Gene info: ID 3596

Gene: IL13

GENE ID: 3596

Synonyms: IL-13|P600

Description: interleukin 13

Gene type: protein-coding

Location: 5q31.1

dbXrefs: Ensembl:ENSG00000169194 MIM:147683 Vega:OTTHUMG00000059723 UniprotKB:P35225

RefSeq: NG_012090.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 20

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.383e-1 (AD) 1.344e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GLB1L2	0.464
CES3	0.457
HAS1	0.453
PGAP3	0.449
TCTE1	0.445
NHLRC1	0.445
BFSP1	0.442
NME9	0.44
CDHR2	0.44
OPRL1	0.439

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HEY2	-0.281
YES1	-0.275
C9orf153	-0.269
HBB	-0.269
CPM	-0.261
MBNL3	-0.26
DNAI2	-0.256
GEM	-0.251
TEAD2	-0.25
HBA2	-0.247

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB05305	Cintredekin Besudotox	BiotechDrug	-	Investigational	Target
DB11914	Lebrikizumab	BiotechDrug	953400-68-5	Investigational	Target
DB11914	Lebrikizumab	BiotechDrug	953400-68-5	Investigational	Target

ID	Drug Name	Action	PubMed
C015262	1,6-hexamethylene diisocyanate	"1,6-hexamethylene diisocyanate results in increased secretion of IL13 protein"	17693426
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of IL13 mRNA	25827057
C552888	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide	"2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide results in decreased expression of IL13 protein"	19458046
C469683	2-(6-((3-(4-(diphenylmethoxy)piperidino)propyl)amino)imidazo(1,2-b)pyridazin-2-yl)-2-methylpropionic acid	"2-(6-((3-(4-(diphenylmethoxy)piperidino)propyl)amino)imidazo(1,2-b)pyridazin-2-yl)-2-methylpropionic acid inhibits the reaction [Dexamethasone results in increased expression of IL13 mRNA]"	12438553
C018855	2-tert-butylhydroquinone	[2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL13 protein	22250088
C018855	2-tert-butylhydroquinone	[2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of IL13 mRNA	22250088
C539252	3-(2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl)phenol	"3-(2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl)phenol results in decreased expression of IL13 protein"	19056934
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased secretion of IL13 protein"	29216392
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of IL13 mRNA"	18648102
C005969	4,4'-diphenylmethane diisocyanate	"4,4'-diphenylmethane diisocyanate results in increased expression of IL13 mRNA"	16940033
C072956	4-nitrososulfamethoxazole	4-nitrososulfamethoxazole results in increased secretion of IL13 protein	22331489
C025637	4-tolyl isocyanate	4-tolyl isocyanate results in increased expression of IL13 mRNA	15664275
C031433	8-(4-sulfophenyl)theophylline	8-(4-sulfophenyl)theophylline inhibits the reaction [9-(2-hydroxy-3-nonyl)adenine results in increased secretion of IL13 protein]	17696452
C031433	8-(4-sulfophenyl)theophylline	8-(4-sulfophenyl)theophylline results in decreased secretion of IL13 protein	17696452
C010192	9-(2-hydroxy-3-nonyl)adenine	8-(4-sulfophenyl)theophylline inhibits the reaction [9-(2-hydroxy-3-nonyl)adenine results in increased secretion of IL13 protein]	17696452
C010192	9-(2-hydroxy-3-nonyl)adenine	9-(2-hydroxy-3-nonyl)adenine results in increased secretion of IL13 protein	17696452
C106538	abacavir	[HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of IL13 protein	23541086
D000082	Acetaminophen	Acetaminophen results in increased expression of IL13 protein	11826401\|1743924
D000082	Acetaminophen	IL13 gene mutant form results in increased susceptibility to Acetaminophen	22107450
D000082	Acetaminophen	IL13 protein results in decreased susceptibility to Acetaminophen	17439248
D000096	Acetone	[Acetone co-treated with Olive Oil] results in increased expression of IL13 mRNA	21252390
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL13 protein]	26138014
D020106	Acrylamide	Acrylamide results in decreased expression of IL13 mRNA	28959563
D000276	Adjuvants, Immunologic	"Adjuvants, Immunologic results in increased secretion of IL13 protein"	22967010
C430898	AGN 194204	AGN 194204 results in decreased expression of IL13 mRNA	16339527
D000393	Air Pollutants	Air Pollutants results in increased expression of IL13 mRNA	28669936
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of IL13 protein"	25172162
D000395	Air Pollutants, Occupational	"TLR4 protein affects the reaction [Air Pollutants, Occupational results in increased expression of IL13 protein]"	25172162
D000420	Albuterol	[Albuterol co-treated with Albuterol] results in increased expression of IL13 protein	11897990
C103303	alitretinoin	alitretinoin results in increased expression of IL13 mRNA	17118196
C103303	alitretinoin	alitretinoin results in increased expression of IL13 protein	17118196
D000485	Allergens	bis(tri-n-butyltin)oxide inhibits the reaction [Allergens results in decreased expression of IL13 protein]	17669578
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of IL13 protein	26025059
D000535	Aluminum	Aluminum results in increased secretion of IL13 protein	22967010
D000536	Aluminum Hydroxide	Aluminum Hydroxide results in increased expression of IL13 mRNA	9328138
C026967	Amb a I protein, Ambrosia artemisiifolia	"[Particulate Matter co-treated with Amb a I protein, Ambrosia artemisiifolia] results in increased expression of IL13 mRNA"	9036991
C026967	Amb a I protein, Ambrosia artemisiifolia	"[Vehicle Emissions co-treated with Amb a I protein, Ambrosia artemisiifolia] results in increased expression of IL13 mRNA"	9036991
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IL13 mRNA	16483693
D019380	Anti-HIV Agents	Anti-HIV Agents results in decreased expression of IL13 mRNA	10202824
D000936	Antigen-Antibody Complex	Antigen-Antibody Complex results in increased expression of IL13 mRNA	25451590
D000936	Antigen-Antibody Complex	shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of IL13 mRNA]	25451590
D000941	Antigens	Antigens results in increased secretion of IL13 protein	16160912
D039741	Antigens, Dermatophagoides	"[Antigens, Dermatophagoides co-treated with Nanotubes, Carbon] results in increased expression of IL13 mRNA"	26091108
D039741	Antigens, Dermatophagoides	"Antigens, Dermatophagoides results in increased expression of IL13 mRNA"	26091108
D039741	Antigens, Dermatophagoides	"Antigens, Dermatophagoides results in increased expression of IL13 protein"	20064775\|2406027
D039741	Antigens, Dermatophagoides	"GATA3 protein affects the reaction [[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"	27315767
D039741	Antigens, Dermatophagoides	"GATA3 protein affects the reaction [[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"	27315767
D039741	Antigens, Dermatophagoides	"[Methoxychlor co-treated with Antigens, Dermatophagoides] affects the expression of IL13 protein"	21864637
D039741	Antigens, Dermatophagoides	"[Parathion co-treated with Antigens, Dermatophagoides] affects the expression of IL13 protein"	21864637
D039741	Antigens, Dermatophagoides	"[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased secretion of IL13 protein"	27315767
D039741	Antigens, Dermatophagoides	"Particulate Matter promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL13 protein]"	24060272
D039741	Antigens, Dermatophagoides	"RAG2 protein affects the reaction [[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"	27315767
D039741	Antigens, Dermatophagoides	"RAG2 protein affects the reaction [[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"	27315767
D039741	Antigens, Dermatophagoides	"[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased secretion of IL13 protein"	27315767
D039741	Antigens, Dermatophagoides	"Vehicle Emissions promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL13 protein]"	24060272
D052179	Antigens, Plant	"Antigens, Plant results in increased expression of IL13 mRNA"	21334316
D052179	Antigens, Plant	"zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL13 mRNA]"	21334316
C005752	araldite	araldite results in increased expression of IL13 mRNA	14599759
D001151	Arsenic	Arsenic results in increased methylation of IL13 gene	27838757
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [GATA3 protein binds to IL13 promoter]	19080345
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of IL13 mRNA	19080345
C006632	arsenic trioxide	arsenic trioxide results in decreased secretion of IL13 protein	19080345
D001241	Aspirin	IL13 polymorphism affects the susceptibility to Aspirin	22123380
D001397	Azoxymethane	Azoxymethane results in increased expression of IL13 protein	20431929
C416282	BAY 11-7085	"BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]"	17015710
D001507	Beclomethasone	Beclomethasone inhibits the reaction [IL13 protein results in increased expression of CCL11 protein]	17988555
D001507	Beclomethasone	Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]	17988555
D001507	Beclomethasone	Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 protein]	17988555
D001507	Beclomethasone	Beclomethasone results in increased activity of IL13 protein	17988555
D019324	beta-Naphthoflavone	beta-Naphthoflavone promotes the reaction [Plant Extracts results in increased expression of IL13 protein]	22491429
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IL13 mRNA	22228805
D047090	beta-Lactams	IL13 gene polymorphism affects the susceptibility to beta-Lactams	20485159
D001688	Biological Products	Biological Products inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 mRNA]	23200891
C006780	bisphenol A	[bisphenol A co-treated with OVAL protein] results in increased expression of IL13 mRNA	27087817
C006780	bisphenol A	[OVAL protein co-treated with bisphenol A] results in increased expression of IL13 protein	24950052
C006780	bisphenol A	bisphenol A results in decreased expression of IL13 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide inhibits the reaction [Allergens results in decreased expression of IL13 protein]	17669578
D001761	Bleomycin	IL13 gene mutant form results in decreased susceptibility to Bleomycin	15322207
D001761	Bleomycin	IL13 protein affects the reaction [Bleomycin results in increased expression of RETNLA mRNA]	15322207
C546611	brevetoxin 2	brevetoxin 2 results in increased expression of IL13 mRNA	20498034
C006794	brevianamide A	brevianamide A results in increased expression of IL13 mRNA	19818335
D019819	Budesonide	Budesonide inhibits the reaction [IL13 protein results in increased expression of CCL11 protein]	17988555
D019819	Budesonide	Budesonide inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]	17988555
D019819	Budesonide	Budesonide inhibits the reaction [IL13 protein results in increased expression of IL6 protein]	17988555
D019819	Budesonide	Budesonide results in increased activity of IL13 protein	17988555
C018475	butyraldehyde	butyraldehyde results in decreased expression of IL13 mRNA	26079696
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL13 protein]	26138014
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of and results in increased secretion of IL13 protein	26138014
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of IL13 mRNA	12160620
D000001	Calcimycin	[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL13 protein	12789233
D000001	Calcimycin	Calcimycin results in increased expression of IL13 mRNA	12789233
D000001	Calcimycin	fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL13 protein]	12789233
D000001	Calcimycin	fisetin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA]	12789233
D000001	Calcimycin	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL13 mRNA]	21331654
D000001	Calcimycin	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL13 mRNA	21331654
D000001	Calcimycin	Calcimycin results in increased expression of IL13 mRNA	25451590
D000001	Calcimycin	shikonin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA]	25451590
D000001	Calcimycin	Calcimycin results in increased expression of IL13 mRNA	17950587
D000001	Calcimycin	Luteolin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA]	17950587
D000001	Calcimycin	thunberginol B inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA]	17950587
D002118	Calcium	IL13 protein inhibits the reaction [IL11 protein results in increased abundance of Calcium]	12110441
D002211	Capsaicin	Capsaicin results in increased expression of IL13 protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin results in increased expression of IL13 protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL13 protein]	22150557
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IL13 mRNA	18263696
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of IL13 protein	17412915
D002251	Carbon Tetrachloride	IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL13 protein]	17412915
D002713	Chlorine	Chlorine results in increased expression of IL13 protein	23146759
C031294	chlorobenzene	CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]	18514500
C031294	chlorobenzene	chlorobenzene results in increased expression of IL13 protein	18514500
D002725	Chloroform	Chloroform results in increased expression of IL13 protein	16879906
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of IL13 mRNA	22265773
C055162	clopidogrel	clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 mRNA]	19172522
C000593591	coagulin-L	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein]	27568862
C000593591	coagulin-L	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein]	27568862
D003033	Coal Tar	Coal Tar inhibits the reaction [[IL4 protein co-treated with IL13 protein] results in decreased expression of FLG mRNA]	23348739
D003033	Coal Tar	Coal Tar inhibits the reaction [[IL4 protein co-treated with IL13 protein] results in decreased expression of HRNR mRNA]	23348739
D003033	Coal Tar	Coal Tar inhibits the reaction [[IL4 protein co-treated with IL13 protein] results in decreased expression of IVL mRNA]	23348739
D003033	Coal Tar	Coal Tar inhibits the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CCL26 mRNA]	23348739
D003033	Coal Tar	Coal Tar inhibits the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]	23348739
D005576	Colforsin	Colforsin results in decreased expression of IL13 mRNA	16083514
D005576	Colforsin	Colforsin results in decreased secretion of IL13 protein	16083514
D003300	Copper	Copper deficiency results in increased expression of IL13 mRNA	26033743
D003435	Crotalid Venoms	Crotalid Venoms results in increased expression of IL13 mRNA	29248447
C038459	curdlan	curdlan affects the expression of IL13 mRNA	19904525
C038459	curdlan	curdlan results in increased expression of IL13 mRNA	23543010
C556733	dechlorane 602	dechlorane 602 results in increased expression of IL13 mRNA	27081854
C556733	dechlorane 602	dechlorane 602 results in increased expression of IL13 protein	27081854
C451162	Dermatophagoides pteronyssinus antigen p 1	[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] inhibits the reaction [Ozone results in increased expression of IL13 mRNA]	28529118
C451163	Dermatophagoides pteronyssinus antigen p 2	[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] inhibits the reaction [Ozone results in increased expression of IL13 mRNA]	28529118
C494355	desisobutyrylciclesonide	desisobutyrylciclesonide inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]	26003274
C494355	desisobutyrylciclesonide	desisobutyrylciclesonide inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 protein]	26003274
C494355	desisobutyrylciclesonide	desisobutyrylciclesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]]	26003274
D003907	Dexamethasone	"2-(6-((3-(4-(diphenylmethoxy)piperidino)propyl)amino)imidazo(1,2-b)pyridazin-2-yl)-2-methylpropionic acid inhibits the reaction [Dexamethasone results in increased expression of IL13 mRNA]"	12438553
D003907	Dexamethasone	Dexamethasone inhibits the reaction [IL13 protein results in increased secretion of CSF2 protein]	12077271
D003907	Dexamethasone	Dexamethasone inhibits the reaction [IL13 protein results in increased secretion of CXCL8 protein]	12077271
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein]	27568862
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein]	27568862
D003907	Dexamethasone	Dexamethasone results in decreased expression of IL13 protein	19056934
D003907	Dexamethasone	Dexamethasone results in increased expression of IL13 mRNA	22842586
D003907	Dexamethasone	Dexamethasone results in increased expression of IL13 protein	22842586
D003994	Bucladesine	Bucladesine results in decreased expression of IL13 mRNA	16083514
D003994	Bucladesine	Bucladesine results in decreased secretion of IL13 protein	16083514
D004041	Dietary Fats	[[TCRD protein affects the susceptibility to Dietary Fats] which affects the susceptibility to Ozone] which affects the expression of IL13 protein	27472835
D004052	Diethylnitrosamine	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of IL13 gene	23968726
D004052	Diethylnitrosamine	Diethylnitrosamine affects the expression of IL13 protein	25051504
D002117	Calcitriol	[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein] affects the phosphorylation of STAT6 protein	26091108
D002117	Calcitriol	[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with IL4 protein] affects the phosphorylation of STAT6 protein	26091108
D002117	Calcitriol	"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"	26091108
D002117	Calcitriol	"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon co-treated with IL4 protein] affects the phosphorylation of STAT6 protein"	26091108
D002117	Calcitriol	"[IL13 protein co-treated with IL4 protein co-treated with Nanotubes, Carbon] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]"	26091108
D002117	Calcitriol	[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]	26091108
D002117	Calcitriol	IL13 protein inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]	26091108
D002117	Calcitriol	"IL13 protein inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the secretion of IL1B protein]"	26091108
D002117	Calcitriol	"[IL4 protein co-treated with IL13 protein] inhibits the reaction [Nanotubes, Carbon promotes the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA]]"	26091108
D002117	Calcitriol	leflunomide inhibits the reaction [[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]]	26091108
D004137	Dinitrochlorobenzene	Biological Products inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 mRNA]	23200891
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of IL13 mRNA	23200891\|2345414
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of IL13 protein	23133493
D004137	Dinitrochlorobenzene	Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 mRNA]	23454147
D004137	Dinitrochlorobenzene	Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 protein]	23133493
D004137	Dinitrochlorobenzene	Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 protein]	23133493
C034638	dinitrophenyl-bovine serum albumin	desisobutyrylciclesonide inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]	26003274
C034638	dinitrophenyl-bovine serum albumin	desisobutyrylciclesonide inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 protein]	26003274
C034638	dinitrophenyl-bovine serum albumin	desisobutyrylciclesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]]	26003274
C034638	dinitrophenyl-bovine serum albumin	Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]	26003274
C034638	dinitrophenyl-bovine serum albumin	Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 protein]	26003274
C058064	dinitrophenyl-human serum albumin conjugate	dinitrophenyl-human serum albumin conjugate results in increased secretion of IL13 protein	26621445
C058064	dinitrophenyl-human serum albumin conjugate	resveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased secretion of IL13 protein]	26621445
D022681	Diphtheria-Tetanus-acellular Pertussis Vaccines	Diphtheria-Tetanus-acellular Pertussis Vaccines results in increased expression of IL13 protein	16299307
C076946	donepezil	donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]]	26114860
D004391	Dust	Dust inhibits the reaction [Ovalbumin results in decreased expression of IL13 mRNA]	17578863
D004391	Dust	Dust inhibits the reaction [Ovalbumin results in decreased expression of IL13 protein]	17578863
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D004391	Dust	[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein	26882889
D004391	Dust	Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D004391	Dust	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D004391	Dust	TLR4 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D004642	Emodin	Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein]	22484343
C053090	epinastine	epinastine results in decreased expression of IL13 mRNA	16534218
C053090	epinastine	epinastine results in decreased expression of IL13 protein	16534218
D004974	Etazolate	Etazolate results in decreased expression of IL13 mRNA	16083514
D004974	Etazolate	Etazolate results in decreased secretion of IL13 protein	16083514
D004977	Ethambutol	Ethambutol results in increased secretion of IL13 protein	27933861
D019830	Adenosine-5'-(N-ethylcarboxamide)	Adenosine-5'-(N-ethylcarboxamide) results in increased secretion of IL13 protein	17696452
C036216	ethylene	ethylene results in increased expression of IL13	26367701
D015025	Zearalenone	Zearalenone results in increased expression of IL13 mRNA	27757495
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]	21203431
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]	21203431
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]	21203431
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein]	21203431
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]	21203431
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein]	21203431
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein]	21203431
C077139	fidarestat	fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein]	21203431
C077139	fidarestat	fidarestat results in decreased susceptibility to IL13 protein	21203431
C077139	fidarestat	fidarestat inhibits the reaction [Plant Extracts results in increased expression of IL13 mRNA]	21203431
C017875	fisetin	fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL13 protein]	12789233
C017875	fisetin	fisetin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA]	12789233
D005557	Formaldehyde	Formaldehyde results in increased expression of IL13 mRNA	12161283
D000068759	Formoterol Fumarate	desisobutyrylciclesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]]	26003274
D000068759	Formoterol Fumarate	Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]	26003274
D000068759	Formoterol Fumarate	Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 protein]	26003274
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of IL13 mRNA	9328138
C005023	fulvic acid	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL13 mRNA]	21331654
D008299	Maleic Anhydrides	Maleic Anhydrides results in increased expression of IL13 mRNA	14599759
C064925	gadodiamide	gadodiamide results in increased expression of IL13 mRNA	19404939
C064925	gadodiamide	gadodiamide results in increased expression of IL13 protein	19404939
C038958	gadolinium chloride	gadolinium chloride results in increased expression of IL13 mRNA	19404939
D019786	Gadolinium DTPA	Gadolinium DTPA results in increased expression of IL13 mRNA	19404939
D019786	Gadolinium DTPA	Gadolinium DTPA results in increased expression of IL13 protein	19404939
C056507	gemcitabine	gemcitabine results in increased expression of IL13 protein	20531411
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in decreased expression of IL13 mRNA	21782745
D005839	Gentamicins	Gentamicins results in decreased expression of IL13 protein	25051504
D005978	Glutathione	Glutathione inhibits the reaction [[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein]	17079650
D005978	Glutathione	[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein	18214930
C010974	glyphosate	glyphosate results in increased expression of IL13 protein	25172162
C010974	glyphosate	IL13 protein affects the reaction [glyphosate results in increased expression of IL33 protein]	25172162
C010974	glyphosate	IL13 protein affects the reaction [glyphosate results in increased expression of IL5 protein]	25172162
C010974	glyphosate	IL13 protein affects the reaction [glyphosate results in increased expression of TSLP protein]	25172162
D006108	Graphite	Graphite results in increased secretion of IL13 protein	27440207
D007975	Leukotriene B4	IL13 protein results in increased abundance of Leukotriene B4	12654629
D007975	Leukotriene B4	zileuton inhibits the reaction [IL13 protein results in increased abundance of Leukotriene B4]	12654629
D012701	Serotonin	IL13 protein affects the susceptibility to Serotonin	12370375
D006861	Hydrogen Peroxide	[IL13 protein co-treated with IFNG protein] results in increased abundance of Hydrogen Peroxide	24518246
D006918	Hydroxyurea	Hydroxyurea affects the expression of IL13 protein	15927844
C119203	ilomastat	ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein]	18852015
C114843	incomplete Freund's adjuvant	incomplete Freund's adjuvant results in increased expression of IL13 mRNA	9328138
D015759	Ionomycin	lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA]	22398747
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA	22398747
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA	25613284
C015301	isophorone diisocyanate	isophorone diisocyanate results in increased secretion of IL13 protein	17693426
C067713	lactacystin	lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA]	22398747
D007840	Latex	Latex analog results in increased expression of IL13 mRNA	24768652
C045463	leflunomide	leflunomide inhibits the reaction [[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]]	26091108
D017999	Leukotriene E4	IL13 protein results in increased abundance of Leukotriene E4	12654629
D008012	Lidocaine	Lidocaine results in decreased expression of IL13 protein	18382663
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of IL13 protein"	19878665
D008070	Lipopolysaccharides	[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein] affects the phosphorylation of STAT6 protein	26091108
D008070	Lipopolysaccharides	[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with IL4 protein] affects the phosphorylation of STAT6 protein	26091108
D008070	Lipopolysaccharides	"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"	26091108
D008070	Lipopolysaccharides	"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon co-treated with IL4 protein] affects the phosphorylation of STAT6 protein"	26091108
D008070	Lipopolysaccharides	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein]	27568862
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein]	27568862
D008070	Lipopolysaccharides	Glutathione inhibits the reaction [[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein]	17079650
D008070	Lipopolysaccharides	"[IL13 protein co-treated with IL4 protein co-treated with Nanotubes, Carbon] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]"	26091108
D008070	Lipopolysaccharides	[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]	26091108
D008070	Lipopolysaccharides	IL13 protein inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]	26091108
D008070	Lipopolysaccharides	"IL13 protein inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the secretion of IL1B protein]"	26091108
D008070	Lipopolysaccharides	"[IL4 protein co-treated with IL13 protein] inhibits the reaction [Nanotubes, Carbon promotes the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA]]"	26091108
D008070	Lipopolysaccharides	leflunomide inhibits the reaction [[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]]	26091108
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL13 protein	19020770\|2756886
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased secretion of IL13 protein	28065790
D008070	Lipopolysaccharides	[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein	17079650
D008070	Lipopolysaccharides	Triclosan inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 mRNA]	20507366
D008070	Lipopolysaccharides	clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 mRNA]	19172522
D008070	Lipopolysaccharides	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein]	27568862
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein]	27568862
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL13 protein	27568862
D008070	Lipopolysaccharides	MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL13 protein]	24453940
D008070	Lipopolysaccharides	[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased secretion of IL13 protein	24453940
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of IL13 mRNA	15998543
C009900	lipoteichoic acid	lipoteichoic acid results in increased expression of IL13 mRNA	15998543
D017997	Leukotriene C4	Leukotriene C4 results in increased expression of IL13 mRNA	12388339
D017997	Leukotriene C4	IL13 protein results in increased abundance of Leukotriene C4	12654629
D017997	Leukotriene C4	[IL13 protein results in increased abundance of Leukotriene C4] which results in increased secretion of MUC5AC protein	12654629
D017998	Leukotriene D4	IL13 protein results in increased abundance of Leukotriene D4	12654629
D017998	Leukotriene D4	[IL13 protein results in increased abundance of Leukotriene D4] which results in increased secretion of MUC5AC protein	12654629
D047311	Luteolin	Luteolin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA]	17950587
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of IL13 protein	21984480
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of CHIL3 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of MGL2 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA]	26497364
D008687	Metformin	Metformin inhibits the reaction [IL13 protein results in increased expression of RETNLA mRNA]	26497364
D008727	Methotrexate	Methotrexate results in decreased secretion of IL13 protein	27605418
D008727	Methotrexate	Methotrexate affects the expression of IL13 mRNA	18502557
D008731	Methoxychlor	"[Methoxychlor co-treated with Antigens, Dermatophagoides] affects the expression of IL13 protein"	21864637
D008731	Methoxychlor	Methoxychlor results in increased expression of IL13 protein	22842586
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in decreased expression of IL13 mRNA	21782745
C013606	methylene bis(4-cyclohexylisocyanate)	methylene bis(4-cyclohexylisocyanate) results in increased expression of IL13 mRNA	16940033
C059330	methylene diisocyanate	methylene diisocyanate results in increased secretion of IL13 protein	17693426
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]	26114860
D015655	1-Methyl-4-phenylpyridinium	donepezil inhibits the reaction [1-Methyl-4-phenylpyridinium inhibits the reaction [IL4 protein results in increased expression of IL13]]	26114860
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of IL13 protein	20045430
D009020	Morphine	Morphine results in increased expression of IL13 protein	16210602
D009151	Mustard Gas	TNF protein affects the reaction [Mustard Gas affects the expression of IL13 mRNA]	16173061
D009151	Mustard Gas	ilomastat inhibits the reaction [Mustard Gas results in increased expression of IL13 protein]	18852015
D009151	Mustard Gas	Mustard Gas results in increased expression of IL13 protein	18852015
D009173	Mycophenolic Acid	Mycophenolic Acid results in increased expression of IL13 mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in increased expression of IL13 mRNA	19818335
C510788	N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine	"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in decreased expression of IL13 protein"	16339999
C487056	N-Acetylcysteinamide	N-Acetylcysteinamide inhibits the reaction [Ovalbumin results in increased expression of IL13 protein]	18160846
D037742	Nanotubes, Carbon	"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"	26091108
D037742	Nanotubes, Carbon	"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon co-treated with IL4 protein] affects the phosphorylation of STAT6 protein"	26091108
D037742	Nanotubes, Carbon	"[IL13 protein co-treated with IL4 protein co-treated with Nanotubes, Carbon] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]"	26091108
D037742	Nanotubes, Carbon	"IL13 protein inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the secretion of IL1B protein]"	26091108
D037742	Nanotubes, Carbon	"[IL4 protein co-treated with IL13 protein] inhibits the reaction [Nanotubes, Carbon promotes the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA]]"	26091108
D037742	Nanotubes, Carbon	"[Antigens, Dermatophagoides co-treated with Nanotubes, Carbon] results in increased expression of IL13 mRNA"	26091108
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of IL13 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of IL13 mRNA"	22293422\|2604865
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of IL13 protein"	27106021
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased secretion of IL13 protein"	19371758
D037742	Nanotubes, Carbon	"[PTGS2 gene mutant form results in increased susceptibility to [Nanotubes, Carbon co-treated with OVAL protein]] which results in increased expression of IL13 mRNA"	23642096
D037742	Nanotubes, Carbon	"[PTGS2 gene mutant form results in increased susceptibility to [Nanotubes, Carbon co-treated with OVAL protein]] which results in increased expression of IL13 protein"	23642096
D009285	Naphthoquinones	Naphthoquinones promotes the reaction [OVAL protein results in increased expression of IL13 protein]	17318628
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin results in increased expression of IL13 protein]	22150557
C015380	neoechinulin	neoechinulin results in increased expression of IL13 mRNA	19818335
D009532	Nickel	Nickel results in increased expression of IL13 mRNA	24768652\|2558310
D009532	Nickel	[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of IL13 protein	24499286
C022838	nickel chloride	nickel chloride affects the expression of IL13 mRNA	24670797
D009585	Nitrogen Dioxide	Nitrogen Dioxide results in increased expression of IL13 mRNA	28669936
D009585	Nitrogen Dioxide	Nitrogen Dioxide results in decreased methylation of IL13 promoter	28935613
D009585	Nitrogen Dioxide	Nitrogen Dioxide results in increased expression of IL13 protein	28935613
D009585	Nitrogen Dioxide	[OVAL protein promotes the reaction [Nitrogen Dioxide results in increased susceptibility to OVAL protein]] which results in increased expression of IL13 protein	28935613
C025589	ochratoxin A	ochratoxin A results in increased acetylation of IL13 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of IL13 promoter] which results in increased expression of IL13 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of IL13 mRNA	29098329
D000069463	Olive Oil	[Acetone co-treated with Olive Oil] results in increased expression of IL13 mRNA	21252390
D009943	Organophosphorus Compounds	Organophosphorus Compounds results in increased expression of IL13 mRNA	23557688
D010047	Ovalbumin	Dust inhibits the reaction [Ovalbumin results in decreased expression of IL13 mRNA]	17578863
D010047	Ovalbumin	Dust inhibits the reaction [Ovalbumin results in decreased expression of IL13 protein]	17578863
D010047	Ovalbumin	Emodin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein]	22484343
D010047	Ovalbumin	LTC4S promotes the reaction [Ovalbumin results in increased expression of IL13 protein]	21429049
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D010047	Ovalbumin	N-Acetylcysteinamide inhibits the reaction [Ovalbumin results in increased expression of IL13 protein]	18160846
D010047	Ovalbumin	[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein	26882889
D010047	Ovalbumin	Ovalbumin results in decreased expression of IL13 mRNA	17578863
D010047	Ovalbumin	Ovalbumin results in decreased expression of IL13 protein	17578863
D010047	Ovalbumin	Ovalbumin results in increased expression of IL13 mRNA	12794006
D010047	Ovalbumin	Ovalbumin results in increased expression of IL13 protein	18160846\|1826115
D010047	Ovalbumin	Ovalbumin results in increased secretion of IL13 protein	22484343
D010047	Ovalbumin	PH 163 inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]	12794006
D010047	Ovalbumin	Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D010047	Ovalbumin	"thieno(2,3-c)isoquinolin-5-one inhibits the reaction [Ovalbumin results in increased expression of IL13 protein]"	18261157
D010047	Ovalbumin	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D010047	Ovalbumin	TLR4 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
D010047	Ovalbumin	verlukast inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]	12794006
D010047	Ovalbumin	zileuton inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]	12794006
D010126	Ozone	[Dermatophagoides pteronyssinus antigen p 1 co-treated with Dermatophagoides pteronyssinus antigen p 2] inhibits the reaction [Ozone results in increased expression of IL13 mRNA]	28529118
D010126	Ozone	Ozone results in increased expression of IL13 mRNA	28529118
D010126	Ozone	[CPE affects the susceptibility to Ozone] which affects the expression of IL13 mRNA	23434795
D010126	Ozone	IL13 protein affects the reaction [Ozone results in increased expression of CCL20 protein]	23434795
D010126	Ozone	IL13 protein affects the reaction [Ozone results in increased expression of CXCL1 mRNA]	18417511
D010126	Ozone	IL13 protein affects the reaction [Ozone results in increased expression of IL6 protein]	18417511
D010126	Ozone	IL13 protein results in increased susceptibility to Ozone	18417511
D010126	Ozone	IL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL13 protein]	27472835
D010126	Ozone	[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL13 protein	27472835
D010126	Ozone	[[TCRD protein affects the susceptibility to Dietary Fats] which affects the susceptibility to Ozone] which affects the expression of IL13 protein	27472835
D010126	Ozone	Ozone results in increased expression of IL13 protein	28623178
D010269	Paraquat	Paraquat results in increased expression of IL13 mRNA	17215068
D010269	Paraquat	Paraquat results in decreased expression of IL13 mRNA	17077588
D010278	Parathion	"[Parathion co-treated with Antigens, Dermatophagoides] affects the expression of IL13 protein"	21864637
D010278	Parathion	Parathion results in increased expression of IL13 mRNA	22842586
D010278	Parathion	Parathion results in increased expression of IL13 protein	22842586
D052638	Particulate Matter	IL13 protein affects the reaction [Particulate Matter results in increased expression of CCL18 protein]	16890758
D052638	Particulate Matter	"[Particulate Matter co-treated with Amb a I protein, Ambrosia artemisiifolia] results in increased expression of IL13 mRNA"	9036991
D052638	Particulate Matter	[Particulate Matter co-treated with IL13 protein] results in increased expression of CCL11 protein	12576300
D052638	Particulate Matter	Particulate Matter results in increased expression of IL13 mRNA	8765825
D052638	Particulate Matter	Particulate Matter results in increased expression of IL13 protein	16890758
D052638	Particulate Matter	"GATA3 protein affects the reaction [[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"	27315767
D052638	Particulate Matter	[NFE2L2 gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of IL13 protein	18614404
D052638	Particulate Matter	OVAL protein promotes the reaction [Particulate Matter results in increased expression of IL13 protein]	23896513
D052638	Particulate Matter	"[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased secretion of IL13 protein"	27315767
D052638	Particulate Matter	"Particulate Matter promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL13 protein]"	24060272
D052638	Particulate Matter	Particulate Matter promotes the reaction [OVAL protein results in increased expression of IL13 mRNA]	20562226
D052638	Particulate Matter	Particulate Matter results in decreased expression of IL13 mRNA	23638009
D052638	Particulate Matter	Particulate Matter results in increased expression of IL13	20061214
D052638	Particulate Matter	Particulate Matter results in increased expression of IL13 mRNA	16979384\|2170821
D052638	Particulate Matter	Particulate Matter results in increased expression of IL13 protein	17620185\|2389651
D052638	Particulate Matter	[Particulate Matter results in increased susceptibility to OVAL protein] which results in increased expression of IL13 mRNA	24365139
D052638	Particulate Matter	[Particulate Matter results in increased susceptibility to OVAL protein] which results in increased expression of IL13 protein	24365139\|2849585
D052638	Particulate Matter	[Polycyclic Aromatic Hydrocarbons co-treated with Particulate Matter] results in increased expression of IL13 protein	19654922
D052638	Particulate Matter	"RAG2 protein affects the reaction [[Particulate Matter co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"	27315767
D052638	Particulate Matter	[TBX21 gene mutant form results in increased susceptibility to Particulate Matter] which results in increased expression of IL13 protein	24499286
D052638	Particulate Matter	Particulate Matter results in increased expression of IL13 protein	22134058
D010365	Patulin	[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein	18214930
D010396	Penicillamine	Penicillamine results in decreased expression of IL13 mRNA	19575532
D010396	Penicillamine	Penicillamine results in increased expression of IL13 mRNA	19575532
D010476	Perfume	Perfume results in increased expression of IL13 mRNA	24768652
D010575	Pesticides	Pesticides results in increased expression of IL13 mRNA	23557688
D015232	Dinoprostone	Dinoprostone results in increased secretion of IL13 protein	15788148
C104857	PH 163	PH 163 inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]	12794006
C104857	PH 163	PH 163 inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]	12654629
C433028	Phe-Leu boronic acid	Phe-Leu boronic acid results in decreased expression of IL13 protein	11477338
D010634	Phenobarbital	Phenobarbital results in increased expression of IL13 mRNA	19162173
C119222	phorbol-12-myristate	[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL13 protein	12789233
C119222	phorbol-12-myristate	fisetin inhibits the reaction [[Calcimycin co-treated with phorbol-12-myristate] results in increased expression of IL13 protein]	12789233
D010706	Phosmet	Phosmet results in increased expression of IL13 mRNA	22265773
D009764	o-Phthalaldehyde	o-Phthalaldehyde results in increased expression of IL13 mRNA	21785612
C043103	phthalic anhydride	phthalic anhydride results in increased expression of IL13 mRNA	21252390
C043103	phthalic anhydride	phthalic anhydride results in increased expression of IL13 mRNA	14599759
C043103	phthalic anhydride	phthalic anhydride results in increased expression of IL13 protein	20219652
C060836	pioglitazone	"pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]"	17015710
D010882	Piperonyl Butoxide	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of IL13 gene	23968726
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of IL13 mRNA	22842586
D010936	Plant Extracts	Plant Extracts results in decreased expression of IL13 mRNA	23557933
D010936	Plant Extracts	beta-Naphthoflavone promotes the reaction [Plant Extracts results in increased expression of IL13 protein]	22491429
D010936	Plant Extracts	fidarestat inhibits the reaction [Plant Extracts results in increased expression of IL13 mRNA]	21203431
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 mRNA]	23454147
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 protein]	23133493
D010936	Plant Extracts	Plant Extracts results in increased expression of IL13 mRNA	21203431
D010936	Plant Extracts	Plant Extracts results in increased expression of IL13 protein	22491429
D010936	Plant Extracts	Plant Extracts results in increased secretion of IL13 protein	21804081
D010936	Plant Extracts	Tetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased expression of IL13 protein]	22491429
D010936	Plant Extracts	Tetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased secretion of IL13 protein]	21804081
D011063	Poly A-U	Poly A-U results in increased expression of IL13 mRNA	9328138
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons results in increased expression of IL13 protein	25048800
D011084	Polycyclic Aromatic Hydrocarbons	[Polycyclic Aromatic Hydrocarbons co-treated with Particulate Matter] results in increased expression of IL13 protein	19654922
D011112	Polymyxin B	Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of IL13 protein]	26882889
C467566	pomalidomide	pomalidomide results in decreased secretion of IL13 protein	15292067
D011239	Prednisolone	Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 protein]	23133493
D011241	Prednisone	Prednisone results in decreased expression of IL13 protein	15523430
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of IL13 mRNA	19162173
C046386	Quil A	Quil A results in increased expression of IL13 mRNA	9328138
C059514	resveratrol	resveratrol inhibits the reaction [IL13 protein results in increased expression of CCL11 mRNA]	22254182
C059514	resveratrol	resveratrol inhibits the reaction [IL13 protein results in increased secretion of CCL11 protein]	22254182
C059514	resveratrol	resveratrol results in decreased expression of IL13 mRNA	23224687
C059514	resveratrol	resveratrol results in decreased secretion of IL13 protein	23251493
C059514	resveratrol	resveratrol results in decreased susceptibility to IL13 protein	22254182
C059514	resveratrol	resveratrol results in decreased expression of IL13 protein	22962611\|2298605
C059514	resveratrol	resveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased secretion of IL13 protein]	26621445
C034206	Ribomunyl	[IL13 protein co-treated with CSF2 protein co-treated with Ribomunyl co-treated with IFNG protein] results in increased expression of CCR7 protein	18952292
C034206	Ribomunyl	[IL13 protein co-treated with CSF2 protein co-treated with Ribomunyl co-treated with IFNG protein] results in increased expression of MUC1 protein	18952292
D012293	Rifampin	Rifampin results in increased secretion of IL13 protein	27933861
D020889	Rolipram	Rolipram results in decreased expression of IL13 mRNA	16083514
D020889	Rolipram	Rolipram results in decreased secretion of IL13 protein	16083514
C089730	rosiglitazone	"rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]"	17015710
C099445	S 28463	S 28463 results in decreased expression of IL13 protein	16361354
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of IL13 protein"	17200189
D017632	Asbestos, Serpentine	"PRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL13 protein]"	17200189
C016101	shikonin	shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of IL13 mRNA]	25451590
C016101	shikonin	shikonin inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA]	25451590
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of IL13 mRNA	24211531
D012822	Silicon Dioxide	Silicon Dioxide results in increased secretion of IL13 protein	22300531
D019821	Simvastatin	Simvastatin results in decreased expression of IL13 mRNA	17169357
D019821	Simvastatin	Simvastatin results in decreased expression of IL13 protein	17169357
D000068900	Sitagliptin Phosphate	Sitagliptin Phosphate inhibits the reaction [OVAL protein results in increased expression of IL13 protein]	22733167
C017947	sodium arsenite	sodium arsenite results in decreased expression of IL13 mRNA	12676792
C017947	sodium arsenite	sodium arsenite results in increased expression of IL13 mRNA	21281968
C525422	SRT1720	SRT1720 inhibits the reaction [OVAL protein results in increased expression of IL13 protein]	23062010
D013241	Sterigmatocystin	Sterigmatocystin results in increased expression of IL13 mRNA	19818335
D013458	Sulfur Dioxide	Sulfur Dioxide promotes the reaction [OVAL protein results in increased expression of IL13 mRNA]	29288730
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of IL13 protein]	22150557
C473478	sunitinib	IL13 polymorphism affects the susceptibility to sunitinib	26387812
D016593	Terfenadine	Terfenadine inhibits the reaction [IL4 protein results in increased expression of IL13 protein]	12925206
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased expression of IL13 protein]	22491429
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased secretion of IL13 protein]	21804081
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to IL13 promoter]	19654925
D013755	Tetradecanoylphorbol Acetate	[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein] affects the phosphorylation of STAT6 protein	26091108
D013755	Tetradecanoylphorbol Acetate	[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with IL4 protein] affects the phosphorylation of STAT6 protein	26091108
D013755	Tetradecanoylphorbol Acetate	"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein"	26091108
D013755	Tetradecanoylphorbol Acetate	"[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon co-treated with IL4 protein] affects the phosphorylation of STAT6 protein"	26091108
D013755	Tetradecanoylphorbol Acetate	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL13 mRNA]	21331654
D013755	Tetradecanoylphorbol Acetate	"[IL13 protein co-treated with IL4 protein co-treated with Nanotubes, Carbon] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]"	26091108
D013755	Tetradecanoylphorbol Acetate	[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]	26091108
D013755	Tetradecanoylphorbol Acetate	IL13 protein inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]	26091108
D013755	Tetradecanoylphorbol Acetate	"IL13 protein inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the secretion of IL1B protein]"	26091108
D013755	Tetradecanoylphorbol Acetate	"[IL4 protein co-treated with IL13 protein] inhibits the reaction [Nanotubes, Carbon promotes the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA]]"	26091108
D013755	Tetradecanoylphorbol Acetate	leflunomide inhibits the reaction [[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]]	26091108
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL13 mRNA	21331654
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of IL13 mRNA	10428506
D013755	Tetradecanoylphorbol Acetate	lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA]	22398747
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA	22398747
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA	25613284
D013806	Theophylline	Theophylline results in decreased expression of IL13 mRNA	16083514
D013806	Theophylline	Theophylline results in decreased expression of IL13 protein	16083514
D013806	Theophylline	Theophylline results in decreased secretion of IL13 protein	16083514
C475227	thieno(2,3-c)isoquinolin-5-one	"thieno(2,3-c)isoquinolin-5-one inhibits the reaction [Ovalbumin results in increased expression of IL13 protein]"	18261157
D013849	Thimerosal	Glutathione inhibits the reaction [[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein]	17079650
D013849	Thimerosal	[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein	17079650
D013853	Thioacetamide	Thioacetamide results in decreased secretion of IL13 protein	27605418
C079056	thunberginol B	thunberginol B inhibits the reaction [Calcimycin results in increased expression of IL13 mRNA]	17950587
C009495	titanium dioxide	titanium dioxide results in increased expression of IL13 mRNA	19695317
C009495	titanium dioxide	titanium dioxide results in increased expression of IL13 protein	23557971
C402696	TMC 120A	TMC 120A results in decreased expression of IL13 mRNA	19818335
C402696	TMC 120A	TMC 120A results in increased expression of IL13 mRNA	19818335
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of IL13 mRNA	18087596
D014051	Toluene 2,4-Diisocyanate	"BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]"	17015710
D014051	Toluene 2,4-Diisocyanate	"CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA]"	15590890
D014051	Toluene 2,4-Diisocyanate	"pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]"	17015710
D014051	Toluene 2,4-Diisocyanate	"PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]"	17015710
D014051	Toluene 2,4-Diisocyanate	"rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]"	17015710
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA"	11243917\|1559089
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of IL13 protein"	17015710\|1942894
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein"	17693426\|2832985
D014051	Toluene 2,4-Diisocyanate	"TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]"	28329851
D014212	Tretinoin	Tretinoin results in increased expression of IL13 mRNA	17118196
D014212	Tretinoin	Tretinoin results in increased expression of IL13 protein	17118196
D014260	Triclosan	Triclosan inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 mRNA]	20507366
C015559	trimellitic anhydride	trimellitic anhydride results in decreased methylation of IL13 promoter	24675093
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of IL13 mRNA	14599759
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of IL13 protein	20219652
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IL13 mRNA"	26743178
D014612	Vaccines	IL13 gene mutant form affects the susceptibility to Vaccines	22967010
D014635	Valproic Acid	Valproic Acid results in increased methylation of IL13 gene	29154799
D014638	Vanadates	Vanadates results in increased expression of IL13 mRNA	27427241
D001335	Vehicle Emissions	IL13 protein affects the reaction [Vehicle Emissions results in increased expression of CCL18 protein]	16890758
D001335	Vehicle Emissions	"[Vehicle Emissions co-treated with Amb a I protein, Ambrosia artemisiifolia] results in increased expression of IL13 mRNA"	9036991
D001335	Vehicle Emissions	[Vehicle Emissions co-treated with IL13 protein] results in increased expression of CCL11 protein	12576300
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of IL13	19914270
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of IL13 mRNA	28669936\|8765825
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of IL13 protein	16890758
D001335	Vehicle Emissions	"GATA3 protein affects the reaction [[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"	27315767
D001335	Vehicle Emissions	[NFE2L2 gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of IL13 protein	18614404
D001335	Vehicle Emissions	"RAG2 protein affects the reaction [[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased expression of IL13 protein]"	27315767
D001335	Vehicle Emissions	"[Vehicle Emissions co-treated with Antigens, Dermatophagoides] results in increased secretion of IL13 protein"	27315767
D001335	Vehicle Emissions	"Vehicle Emissions promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL13 protein]"	24060272
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of IL13 mRNA	16979384
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of IL13 protein	17620185
D001335	Vehicle Emissions	[Vehicle Emissions results in increased susceptibility to OVAL protein] which results in increased expression of IL13 mRNA	24365139
D001335	Vehicle Emissions	[Vehicle Emissions results in increased susceptibility to OVAL protein] which results in increased expression of IL13 protein	24365139\|2849585
C059141	verlukast	verlukast inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]	12794006
C059141	verlukast	verlukast inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]	12654629
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of IL13 protein	16879906
C029297	vinylidene chloride	vinylidene chloride results in increased expression of IL13 protein	16879906
C063449	zileuton	zileuton affects the expression of IL13 protein	15927844
C063449	zileuton	zileuton inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]	12794006
C063449	zileuton	zileuton inhibits the reaction [IL13 protein results in increased abundance of Leukotriene B4]	12654629
C063449	zileuton	zileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA]	12654629
C063449	zileuton	zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]	12654629
C063449	zileuton	zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]	12654629
C067172	zopolrestat	"zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL13 mRNA]"	21334316

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005125	cytokine activity	-	IEA	-
GO:0005144	interleukin-13 receptor binding	-	IEA	-
GO:0005515	protein binding	-	IPI	18243101 20223216

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001774	microglial cell activation	-	IEA	-
GO:0002639	positive regulation of immunoglobulin production	-	IEA	-
GO:0006954	inflammatory response	-	IEA	-
GO:0006955	immune response	-	IEA	-
GO:0010155	regulation of proton transport	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0030890	positive regulation of B cell proliferation	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0032723	positive regulation of connective tissue growth factor production	-	IEA	-
GO:0033861	negative regulation of NAD(P)H oxidase activity	-	IEA	-
GO:0035094	response to nicotine	-	IEA	-
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	-	IEA	-
GO:0043032	positive regulation of macrophage activation	-	IEA	-
GO:0043306	positive regulation of mast cell degranulation	-	IEA	-
GO:0045471	response to ethanol	-	IEA	-
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	-
GO:0050714	positive regulation of protein secretion	-	IEA	-
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	-	IEA	-
GO:0071260	cellular response to mechanical stimulus	-	IEA	-
GO:0071635	negative regulation of transforming growth factor beta production	-	IEA	-
GO:1901215	negative regulation of neuron death	-	IEA	-
GO:1901247	negative regulation of lung ciliated cell differentiation	-	NAS	20539013
GO:1901251	positive regulation of lung goblet cell differentiation	-	NAS	20539013
GO:1903660	negative regulation of complement-dependent cytotoxicity	-	IMP	16034134
GO:2000231	positive regulation of pancreatic stellate cell proliferation	-	IEA	-
GO:2000352	negative regulation of endothelial cell apoptotic process	-	IMP	16034134

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IDA	20041150
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	ISS	16275384
GO:0005737	cytoplasm	-	IEA	-
GO:0009897	external side of plasma membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04630	Jak-STAT signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa05310	Asthma

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS
R-HSA-9012546	Interleukin-18 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19995275	Il13 promoter (-1055) polymorphisms associated with chronic obstructive pulmonary disease in Taiwanese. (2009 Dec)	Liu SF	Exp Lung Res
24314122	Interaction of prenatal maternal smoking, interleukin 13 genetic variants and DNA methylation influencing airflow and airway reactivity. (2013 Dec 6)	Patil VK	Clin Epigenetics
19554022	Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking. (2009 Dec)	Duffin KC	J Invest Dermatol
19254294	Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort. (2009 Aug)	Black S	Allergy
28912468	Cytokine-based Predictive Models to Estimate the Probability of Chronic Periodontitis: Development of Diagnostic Nomograms. (2017 Sep 14)	Tomas I	Sci Rep
15007352	Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. (2004 Mar)	Liu X	J Allergy Clin Immunol
20975284	Case-control study of eczema associated with IL13 genetic polymorphisms in Japanese children. (2011)	Miyake Y	Int Arch Allergy Immunol
21613309	IL13 gene polymorphism is a marker for psoriatic arthritis among psoriasis patients. (2011 Sep)	Eder L	Ann Rheum Dis
19968631	Gene-gene and gene-environment interactions on IgE production in prenatal stage. (2010 Jun 1)	Yang KD	Allergy
17346294	IL13 gene polymorphism association with cord serum immunoglobulin E. (2007 Jun)	Sadeghnejad A	Pediatr Allergy Immunol
20217071	Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function. (2010 Apr)	Pan F	Immunogenetics
26986948	An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma. (2016)	Accordini S	PLoS One
28631723	Pharmacogenetic biomarkers of response in Crohn's disease. (2018 Jan)	Linares-Pineda TM	Pharmacogenomics J
22023794	Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study. (2011 Oct 25)	Miyake Y	BMC Med Genet
18815020	Genetic variation of IL13 as a risk factor of reduced lung function in children and adolescents: a cross-sectional population-based study in Korea. (2009 Feb)	Park HW	Respir Med
28930110	Cytokine single-nucleotide polymorphisms and risk of non-small-cell lung cancer. (2017 Dec)	Perez-Ramirez C	Pharmacogenet Genomics
18186920	IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study. (2008 Jan 10)	Sadeghnejad A	Respir Res
12353662	Gender differences in the allergic response of mice neonatally exposed to environmental tobacco smoke. (2002 Mar)	Seymour BW	Dev Immunol
12897746	Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. (2003 Aug)	Liu X	J Allergy Clin Immunol
22013915	IL13 genetic polymorphisms, smoking, and eczema in women: a case-control study in Japan. (2011 Oct 21)	Miyake Y	BMC Med Genet