Gene: IL13RA2

3598
CD213A2|CT19|IL-13R|IL13BP
interleukin 13 receptor subunit alpha 2
protein-coding
Xq23
Ensembl:ENSG00000123496 MIM:300130 Vega:OTTHUMG00000022229 UniprotKB:Q14627
NG_012514.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXorf570.803
HTR2C0.789
KLHL130.761
COCH0.76
PENK0.757
SLITRK60.723
PEG100.713
SLC5A70.704
ISL10.696
SCN9A0.694

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZIC2-0.458
PDGFRB-0.433
ZIC5-0.419
CDKN2C-0.394
ANPEP-0.389
SLC12A7-0.387
OTX1-0.387
RGL3-0.384
SLC6A12-0.382
PPP1R13L-0.379

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05078AER001Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of IL13RA2 mRNA28329830
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in decreased expression of IL13RA2 mRNA25827057
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL13RA2 mRNA"25614096
C0020104-(2-aminoethyl)benzenesulfonylfluoride4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA]20660070
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of IL13RA2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL13RA2 mRNA16483693
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of IL13RA2 mRNA19962721
D001151ArsenicArsenic results in decreased expression of IL13RA2 mRNA19962721
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of IL13RA2 mRNA"25351596
D001280AtrazineAtrazine results in increased expression of IL13RA2 mRNA25929836
C547126AZM551248AZM551248 results in increased expression of IL13RA2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL13RA2 mRNA22316170
D004958Estradiol4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA]20660070
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of IL13RA2 mRNA25878060
D004958EstradiolEstradiol results in increased expression of IL13RA2 mRNA21795739
D004958EstradiolN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA]20660070
D004958EstradiolU 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA]20660070
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of IL13RA2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of IL13RA2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of IL13RA2 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of IL13RA2 mRNA18958704
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IL13RA2 mRNA18560533
D019256Cadmium ChlorideTNF affects the reaction [Cadmium Chloride results in increased expression of IL13RA2 mRNA]18560533
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of IL13RA2 mRNA18654764
C459604candoxincandoxin results in increased expression of IL13RA2 mRNA16309724
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IL13RA2 mRNA25827057
D002251Carbon TetrachlorideNT5E gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL13RA2 mRNA]18263696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of IL13RA2 mRNA23650126
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of IL13RA2 mRNA18654764
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of IL13RA2 mRNA20971185
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of IL13RA2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of IL13RA2 mRNA28628672
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of IL13RA2 mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IL13RA2 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of IL13RA2 mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IL13RA2 mRNA17557909
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IL13RA2 mRNA23550701
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of IL13RA2 mRNA28329830
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of IL13RA2 mRNA19962721
D005459FluoridesFluorides results in decreased expression of IL13RA2 mRNA19962721
D005492Folic Acid[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL13RA2 mRNA22975265
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of IL13RA2 mRNA24657277
C039281furanfuran results in increased expression of IL13RA2 mRNA27387713
C010176halofuginonehalofuginone results in increased expression of IL13RA2 mRNA17180598
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of IL13RA2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of IL13RA2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of IL13RA2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of IL13RA2 mRNA28628672
D007854LeadLead affects the expression of IL13RA2 mRNA28903495
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of IL13RA2 mRNA18654764
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IL13RA2 mRNA21641980
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of IL13RA2 mRNA24657277
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IL13RA2 mRNA26011545
D015735MifepristoneMifepristone results in increased expression of IL13RA2 mRNA17584828
D008942MitoxantroneIL13RA2 protein affects the susceptibility to Mitoxantrone16217747
C523799MRK 003MRK 003 results in decreased expression of IL13RA2 mRNA21169257
D009151Mustard GasMustard Gas results in increased expression of IL13RA2 mRNA25102026
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA]20660070
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IL13RA2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL13RA2 mRNA"25554681
D009532NickelNickel results in increased expression of IL13RA2 mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of IL13RA2 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of IL13RA2 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of IL13RA2 mRNA20660070
D017239PaclitaxelIL13RA2 protein affects the susceptibility to Paclitaxel16217747
D000068437Pemetrexed[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of IL13RA2 mRNA22975265
D010938Plant OilsPlant Oils results in increased expression of IL13RA2 mRNA23370395
D011374Progesterone4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA]20660070
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA20660070
D011374ProgesteroneN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA]20660070
D011374ProgesteroneProgesterone results in decreased expression of IL13RA2 mRNA20660070|2086464
D011374ProgesteroneU 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA]20660070
C093642SB 203580SB 203580 results in decreased expression of IL13RA2 mRNA20660070
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IL13RA2 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of IL13RA2 mRNA25351596
C016104sodium bichromatesodium bichromate results in increased expression of IL13RA2 mRNA24612858
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of IL13RA2 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL13RA2 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL13RA2 mRNA26232522
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of IL13RA2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of IL13RA2 mRNA23724009
D014212TretinoinTretinoin results in increased expression of IL13RA2 mRNA16012519
C032910triadimefontriadimefon results in decreased expression of IL13RA2 mRNA26790661
D017973Tungsten CompoundsTungsten Compounds results in increased expression of IL13RA2 mRNA28666766
C113580U 0126U 0126 promotes the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of IL13RA2 mRNA]20660070
C113580U 0126U 0126 results in decreased expression of IL13RA2 mRNA20660070
D014635Valproic AcidValproic Acid results in decreased methylation of IL13RA2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of IL13RA2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of IL13RA2 mRNA17963808
D014747VinblastineIL13RA2 protein affects the susceptibility to Vinblastine16217747
C111237vorinostatvorinostat results in increased expression of IL13RA2 mRNA27188386
C088658zoledronic acidzoledronic acid results in increased expression of IL13RA2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004896cytokine receptor activity-TAS9725226  
GO:0005515protein binding-IPI20223216  
GO:0019955cytokine binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002638negative regulation of immunoglobulin production-IEA-  
GO:0016064immunoglobulin mediated immune response-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0043305negative regulation of mast cell degranulation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-TAS9083087  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25110223rs1801275 Interleukin-4 receptor alpha polymorphism in familial hypercholesterolemia. (2014 Jul-Aug)Sanchez Munoz-Torrero JFJ Clin Lipidol