C5239344(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester"4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester inhibits the reaction [AGT protein modified form results in increased secretion of [IL12A protein binds to IL12B protein]]"24456201
C4086904-cresol sulfate4-cresol sulfate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A protein]26784855
C0255664-methylhistamine4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]11752121|1236486
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole inhibits the reaction [CL 075 results in increased expression of IL12A mRNA]"27783115
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]"27783115
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]"27783115
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]21237301
D000119Acetylmuramyl-Alanyl-Isoglutamine[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12A mRNA16299289
D000119Acetylmuramyl-Alanyl-Isoglutamine[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]16299289
D000119Acetylmuramyl-Alanyl-Isoglutamine[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]16299289
D000119Acetylmuramyl-Alanyl-Isoglutamine[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]18490488
D000119Acetylmuramyl-Alanyl-Isoglutamine[Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA18490488
D000119Acetylmuramyl-Alanyl-Isoglutamine[Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]18490488
D000119Acetylmuramyl-Alanyl-Isoglutamineresiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]18490488
D000242Cyclic AMPCyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein]15843518
D037361Adenylate Cyclase ToxinAdenylate Cyclase Toxin inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]14977963
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IL12A protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IL12A mRNA22100608
C103303alitretinoinalitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]17475839
C103303alitretinoinalitretinoin results in decreased expression of [IL12A protein binds to IL12B protein]17118196
D000639Amitriptyline[Amitriptyline co-treated with Fluoxetine co-treated with Mianserin] inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]28263824
D000639Amitriptyline[Amitriptyline co-treated with Fluoxetine co-treated with Mianserin] results in decreased expression of IL12A mRNA28263824
D000639AmitriptylineAmitriptyline inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]28263824
D000639AmitriptylineAmitriptyline results in decreased expression of IL12A mRNA28263824
D000639Amitriptylinepyrrolidine dithiocarbamic acid inhibits the reaction [Amitriptyline results in decreased expression of IL12A mRNA]28263824
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL12A mRNA16483693
C076207amthamineamthamine results in decreased expression of IL12A protein9819373
C031385anthranilic acidanthranilic acid analog inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein]15799959
D000965AntimonyIL12A protein affects the susceptibility to Antimony11023473
D001151ArsenicArsenic results in decreased expression of IL12A mRNA27838757
C015001arsenite"arsenite inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL12A mRNA]"25680285
C015001arsenite"arsenite inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of [IL12B protein binds to IL12A protein]]"25680285
C015001arsenite"arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]"25680285
C015001arsenite"arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]"25680285
C015001arsenite"NFE2L2 mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]"25680285
C015001arsenite"NFE2L2 mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]]"25680285
C015001arsenite"arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]"25680285
C015001arsenite"NFE2L2 gene mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]"25680285
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of IL12A mRNA"24160326
D001241AspirinAspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]]15379866
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of IL12A mRNA12492458
D001280AtrazineAtrazine results in increased expression of IL12A mRNA23358194
D001379AzathioprineAzathioprine results in increased expression of [IL12A protein binds to IL12B protein]19584951
C416282BAY 11-7085BAY 11-7085 inhibits the reaction [[IFNG protein co-treated with nickel sulfate] results in increased expression of IL12A mRNA]20525893
C071435BAY u9773BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]19118273
D001554BenzeneIL12A gene SNP affects the susceptibility to Benzene16230423
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IL12A mRNA18164116
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IL12A mRNA"20382639
C090535benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinalbenzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]11006016
D004958Estradiol"Estradiol inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of [IL12A protein binds to IL12B protein]]"20130130
D004958EstradiolEstradiol results in increased expression of [IL12A protein binds to IL12B protein]20130130
D004958Estradiol"[Progesterone co-treated with Estradiol] inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of [IL12A protein binds to IL12B protein]]"20130130
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of IL12A mRNA19693291
D004958EstradiolEstradiol results in decreased expression of IL12A mRNA19693291
D047071beta-Glucans[beta-Glucans co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA18490488
D047071beta-Glucans[beta-Glucans co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]18490488
D047071beta-GlucansIFNG protein promotes the reaction [beta-Glucans results in increased expression of [IL12A protein binds to IL12B protein]]18490488
C002503betulinbetulin results in increased expression of IL12A mRNA25756279
C002503betulinbetulin results in increased secretion of [IL12A protein binds to IL12B protein]25756279
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of IL12A mRNA26496021
D002087ButyratesButyrates results in decreased expression of IL12A mRNA11024006
D002087ButyratesButyrates results in decreased expression of [IL12A protein binds to IL12B protein]11024006
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of IL12A mRNA alternative form24583143
D002110CaffeineCaffeine results in decreased expression of IL12A mRNA28089782
C004519caramiphen"caramiphen inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of IL12A mRNA]"27655295
D002219CarbamatesCarbamates analog results in increased expression of IL12A protein19111005|1937625
D002220CarbamazepineCarbamazepine results in decreased expression of IL12A mRNA22790970
C043211carvedilolcarvedilol promotes the reaction [Hemagglutinins results in increased expression of [IL12A protein binds to IL12B protein]]15229385
C043211carvedilolcarvedilol promotes the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]15229385
C054133casticincasticin results in decreased expression of IL12A mRNA27862857
D002713ChlorineChlorine results in increased expression of IL12A protein23146759
C007020chlorophyllinchlorophyllin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]16275627
D002737ChloropreneChloroprene results in decreased expression of IL12A mRNA23125180
D002772Cholera ToxinCholera Toxin results in decreased expression of IL12A mRNA9927516
D002772Cholera ToxinCholera Toxin results in decreased expression of [IL12A protein binds to IL12B protein]9927516
C012843cinnamic aldehydecinnamic aldehyde affects the expression of IL12A mRNA28219650
C012843cinnamic aldehydeNFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of IL12A mRNA]28219650
C551788CL 075"6-formylindolo(3,2-b)carbazole inhibits the reaction [CL 075 results in increased expression of IL12A mRNA]"27783115
C551788CL 075CL 075 results in increased expression of IL12A mRNA27783115
C551788CL 075Tetrachlorodibenzodioxin inhibits the reaction [CL 075 results in increased expression of IL12A mRNA]27783115
D002994ClofibrateClofibrate results in increased expression of IL12A mRNA17585979
D005576ColforsinColforsin results in decreased expression of IL12A protein10996031
C423449CpG ODN 1826[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] results in increased secretion of [IL12A protein binds to IL12B protein]21097750
C423449CpG ODN 1826Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]21097750
C513533CpG ODN 2006CpG ODN 2006 results in increased expression of IL12A mRNA16973119
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]23452621
D003520Cyclophosphamide[Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of [IL12A protein binds to IL12B protein]29228376
D016572CyclosporineCyclosporine results in increased expression of IL12A mRNA20106945|2556210
D016572CyclosporineCyclosporine inhibits the reaction [Zymosan results in increased expression of [IL12A protein binds to IL12B protein]]17312158
D003603CytotoxinsCytotoxins results in increased expression of [IL12A protein binds to IL12B protein]16291660
C004742daidzeindaidzein inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]21945492
C568335DCB-SLE1DCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]21677146
D013759DronabinolDronabinol results in decreased expression of IL12A mRNA16616335
C007262deoxynivalenoldeoxynivalenol results in increased expression of IL12A mRNA27757495
C007262deoxynivalenoldeoxynivalenol results in increased expression of IL12A mRNA9707511
D003907Dexamethasone"Dexamethasone inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of IL12A mRNA]"27655295
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]22185406
D003907DexamethasoneDexamethasone results in increased expression of IL12A mRNA22185406
D016264Dextran SulfateIL12A protein affects the susceptibility to Dextran Sulfate12940437
D003976DiazinonDiazinon results in increased methylation of IL12A gene22964155
D002945CisplatinCisplatin results in increased expression of IL12A mRNA19561079|2739243
D004041Dietary FatsDietary Fats results in decreased expression of IL12A mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of IL12A mRNA18164116
D004110DiltiazemDiltiazem inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]15652234
D004110DiltiazemDiltiazem inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]15652234
D004110DiltiazemDiltiazem inhibits the reaction [[NFKB1 protein binds to RELA protein] which binds to IL12A promoter]15652234
D004110DiltiazemDiltiazem results in decreased expression of IL12A mRNA15652234
D017259DimapritDimaprit inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]11752121|1236486
D008559Memantine"Memantine inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of IL12A mRNA]"27655295
D0151279,10-Dimethyl-1,2-benzanthracene"IL12A results in decreased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"22359662
D004121Dimethyl Sulfoxide"Dimethyl Sulfoxide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12A mRNA]"26394380
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of IL12A mRNA28219650
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IL12A mRNA25449201
D004317Doxorubicin[Doxorubicin co-treated with Cyclophosphamide] results in decreased expression of [IL12A protein binds to IL12B protein]29228376
D004365Drugs, Chinese Herbal"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]"15894585
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of IL12A mRNA"15894585
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]"15894585
D004365Drugs, Chinese Herbal"helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]"15894585
D004365Drugs, Chinese Herbal"SB 203580 inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]"15894585
D004391DustDust results in increased expression of [IL12A protein binds to IL12B protein]26882889
D004391DustMYD88 gene mutant form inhibits the reaction [Dust results in increased expression of [IL12A protein binds to IL12B protein]]26882889
D004391DustMYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]26882889
D004391Dust[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]26882889
D004391DustPolymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]26882889
D004391DustTLR2 gene mutant form inhibits the reaction [Dust results in increased expression of [IL12A protein binds to IL12B protein]]26882889
D004391DustTLR4 gene mutant form inhibits the reaction [Dust results in increased expression of [IL12A protein binds to IL12B protein]]26882889
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased secretion of [IL12A protein binds to IL12B protein]"24456201
C031818enterotoxin B, staphylococcal"enterotoxin B, staphylococcal results in increased expression of and results in increased secretion of [IL12A protein binds to IL12B protein]"25556216
D004768EnterotoxinsEnterotoxins results in increased expression of IL12A mRNA16115702
D004964EstriolEstriol results in increased expression of IL12A mRNA21317386
D000431EthanolEthanol inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]10798593
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of IL12A mRNA23649840
D005054EugenolEugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]21237301
D015738FamotidineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]11752121|1236486
C039537FK 565[FK 565 co-treated with Lipid A] results in increased expression of IL12A mRNA16299289
C039537FK 565[FK 565 co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]16299289
C039537FK 565[FK 565 co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]16299289
D005473Fluoxetine[Amitriptyline co-treated with Fluoxetine co-treated with Mianserin] inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]28263824
D005473Fluoxetine[Amitriptyline co-treated with Fluoxetine co-treated with Mianserin] results in decreased expression of IL12A mRNA28263824
D005473FluoxetineFluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]28263824
D005473FluoxetineFluoxetine results in decreased expression of IL12A mRNA28263824
D005473Fluoxetinepyrrolidine dithiocarbamic acid inhibits the reaction [Fluoxetine results in decreased expression of IL12A mRNA]28263824
D005620Freund's AdjuvantFreund's Adjuvant promotes the reaction [Urethane results in decreased expression of IL12A mRNA]12810352
C492995fumigaclavine Cfumigaclavine C results in decreased expression of IL12A mRNA16023606
C056933fumonisin B1fumonisin B1 results in increased expression of IL12A mRNA27757495
D062610Fungal PolysaccharidesFungal Polysaccharides results in increased secretion of [IL12A protein co-treated with IL12B protein]28235615
C043055gallium arsenidegallium arsenide results in increased expression of IL12A mRNA14560044
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]23452621
D005839GentamicinsGentamicins results in decreased expression of IL12A mRNA22061828
D005839GentamicinsGentamicins results in decreased expression of IL12A protein25051504
C027478glucuronoxylomannanglucuronoxylomannan results in decreased secretion of [IL12A protein binds to IL12B protein]12864811
D019695Glycyrrhizic Acid[Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12A mRNA11412311
D019695Glycyrrhizic Acid[Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]11412311
C054591hachimijioganhachimijiogan results in decreased expression of IL12A mRNA12022442
C001329helenalin"helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]"15894585
C001329helenalinhelenalin inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]15894585
D006388Hemagglutininscarvedilol promotes the reaction [Hemagglutinins results in increased expression of [IL12A protein binds to IL12B protein]]15229385
D006388HemagglutininsHemagglutinins results in increased expression of [IL12A protein binds to IL12B protein]15229385
D006632HistamineCyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein]15843518
D006632HistamineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]11752121|1236486
D006632HistamineHistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]11752121|1236486
D006632HistamineHistamine results in decreased expression of IL12A mRNA9819373
D006632HistamineHistamine results in decreased expression of IL12A protein9819373
D006632Histamine[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12A protein15843518
D006632Histamine[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein15843518
D006632HistamineHistamine results in increased expression of IL12A protein15843518
D006632HistamineHRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]11752121
D006632HistamineHRH2 protein promotes the reaction [Histamine results in decreased expression of IL12A protein]9819373
D006632Histamine[IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]11752121
D006632Histamine[IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]11752121
D006632HistamineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]11752121
D006632HistamineRanitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein]9819373
D006632HistamineU 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein]15843518
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of [IL12A protein binds to IL12B protein]16249388
C038366ibudilastibudilast results in decreased expression of IL12A mRNA14664469
C038366ibudilastibudilast results in decreased expression of [IL12A protein binds to IL12B protein]14664469
C056493imiquimod[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]21097750
C056493imiquimodTetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]21097750
C016517indole-3-carbinolindole-3-carbinol inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]27783115
C016517indole-3-carbinolindole-3-carbinol inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]27783115
D007213IndomethacinIndomethacin results in increased expression of [IL12A protein binds to IL12B protein]11703811
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL12A mRNA25613284
D007501IronIron affects the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein]15799959
D007502Iron Chelating AgentsIron Chelating Agents analog inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein]15799959
D017953IsocyanatesIsocyanates analog results in increased expression of IL12A protein19111005
D007538IsoniazidIsoniazid results in increased secretion of IL12A protein28444390
D007545IsoproterenolIsoproterenol results in decreased expression of IL12A protein24286936
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL12A mRNA23430699|2675264
D007608Kainic AcidIL12A protein affects the susceptibility to Kainic Acid15474355
D007649KetamineKetamine results in increased expression of IL12A mRNA20080153
D007854LeadLead results in increased expression of and results in increased secretion of [IL12A protein binds to IL12B protein]28973681
C008261lead acetatelead acetate results in decreased expression of IL12A mRNA21829687
D008050Lipid A[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12A mRNA16299289
D008050Lipid A[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]16299289
D008050Lipid A[FK 565 co-treated with Lipid A] results in increased expression of IL12A mRNA16299289
D008050Lipid A[FK 565 co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]16299289
D008050Lipid ALipid A results in increased expression of IL12A mRNA16299289
D008050Lipid ALipid A results in increased expression of [IL12A protein binds to IL12B protein]16299289
C482199lipopolysaccharide, E coli O55-B5"2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]"25680285
C482199lipopolysaccharide, E coli O55-B5"2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]"25680285
C482199lipopolysaccharide, E coli O55-B5"arsenite inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL12A mRNA]"25680285
C482199lipopolysaccharide, E coli O55-B5"arsenite inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of [IL12B protein binds to IL12A protein]]"25680285
C482199lipopolysaccharide, E coli O55-B5"arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]"25680285
C482199lipopolysaccharide, E coli O55-B5"arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]"25680285
C482199lipopolysaccharide, E coli O55-B5"[IFNG protein co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL12A mRNA"25680285
C482199lipopolysaccharide, E coli O55-B5"[IFNG protein co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of [IL12B protein binds to IL12A protein]"25680285
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA"25680285
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]"25680285
C482199lipopolysaccharide, E coli O55-B5"NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]"25680285
C482199lipopolysaccharide, E coli O55-B5"NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]]"25680285
C482199lipopolysaccharide, E coli O55-B5"NFE2L2 mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]"25680285
C482199lipopolysaccharide, E coli O55-B5"NFE2L2 mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]]"25680285
C482199lipopolysaccharide, E coli O55-B5"arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]"25680285
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA"25680285
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A protein"23604539
C482199lipopolysaccharide, E coli O55-B5"neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A protein]"23604539
C482199lipopolysaccharide, E coli O55-B5"NFE2L2 gene mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]"25680285
C440499lipopolysaccharide, Escherichia coli O111 B4"Dimethyl Sulfoxide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12A mRNA]"26394380
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12A mRNA"26394380
D008070Lipopolysaccharides[Amitriptyline co-treated with Fluoxetine co-treated with Mianserin] inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]28263824
D008070LipopolysaccharidesAmitriptyline inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]28263824
D008070LipopolysaccharidesFluoxetine inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]28263824
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL12A mRNA28263824
D008070LipopolysaccharidesMianserin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]28263824
D008070Lipopolysaccharides2-chloro-5-nitrobenzanilide inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]17475839
D008070Lipopolysaccharides"6-formylindolo(3,2-b)carbazole inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]"27783115
D008070Lipopolysaccharides[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]16299289
D008070LipopolysaccharidesAHR protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]27783115
D008070Lipopolysaccharidesalitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]17475839
D008070LipopolysaccharidesAspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]]15379866
D008070Lipopolysaccharidescarvedilol promotes the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]15229385
D008070LipopolysaccharidesCDX2 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]27783115
D008070LipopolysaccharidesDiltiazem inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]15652234
D008070LipopolysaccharidesDiltiazem inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]15652234
D008070LipopolysaccharidesDinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]11369638
D008070Lipopolysaccharides[FK 565 co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]16299289
D008070LipopolysaccharidesIL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]9637507
D008070Lipopolysaccharidesindole-3-carbinol inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]27783115
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]15379866
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL12A mRNA12470611|1551632
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]10651989|1522938
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]11369638|1747583
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of [IL12B protein binds to IL12A protein]15135313
D008070Lipopolysaccharidesresveratrol promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12B protein co-treated with IL12A protein]]15135313
D008070Lipopolysaccharides[Ribavirin co-treated with IFNA2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]9722937
D008070LipopolysaccharidesRibavirin promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]9722937
D008070Lipopolysaccharidesrosiglitazone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]17475839
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]27783115
D008070Lipopolysaccharidestrichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]12470611
D008070Lipopolysaccharides4-cresol sulfate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A protein]26784855
D008070LipopolysaccharidesAdenylate Cyclase Toxin inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]14977963
D008070Lipopolysaccharidesbenzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]11006016
D008070LipopolysaccharidesCD14 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]11123339
D008070Lipopolysaccharideschlorophyllin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]16275627
D008070Lipopolysaccharidesdaidzein inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]21945492
D008070LipopolysaccharidesDCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]21677146
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]22185406
D008070LipopolysaccharidesEthanol inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]10798593
D008070Lipopolysaccharides[Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12A mRNA11412311
D008070Lipopolysaccharides[Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]11412311
D008070LipopolysaccharidesIFNG protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]10415056
D008070LipopolysaccharidesIRF1 protein affects the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]10415056
D008070LipopolysaccharidesIRF1 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]10415056
D008070LipopolysaccharidesIRF1 protein affects the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]10415056
D008070LipopolysaccharidesIRF2 protein affects the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]10415056
D008070LipopolysaccharidesITGAM protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]11123339
D008070LipopolysaccharidesITGAM protein affects the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]11123339
D008070Lipopolysaccharides[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] results in increased secretion of [IL12A protein binds to IL12B protein]21097750
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]11529938
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased secretion of IL12A protein14996416
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL12A mRNA10415056|1100601
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL12A protein26784855
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]10798593|1902077
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]10415056|1112333
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]15933225
D008070Lipopolysaccharidesmethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]15933225
D008070LipopolysaccharidesParticulate Matter inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]19805405
D008070Lipopolysaccharides[resiquimod co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]15851485
D008070Lipopolysaccharidesresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL12A protein]14996416
D008070LipopolysaccharidesSB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]11006016
D008070LipopolysaccharidesSulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]11529938
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]21097750
D008070LipopolysaccharidesTLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]11123339
D008070LipopolysaccharidesVehicle Emissions inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]19805405
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL12A mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL12A mRNA15998543
D008070LipopolysaccharidesIFNG protein promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12B protein co-treated with IL12A protein]]15135313
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]16321413
D008070Lipopolysaccharidesresveratrol inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12B protein co-treated with IL12A protein]]]15135313
C009900lipoteichoic acidlipoteichoic acid results in increased expression of IL12A mRNA15998543
C068562loxoribineloxoribine results in increased expression of IL12A protein15777634
C068562loxoribineloxoribine results in increased expression of [IL12A protein binds to IL12B protein]15777634
C068562loxoribineU 0126 promotes the reaction [loxoribine results in increased expression of IL12A protein]15777634
C068562loxoribineU 0126 promotes the reaction [loxoribine results in increased expression of [IL12A protein binds to IL12B protein]]15777634
D017998Leukotriene D4BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]19118273
D017998Leukotriene D4Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]19118273
D017998Leukotriene D4montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]19118273
D017998Leukotriene D4zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]19118273
C480546lupanelupane results in increased secretion of [IL12A protein binds to IL12B protein]16388738
D008345ManganeseManganese results in increased expression of IL12A mRNA17175027
C025340manganese chloridemanganese chloride promotes the reaction [SNCA protein results in increased expression of [IL12A protein binds to IL12B protein]]28539244
C025340manganese chloridemanganese chloride results in increased expression of IL12A mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of [IL12A protein binds to IL12B protein]28539244
C013592mangiferinmangiferin results in decreased expression of IL12A mRNA15135318
D008466MechlorethamineMechlorethamine results in increased expression of IL12A mRNA26273949
D008558MelphalanMelphalan results in increased expression of IL12A mRNA22363485
C033266Menhaden oilMenhaden oil results in decreased expression of [IL12A protein binds to IL12B protein]10065739
D008627Mercuric ChlorideMercuric Chloride results in increased expression of [IL12A protein binds to IL12B protein]21984480
D008727MethotrexateMethotrexate results in decreased expression of IL12A mRNA22133036
D008748MethylcholanthreneMethylcholanthrene results in increased expression of IL12A mRNA14993811
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]15933225
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]16321413
C005227methyl isothiocyanatemethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]15933225
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IL12A mRNA23649840
D008803Mianserin[Amitriptyline co-treated with Fluoxetine co-treated with Mianserin] inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]28263824
D008803Mianserin[Amitriptyline co-treated with Fluoxetine co-treated with Mianserin] results in decreased expression of IL12A mRNA28263824
D008803MianserinMianserin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]28263824
D008803MianserinMianserin results in decreased expression of IL12A mRNA28263824
C093875montelukastmontelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]19118273
D009020MorphineMorphine affects the expression of [IL12A protein binds to IL12B protein]16299287
D009173Mycophenolic AcidMycophenolic Acid results in decreased expression of IL12A mRNA26394380
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosineN(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]16116186
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosinePertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]16116186
C084956N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosinewortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]16116186
C002701neocuproine"neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A protein]"23604539
C029938nickel sulfateBAY 11-7085 inhibits the reaction [[IFNG protein co-treated with nickel sulfate] results in increased expression of IL12A mRNA]20525893
C029938nickel sulfate[IFNG protein co-treated with nickel sulfate] results in increased expression of IL12A mRNA20525893
C029938nickel sulfate[IFNG protein co-treated with nickel sulfate] results in increased secretion of IL12A protein20525893
C029938nickel sulfateIRF1 mRNA affects the reaction [[IFNG protein co-treated with nickel sulfate] results in increased expression of IL12A mRNA]20525893
C029938nickel sulfateIRF1 mRNA affects the reaction [[IFNG protein co-treated with nickel sulfate] results in increased secretion of IL12A protein]20525893
C029938nickel sulfatepyrazolanthrone inhibits the reaction [[IFNG protein co-treated with nickel sulfate] results in increased expression of IL12A mRNA]20525893
C029938nickel sulfateSB 203580 inhibits the reaction [[IFNG protein co-treated with nickel sulfate] results in increased expression of IL12A mRNA]20525893
D009534NiclosamideNiclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]26297436
D009538NicotineAcetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]21237301
D009538NicotineEugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]21237301
D009538NicotineNicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]21237301
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of IL12A mRNA22561872
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of [IL12A protein binds to IL12B protein]"10065739
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"caramiphen inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of IL12A mRNA]"27655295
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"Dexamethasone inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of IL12A mRNA]"27655295
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"Memantine inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of IL12A mRNA]"27655295
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of IL12A mRNA"27655295
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"pralidoxime inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of IL12A mRNA]"27655295
D010047OvalbuminMYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]26882889
D010047Ovalbumin[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]26882889
D010047OvalbuminPolymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]26882889
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of IL12A mRNA17175027|2345262
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]23452621
D010126Ozone[Vehicle Emissions co-treated with Ozone] results in decreased expression of [IL12A protein binds to IL12B protein]27058360
D017239PaclitaxelCD14 protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]11123339
D017239PaclitaxelITGAM protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]11123339
D017239PaclitaxelITGAM protein affects the reaction [Paclitaxel results in increased secretion of [IL12A protein binds to IL12B protein]]11123339
D017239PaclitaxelPaclitaxel results in increased expression of IL12A mRNA11123339
D017239PaclitaxelPaclitaxel results in increased secretion of [IL12A protein binds to IL12B protein]11123339
D017239PaclitaxelTLR4 protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]11123339
D000073878Palm OilPalm Oil results in decreased expression of IL12A mRNA18042831
C508075Pam(3)CSK(4) peptide[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]18490488
C508075Pam(3)CSK(4) peptideresiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]18490488
D052638Particulate MatterParticulate Matter inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]19805405
D052638Particulate MatterParticulate Matter results in decreased expression of IL12A mRNA23638009
D052638Particulate MatterParticulate Matter results in increased expression of IL12A mRNA23638009
D052638Particulate MatterParticulate Matter results in increased expression of IL12A mRNA24216475
C008776pelargonic acidpelargonic acid results in increased expression of IL12A mRNA18652873
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]16116186
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]16116186
D015232DinoprostoneDinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]11369638
D015240Phorbol 12,13-Dibutyrate"Phorbol 12,13-Dibutyrate results in increased expression of IL12A mRNA"15516327
D010726Phosphodiesterase InhibitorsPhosphodiesterase Inhibitors results in decreased expression of IL12A mRNA14664469
D010726Phosphodiesterase InhibitorsPhosphodiesterase Inhibitors results in decreased expression of [IL12A protein binds to IL12B protein]14664469
C006253pirinixic acidpirinixic acid results in decreased expression of IL12A protein20131406
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]23452621
D011070Poly I-C"6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]"27783115
D011070Poly I-Cindole-3-carbinol inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]27783115
D011070Poly I-CPoly I-C results in increased expression of IL12A mRNA27783115
D011070Poly I-CTetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]27783115
D011112Polymyxin BPolymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of [IL12A protein binds to IL12B protein]]26882889
D059808PolyphenolsPolyphenols results in decreased expression of IL12A mRNA16293270
D011134Polysaccharides2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]15894585
D011134Polysaccharideshelenalin inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]15894585
D011134PolysaccharidesPolysaccharides results in increased expression of IL12A mRNA15894585
D011134PolysaccharidesPolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]15894585
D011134PolysaccharidesSB 203580 inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]15894585
C028797pralidoxime"pralidoxime inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of IL12A mRNA]"27655295
D011241PrednisonePrednisone results in increased expression of [IL12A protein binds to IL12B protein]19584951
C009042pristaneIL12A protein affects the susceptibility to pristane12911539
D011374Progesterone"[Progesterone co-treated with Estradiol] inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of [IL12A protein binds to IL12B protein]]"20130130
D011374Progesterone"Progesterone inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of [IL12A protein binds to IL12B protein]]"20130130
D011374ProgesteroneProgesterone results in increased expression of [IL12A protein binds to IL12B protein]20130130
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of IL12A mRNA19693291
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [[IFNG protein co-treated with nickel sulfate] results in increased expression of IL12A mRNA]20525893
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Amitriptyline results in decreased expression of IL12A mRNA]28263824
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Fluoxetine results in decreased expression of IL12A mRNA]28263824
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of IL12A mRNA19429434
D011899RanitidineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]11752121
D011899RanitidineRanitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein]9819373
C402365resiquimod[Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA18490488
C402365resiquimod[Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]18490488
C402365resiquimod[beta-Glucans co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA18490488
C402365resiquimod[beta-Glucans co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]18490488
C402365resiquimodIFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]]18490488
C402365resiquimodresiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]18490488
C402365resiquimod[Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]18490488
C402365resiquimod[resiquimod co-treated with Lipopolysaccharides] results in increased secretion of [IL12A protein binds to IL12B protein]15851485
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]23452621
C059514resveratrolresveratrol promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12B protein co-treated with IL12A protein]]15135313
C059514resveratrolresveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL12A protein]14996416
C059514resveratrolresveratrol inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12B protein co-treated with IL12A protein]]]15135313
D012254Ribavirin[Ribavirin co-treated with IFNA2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]9722937
D012254RibavirinRibavirin promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]9722937
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]]16872382
C045282roquinimexroquinimex results in decreased expression of IL12A mRNA15270847
C089730rosiglitazonerosiglitazone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]17475839
C099445S 28463S 28463 results in decreased expression of [IL12A protein binds to IL12B protein]16361354
C121329sanglifehrin Asanglifehrin A results in decreased expression of IL12A mRNA12847216
C121329sanglifehrin Asanglifehrin A results in decreased expression of [IL12A protein binds to IL12B protein]12847216
C093642SB 203580"SB 203580 inhibits the reaction [Drugs, Chinese Herbal results in increased secretion of [IL12A protein binds to IL12B protein]]"15894585
C093642SB 203580SB 203580 inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased expression of IFNG protein]10952721
C093642SB 203580SB 203580 inhibits the reaction [Polysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]15894585
C093642SB 203580SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]11006016
C093642SB 203580SB 203580 inhibits the reaction [[IFNG protein co-treated with nickel sulfate] results in increased expression of IL12A mRNA]20525893
D012822Silicon DioxideIL12A gene mutant form promotes the reaction [Silicon Dioxide results in increased expression of and results in increased secretion of IL12B protein]12193738
D012822Silicon DioxideIL12A gene mutant form results in increased susceptibility to Silicon Dioxide12193738
D020123SirolimusSirolimus inhibits the reaction [IL4 protein results in increased expression of [IL12A protein binds to IL12B protein]]12531798
C517409statticstattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]26297436
D012460SulfasalazineSulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]11529938
D013739TestosteroneTestosterone results in decreased expression of IL12A mRNA19693291
D013739TestosteroneTestosterone results in increased expression of IL12A mRNA19693291
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of IL12A mRNA26496021
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]27783115
D013749TetrachlorodibenzodioxinCDX2 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]]27783115
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CL 075 results in increased expression of IL12A mRNA]27783115
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]27783115
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]27783115
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]21097750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]21097750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]21097750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL12A mRNA12167310
D013755Tetradecanoylphorbol Acetate"IL12A results in decreased susceptibility to [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate]"22359662
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL12A mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of [IL12A protein binds to IL12B protein]11788559
D013806TheophyllineTheophylline results in decreased expression of [IL12A protein binds to IL12B protein]15569413
C009495titanium dioxidetitanium dioxide results in increased expression of IL12A mRNA19695317
C009495titanium dioxidetitanium dioxide results in decreased expression of IL12A mRNA23409001
D014050TolueneToluene affects the expression of IL12A mRNA21601613
D014050TolueneToluene results in decreased expression of IL12A mRNA22057034
D014118Toxins, Biological"Toxins, Biological affects the expression of IL12A mRNA"19682533
D001371trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of IL12A mRNA"9756745
D001371trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of [IL12A protein binds to IL12B protein]"9756745
D014212TretinoinRARA protein affects the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]]16872382
D014212TretinoinRo 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]]16872382
D014212TretinoinTretinoin results in decreased expression of IL12A mRNA15189689|1687238
D014212TretinoinTretinoin results in decreased expression of [IL12A protein binds to IL12B protein]17118196
C012589trichostatin Atrichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]12470611
C012589trichostatin Atrichostatin A results in increased expression of IL12A mRNA12470611
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of IL12A mRNA15973123
C001899triptolidetriptolide results in decreased expression of [IL12A protein binds to IL12B protein]15663903
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IL12A mRNA"26743178
D014415TunicamycinTunicamycin inhibits the reaction [IL12A protein binds to IL12B protein]10779781
D014415TunicamycinTunicamycin results in decreased N-linked glycosylation of IL12A protein10779781
D014415TunicamycinTunicamycin results in decreased secretion of [IL12A protein binds to IL12B protein]10779781
C113580U 0126U 0126 inhibits the reaction [[Histamine results in increased activity of HRH4 protein] which results in decreased expression of IL12A protein]15843518
C113580U 0126U 0126 inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased expression of IFNG protein]10952721
C113580U 0126U 0126 promotes the reaction [loxoribine results in increased expression of IL12A protein]15777634
C113580U 0126U 0126 promotes the reaction [loxoribine results in increased expression of [IL12A protein binds to IL12B protein]]15777634
D014520UrethaneFreund's Adjuvant promotes the reaction [Urethane results in decreased expression of IL12A mRNA]12810352
D058425Vaccines, Virus-Like Particle"Estradiol inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of [IL12A protein binds to IL12B protein]]"20130130
D058425Vaccines, Virus-Like Particle"[Progesterone co-treated with Estradiol] inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of [IL12A protein binds to IL12B protein]]"20130130
D058425Vaccines, Virus-Like Particle"Progesterone inhibits the reaction [Vaccines, Virus-Like Particle results in increased expression of [IL12A protein binds to IL12B protein]]"20130130
D058425Vaccines, Virus-Like Particle"Vaccines, Virus-Like Particle results in increased expression of [IL12A protein binds to IL12B protein]"20130130
D001335Vehicle Emissions[Vehicle Emissions co-treated with Ozone] results in decreased expression of [IL12A protein binds to IL12B protein]27058360
D001335Vehicle EmissionsVehicle Emissions inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]19805405
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IL12A gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of IL12A mRNA16007645
D001335Vehicle EmissionsVehicle Emissions results in increased expression of IL12A mRNA24216475
C121611VIVIT peptideVIVIT peptide inhibits the reaction [Zymosan results in increased expression of [IL12A protein binds to IL12B protein]]17312158
D014859WarfarinWarfarin results in increased expression of IL12A mRNA22342526
C009687wortmanninwortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]16116186
C009687wortmanninwortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]16116186
C009687wortmanninwortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]16116186
C063449zileutonzileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]19118273
D015054ZymosanZymosan results in increased expression of IL12A mRNA17988736
D015054ZymosanIFNG protein promotes the reaction [[Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]]18490488
D015054ZymosanIFNG protein promotes the reaction [Zymosan results in increased expression of [IL12A protein binds to IL12B protein]]18490488
D015054Zymosan[Zymosan co-treated with resiquimod] results in increased expression of [IL12A protein binds to IL12B protein]18490488
D015054ZymosanCyclosporine inhibits the reaction [Zymosan results in increased expression of [IL12A protein binds to IL12B protein]]17312158
D015054ZymosanIRF1 protein affects the reaction [Zymosan affects the expression of [IL12A protein binds to IL12B protein]]10415056
D015054ZymosanIRF2 protein affects the reaction [Zymosan affects the expression of [IL12A protein binds to IL12B protein]]10415056
D015054ZymosanTLR2 protein promotes the reaction [Zymosan results in increased expression of [IL12A protein binds to IL12B protein]]17312158
D015054ZymosanVIVIT peptide inhibits the reaction [Zymosan results in increased expression of [IL12A protein binds to IL12B protein]]17312158
D015054ZymosanZymosan results in increased expression of [IL12A protein binds to IL12B protein]17312158
D015054ZymosanZymosan results in increased expression of IL12A mRNA16973119

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activitycontributes_toIDA1674604  
GO:0005125cytokine activitycontributes_toTAS1673147  
GO:0005143interleukin-12 receptor binding-NAS1674604  
GO:0005515protein binding-IPI7527811  10899108  11023671  
GO:0008083growth factor activitycontributes_toIDA1674604  
GO:0008083growth factor activitycontributes_toNAS1673147  
GO:0042163interleukin-12 beta subunit binding-IPI11023671  
GO:0045513interleukin-27 binding-IPI9342359  
GO:0046982protein heterodimerization activity-IPI1674604  11023671  
GO ID GO Term Qualifier Evidence PubMed
GO:0001916positive regulation of T cell mediated cytotoxicity-IDA1674604  2204066  
GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target-IDA7903063  
GO:0006955immune response-TAS9789052  
GO:0007050cell cycle arrest-IDA16942485  
GO:0008283cell proliferation-IEA-  
GO:0009615response to virus-IEP16548883  
GO:0010224response to UV-B-IDA8992506  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0016477cell migration-IDA7903063  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032496response to lipopolysaccharide-IDA7605994  8557999  
GO:0032609interferon-gamma production-IEA-  
GO:0032700negative regulation of interleukin-17 production-IDA16482511  
GO:0032729positive regulation of interferon-gamma production-IDA1674604  11114383  19088061  
GO:0032816positive regulation of natural killer cell activation-IDA1674604  
GO:0032946positive regulation of mononuclear cell proliferation-IMP11023671  
GO:0034393positive regulation of smooth muscle cell apoptotic process-IDA16942485  
GO:0035711T-helper 1 cell activation-IEA-  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0035744T-helper 1 cell cytokine production-IEA-  
GO:0042102positive regulation of T cell proliferation-IEA-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IDA12372421  
GO:0042832defense response to protozoan-IEA-  
GO:0045582positive regulation of T cell differentiation-IEA-  
GO:0045785positive regulation of cell adhesion-IDA7903063  
GO:0045954positive regulation of natural killer cell mediated cytotoxicity-IDA2204066  
GO:0048662negative regulation of smooth muscle cell proliferation-IDA16942485  
GO:0050671positive regulation of lymphocyte proliferation-IDA1674604  2204066  
GO:0050830defense response to Gram-positive bacterium-IEP1357073  
GO:0051135positive regulation of NK T cell activation-IDA19088061  
GO:0070757interleukin-35-mediated signaling pathway-TAS-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0097191extrinsic apoptotic signaling pathway-IDA16942485  
GO:0098586cellular response to virus-IMP25754930  
GO:2000510positive regulation of dendritic cell chemotaxis-IMP25754930  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA16456693  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0009986cell surface-IEA-  
GO:0031906late endosome lumen-TAS-  
GO:0043514interleukin-12 complex-IDA2204066  11023671  11114383  
GO:0043514interleukin-12 complex-NAS1674604  14718574  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05143African trypanosomiasis
hsa05144Malaria
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa05330Allograft rejection
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-447115Interleukin-12 family signalingIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-6783783Interleukin-10 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-8984722Interleukin-35 SignallingTAS
R-HSA-9020591Interleukin-12 signalingTAS
R-HSA-9020591Interleukin-12 signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28930110Cytokine single-nucleotide polymorphisms and risk of non-small-cell lung cancer. (2017 Dec)Perez-Ramirez CPharmacogenet Genomics
22614250Contribution of IL12A and IL12B polymorphisms to the risk of cervical cancer. (2012 Oct)Roszak APathol Oncol Res
26267705Epigenetics and Primary Biliary Cirrhosis: a Comprehensive Review and Implications for Autoimmunity. (2016 Jun)Xie YQClin Rev Allergy Immunol