Gene: IL16

3603
LCF|NIL16|PRIL16|prIL-16
interleukin 16
protein-coding
15q25.1
Ensembl:ENSG00000172349 MIM:603035 Vega:OTTHUMG00000144186 UniprotKB:Q14005
NG_029933.1
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.859e-1 (AD)  1.901e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14899065chr15:81587108IL162.500e-18Smoking27651444
cg14899065chr15:81587108IL161.700e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD330.833
DOCK20.832
IL10RA0.83
TLR60.825
NCKAP1L0.823
AOAH0.82
SYK0.82
CD370.818
PARVG0.815
MYO1F0.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.372
HPDL-0.343
ZSCAN1-0.328
ARSF-0.311
FAM180B-0.309
ABCD2-0.308
CPLX3-0.307
REN-0.297
C1orf53-0.292
ZNRF4-0.291

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in decreased expression of IL16 mRNA"24273086
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IL16 mRNA"27291303
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of IL16 mRNA"20406850
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IL16 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of IL16 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL16 protein]26138014
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IL16 gene27153756
D000393Air PollutantsAir Pollutants affects the expression of IL16 mRNA26618301
C069357alpha-methylhistaminealpha-methylhistamine results in increased expression of IL16 protein12235264
C069357alpha-methylhistamineHRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein]12235264
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL16 mRNA24449571
D001151ArsenicArsenic affects the methylation of IL16 gene25304211
D001151ArsenicArsenic results in increased expression of IL16 mRNA27838757
D001280AtrazineAtrazine results in increased expression of IL16 mRNA22378314
D001554BenzeneBenzene results in increased expression of IL16 mRNA15929907
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL16 mRNA22228805
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of IL16 mRNA25470364
C006780bisphenol Abisphenol A results in increased expression of IL16 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of IL16 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of IL16 mRNA18180321
C546611brevetoxin 2brevetoxin 2 results in increased expression of IL16 mRNA20498034
C006794brevianamide Abrevianamide A results in increased expression of IL16 mRNA19818335
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL16 protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IL16 protein26138014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IL16 mRNA18804290
D002737ChloropreneChloroprene results in decreased expression of IL16 mRNA23125180
D002927CimetidineCimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]12235264
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of and results in increased secretion of IL16 protein23624239
C000488cladosporincladosporin results in increased expression of IL16 mRNA19818335
C086108clobenpropitclobenpropit results in increased expression of IL16 protein12235264
C086108clobenpropitHRH2 protein promotes the reaction [clobenpropit results in increased expression of IL16 protein]12235264
C488583Clostridium difficile lethal toxin BClostridium difficile lethal toxin B results in increased secretion of IL16 protein25497110
D003042CocaineCocaine results in decreased expression of IL16 mRNA27899881
C038459curdlancurdlan affects the expression of IL16 mRNA19904525
D003520CyclophosphamideCyclophosphamide results in decreased expression of IL16 mRNA21041162
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in decreased expression of IL16 mRNA26894911
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of IL16 mRNA26894911
D003907DexamethasoneDexamethasone results in decreased expression of IL16 mRNA21041162
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of IL16 mRNA26924002
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of IL16 mRNA21041162
D002117CalcitriolCalcitriol results in decreased expression of IL16 mRNA26485663
D017259DimapritDimaprit results in increased expression of IL16 protein12235264
D017259DimapritHRH2 protein promotes the reaction [Dimaprit results in increased expression of IL16 protein]12235264
D005054EugenolEugenol results in increased expression of and results in increased secretion of IL16 protein23624239
C056507gemcitabinegemcitabine results in increased expression of IL16 protein20531411
D005839GentamicinsGentamicins results in increased expression of IL16 mRNA22061828
D006632HistamineCimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]12235264
D006632HistamineHistamine results in increased expression of IL16 protein12235264
D006632HistamineHRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]12235264
D006632Histaminethioperamide inhibits the reaction [Histamine results in increased expression of IL16 protein]12235264
D017313FenretinideFenretinide results in decreased expression of IL16 mRNA28973697
C011582IMOL S-140IMOL S-140 results in increased expression of IL16 mRNA26894911
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL16 mRNA25613284
D007854LeadLead affects the expression of IL16 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of IL16 mRNA"24972896
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Simvastatin] results in increased expression of IL16 mRNA15665042
D008558MelphalanMelphalan results in decreased expression of IL16 mRNA22363485
D008727MethotrexateMethotrexate results in decreased expression of IL16 mRNA17400583
D008748MethylcholanthreneMethylcholanthrene results in increased expression of IL16 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IL16 mRNA23649840
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of IL16 mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate affects the expression of IL16 mRNA26924002
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of IL16 mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of IL16 mRNA19818335
C064769N-acetylsphingosineN-acetylsphingosine results in increased expression of IL16 mRNA18270325
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IL16 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IL16 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of IL16 mRNA19812364
C490266neoechinulin Aneoechinulin A results in increased expression of IL16 mRNA19818335
D009532NickelNickel results in increased expression of and results in increased secretion of IL16 protein23624239
D009532NickelNickel results in increased expression of IL16 mRNA25583101
D052638Particulate MatterParticulate Matter affects the expression of IL16 mRNA26618301
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of IL16 mRNA23948077
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [HRH4 protein results in increased expression of IL16 protein]12235264
D011441PropylthiouracilPropylthiouracil results in increased expression of IL16 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IL16 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of IL16 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of IL16 mRNA19073995
D019821Simvastatin[Lipopolysaccharides co-treated with Simvastatin] results in increased expression of IL16 mRNA15665042
C017947sodium arsenitesodium arsenite results in decreased expression of IL16 mRNA24516582
D012969Sodium FluorideSodium Fluoride results in increased expression of IL16 mRNA27862939
D012999SomanSoman results in decreased expression of IL16 mRNA19281266
D013241SterigmatocystinSterigmatocystin results in increased expression of IL16 mRNA19818335
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of IL16 mRNA25470364
C582340tetradecabromodiphenoxybenzenetetradecabromodiphenoxybenzene results in decreased expression of IL16 mRNA26894911
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL16 mRNA25613284
D008063Thioctic AcidThioctic Acid results in decreased expression of IL16 protein20927401
C052075thioperamidethioperamide inhibits the reaction [Histamine results in increased expression of IL16 protein]12235264
C009495titanium dioxidetitanium dioxide affects the expression of IL16 mRNA19695317
C009495titanium dioxidetitanium dioxide results in decreased expression of IL16 mRNA23557971
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of IL16 mRNA"25242413
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of IL16 mRNA"24273086
C541743tris(2,3-dibromopropyl)isocyanurate"tris(2,3-dibromopropyl)isocyanurate results in decreased expression of IL16 mRNA"24273086
D014317Tritolyl PhosphatesTritolyl Phosphates results in decreased expression of IL16 mRNA24273086
D014520UrethaneUrethane results in increased expression of IL16 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of IL16 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IEA-  
GO:0042609CD4 receptor binding-IPI24942581  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006955immune response-TAS9144227  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0016032viral process-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030595leukocyte chemotaxis-IEA-  
GO:0050930induction of positive chemotaxis-IEA-  
GO:0051924regulation of calcium ion transport-IDA24942581  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449836Other interleukin signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29566963Analysis of the relationship between interleukin polymorphisms within miRNA-binding regions and alcoholic liver disease. (2018 May)Novo-Veleiro IRev Clin Esp
28930110Cytokine single-nucleotide polymorphisms and risk of non-small-cell lung cancer. (2017 Dec)Perez-Ramirez CPharmacogenet Genomics
24983941Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. (2014)Tang WPLoS One
15886011Interleukin-12 and interleukin-16 in periodontal disease. (2005 Jul 7)Tsai ISCytokine