Gene: IL15

3600
IL-15
interleukin 15
protein-coding
4q31.21
Ensembl:ENSG00000164136 MIM:600554 Vega:OTTHUMG00000133418 UniprotKB:P40933
NG_029605.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.513e-1 (AD)  5.363e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX60L0.881
SP140L0.855
SAMD90.854
EPSTI10.833
NLRC50.824
GBP50.821
TLR30.818
SP1000.818
CEACAM10.806
SP1400.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.43
SCRT1-0.428
KCNIP3-0.41
KCNN1-0.394
ASPDH-0.393
HAGHL-0.386
PANX2-0.384
TMEM179-0.384
RAB26-0.381
HRH3-0.381

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01327CefazolinSmall Molecule25953-19-9ApprovedTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of IL15 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL15 mRNA"28351761
C0312853-xylene3-xylene results in decreased expression of IL15 mRNA12815608
C583459(4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate"(4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein]"23395935
D000082AcetaminophenAcetaminophen results in increased expression of IL15 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of IL15 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL15 protein]26138014
D000119Acetylmuramyl-Alanyl-Isoglutamine[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL15 mRNA16299289
D020106AcrylamideAcrylamide results in increased expression of IL15 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IL15 protein20106945
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of IL15 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL15 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL15 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of IL15 mRNA20458559
C006632arsenic trioxidearsenic trioxide results in increased expression of IL15 mRNA22521957
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL15 mRNA28351761
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IL15 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IL15 mRNA"19150397|2038263
D004958EstradiolEstradiol affects the expression of IL15 mRNA14699072
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of IL15 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of IL15 mRNA23019147
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of IL15 mRNA18692832
C095105bexarotenebexarotene results in increased expression of IL15 mRNA17178900
C006780bisphenol Abisphenol A results in decreased expression of IL15 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of IL15 mRNA20977926
D002084Butylated HydroxytolueneButylated Hydroxytoluene affects the expression of IL15 mRNA18539377
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of IL15 mRNA15336504
D002104CadmiumCadmium results in increased expression of IL15 mRNA21120746
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL15 protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IL15 protein26138014
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IL15 mRNA15963342
C043561chrysinchrysin results in decreased expression of IL15 mRNA20816778
C000488cladosporincladosporin results in increased expression of IL15 mRNA19818335
C000593591coagulin-Lcoagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 protein]27568862
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of IL15 mRNA20971185
D003345CorticosteroneCorticosterone results in increased expression of IL15 mRNA15755911
D003520Cyclophosphamide"(4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein]"23395935
D003520CyclophosphamideCyclophosphamide results in decreased secretion of IL15 protein23395935
D003520CyclophosphamideLevamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein]23395935
D016572CyclosporineCyclosporine results in increased expression of IL15 mRNA20106945|2798913
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of and results in increased secretion of IL15 protein28659758
D003703DemecolcineDemecolcine results in increased expression of IL15 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in increased expression of IL15 mRNA27757495
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 protein]27568862
D003907DexamethasoneDexamethasone results in increased expression of IL15 mRNA16144937
D003907DexamethasoneDexamethasone results in increased expression of IL15 mRNA21041162
D003907DexamethasoneDexamethasone results in decreased expression of IL15 mRNA14618091
D016264Dextran SulfateIL15 protein results in increased susceptibility to Dextran Sulfate16162679
D016264Dextran SulfateDextran Sulfate results in decreased expression of IL15 mRNA16375993
D016264Dextran SulfateOligosaccharides inhibits the reaction [Dextran Sulfate results in decreased expression of IL15 mRNA]16375993
D002945CisplatinCisplatin results in decreased expression of IL15 mRNA27392435
D002945CisplatinCisplatin results in increased expression of IL15 mRNA21151649
D004041Dietary FatsDietary Fats results in increased expression of IL15 mRNA18042831
C058705diethyl malatediethyl malate affects the expression of IL15 mRNA24814887
D004642EmodinEmodin results in increased expression of IL15 mRNA15612046
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IL15 mRNA17351261
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of IL15 mRNA23649840
C039537FK 565[FK 565 co-treated with Lipid A] results in increased expression of IL15 mRNA16299289
D005557FormaldehydeFormaldehyde results in increased expression of IL15 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of IL15 mRNA12161283
D005620Freund's Adjuvant[Urethane co-treated with Freund's Adjuvant] results in increased expression of IL15 mRNA12400877
C056507gemcitabinegemcitabine results in decreased expression of IL15 protein20531411
D019833GenisteinGenistein results in decreased expression of IL15 mRNA20816778
D006581HexachlorobenzeneHexachlorobenzene results in decreased expression of IL15 mRNA15159207
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL15 mRNA25613284
C051890irinotecanirinotecan affects the expression of IL15 mRNA20097248
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL15 mRNA26387944
D008050Lipid A[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL15 mRNA16299289
D008050Lipid A[FK 565 co-treated with Lipid A] results in increased expression of IL15 mRNA16299289
D008050Lipid ALipid A results in increased expression of IL15 mRNA16299289
D008070Lipopolysaccharidescoagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 protein]27568862
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 protein]27568862
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL15 protein27568862
D008070Lipopolysaccharides[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL15 protein18437699
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL15 mRNA10975854|2547295
D008070Lipopolysaccharidesnotoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 mRNA]25472953
D008070Lipopolysaccharides[TNF protein co-treated with IL1B protein co-treated with IFNG protein co-treated with Lipopolysaccharides] results in increased expression of IL15 mRNA20816778
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IL15 mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of IL15 protein20045430
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of IL15 mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of IL15 mRNA19818335
D009532NickelNickel results in increased expression of IL15 mRNA24768652|2558310
C022838nickel chloride[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL15 protein18437699
C029938nickel sulfatenickel sulfate affects the expression of IL15 mRNA18202158
C072936notoginsenoside R1notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 mRNA]25472953
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of IL15 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of IL15 mRNA20971185
D009844OligosaccharidesOligosaccharides inhibits the reaction [Dextran Sulfate results in decreased expression of IL15 mRNA]16375993
D010081OxazoloneOxazolone results in increased expression of IL15 mRNA11379042
D010100OxygenIL15 protein affects the reaction [Oxygen deficiency results in increased expression of TKTL1 mRNA]27129235
D010100Oxygen[IL15 protein co-treated with Oxygen deficiency] results in increased expression of EGLN1 mRNA27129235
D010100Oxygen[IL15 protein co-treated with Oxygen deficiency] results in increased expression of PGK1 mRNA27129235
D010100Oxygen[IL15 protein co-treated with Oxygen deficiency] results in increased expression of PKM mRNA27129235
D010100Oxygen[IL15 protein co-treated with Oxygen deficiency] results in increased expression of TPI1 mRNA27129235
D010100OxygenIL15 protein promotes the reaction [Oxygen deficiency results in increased expression of PDK1 mRNA]27129235
D010100OxygenIL15 protein promotes the reaction [Oxygen deficiency results in increased expression of PFKFB3 mRNA]27129235
D000073878Palm OilPalm Oil results in increased expression of IL15 mRNA18042831
D010269ParaquatParaquat results in decreased expression of IL15 mRNA17077588
D052638Particulate MatterParticulate Matter analog results in increased expression of IL15 protein28101945
D052638Particulate MatterParticulate Matter results in decreased expression of IL15 protein28189646
C506614PD 0325901PD 0325901 inhibits the reaction [[IL15 protein co-treated with IL18 protein] results in increased secretion of IFNG protein]27563819
C506614PD 0325901PD 0325901 inhibits the reaction [IL15 protein results in increased expression of KLRK1 protein]27563819
C506614PD 0325901PD 0325901 inhibits the reaction [IL15 protein results in increased expression of NCR3 protein]27563819
C506614PD 0325901PD 0325901 inhibits the reaction [IL15 protein results in increased secretion of IFNG protein]27563819
C008776pelargonic acidpelargonic acid results in increased expression of IL15 mRNA11379042
D010396PenicillaminePenicillamine results in increased expression of IL15 mRNA19575532
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of and results in increased secretion of IL15 protein28659758
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of IL15 mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of IL15 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of IL15 mRNA18692832
D011374ProgesteroneProgesterone results in increased expression of IL15 mRNA17404688|1869283
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of and results in increased secretion of IL15 protein28659758
C012526quercitrinquercitrin results in decreased expression of IL15 mRNA25193878
D015125OxyquinolineOxyquinoline results in increased expression of IL15 mRNA15612046
C013672riddelliineriddelliine results in increased expression of IL15 mRNA18047727
D012402RotenoneRotenone results in increased secretion of IL15 protein28903492
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IL15 mRNA23806026
D012834SilverSilver results in increased expression of IL15 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of IL15 mRNA21911445
D053260SootSoot analog results in increased expression of IL15 mRNA25056782
D013241SterigmatocystinSterigmatocystin results in increased expression of IL15 mRNA19818335
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL15 mRNA28351761
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL15 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL15 mRNA12167310|2821309
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IL15 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL15 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL15 mRNA25613284
D007978LevamisoleLevamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein]23395935
C402696TMC 120ATMC 120A results in decreased expression of IL15 mRNA19818335
C402696TMC 120ATMC 120A results in increased expression of IL15 mRNA19818335
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IL15 mRNA28111298
C479163tofacitinibtofacitinib inhibits the reaction [IL15 protein results in increased phosphorylation of STAT5A protein]21155605
C479163tofacitinibtofacitinib inhibits the reaction [IL15 protein results in increased phosphorylation of STAT5B protein]21155605
C479163tofacitinibtofacitinib results in decreased activity of IL15 protein23269601
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of IL15 mRNA"11243917|1137904
D014212TretinoinTretinoin results in decreased expression of IL15 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of IL15 mRNA20488242
C012589trichostatin Atrichostatin A results in increased expression of IL15 mRNA24935251
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of IL15 protein23596210
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IL15 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IL15 mRNA"26179874
D017974Uranium CompoundsUranium Compounds results in increased expression of IL15 mRNA19654044
D014520Urethane[Urethane co-treated with Freund's Adjuvant] results in increased expression of IL15 mRNA12400877
D014520UrethaneUrethane results in increased expression of IL15 mRNA12400877
D014635Valproic AcidValproic Acid results in increased expression of IL15 mRNA24935251|2800136
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of IL15 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of IL15 protein28189646
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IL15 gene25560391
D014750VincristineVincristine results in increased expression of IL15 mRNA23649840
D014800VitalliumVitallium analog results in increased expression of IL15 mRNA23825117
D019287Zinc SulfateZinc Sulfate results in decreased expression of IL15 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IEA-  
GO:0005126cytokine receptor binding-IEA-  
GO:0005515protein binding-IPI16284400  23104097  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0001779natural killer cell differentiation-IEA-  
GO:0001866NK T cell proliferation-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-IEA-  
GO:0007165signal transduction-TAS8178155  
GO:0007260tyrosine phosphorylation of STAT protein-IDA12244150  
GO:0007267cell-cell signaling-TAS7759105  
GO:0007568aging-IEA-  
GO:0008284positive regulation of cell proliferation-TAS10851076  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0014732skeletal muscle atrophy-IEA-  
GO:0030212hyaluronan metabolic process-IEA-  
GO:0032740positive regulation of interleukin-17 production-IDA16482511  
GO:0032819positive regulation of natural killer cell proliferation-IEA-  
GO:0032825positive regulation of natural killer cell differentiation-IEA-  
GO:0034105positive regulation of tissue remodeling-IC16482511  
GO:0035723interleukin-15-mediated signaling pathway-IDA24942581  
GO:0035723interleukin-15-mediated signaling pathway-TAS-  
GO:0042102positive regulation of T cell proliferation-IEA-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IEA-  
GO:0045062extrathymic T cell selection-IEA-  
GO:0045580regulation of T cell differentiation-IEA-  
GO:0048469cell maturation-IEA-  
GO:0048535lymph node development-IEA-  
GO:0048662negative regulation of smooth muscle cell proliferation-IEA-  
GO:0050691regulation of defense response to virus by host-IEA-  
GO:0050729positive regulation of inflammatory response-IC16482511  
GO:0050778positive regulation of immune response-IEA-  
GO:0071305cellular response to vitamin D-IEA-  
GO:1904100positive regulation of protein O-linked glycosylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-TAS10851076  
GO:0005768endosome-TAS-  
GO:0005794Golgi apparatus-TAS10851076  
GO:0005829cytosol-IDA-  
GO:0009986cell surface-IEA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04672Intestinal immune network for IgA production
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-451927Interleukin-2 family signalingIEA
R-HSA-8983432Interleukin-15 signalingTAS
R-HSA-8983432Interleukin-15 signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25363549Early and exudative age-related macular degeneration is associated with increased plasma levels of soluble TNF receptor II. (2015 May)Faber CActa Ophthalmol
22674296Interleukin genes and associations with colon and rectal cancer risk and overall survival. (2013 Feb 15)Bondurant KLInt J Cancer
19188921Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15. (2009 Jul)Liu YZMol Psychiatry
19505916Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. (2009 Jun)Van Dyke ALCancer Epidemiol Biomarkers Prev
28185567From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration. (2016 Nov 22)Gomez-Cabrero DBMC Bioinformatics