Gene: AQP3

360
AQP-3|GIL
aquaporin 3 (Gill blood group)
protein-coding
9p13.3
Ensembl:ENSG00000165272 MIM:600170 Vega:OTTHUMG00000019769 UniprotKB:Q92482
NG_007476.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.615e-1 (AD)  3.275e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VDR0.607
INHBA0.568
ARID3A0.548
SPOCD10.544
FAM83G0.537
SDC10.535
KCNK60.533
SFN0.525
TACSTD20.515
PDIA50.513

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIAPH3-0.283
FBXL22-0.278
LYPD6-0.263
ABCD2-0.257
GLIPR1L2-0.246
RFTN2-0.238
NPFFR1-0.237
GABRG1-0.232
PAQR8-0.232
C5-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in decreased expression of AQP3 mRNA"19641517
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of AQP3 mRNA"23829299
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of AQP3 mRNA"21920950
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of AQP3 protein]18214481
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AQP3 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of AQP3 mRNA"19167446
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of AQP3 protein]16848764|1821448
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of AQP3 mRNA"23829299
C0073032,5-diaminotoluene"2,5-diaminotoluene results in decreased expression of AQP3 mRNA"15140218
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of AQP3 mRNA"20638727
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of AQP3 mRNA16788091
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [EGF protein results in increased expression of AQP3 protein]"16848764|1821448
C0297284-phenylenediamine4-phenylenediamine results in decreased expression of AQP3 mRNA15140218
C0581765-nitro-2-(3-phenylpropylamino)benzoic acid5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA]12542607
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of AQP3 mRNA"26238291
D000082AcetaminophenAcetaminophen results in increased expression of AQP3 mRNA21420995|2223033
D000242Cyclic AMPCyclic AMP results in increased expression of AQP3 mRNA12542607
D000242Cyclic AMPN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of AQP3 mRNA]12542607
D000242Cyclic AMPN-(2-aminoethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of AQP3 mRNA]12542607
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AQP3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AQP3 mRNA21632981|2164198
D000393Air PollutantsAir Pollutants analog results in increased expression of AQP3 mRNA21757418
D000447AldehydesAldehydes results in decreased expression of AQP3 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AQP3 mRNA16483693
D000667AmpicillinAmpicillin results in decreased expression of AQP3 mRNA21632981
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of AQP3 mRNA24449571
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AQP3 mRNA17696278
D016718Arachidonic AcidArachidonic Acid results in decreased expression of AQP3 mRNA16704987
D001151ArsenicAQP3 gene SNP affects the susceptibility to Arsenic22306368
C042120arsenic pentoxidearsenic pentoxide results in decreased expression of AQP3 mRNA22214486
C006632arsenic trioxidearsenic trioxide results in increased expression of AQP3 mRNA22214486
C015001arsenitearsenite results in increased expression of AQP3 mRNA19442679
C015001arsenitearsenite results in increased expression of AQP3 protein19442679
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of AQP3 mRNA17639512
D001379AzathioprineAzathioprine results in increased expression of AQP3 mRNA22623647
C547126AZM551248AZM551248 results in decreased expression of AQP3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of AQP3 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AQP3 mRNA21632981|2187194
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]]23545307
D004958EstradiolEstradiol affects the expression of AQP3 mRNA14699072
D004958EstradiolEstradiol results in decreased expression of AQP3 mRNA25321415
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of AQP3 mRNA17404688
D004958EstradiolEstradiol results in increased expression of AQP3 mRNA24052564
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of AQP3 mRNA]24052564
D004958EstradiolEstradiol results in increased expression of AQP3 mRNA20381596|2694572
D004958EstradiolIsoflavones inhibits the reaction [Estradiol results in increased expression of AQP3 mRNA]20381596
D004958EstradiolPlant Preparations inhibits the reaction [Estradiol results in increased expression of AQP3 mRNA]26945725
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of AQP3 mRNA27685785
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of AQP3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of AQP3 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of AQP3 mRNA20977926
C018475butyraldehydebutyraldehyde results in decreased expression of AQP3 mRNA26079696
C459604candoxincandoxin results in decreased expression of AQP3 mRNA16309724
D002220CarbamazepineCarbamazepine affects the expression of AQP3 mRNA25979313
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of AQP3 mRNA24763279
D002713ChlorineChlorine results in decreased expression of AQP3 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of AQP3 mRNA18636392
D002726Chlorogenic AcidChlorogenic Acid results in increased expression of AQP3 mRNA20706672
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP3 mRNA20938992
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of AQP3 mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of AQP3 mRNA16197558
D002994ClofibrateClofibrate results in increased expression of AQP3 mRNA22008526
D002995Clofibric AcidClofibric Acid affects the expression of AQP3 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of AQP3 mRNA19376846
C018021cobaltous chloride[AQP3 protein results in increased stability of EPAS1 protein] promotes the reaction [cobaltous chloride results in increased expression of EPAS1 protein]23545307
D003300CopperCopper inhibits the reaction [AQP3 protein results in increased transport of Water]19684221
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of AQP3 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of AQP3 mRNA19549813
D019327Copper SulfateCopper Sulfate inhibits the reaction [AQP3 protein results in increased transport of Water]22687538
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of AQP3 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of AQP3 mRNA19167446
D003474CurcuminCurcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]18214481
D003474CurcuminCurcumin results in decreased expression of AQP3 protein18214481
D016572CyclosporineCyclosporine results in decreased expression of AQP3 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of AQP3 mRNA21632981|2556210
C089595cylindrospermopsincylindrospermopsin results in decreased expression of AQP3 mRNA24921660
D003907DexamethasoneDexamethasone promotes the reaction [AQP3 protein results in increased transport of Water]9374739
D003907DexamethasoneDexamethasone results in increased expression of AQP3 mRNA9374739
D003907DexamethasoneDexamethasone results in increased expression of AQP3 protein9374739
D003907DexamethasoneMercuric Chloride inhibits the reaction [Dexamethasone promotes the reaction [AQP3 protein results in increased transport of Water]]9374739
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of AQP3 mRNA28962523
C000944dicrotophosdicrotophos results in decreased expression of AQP3 mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of AQP3 mRNA25242112
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of AQP3 mRNA15591538
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of AQP3 mRNA"19480007
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of AQP3 mRNA17547211
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of AQP3 mRNA21362464
D004317DoxorubicinDoxorubicin results in decreased expression of AQP3 protein9573539
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of AQP3 mRNA20706672
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AQP3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AQP3 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AQP3 mRNA15576828
C001209fenamic acidfenamic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA]12542607
C006012fenofibric acid[fenofibric acid binds to PPARA protein] which results in increased expression of AQP3 mRNA16197558
D005473FluoxetineFluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 mRNA]25766885
D005473FluoxetineFluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 protein]25766885
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP3 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of AQP3 mRNA12679049
C069837fullerene C60fullerene C60 results in increased expression of AQP3 mRNA19167457
C039281furanfuran results in decreased expression of AQP3 mRNA27387713
C039281furanfuran results in increased expression of AQP3 mRNA25539665
D019833GenisteinGenistein results in increased expression of AQP3 mRNA20706672
D019833GenisteinGenistein results in increased expression of AQP3 mRNA20381596
D005947GlucoseGlucose promotes the reaction [AQP3 protein results in increased transport of Glycerol]12234316
D005947GlucoseGlucose results in increased expression of AQP3 mRNA12234316
D005947GlucoseGlucose results in increased expression of AQP3 protein12234316
D005990GlycerolAQP3 protein results in increased transport of Glycerol19684221
D005990GlycerolAQP3 protein results in increased transport of Glycerol12234316
D005990GlycerolGlucose promotes the reaction [AQP3 protein results in increased transport of Glycerol]12234316
D005990GlycerolAQP3 protein results in increased uptake of Glycerol9733774
D005990GlycerolAQP3 protein results in increased transport of Glycerol9514918
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of AQP3 mRNA24763279
C000625835HFPO2 compoundHFPO2 compound results in increased expression of AQP3 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of AQP3 mRNA27553808
D017313FenretinideFenretinide results in decreased expression of AQP3 mRNA28973697
D012701SerotoninFluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 mRNA]25766885
D012701SerotoninSerotonin results in increased expression of AQP3 mRNA25766885
D012701Serotonin[Serotonin results in increased localization of and results in increased activity of PPARG protein] which results in increased expression of AQP3 mRNA25766885
D012701SerotoninFluoxetine inhibits the reaction [Serotonin results in increased expression of AQP3 protein]25766885
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AQP3 mRNA25613284
D007529IsoflavonesIsoflavones inhibits the reaction [Estradiol results in increased expression of AQP3 mRNA]20381596
C544151jinfukangjinfukang results in decreased expression of AQP3 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of AQP3 mRNA17085751
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of AQP3 mRNA26911376
C045463leflunomideleflunomide results in increased expression of AQP3 mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of AQP3 mRNA21362464
D008094LithiumLithium results in decreased expression of AQP3 protein10966935
D008094LithiumLithium results in decreased expression of AQP3 protein15687245
D008154LucanthoneLucanthone results in increased expression of AQP3 mRNA21148553
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of AQP3 mRNA18497975
D008623MercaptoethanolMercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]]9124401
D008627Mercuric ChlorideMercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]]9124401
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]9124401
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [Dexamethasone promotes the reaction [AQP3 protein results in increased transport of Water]]9374739
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of AQP3 protein19513079
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]22687538
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of AQP3 protein25766885
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of AQP3 mRNA25854323
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of AQP3 protein25854323
D008628MercuryMercury inhibits the reaction [AQP3 protein results in increased transport of Water]19684221
D008628MercuryMercury results in decreased activity of AQP3 protein19109372
D008713MethimazoleMethimazole results in increased expression of AQP3 mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AQP3 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of AQP3 mRNA17696278
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AQP3 mRNA23179753|2800136
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AQP3 mRNA25854323
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AQP3 protein25854323
D009020MorphineMorphine results in increased expression of AQP3 mRNA25766885
D009020MorphineMorphine results in increased expression of AQP3 protein25766885
C523799MRK 003AQP3 results in increased susceptibility to MRK 00319903844
C500085muraglitazarmuraglitazar results in increased expression of AQP3 mRNA21515302
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of AQP3 mRNA]12542607
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [VIP protein results in increased expression of AQP3 mRNA]12542607
C044388N-(2-aminoethyl)-5-isoquinolinesulfonamideN-(2-aminoethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of AQP3 mRNA]12542607
C044388N-(2-aminoethyl)-5-isoquinolinesulfonamideN-(2-aminoethyl)-5-isoquinolinesulfonamide inhibits the reaction [VIP protein results in increased expression of AQP3 mRNA]12542607
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AQP3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AQP3 mRNA"25554681
D009532NickelNickel inhibits the reaction [AQP3 protein results in increased transport of Water]19684221
D009532NickelNickel results in increased expression of AQP3 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of AQP3 mRNA16780908|2071313
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine results in decreased expression of AQP3 mRNA12102619
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of AQP3 mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of AQP3 mRNA20971185
C485800osajinosajin results in increased expression of AQP3 mRNA20706672
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of AQP3 mRNA23212921
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of AQP3 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of AQP3 mRNA25729387
C030110oxaliplatin[Topotecan co-treated with oxaliplatin] results in decreased expression of AQP3 mRNA25729387
D010100OxygenAQP3 protein promotes the reaction [Oxygen deficiency results in increased expression of EGLN3 mRNA]23545307
D010100OxygenAQP3 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]23545307
D010100Oxygen[AQP3 protein results in increased stability of EPAS1 protein] promotes the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]23545307
D010100Oxygenbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Oxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]]23545307
D010100Oxygen[Oxygen deficiency co-treated with AQP3 protein] results in increased expression of EGLN1 mRNA23545307
D010100Oxygen[Oxygen deficiency co-treated with AQP3 protein] results in increased expression of PGK1 mRNA23545307
D010100OxygenOxygen deficiency inhibits the reaction [AQP3 protein results in decreased expression of EGLN3 mRNA]23545307
D010100OxygenOxygen inhibits the reaction [AQP3 protein results in increased stability of EPAS1 protein]23545307
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of AQP3 mRNA18636392
D052638Particulate MatterParticulate Matter results in increased expression of AQP3 mRNA22178795
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of AQP3 mRNA26705709
C046012pentanalpentanal results in decreased expression of AQP3 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of AQP3 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of AQP3 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of AQP3 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AQP3 mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of AQP3 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of AQP3 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AQP3 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of AQP3 mRNA17426115|1830175
C006253pirinixic acidpirinixic acid results in increased expression of AQP3 mRNA19162173|2248451
D028321Plant PreparationsPlant Preparations inhibits the reaction [Estradiol results in increased expression of AQP3 mRNA]26945725
C474837pomiferinpomiferin results in increased expression of AQP3 mRNA20706672
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of AQP3 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of AQP3 mRNA17404688
C005556propionaldehydepropionaldehyde results in decreased expression of AQP3 mRNA26079696
D011429PropolisPropolis results in increased expression of AQP3 mRNA20706672
D011441PropylthiouracilPropylthiouracil results in increased expression of AQP3 mRNA22504374
C033607puerarinpuerarin results in increased expression of AQP3 mRNA20706672
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of AQP3 protein9013444
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of AQP3 mRNA17639512
D011794QuercetinQuercetin results in increased expression of AQP3 mRNA21632981|2645488
D015125OxyquinolineOxyquinoline results in decreased expression of AQP3 mRNA21632981
C031389resorcinolresorcinol results in increased expression of AQP3 mRNA22623647
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AQP3 mRNA]26454884
C059514resveratrolresveratrol results in increased expression of AQP3 mRNA20706672|2645488
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of AQP3 mRNA21127053
C529148rosavinrosavin results in increased expression of AQP3 mRNA20706672
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of AQP3 mRNA19244175
D012643SeleniumSelenium results in increased expression of AQP3 mRNA19244175
C009250sevofluranesevoflurane results in increased expression of AQP3 mRNA26206149
C009250sevofluranesevoflurane affects the expression of AQP3 mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AQP3 mRNA25895662
D012906SmokeSmoke results in decreased expression of AQP3 mRNA21095227
C009277sodium arsenatesodium arsenate results in increased expression of AQP3 mRNA21795629
C017947sodium arseniteAQP3 results in increased susceptibility to sodium arsenite16672223
C016104sodium bichromatesodium bichromate results in increased expression of AQP3 mRNA22561333
D053260SootSoot results in increased expression of AQP3 mRNA26551751
C501413tesaglitazartesaglitazar results in increased expression of AQP3 mRNA21515302
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of AQP3 mRNA26496021
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AQP3 mRNA]26454884
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of AQP3 mRNA26454884
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of AQP3 protein26454884
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AQP3 mRNA11489354|2010694
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AQP3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of AQP3 mRNA]24052564
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AQP3 mRNA26454884
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AQP3 mRNA25613284
D013890ThioureaThiourea results in increased expression of AQP3 mRNA15248066
C009495titanium dioxidetitanium dioxide results in decreased expression of AQP3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AQP3 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of AQP3 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of AQP3 mRNA25729387
D019772Topotecan[Topotecan co-treated with oxaliplatin] results in decreased expression of AQP3 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of AQP3 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of AQP3 mRNA23724009
D014212TretinoinTretinoin results in increased expression of AQP3 mRNA16788091
C034613triacsin Ctriacsin C results in decreased expression of AQP3 mRNA16704987
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of AQP3 mRNA15140218
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of AQP3 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of AQP3 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of AQP3 mRNA21515302
C113580U 0126U 0126 inhibits the reaction [EGF protein results in increased expression of AQP3 protein]16848764|1821448
D014508UreaAQP3 protein results in increased transport of Urea19684221
D014520UrethaneUrethane results in increased expression of AQP3 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of AQP3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of AQP3 mRNA28001369
D014640VancomycinVancomycin results in increased expression of AQP3 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of AQP3 mRNA23940539
C029297vinylidene chloridevinylidene chloride results in decreased expression of AQP3 mRNA26682919
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of AQP3 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of AQP3 mRNA19244175
D014867WaterAQP3 protein results in increased transport of Water19684221
D014867WaterCopper inhibits the reaction [AQP3 protein results in increased transport of Water]19684221
D014867WaterMercury inhibits the reaction [AQP3 protein results in increased transport of Water]19684221
D014867WaterNickel inhibits the reaction [AQP3 protein results in increased transport of Water]19684221
D014867WaterZinc inhibits the reaction [AQP3 protein results in increased transport of Water]19684221
D014867WaterAQP3 protein results in increased transport of Water9124401|9374739
D014867WaterDexamethasone promotes the reaction [AQP3 protein results in increased transport of Water]9374739
D014867WaterMercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]]9124401
D014867WaterMercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]9124401
D014867WaterMercuric Chloride inhibits the reaction [Dexamethasone promotes the reaction [AQP3 protein results in increased transport of Water]]9374739
D014867WaterAQP3 protein results in increased transport of Water22687538
D014867WaterCopper Sulfate inhibits the reaction [AQP3 protein results in increased transport of Water]22687538
D014867WaterMercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]22687538
D014867WaterWater deficiency results in increased expression of AQP3 mRNA15462210|9124401
D014867WaterWater deficiency results in increased expression of AQP3 protein9124401
D015032ZincZinc inhibits the reaction [AQP3 protein results in increased transport of Water]19684221

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-NAS7543093  
GO:0015204urea transmembrane transporter activity-IBA21873635  
GO:0015250water channel activity-EXP1373524  1510932  7530250  9369468  9405233  9806845  
9829975  10318966  10510269  10564231  11001937  11034202  
11076974  11573934  12084581  14701836  15948717  16596446  
17178220  18202181  18501347  18511455  18762715  21251984  
GO:0015250water channel activity-TAS17943189  
GO:0015254glycerol channel activity-EXP9369468  9405233  10510269  10564231  11573934  12084581  
16596446  18762715  
GO:0015254glycerol channel activity-IDA17943189  
GO ID GO Term Qualifier Evidence PubMed
GO:0002684positive regulation of immune system process-IDA17943189  
GO:0003091renal water homeostasis-TAS-  
GO:0006833water transport-TAS17943189  
GO:0007588excretion-TAS7543093  
GO:0015793glycerol transport-IEA-  
GO:0015840urea transport-IEA-  
GO:0032526response to retinoic acid-IDA17943189  
GO:0033280response to vitamin D-TAS17943189  
GO:0042476odontogenesis-IEP12522663  
GO:0045616regulation of keratinocyte differentiation-TAS17943189  
GO:0051592response to calcium ion-TAS17943189  
GO:0055085transmembrane transport-IEA-  
GO:0070295renal water absorption-IEA-  
GO:0071456cellular response to hypoxia-IDA24462679  
GO:0090650cellular response to oxygen-glucose deprivation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IDA18718702  19545896  
GO:0005886plasma membrane-IDA14521551  18718702  19545896  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IDA18718702  
GO:0016021integral component of membrane-IC17943189  
GO:0016323basolateral plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04962Vasopressin-regulated water reabsorption
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-432040Vasopressin regulates renal water homeostasis via AquaporinsTAS
R-HSA-432047Passive transport by AquaporinsTAS
R-HSA-445717Aquaporin-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27824951Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues. (2016)Marzi CPLoS One