Gene: IL17A

3605
CTLA-8|CTLA8|IL-17|IL-17A|IL17
interleukin 17A
protein-coding
6p12.2
Ensembl:ENSG00000112115 MIM:603149 Vega:OTTHUMG00000014840 UniprotKB:Q16552
NG_033021.1
PubMed
ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.588e-1 (AD)  7.463e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR5H20.871
HIST1H2AA0.866
OR4C460.864
OR4C120.864
KRTAP6-20.864
OR5T20.864
OR5M10.864
TSPY30.864
OR8K30.864
KRTAP27-10.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OMG-0.337
FUT9-0.302
THY1-0.287
GDF10-0.281
CNNM1-0.279
SH3GL2-0.276
CPEB3-0.275
LGI1-0.271
C1orf53-0.271
ATP8A1-0.271

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09029SecukinumabBiotechDrug1229022-83-6ApprovedTarget
DB11569IxekizumabBiotechDrug1143503-69-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D results in increased expression of IL17A protein"20211254
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL17A protein results in increased expression of CCL2 protein]12016129
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL17A protein results in increased expression of CXCL8 protein]12016129
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL17A protein results in increased expression of IL6 protein]12016129
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL17A protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]12016129
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL17A protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]12016129
C1045642-(4-acetoxyphenyl)-2-chloro-N-methylethylamine2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine results in decreased expression of IL17A protein19997594
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]"17982072
C5708532-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide"2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [Diethylnitrosamine results in increased secretion of IL17A protein]"27553677
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased expression of and results in decreased secretion of IL17A protein25203682
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased expression of IL17A mRNA25203682
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased expression of IL17A mRNA25203682
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]27613480
C5241064-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acidstannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of IL17A protein]]23611540
C5241064-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of IL17A protein]23611540
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IL17A mRNA12419474
C1118556-formylindolo(3,2-b)carbazole"[6-formylindolo(3,2-b)carbazole binds to and results in increased activity of AHR protein] which results in increased expression of and results in increased secretion of IL17A protein"25203682
C1118556-formylindolo(3,2-b)carbazole"[6-formylindolo(3,2-b)carbazole binds to and results in increased activity of AHR protein] which results in increased expression of IL17A mRNA"25203682
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of IL17A mRNA"25203682
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of IL17A protein"25716673
D000082AcetaminophenAcetaminophen results in increased expression of IL17A protein28435131
D000082Acetaminophen[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL17A protein]28435131
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IL17A protein]20431929
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Trichloroethylene results in increased expression of IL17A mRNA]23993974
C499366Active Hexose Correlated CompoundActive Hexose Correlated Compound results in increased expression of and results in increased secretion of IL17A protein22531483
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IL17A mRNA19770486
C430898AGN 194204AGN 194204 results in decreased expression of IL17A mRNA16339527
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL17A mRNA16483693
D000941Antigens[deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of IL17A protein28935500
D000941Antigens[ochratoxin A results in increased susceptibility to Antigens] which results in increased expression of IL17A protein28935500
D039741Antigens, Dermatophagoides"[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL17A mRNA"23499868
D039741Antigens, Dermatophagoides"[Antigens, Dermatophagoides co-treated with Particulate Matter] results in increased expression of IL17A protein"24060272
D039741Antigens, Dermatophagoides"[Antigens, Dermatophagoides co-treated with Vehicle Emissions] results in increased expression of IL17A protein"24060272
D039741Antigens, Dermatophagoides"[Methoxychlor co-treated with Antigens, Dermatophagoides] affects the expression of IL17A protein"21864637
D039741Antigens, Dermatophagoides"oleanolic acid 3-acetate inhibits the reaction [[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL17A mRNA]"23499868
D039741Antigens, Dermatophagoides"[Parathion co-treated with Antigens, Dermatophagoides] affects the expression of IL17A protein"21864637
D001151ArsenicArsenic affects the expression of IL17A mRNA28793237
D001151ArsenicArsenic results in decreased secretion of and results in decreased expression of IL17A protein22617429
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of IL17A mRNA28793237
D001151ArsenicArsenic results in increased expression of IL17A protein27289040
D001194AsbestosAsbestos results in increased expression of IL17A protein25162674
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of IL17A protein"28870655
D001241AspirinIL17A polymorphism affects the susceptibility to Aspirin22123380
D001397AzoxymethaneAcetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IL17A protein]20431929
D001397AzoxymethaneAzoxymethane results in increased expression of IL17A protein20431929
C416282BAY 11-7085"BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]"17982072
D019324beta-Naphthoflavonebeta-Naphthoflavone promotes the reaction [Plant Extracts results in increased expression of IL17A protein]22491429
D004958EstradiolEstradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]21501669
D004958Estradiolfulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]]21501669
C004541biochanin Abiochanin A promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
C004541biochanin A[biochanin A results in increased activity of RORA protein] which results in increased expression of IL17A mRNA25583575
C004541biochanin A[biochanin A results in increased activity of RORC protein] which results in increased expression of IL17A mRNA25583575
C006780bisphenol Abisphenol A results in increased expression of IL17A protein27693988
C006780bisphenol Abisphenol A results in decreased expression of IL17A mRNA25181051
D019328Buthionine Sulfoximine[Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein23986454
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of IL17A mRNA28793237
D002104CadmiumCadmium affects the expression of IL17A26051590
D002220CarbamazepineCarbamazepine results in increased expression of IL17A28267586
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IL17A protein17412915
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased secretion of and results in decreased expression of IL17A protein24973641
D002251Carbon TetrachlorideINCB018424 inhibits the reaction [Carbon Tetrachloride results in increased secretion of and results in decreased expression of IL17A protein]24973641
D004390ChlorpyrifosChlorpyrifos results in increased expression of IL17A mRNA22265773
C004692coomassie Brilliant Blue[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL17A protein]28435131
C113861corosolic acidcorosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]26513295
C113861corosolic acidcorosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]26513295
D003513CycloheximideCycloheximide inhibits the reaction [Glucose results in increased secretion of IL17A protein]18310510
D003609DactinomycinDactinomycin inhibits the reaction [Glucose results in increased secretion of IL17A protein]18310510
C004742daidzeindaidzein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
C004742daidzein[daidzein results in increased activity of RORA protein] which results in increased expression of IL17A mRNA25583575
C004742daidzein[daidzein results in increased activity of RORC protein] which results in increased expression of IL17A mRNA25583575
C568335DCB-SLE1DCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL17A mRNA]21677146
C014347decitabine[[decitabine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein] which results in increased expression of IL17A protein18567616
C007262deoxynivalenol[deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of IL17A protein28935500
C007262deoxynivalenoldeoxynivalenol promotes the reaction [nivalenol results in increased expression of IL17A mRNA]27915442
C007262deoxynivalenoldeoxynivalenol results in increased expression of IL17A mRNA23326479|2791544
C007262deoxynivalenoldeoxynivalenol results in increased expression of IL17A protein23326479
D003907DexamethasoneDexamethasone results in decreased expression of IL17A protein19997594
D016264Dextran SulfateADAM17 protein affects the reaction [Dextran Sulfate results in increased expression of IL17A protein]24548422
D016264Dextran SulfateDextran Sulfate results in increased expression of IL17A protein24384223|2454842
D016264Dextran Sulfateresveratrol inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein]24548422|2607469
D016264Dextran Sulfatetripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein]24384223
D016264Dextran SulfateDextran Sulfate results in increased expression of IL17A mRNA20881082
D016264Dextran Sulfatekappa-casein glycomacropeptide inhibits the reaction [Dextran Sulfate results in increased expression of IL17A mRNA]20881082
D003993Dibutyl Phthalate[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein29385629
D003993Dibutyl Phthalatepyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein]29385629
D004008DiclofenacDiclofenac results in increased expression of IL17A protein22285467
D004008DiclofenacDiclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]25450234
D004052Diethylnitrosamine"2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [Diethylnitrosamine results in increased secretion of IL17A protein]"27553677
D004052DiethylnitrosamineDiethylnitrosamine results in increased secretion of IL17A protein27553677
D004137Dinitrochlorobenzene"[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL17A mRNA"23499868
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IL17A mRNA23133493
D004137Dinitrochlorobenzene"oleanolic acid 3-acetate inhibits the reaction [[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL17A mRNA]"23499868
D004137DinitrochlorobenzenePlant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL17A mRNA]23133493
D004137DinitrochlorobenzenePrednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL17A mRNA]23133493
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IL17A mRNA25449201
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of IL17A mRNA23499868
D004139Dinitrofluorobenzeneoleanolic acid 3-acetate inhibits the reaction [Dinitrofluorobenzene results in increased expression of IL17A mRNA]23499868
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein]19940258
D004391Dust[Ovalbumin co-treated with Dust] results in increased expression of IL17A protein26882889
C017435enilconazoleenilconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
C026066enterotoxin A, Staphylococcal"enterotoxin A, Staphylococcal results in increased expression of and results in increased secretion of IL17A protein"26738536
C026066enterotoxin A, Staphylococcal"enterotoxin A, Staphylococcal results in increased expression of IL17A mRNA"26738536
C026066enterotoxin A, Staphylococcal"JAK3 affects the reaction [enterotoxin A, Staphylococcal results in increased secretion of IL17A protein]"26738536
C026066enterotoxin A, Staphylococcal"tofacitinib inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of and results in increased secretion of IL17A protein]"26738536
D000431EthanolEthanol results in increased expression of IL17A protein28843478
C007768formononetinformononetin promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
C007768formononetin[formononetin results in increased activity of RORA protein] which results in increased expression of IL17A mRNA25583575
C007768formononetin[formononetin results in increased activity of RORC protein] which results in increased expression of IL17A mRNA25583575
D005620Freund's Adjuvant3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]27613480
D005620Freund's AdjuvantDiclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]25450234
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of IL17A mRNA25698669|2761348
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of IL17A protein25450234|2761348
D005620Freund's AdjuvantIndomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]25698669
D005620Freund's AdjuvantLuteolin inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]25450234
D005620Freund's AdjuvantMethotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]27613480
D005620Freund's AdjuvantMethotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]27613480
D005620Freund's Adjuvant[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]25698669
D005620Freund's Adjuvantmorin inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]25698669
D005620Freund's Adjuvant[norisoboldine co-treated with COL2A1 protein co-treated with Freund's Adjuvant] results in decreased expression of IL17A protein25481498
D005620Freund's Adjuvanttrikatu inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]27613480
D005620Freund's Adjuvanttrikatu inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]27613480
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]]21501669
C039281furanfuran results in increased expression of IL17A mRNA27387713
D019833GenisteinGenistein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
D019833Genistein[Genistein results in increased activity of RORA protein] which results in increased expression of IL17A mRNA25583575
D019833Genistein[Genistein results in increased activity of RORC protein] which results in increased expression of IL17A mRNA25583575
D005947GlucoseCycloheximide inhibits the reaction [Glucose results in increased secretion of IL17A protein]18310510
D005947GlucoseDactinomycin inhibits the reaction [Glucose results in increased secretion of IL17A protein]18310510
D005947GlucoseGlucose results in increased expression of IL17A mRNA18310510
D005947GlucoseGlucose results in increased secretion of IL17A protein18310510
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of IL17A mRNA]18310510
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased secretion of IL17A protein]18310510
D006221HalothaneEstradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]21501669
D006221Halothanefulvestrant inhibits the reaction [Estradiol inhibits the reaction [Halothane results in increased expression of IL17A protein]]21501669
D006221HalothaneHalothane results in increased expression of IL17A protein19633216|2150166
D006221HalothaneMifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein]]21501669
D006221HalothaneProgesterone promotes the reaction [Halothane results in increased expression of IL17A protein]21501669
C409722hexaconazolehexaconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde results in increased expression of IL17A mRNA28826779
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde results in increased expression of IL17A protein28826779
C056493imiquimodimiquimod results in increased expression of IL17A mRNA25965695|2614947
C056493imiquimodimiquimod results in increased secretion of IL17A protein26149470
C056493imiquimod(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of IL17A mRNA]26149470
C056493imiquimod(+)-JQ1 compound inhibits the reaction [imiquimod results in increased secretion of IL17A protein]26149470
C056493imiquimodresveratrol inhibits the reaction [imiquimod results in increased expression of IL17A mRNA]25965695
C056493imiquimodSR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of IL17A mRNA]]26149470
C056493imiquimodSR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased secretion of IL17A protein]]26149470
C540383INCB018424INCB018424 inhibits the reaction [Carbon Tetrachloride results in increased secretion of and results in decreased expression of IL17A protein]24973641
D007213IndomethacinIndomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]25698669
D007213Indomethacin[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]25698669
D007455Iodine[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein29385629
D007455Iodinepyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein]29385629
D015759Ionomycinbiochanin A promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
D015759Ionomycindaidzein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
D015759Ionomycinenilconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
D015759Ionomycinformononetin promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
D015759IonomycinGenistein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
D015759Ionomycinhexaconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
D015759Ionomycintetraconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA22289359|2558357
D015759IonomycinTO-901317 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359|2558357
D015759Ionomycintriflumizol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA25613284
C051890irinotecanirinotecan results in increased expression of IL17A mRNA26431797
C051890irinotecanirinotecan results in increased expression of IL17A protein26431797
D007538IsoniazidIsoniazid results in increased secretion of IL17A protein28444390
D007545IsoproterenolIsoproterenol results in increased expression of IL17A protein19909738
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL17A mRNA23872705|2638794
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of IL17A protein26590112
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of IL17A mRNA]26149470
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [imiquimod results in increased secretion of IL17A protein]26149470
C561695(+)-JQ1 compoundSR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of IL17A mRNA]]26149470
C561695(+)-JQ1 compoundSR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased secretion of IL17A protein]]26149470
C020251kappa-casein glycomacropeptidekappa-casein glycomacropeptide inhibits the reaction [Dextran Sulfate results in increased expression of IL17A mRNA]20881082
D007840LatexLatex analog results in increased expression of IL17A mRNA24768652
C045463leflunomideleflunomide inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]26640276
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA23199342
D008070Lipopolysaccharidesresveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]23199342
D008070LipopolysaccharidesSIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]23199342
D008070LipopolysaccharidesDCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL17A mRNA]21677146
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased secretion of IL17A protein26918785
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL17A mRNA21677146
D008070Lipopolysaccharides"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL17A protein]"26918785
D047311LuteolinLuteolin inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]25450234
C412811maslinic acidmaslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]26513295
D008727MethotrexateMethotrexate results in decreased expression of IL17A mRNA17400583
D008727MethotrexateMethotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]27613480
D008727MethotrexateMethotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]27613480
D008731Methoxychlor"[Methoxychlor co-treated with Antigens, Dermatophagoides] affects the expression of IL17A protein"21864637
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL17A protein]"26918785
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IL17A protein28526320
C033069methyl salicylatemethyl salicylate results in decreased expression of IL17A protein28826779
C076881methysticinmethysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein]28448946
D008797MetyraponeMetyrapone inhibits the reaction [Ozone results in increased expression of IL17A protein]27037194
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL17A mRNA]18453621
D015735MifepristoneMifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein]]21501669
C070571ML 7ML 7 inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein]19940258
C008548morin[morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]25698669
C008548morinmorin inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]25698669
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IL17A mRNA"22293422
D037742Nanotubes, Carbon"[PTGS2 gene mutant form results in increased susceptibility to [Nanotubes, Carbon co-treated with OVAL protein]] which results in increased expression of IL17A mRNA"23642096
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of IL17A protein20594950
D009532NickelNickel results in increased expression of IL17A mRNA24768652
D009538Nicotine[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA23199342
D009538Nicotineresveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]23199342
D009538NicotineSIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]23199342
C038405nivalenoldeoxynivalenol promotes the reaction [nivalenol results in increased expression of IL17A mRNA]27915442
C038405nivalenolnivalenol results in increased expression of IL17A mRNA27915442
C464745norisoboldine[norisoboldine co-treated with COL2A1 protein co-treated with Freund's Adjuvant] results in decreased expression of IL17A protein25481498
C025589ochratoxin A[ochratoxin A results in increased susceptibility to Antigens] which results in increased expression of IL17A protein28935500
C052658oleanolic acid 3-acetate"oleanolic acid 3-acetate inhibits the reaction [[Antigens, Dermatophagoides co-treated with Dinitrochlorobenzene] results in increased expression of IL17A mRNA]"23499868
C052658oleanolic acid 3-acetateoleanolic acid 3-acetate inhibits the reaction [Dinitrofluorobenzene results in increased expression of IL17A mRNA]23499868
D010047Ovalbumin[Ovalbumin co-treated with Dust] results in increased expression of IL17A protein26882889
C446402ovalbumin-alumovalbumin-alum results in increased expression of IL17A mRNA27884791
C446402ovalbumin-alumPlant Extracts inhibits the reaction [ovalbumin-alum results in increased expression of IL17A mRNA]27884791
D010126OzoneADIPOQ gene mutant form promotes the reaction [Ozone results in increased expression of IL17A mRNA]23755285
D010126Ozone[ADIPOQ protein binds to CDH13 protein] inhibits the reaction [Ozone results in increased expression of IL17A mRNA]23755285
D010126OzoneCDH13 gene mutant form promotes the reaction [Ozone results in increased expression of IL17A mRNA]23755285
D010126Ozone[CPE affects the susceptibility to Ozone] which affects the expression of IL17A mRNA23434795
D010126OzoneOzone results in increased expression of IL17A mRNA23755285
D010126OzoneMetyrapone inhibits the reaction [Ozone results in increased expression of IL17A protein]27037194
D010126OzoneOzone results in increased expression of IL17A protein27037194
D010278Parathion"[Parathion co-treated with Antigens, Dermatophagoides] affects the expression of IL17A protein"21864637
D052638Particulate MatterParticulate Matter results in decreased expression of IL17A protein28189646
D052638Particulate Matter"[Antigens, Dermatophagoides co-treated with Particulate Matter] results in increased expression of IL17A protein"24060272
D052638Particulate MatterCARD9 protein affects the reaction [Particulate Matter results in increased expression of IL17A mRNA]28315386
D052638Particulate MatterParticulate Matter promotes the reaction [OVAL protein results in increased expression of IL17A mRNA]20562226
D052638Particulate MatterParticulate Matter results in increased expression of IL17A20061214
D052638Particulate MatterParticulate Matter results in increased expression of IL17A mRNA28315386
D052638Particulate MatterParticulate Matter results in increased expression of IL17A protein24060272
D052638Particulate Matter[Particulate Matter results in increased susceptibility to OVAL protein] which results in increased expression of IL17A mRNA24365139
D052638Particulate Matter[Particulate Matter results in increased susceptibility to OVAL protein] which results in increased expression of IL17A protein24365139
D010476PerfumePerfume results in increased expression of IL17A mRNA24768652
D010672Phenytoin[Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein23986454
D010706PhosmetPhosmet results in increased expression of IL17A mRNA22265773
D048789PhytoestrogensPhytoestrogens results in decreased expression of IL17A protein24388399
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of IL17A mRNA22842586
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IL17A mRNA19710929
D010936Plant Extractsbeta-Naphthoflavone promotes the reaction [Plant Extracts results in increased expression of IL17A protein]22491429
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL17A mRNA]23133493
D010936Plant ExtractsPlant Extracts inhibits the reaction [ovalbumin-alum results in increased expression of IL17A mRNA]27884791
D010936Plant ExtractsPlant Extracts results in increased expression of IL17A protein22491429
D010936Plant ExtractsPlant Extracts results in increased secretion of IL17A protein21804081
D010936Plant ExtractsTetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased expression of IL17A protein]22491429
D010936Plant ExtractsTetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased secretion of IL17A protein]21804081
D011239PrednisolonePrednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL17A mRNA]23133493
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of IL17A protein]]21501669
D011374ProgesteroneProgesterone promotes the reaction [Halothane results in increased expression of IL17A protein]21501669
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [[Iodine co-treated with Dibutyl Phthalate] results in increased expression of IL17A protein]29385629
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [IL17A protein results in increased activity of NFKB1 protein]12016129
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [IL17A protein results in increased activity of RELA protein]12016129
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [IL17A protein results in increased expression of CCL2 mRNA]12016129
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [IL17A protein results in increased expression of CXCL8 mRNA]12016129
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [IL17A protein results in increased expression of IL6 mRNA]12016129
C059514resveratrolresveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]23199342
C059514resveratrolresveratrol results in decreased expression of IL17A mRNA23224687
C059514resveratrolresveratrol inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein]24548422|2607469
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of IL17A mRNA]18310510
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased secretion of IL17A protein]18310510
C059514resveratrolresveratrol inhibits the reaction [imiquimod results in increased expression of IL17A mRNA]25965695
C059514resveratrolresveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]]26640276
C020491rheinrhein results in increased expression of IL17A protein26784856
C093642SB 203580SB 203580 inhibits the reaction [IL17A protein promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]12016129
C093642SB 203580SB 203580 inhibits the reaction [IL17A protein results in increased expression of CCL2 protein]12016129
C093642SB 203580SB 203580 inhibits the reaction [IL17A protein results in increased expression of CXCL8 protein]12016129
C093642SB 203580SB 203580 inhibits the reaction [IL17A protein results in increased expression of IL6 protein]12016129
C551534SGA 360SGA 360 results in decreased expression of IL17A protein25716673
D012822Silicon DioxideIL17A protein affects the reaction [Silicon Dioxide results in increased expression of CXCL1 protein]20421647
D012822Silicon DioxideIL17A protein affects the reaction [Silicon Dioxide results in increased expression of CXCL2 protein]20421647
D012822Silicon DioxideIL17A protein affects the reaction [Silicon Dioxide results in increased expression of IL1B protein]20421647
D012822Silicon DioxideIL17A protein affects the reaction [Silicon Dioxide results in increased expression of IL6 protein]20421647
D012822Silicon DioxideIL23A protein affects the reaction [Silicon Dioxide results in increased expression of IL17A]20421647
D012822Silicon DioxideIL23A protein affects the reaction [Silicon Dioxide results in increased expression of IL17A protein]20421647
D012822Silicon DioxideSilicon Dioxide results in increased expression of IL17A mRNA20421647
D012822Silicon DioxideSilicon Dioxide results in increased expression of IL17A protein20421647
D019821SimvastatinIFNG affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]18453621
D019821SimvastatinIFNG affects the reaction [Simvastatin results in decreased secretion of IL17A protein]18453621
D019821SimvastatinIL27 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]18453621
D019821SimvastatinIL27 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]18453621
D019821SimvastatinIL4 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]18453621
D019821SimvastatinIL4 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]18453621
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL17A mRNA]18453621
D019821SimvastatinSimvastatin results in decreased expression of IL17A mRNA18453621
D019821SimvastatinSimvastatin results in decreased secretion of IL17A protein18453621|2185693
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of IL17A mRNA28826779
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of IL17A protein28826779
C559087SR 1078SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of IL17A mRNA]]26149470
C559087SR 1078SR 1078 inhibits the reaction [(+)-JQ1 compound inhibits the reaction [imiquimod results in increased secretion of IL17A protein]]26149470
C518404stannous mesoporphyrinstannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of IL17A protein]]23611540
D013311Streptozocinstannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of IL17A protein]]23611540
D013311StreptozocinStreptozocin results in increased expression of IL17A protein23611540
D013311Streptozocin4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of IL17A protein]23611540
C061133tamibaroteneIL17A affects the reaction [tamibarotene results in decreased expression of TGFB1 mRNA]22077062
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased expression of IL17A protein]22491429
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased secretion of IL17A protein]21804081
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL17A mRNA21131560
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of and results in increased secretion of IL17A protein29040756
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL17A protein25716673
C524826tetraconazoletetraconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
D013755Tetradecanoylphorbol Acetatebiochanin A promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
D013755Tetradecanoylphorbol Acetatecorosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]26513295
D013755Tetradecanoylphorbol Acetatecorosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]26513295
D013755Tetradecanoylphorbol Acetatedaidzein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
D013755Tetradecanoylphorbol Acetateenilconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
D013755Tetradecanoylphorbol Acetateformononetin promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
D013755Tetradecanoylphorbol AcetateGenistein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]25583575
D013755Tetradecanoylphorbol Acetatehexaconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
D013755Tetradecanoylphorbol Acetatemaslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL17A mRNA]26513295
D013755Tetradecanoylphorbol Acetatetetraconazole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA22289359|2558357
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of IL17A mRNA26513295
D013755Tetradecanoylphorbol AcetateTO-901317 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359|2558357
D013755Tetradecanoylphorbol Acetatetriflumizol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA25613284
C009438tetrandrineresveratrol inhibits the reaction [tetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]]26640276
C009438tetrandrinetetrandrine inhibits the reaction [COL2A1 protein results in increased expression of IL17A protein]26640276
C009438tetrandrinetetrandrine results in decreased expression of IL17A mRNA26640276
C009495titanium dioxidetitanium dioxide affects the expression of IL17A mRNA19695317
C423915TO-901317TO-901317 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359|2558357
C479163tofacitinib"tofacitinib inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of and results in increased secretion of IL17A protein]"26738536
D014051Toluene 2,4-Diisocyanate"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]"17982072
D014051Toluene 2,4-Diisocyanate"BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]"17982072
D014051Toluene 2,4-Diisocyanate"PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]"17982072
D014051Toluene 2,4-Diisocyanate"PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]"17982072
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in decreased expression of IL17A protein"28826779
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA"17982072
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of IL17A protein"17982072
D014051Toluene 2,4-Diisocyanate"wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]"17982072
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of NFKB1 protein]12016129
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of RELA protein]12016129
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CCL2 mRNA]12016129
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CXCL8 mRNA]12016129
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of IL6 mRNA]12016129
D014241TrichloroethyleneAcetylcysteine inhibits the reaction [Trichloroethylene results in increased expression of IL17A mRNA]23993974
D014241TrichloroethyleneTrichloroethylene results in increased expression of IL17A mRNA23993974
C053549triflumizoltriflumizol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL17A mRNA]22289359
C540456trikatutrikatu inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A mRNA]27613480
C540456trikatutrikatu inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]27613480
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of IL17A mRNA17375199
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of IL17A protein23027085
C050414tripterine[tripterine co-treated with coomassie Brilliant Blue] inhibits the reaction [Acetaminophen results in increased expression of IL17A protein]28435131
C050414tripterinetripterine inhibits the reaction [Dextran Sulfate results in increased expression of IL17A protein]24384223
C001899triptolideIL17A protein promotes the reaction [triptolide results in increased expression of CCL11 mRNA]24949944
C001899triptolideIL17A protein promotes the reaction [triptolide results in increased expression of CXCL1 mRNA]24949944
C001899triptolideIL17A protein promotes the reaction [triptolide results in increased expression of CXCL2 mRNA]24949944
C001899triptolideIL17A protein promotes the reaction [triptolide results in increased expression of FASL mRNA]24949944
C001899triptolideIL17A protein promotes the reaction [triptolide results in increased expression of IL1B mRNA]24949944
C001899triptolidetriptolide results in increased expression of IL17A mRNA24949944
C001899triptolidetriptolide results in increased expression of IL17A protein24949944
C113580U 0126U 0126 inhibits the reaction [IL17A protein results in increased expression of CCL2 protein]12016129
C113580U 0126U 0126 inhibits the reaction [IL17A protein results in increased expression of CXCL8 protein]12016129
C113580U 0126U 0126 inhibits the reaction [IL17A protein results in increased expression of IL6 protein]12016129
C113580U 0126U 0126 inhibits the reaction [IL17A protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]12016129
C113580U 0126U 0126 inhibits the reaction [IL17A protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]12016129
D058425Vaccines, Virus-Like Particle"Vaccines, Virus-Like Particle results in increased expression of IL17A protein"20130130
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of IL17A protein28189646
D001335Vehicle Emissions"[Antigens, Dermatophagoides co-treated with Vehicle Emissions] results in increased expression of IL17A protein"24060272
D001335Vehicle EmissionsVehicle Emissions results in increased expression of IL17A protein24060272
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of IL17A gene25560391
D001335Vehicle Emissions[Vehicle Emissions results in increased susceptibility to OVAL protein] which results in increased expression of IL17A mRNA24365139
D001335Vehicle Emissions[Vehicle Emissions results in increased susceptibility to OVAL protein] which results in increased expression of IL17A protein24365139
C009687wortmannin"wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]"17982072
D015054ZymosanZymosan results in increased expression of IL17A protein19114665

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-TAS7499828  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-TAS7499828  
GO:0007267cell-cell signaling-TAS7499828  
GO:0008219cell death-TAS8390535  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0032747positive regulation of interleukin-23 production-IDA21145111  
GO:0045672positive regulation of osteoclast differentiation-IDA17888176  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16982811  
GO:0050832defense response to fungus-IEA-  
GO:0071347cellular response to interleukin-1-IEA-  
GO:0072537fibroblast activation-IDA21145111  
GO:0097400interleukin-17-mediated signaling pathway-TAS-  
GO:1900017positive regulation of cytokine production involved in inflammatory response-IEA-  
GO:2000778positive regulation of interleukin-6 secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0009897external side of plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22814515Th1/Th2/Th17related cytokines in the bronchoalveolar lavage fluid of patients with sarcoidosis: association with smoking. (2012)Urbankowski TPol Arch Med Wewn
27399111Common variants in IL-17A/IL-17RA axis contribute to predisposition to and progression of congestive heart failure. (2016 Jul)Sandip CMedicine (Baltimore)
28912468Cytokine-based Predictive Models to Estimate the Probability of Chronic Periodontitis: Development of Diagnostic Nomograms. (2017 Sep 14)Tomas ISci Rep
25172546Effect of smoking on immunity in human chronic periodontitis. (2014 Dec)Souto GRImmunobiology
26232300Experimental progressive emphysema in BALB/cJ mice as a model for chronic alveolar destruction in humans. (2015 Oct 1)Limjunyawong NAm J Physiol Lung Cell Mol Physiol
23895419Interleukin 17A rs4711998 A>G polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. (2014 Jan)Yin JDis Esophagus
19968631Gene-gene and gene-environment interactions on IgE production in prenatal stage. (2010 Jun 1)Yang KDAllergy
23036591Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis. (2012 Oct 4)Kazantseva MGArthritis Res Ther
25844618IL-17A Is Elevated in End-Stage Chronic Obstructive Pulmonary Disease and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis. (2015 Jun 1)Roos ABAm J Respir Crit Care Med
24776844Associations between functional polymorphisms in the NFkappaB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. (2014 Dec)Bank SPharmacogenomics J
27003425Inflammatory and Immune Response Genes Polymorphisms are Associated with Susceptibility to Chronic Obstructive Pulmonary Disease in Tatars Population from Russia. (2016 Aug)Korytina GFBiochem Genet