Gene: IL12RB2

3595
-
interleukin 12 receptor subunit beta 2
protein-coding
1p31.3
Ensembl:ENSG00000081985 MIM:601642 Vega:OTTHUMG00000009094 UniprotKB:Q99665
NG_032977.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.045e-1 (AD)  3.896e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3762317chr1:67306899 (GRCh38.p7)A>C / A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XKR40.9
ERC20.896
CLSTN20.895
GABRG30.892
EPHA50.887
OSBPL100.885
NELL10.883
ARHGAP200.881
PTPN30.881
RASGRP10.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.625
COPZ2-0.604
IMPA2-0.598
STON2-0.594
CHST14-0.591
RNF135-0.59
GNG5-0.587
HIST1H1C-0.584
ROM1-0.583
TRIP6-0.578

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of IL12RB2 mRNA]"12451176
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL12RB2 mRNA"25614096
D000082AcetaminophenAcetaminophen results in decreased expression of IL12RB2 mRNA17585979
C430898AGN 194204AGN 194204 results in decreased expression of IL12RB2 mRNA11970994
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of IL12RB2 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of IL12RB2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL12RB2 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of IL12RB2 mRNA15761015
C015001arsenitearsenite results in increased methylation of IL12RB2 promoter23974009
D001761BleomycinBleomycin results in increased expression of IL12RB2 mRNA11350791
D002087ButyratesButyrates results in decreased expression of IL12RB2 protein11024006
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IL12RB2 mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IL12RB2 mRNA12734012
C515179caryophyllene oxidecaryophyllene oxide inhibits the reaction [Ovalbumin results in increased expression of IL12RB2 mRNA]28344896
C007020chlorophyllinchlorophyllin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12RB2 mRNA]16275627
D002772Cholera ToxinCholera Toxin results in decreased expression of IL12RB2 protein9927516
D003300CopperCopper deficiency results in increased expression of IL12RB2 mRNA26033743
D016572CyclosporineCyclosporine results in increased expression of IL12RB2 mRNA11438525
D013759DronabinolDronabinol results in increased expression of IL12RB2 mRNA18163980
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of IL12RB2 mRNA]18792785
D013759DronabinolDronabinol results in decreased expression of IL12RB2 mRNA14741435|1879278
D013759Dronabinolrimonabant inhibits the reaction [Dronabinol results in decreased expression of IL12RB2 mRNA]14741435|1879278
D003907DexamethasoneDexamethasone results in decreased expression of IL12RB2 mRNA9743329
D019422Dietary SucroseDietary Sucrose results in increased expression of IL12RB2 mRNA26033743
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IL12RB2 mRNA17108234
C027478glucuronoxylomannanglucuronoxylomannan results in decreased expression of IL12RB2 protein12047756|1286481
D006152Cyclic GMPCyclic GMP results in increased expression of IL12RB2 mRNA12451176
C054591hachimijioganhachimijiogan results in decreased expression of IL12RB2 mRNA12022442
D007213IndomethacinIndomethacin results in increased expression of IL12RB2 mRNA12228301
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL12RB2 mRNA25613284
D008070Lipopolysaccharideschlorophyllin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12RB2 mRNA]16275627
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL12RB2 mRNA25613284
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of IL12RB2 mRNA10651948
D008627Mercuric ChlorideMercuric Chloride results in increased expression of IL12RB2 mRNA10447925
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IL12RB2 mRNA26011545
D009173Mycophenolic AcidMycophenolic Acid results in decreased expression of IL12RB2 mRNA11562063
D009532NickelNickel results in increased expression of IL12RB2 mRNA24768652|2558310
D009569Nitric OxideNitric Oxide results in increased expression of IL12RB2 mRNA12451176
C093285NOC 18"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [NOC 18 results in increased expression of IL12RB2 mRNA]"12451176
C093285NOC 18NOC 18 results in increased expression of IL12RB2 mRNA12451176
D010047Ovalbumincaryophyllene oxide inhibits the reaction [Ovalbumin results in increased expression of IL12RB2 mRNA]28344896
D010047OvalbuminOvalbumin results in increased expression of IL12RB2 mRNA28344896
D015232DinoprostoneDinoprostone results in decreased expression of IL12RB2 mRNA9743329
C006253pirinixic acidpirinixic acid results in increased expression of IL12RB2 mRNA20813756
D012293RifampinRifampin results in decreased expression of IL12RB2 mRNA24552687
C089032rimonabantrimonabant inhibits the reaction [Dronabinol results in decreased expression of IL12RB2 mRNA]14741435|1879278
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL12RB2 mRNA18684927
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of IL12RB2 protein11441113
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL12RB2 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL12RB2 mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IL12RB2 mRNA19042947
D010853Picryl ChlorideIL12RB2 protein results in increased susceptibility to Picryl Chloride18725520
D014635Valproic AcidValproic Acid affects the expression of IL12RB2 mRNA25979313
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL12RB2 mRNA16979875
D019287Zinc SulfateZinc Sulfate results in increased expression of IL12RB2 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004896cytokine receptor activity-TAS8943050  
GO:0019901protein kinase binding-IEA-  
GO:0019955cytokine binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-TAS8943050  
GO:0008284positive regulation of cell proliferation-TAS8943050  
GO:0018108peptidyl-tyrosine phosphorylation-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0032609interferon-gamma production-IEA-  
GO:0032729positive regulation of interferon-gamma production-IDA11114383  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0070757interleukin-35-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8943050  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009897external side of plasma membrane-IEA-  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-447115Interleukin-12 family signalingIEA
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-8984722Interleukin-35 SignallingTAS
R-HSA-9020591Interleukin-12 signalingIEA
R-HSA-9020591Interleukin-12 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal