Gene: IL15RA

3601
CD215
interleukin 15 receptor subunit alpha
protein-coding
10p15.1
Ensembl:ENSG00000134470 MIM:601070 Vega:OTTHUMG00000017612 UniprotKB:Q13261
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.193e-1 (AD)  7.042e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLAUR0.883
STX110.864
SEMA3F0.86
CASP40.857
APOL10.854
SBNO20.853
TEAD40.853
CLIC10.847
IFI300.844
GBP20.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIT-0.484
MARCH4-0.478
NEUROD6-0.467
CASC15-0.462
CPLX3-0.461
SLC7A4-0.46
KCNIP3-0.455
TMEM179-0.455
HAPLN1-0.452
SLC32A1-0.443

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of IL15RA mRNA"28903501
D000082AcetaminophenAcetaminophen results in decreased expression of IL15RA mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of IL15RA mRNA29067470
D000242Cyclic AMPCyclic AMP results in decreased expression of IL15RA mRNA22117073
D000242Cyclic AMP[Metformin co-treated with Cyclic AMP] results in decreased expression of IL15RA mRNA22117073
D000242Cyclic AMPPPARGC1A mutant form inhibits the reaction [Cyclic AMP results in decreased expression of IL15RA mRNA]22117073
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IL15RA mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL15RA mRNA24449571
D001151ArsenicArsenic affects the methylation of IL15RA gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL15RA mRNA22228805
D004958EstradiolEGF protein promotes the reaction [Estradiol results in increased expression of IL15RA mRNA]24758408
D004958EstradiolEstradiol results in increased expression of IL15RA mRNA24758408
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of IL15RA mRNA18692832
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of IL15RA mRNA18192240
C006780bisphenol Abisphenol A results in decreased expression of IL15RA mRNA21932408
C006780bisphenol Abisphenol A affects the expression of IL15RA mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of IL15RA mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IL15RA mRNA17484886
D003520CyclophosphamideCyclophosphamide results in increased expression of IL15RA mRNA21041162
D016572CyclosporineCyclosporine results in increased expression of IL15RA mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of IL15RA mRNA23958496
D003907DexamethasoneDexamethasone results in increased expression of IL15RA mRNA21041162
D002945Cisplatin[Cisplatin co-treated with RELB mutant form] results in decreased expression of IL15RA mRNA23625948
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of IL15RA mRNA21041162
D004139DinitrofluorobenzeneIL15RA protein results in increased susceptibility to Dinitrofluorobenzene15719370
D004997Ethinyl EstradiolEthinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of IL15RA mRNA]12072388
D017313FenretinideFenretinide results in increased expression of IL15RA mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL15RA mRNA]26582142
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL15RA mRNA]26582142
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL15RA mRNA26582142
D008687Metformin[Metformin co-treated with Cyclic AMP] results in decreased expression of IL15RA mRNA22117073
D008687MetforminMetformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA]22117073
D008687MetforminMetformin results in decreased expression of IL15RA mRNA22117073
D008727MethotrexateMethotrexate results in decreased expression of IL15RA mRNA17400583|2444957
C002950methylformamidemethylformamide analog results in decreased expression of IL15RA mRNA17040096
C002950methylformamidemethylformamide results in decreased expression of IL15RA mRNA17040096
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IL15RA mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IL15RA mRNA"25620056
D009532NickelNickel results in increased expression of IL15RA mRNA24768652|2558310
D010634PhenobarbitalPhenobarbital results in increased expression of IL15RA mRNA19270015
C006253pirinixic acidpirinixic acid results in decreased expression of IL15RA mRNA20813756|2381119
C006253pirinixic acidpirinixic acid results in increased expression of IL15RA mRNA18301758
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of IL15RA mRNA28903501
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of IL15RA mRNA18692832
D016559TacrolimusTacrolimus results in increased expression of IL15RA mRNA23958496
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL15RA mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of IL15RA mRNA25975270
D013853ThioacetamideThioacetamide results in decreased expression of IL15RA mRNA23411599
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of IL15RA gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-TAS7641685  
GO:0005515protein binding-IPI16284400  23104097  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS8530383  
GO:0008283cell proliferation-TAS8530383  
GO:0035723interleukin-15-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005615extracellular space-IEA-  
GO:0005768endosome-TAS-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0031965nuclear membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04672Intestinal immune network for IgA production
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-451927Interleukin-2 family signalingIEA
R-HSA-8983432Interleukin-15 signalingTAS
R-HSA-8983432Interleukin-15 signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26293465Plasma Levels of Soluble Interleukin-2 Receptor alpha: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan. (2015 Oct)Durda PArterioscler Thromb Vasc Biol