Gene: ACADSB

36
2-MEBCAD|ACAD7|SBCAD
acyl-CoA dehydrogenase short/branched chain
protein-coding
10q26.13
Ensembl:ENSG00000196177 MIM:600301 Vega:OTTHUMG00000019200 UniprotKB:P45954
NG_008003.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.574e-1 (AD)  1.456e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HLTF0.919
DPP80.912
NUP1330.9
NDUFS10.899
C6orf1200.892
TAF9B0.892
ATAD10.883
TRPC10.882
PEX190.882
RAB11FIP20.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.552
OR4F29-0.506
MTRNR2L6-0.394
CCDC102A-0.388
PPBP-0.38
SPINK8-0.38
CSAG1-0.375
MTRNR2L10-0.37
PGF-0.366
MTRNR2L9-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of ACADSB mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ACADSB mRNA"19162173
C52473317-ethynyl-5-androstene-3, 7, 17-triol"17-ethynyl-5-androstene-3, 7, 17-triol binds to ACADSB protein"22384159
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of ACADSB mRNA"23829299
C0164032,4-dinitrotoluene"2,4-dinitrotoluene results in decreased expression of ACADSB mRNA"16917068
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ACADSB mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ACADSB mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ACADSB mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACADSB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACADSB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACADSB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACADSB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACADSB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACADSB mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ACADSB mRNA25704631|2906747
D000082AcetaminophenAcetaminophen affects the expression of ACADSB mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ACADSB mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ACADSB gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ACADSB mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ACADSB mRNA24449571
C487081belinostatbelinostat results in increased expression of ACADSB mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACADSB mRNA16545412
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ACADSB mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ACADSB promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACADSB mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACADSB mRNA15034205|2222880
C006780bisphenol Abisphenol A results in decreased expression of ACADSB mRNA25181051
D002104CadmiumCadmium results in increased oxidation of ACADSB protein24496640
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ACADSB mRNA24982889
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of ACADSB mRNA27174168
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ACADSB mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of ACADSB mRNA18178546
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACADSB mRNA"27188386
D002994ClofibrateClofibrate results in decreased expression of ACADSB mRNA18670166
D003010ClorgylineClorgyline results in increased expression of ACADSB mRNA19691856
C018021cobaltous chloridecobaltous chloride results in decreased expression of ACADSB mRNA24386269
D003300CopperCopper results in decreased expression of ACADSB mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of ACADSB mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ACADSB mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of ACADSB mRNA19770486
D064730DexrazoxaneDexrazoxane results in decreased expression of ACADSB mRNA26873546
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of ACADSB mRNA18313992
D004041Dietary FatsDietary Fats results in increased expression of ACADSB mRNA19030233
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of ACADSB mRNA]"23626681
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated results in increased expression of ACADSB mRNA"23626681
D002117CalcitriolCalcitriol results in increased expression of ACADSB mRNA26485663
C118739entinostatentinostat results in increased expression of ACADSB mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACADSB mRNA"27188386
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of ACADSB mRNA16988119
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ACADSB mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ACADSB mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of ACADSB mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ACADSB mRNA23649840
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of ACADSB mRNA21149847
C027185indirubinindirubin results in decreased expression of ACADSB mRNA15056799
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACADSB mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ACADSB mRNA24796395
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ACADSB mRNA"24972896
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of ACADSB mRNA28349193
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ACADSB mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ACADSB mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ACADSB mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of ACADSB promoter"26251327
D015741MetriboloneMetribolone results in decreased expression of ACADSB protein17152098
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of ACADSB protein19716841
D010100OxygenOxygen deficiency results in increased expression of ACADSB mRNA24205000
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ACADSB mRNA20936131
C076994perfluorooctane sulfonic acidPPARA protein promotes the reaction [perfluorooctane sulfonic acid results in increased expression of ACADSB mRNA]20936131
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ACADSB protein26879310
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of ACADSB mRNA]"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ACADSB mRNA18467677|2362668
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of ACADSB mRNA]18467677
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACADSB mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ACADSB mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ACADSB mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ACADSB mRNA18467677|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of ACADSB mRNA]18467677
C006253pirinixic acidpirinixic acid results in decreased expression of ACADSB mRNA19162173
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ACADSB mRNA22714537
D011794QuercetinQuercetin results in decreased expression of ACADSB mRNA21632981
C059514resveratrolresveratrol results in increased expression of ACADSB protein25505154
C089730rosiglitazonerosiglitazone affects the expression of ACADSB mRNA22013433
C089730rosiglitazonerosiglitazone results in increased expression of ACADSB mRNA15520860
D012402RotenoneRotenone results in decreased expression of ACADSB mRNA19013527
C016104sodium bichromatesodium bichromate results in decreased expression of ACADSB mRNA25993096
D013629TamoxifenTamoxifen affects the expression of ACADSB mRNA17555576
C501413tesaglitazartesaglitazar results in decreased expression of ACADSB mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACADSB mRNA20106945|2163298
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ACADSB mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ACADSB mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACADSB mRNA18796159|2121527
D013752TetracyclineTetracycline results in increased expression of ACADSB mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACADSB mRNA25613284
C052342topiramatetopiramate results in increased expression of ACADSB mRNA16979414
C012589trichostatin Atrichostatin A affects the expression of ACADSB mRNA28542535
D014635Valproic AcidValproic Acid results in increased expression of ACADSB mRNA23179753|2915479
D014640VancomycinVancomycin results in increased expression of ACADSB mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ACADSB gene25560391
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of ACADSB mRNA18313992
D015032ZincZinc deficiency results in increased expression of ACADSB mRNA18356318
D015032ZincZinc results in increased expression of ACADSB mRNA17074742
D019287Zinc SulfateZinc Sulfate results in increased expression of ACADSB mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003995acyl-CoA dehydrogenase activity-EXP10832746  11013134  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006631fatty acid metabolic process-IEA-  
GO:0009083branched-chain amino acid catabolic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00071Fatty acid degradation
hsa00280Valine, leucine and isoleucine degradation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70895Branched-chain amino acid catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17143180Association of genetic polymorphisms of ACADSB and COMT with human hypertension. (2007 Jan)Kamide KJ Hypertens