Gene: IL18

3606
IGIF|IL-18|IL-1g|IL1F4
interleukin 18
protein-coding
11q23.1
Ensembl:ENSG00000150782 MIM:600953 Vega:OTTHUMG00000167006 UniprotKB:Q14116
NG_028143.1
PubMed
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.187e-1 (AD)  4.187e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYK0.939
TBXAS10.921
RNASE60.92
HLA-DMB0.915
CD370.914
CD860.913
HLA-DOA0.906
CLEC7A0.906
BTK0.902
APBB1IP0.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.477
KCNIP3-0.446
WNT7A-0.434
CHRNA4-0.427
KREMEN2-0.425
YBX2-0.411
MAGIX-0.406
CPLX3-0.404
MARCH4-0.4
BDH1-0.391

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0394111,2-dibromo-2,4-dicyanobutane"1,2-dibromo-2,4-dicyanobutane results in increased expression of IL18 protein"23063874
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of IL18 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of IL18 mRNA"21354444|2890350
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of IL18 mRNA"20453058
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [BSG protein results in increased secretion of IL18 protein]19561311
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL18 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]19561311
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL18 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]19561311
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of IL18 mRNA"25710175
C4337712-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased secretion of IL18 protein11226294
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of IL18 mRNA"21703328
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased secretion of IL18 protein20421217
C5236683-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]"27311643
C5236683-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein]"27311643
C0312853-xylene3-xylene results in decreased expression of IL18 mRNA12815608
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of IL18 mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of IL18 mRNA"27567155
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA12419474
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA19191707
C0255664-methylhistamine4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]11752121
C0255664-methylhistamine4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]11752121|1236486
C0255664-methylhistamine4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]11752121|1236486
C0255664-methylhistamine4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]11752121|1236486
C0255664-methylhistamine4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]11752121
C0275634-nitrobenzyl bromide4-nitrobenzyl bromide results in increased expression of IL18 protein23063874
C0297284-phenylenediamine4-phenylenediamine results in increased expression of IL18 protein23063874|2758566
C0297284-phenylenediaminePRDM1 protein promotes the reaction [4-phenylenediamine results in increased expression of IL18 protein]27585668
C099958acanthoic acidacanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA]28964808
C099958acanthoic acidacanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]28964808
C099958acanthoic acidacanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]28964808
C099958acanthoic acidPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]]28964808
C099958acanthoic acidacanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]28964808
D000082AcetaminophenAcetaminophen results in increased expression of IL18 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of IL18 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of IL18 mRNA17585979|1916485
D000082AcetaminophenAcetaminophen results in increased expression of IL18 protein20102673
D000082AcetaminophenAspirin inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA]19164858
D000082AcetaminophenPlant Preparations inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA]20102673
D000082AcetaminophenPlant Preparations inhibits the reaction [Acetaminophen results in increased expression of IL18 protein]20102673
C056165acetovanilloneacetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA]28539244
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]27311643
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein]27311643
D000255Adenosine Triphosphate[Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein17404311
D000255Adenosine Triphosphate[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein26431797
D000255Adenosine Triphosphate[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA24149798|2643179
D000255Adenosine Triphosphate[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein24149798
D000255Adenosine Triphosphateresveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA]24149798
D000255Adenosine Triphosphateresveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]24149798
D000255Adenosine Triphosphate"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]"27311643
D000255Adenosine TriphosphateAcetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]27311643
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased secretion of IL18 protein27311643
D000255Adenosine Triphosphatediphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]27311643
D000255Adenosine Triphosphate[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein26431797
D000255Adenosine Triphosphate[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA26431797
D000276Adjuvants, Immunologic"[Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein"17404311
D000276Adjuvants, Immunologic"CASP1 protein affects the reaction [[Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein]"17404311
D000276Adjuvants, Immunologic"[Adjuvants, Immunologic results in increased activity of NLRP3 protein] which results in increased expression of IL18"19439372
D000276Adjuvants, Immunologic"Adjuvants, Immunologic results in increased secretion of IL18 protein"22967010
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IL18 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of IL18 gene27153756
D000450AldosteroneAGT protein alternative form promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450AldosteroneAldosterone results in increased expression of IL18 mRNA18660453
D000450AldosteroneAldosterone results in increased expression of IL18 protein18660453
D000450AldosteroneBezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450AldosteroneCycloheximide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450Aldosterone[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450Aldosterone[EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450Aldosteroneeplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450Aldosterone"exoenzyme C3, Clostridium botulinum inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]"18660453
D000450Aldosteronefasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450AldosteroneMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]18660453
D000450Aldosteroneolmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450Aldosteronepioglitazone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450Aldosteroneprolinedithiocarbamate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450AldosteroneSimvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450AldosteroneSN50 peptide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000450AldosteroneSpironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]22426011
D000493AllopurinolAllopurinol inhibits the reaction [Streptozocin results in increased expression of IL18 protein]23647015
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of IL18 mRNA28522335
D000534Alum Compounds[Alum Compounds co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein17404311
D000534Alum CompoundsCASP1 protein affects the reaction [[Alum Compounds co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein]17404311
D000534Alum Compounds[Alum Compounds results in increased activity of NLRP3 protein] which results in increased expression of IL1819439372
D000535AluminumAluminum results in increased secretion of IL18 protein22967010
C012714aluminum phosphate[aluminum phosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein17404311
C041524aluminum sulfatealuminum sulfate results in increased expression of IL18 protein16100009
D000638AmiodaroneAmiodarone promotes the reaction [Dexamethasone results in decreased expression of IL18 mRNA]25900201
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IL18 mRNA16483693
C031385anthranilic acidanthranilic acid analog inhibits the reaction [IL18 protein results in increased secretion of IFNG protein]15799959
D052179Antigens, Plant"Antigens, Plant results in increased expression of IL18 mRNA"21334316
D052179Antigens, Plant"zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL18 mRNA]"21334316
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL18 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of IL1820693187
C015001arsenitearsenite results in decreased expression of IL18 mRNA16085347
C015001arsenitecaffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL18 mRNA]16085347
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of IL18 protein"20855422
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of IL18 mRNA"27083413
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of IL18 mRNA"24160326
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased secretion of IL18 protein"23937860
D001241AspirinIL18 polymorphism affects the susceptibility to Aspirin21692767
D001241AspirinAspirin inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA]19164858
D001280AtrazineAtrazine results in decreased expression of IL18 mRNA22378314
D001566BenzocaineBenzocaine results in increased activity of IL18 protein15840424
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IL18 mRNA21632981
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of IL18 mRNA]22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]15178407
C020711beryllium sulfateberyllium sulfate results in increased expression of IL18 mRNA16100009
C020711beryllium sulfateberyllium sulfate results in increased expression of IL18 protein16100009
D004958EstradiolEstradiol results in increased expression of IL18 mRNA22226936
D004958EstradiolEstradiol results in increased secretion of IL18 protein22226936
D004958EstradiolEstradiol affects the expression of IL18 mRNA22574217
D004958EstradiolEstradiol results in decreased expression of IL18 mRNA25878060
D004958EstradiolEstradiol results in increased expression of IL18 mRNA23373633|2587806
C095105bexarotenebexarotene results in decreased expression of IL18 mRNA16648578
D001629BezafibrateBezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D001629BezafibrateBezafibrate inhibits the reaction [AGT protein alternative form results in increased expression of IL18 mRNA]18660453
D001629BezafibrateBezafibrate inhibits the reaction [EDN1 protein results in increased expression of IL18 mRNA]18660453
D001663BilirubinBilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]18215737
D001663BilirubinBilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]18215737
D001663BilirubinBilirubin results in decreased susceptibility to IL18 protein18215737
D001664BiliverdineBiliverdine inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]18215737
D001664BiliverdineBiliverdine inhibits the reaction [IL18 protein results in increased expression of PTEN protein]18215737
D001664BiliverdineBiliverdine results in decreased susceptibility to IL18 protein18215737
C006780bisphenol Abisphenol A results in increased expression of IL18 mRNA25878060
C006780bisphenol Abisphenol A results in increased secretion of IL18 protein25878060
C006780bisphenol Abisphenol A results in increased expression of IL18 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of IL18 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of IL18 mRNA12075121
C006780bisphenol Abisphenol A results in increased expression of IL18 mRNA28285737
C006780bisphenol ASodium Selenite inhibits the reaction [bisphenol A results in increased expression of IL18 mRNA]28285737
D001786Blood Glucose[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 mRNA26464617
D001786Blood Glucose[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 protein26464617
D001786Blood Glucoseresveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 mRNA]26464617
D001786Blood Glucoseresveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 protein]26464617
C006794brevianamide Abrevianamide A results in increased expression of IL18 mRNA19818335
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL18 mRNA22079614
D020148Butyric AcidButyric Acid results in increased expression of IL18 mRNA17928716
C584509C646 compoundC646 compound results in increased expression of IL18 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IL18 protein28759707
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL18 mRNA]16085347
C005563captaxcaptax results in increased expression of IL18 protein23063874
D002248Carbon MonoxideCarbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]18215737
D002248Carbon MonoxideCarbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein]18215737
D002248Carbon MonoxideCarbon Monoxide results in decreased susceptibility to IL18 protein18215737
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of IL18 mRNA27339419
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of IL18 mRNA16039398
D002509CephaloridineCephaloridine results in increased expression of IL18 mRNA18500788
C026690cerous chloridecerous chloride results in increased expression of IL1823712967
D002706ChlordanChlordan results in decreased expression of IL18 mRNA23153324
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of IL18 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of IL18 mRNA17851650
C100187chloropicrinchloropicrin results in increased expression of IL18 mRNA26352163
C418118CI 1044CI 1044 results in increased expression of IL18 mRNA17569694
D002927CimetidineCASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]16723495
D002927CimetidineCimetidine results in increased expression of IL18 protein16723495
D002927CimetidineFamotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]16723495
D002927CimetidineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cimetidine results in increased expression of IL18 protein]16723495
D002927CimetidineRanitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]16723495
D002927CimetidineCimetidine results in increased expression of IL18 protein16723495
D002927CimetidineHRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]16723495
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of IL18 protein23063874
C020722cinnamyl alcoholcinnamyl alcohol results in increased expression of IL18 protein23063874
C007076citralcitral results in increased expression of IL18 protein23063874
C000488cladosporincladosporin results in increased expression of IL18 mRNA19818335
D002976ClenbuterolClenbuterol results in increased expression of IL18 mRNA15178407
D002976ClenbuterolClenbuterol results in increased expression of IL18 protein15178407
D002994ClofibrateClofibrate results in decreased expression of IL18 mRNA17585979
D003035Cobalt[Cobalt co-treated with Organometallic Compounds] results in increased expression of IL18 mRNA22147119
D003035CobaltCobalt results in increased expression of IL18 mRNA22147119
D003035Cobalt[Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA22198552
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]18215737
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]18215737
C007095cobaltiprotoporphyrincobaltiprotoporphyrin results in decreased susceptibility to IL18 protein18215737
C018021cobaltous chloridecobaltous chloride results in increased expression of IL18 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of IL18 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of IL18 mRNA19549813
C007133cortisol succinatecortisol succinate results in decreased secretion of IL18 protein20421217
D003474CurcuminCurcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]16368150
D003474CurcuminCurcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]16368150
D003474CurcuminCurcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]17399992
D003474CurcuminCurcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]17399992
D003474CurcuminCurcumin results in decreased expression of IL18 mRNA17399992
D003474CurcuminCurcumin results in decreased expression of IL18 protein17399992
D003474CurcuminCurcumin results in decreased expression of IL18 mRNA16751071
D003474CurcuminCurcumin results in decreased expression of IL1818462866
C038459curdlancurdlan affects the expression of IL18 mRNA19904525
D003513CycloheximideCycloheximide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D003520CyclophosphamideCyclophosphamide results in increased expression of IL18 protein18848347
D016572CyclosporineCyclosporine results in decreased expression of IL18 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of IL18 mRNA20106945
D016572CyclosporineCyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]16442096
C072247cyclo(Trp-Asp-Pro-Val-Leu)[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
C568335DCB-SLE1DCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL18 protein]21677146
C568335DCB-SLE1DCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]21677146
C007262deoxynivalenoldeoxynivalenol results in decreased expression of IL18 mRNA22968694
D003907DexamethasoneDexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]18951874
D003907DexamethasoneHydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]18951874
D003907DexamethasoneTheophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]18951874
D003907DexamethasoneTheophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]18951874
D003907DexamethasoneTobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]18951874
D003907DexamethasoneAmiodarone promotes the reaction [Dexamethasone results in decreased expression of IL18 mRNA]25900201
D003907DexamethasoneDexamethasone inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]25448682
D003907DexamethasoneDexamethasone results in decreased expression of IL18 mRNA25900201
D003907DexamethasoneDexamethasone results in increased expression of IL18 mRNA21041162
D016264Dextran SulfateDexamethasone inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]25448682
D016264Dextran SulfateDextran Sulfate results in increased expression of IL18 protein25448682
D016264Dextran Sulfatefraxinellone inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]25448682
D016264Dextran SulfateIL18 protein affects the susceptibility to Dextran Sulfate12940437
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of IL18 mRNA20705681
D002945CisplatinCisplatin results in decreased expression of IL1817021654
D002945CisplatinCisplatin results in increased expression of IL18 mRNA27594783
D002945CisplatinCisplatin results in increased expression of IL18 mRNA21151649
D002945CisplatinCisplatin results in increased expression of IL18 protein25308879
C000944dicrotophosdicrotophos results in decreased expression of IL18 mRNA28302478
D004026DieldrinDieldrin affects the expression of IL18 mRNA22546817
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL18 mRNA27070252
D004041Dietary Fatsresveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL18 mRNA]27070252
D004041Dietary FatsDietary Fats results in decreased expression of IL18 mRNA18457598
D004041Dietary FatsDietary Fats results in decreased expression of IL18 protein19680557
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL18 mRNA27070252
D019422Dietary Sucroseresveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL18 mRNA]27070252
C034281diethylaminediethylamine results in increased activity of IL18 protein15840424
C058705diethyl malatediethyl malate affects the expression of IL18 mRNA24814887
C014476diethyl maleatediethyl maleate results in increased expression of IL18 protein23063874
D017259DimapritDimaprit inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]11752121
D017259DimapritDimaprit inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]11752121|1236486
D017259DimapritDimaprit inhibits the reaction [IL18 protein results in increased expression of IFNG protein]11752121|1236486
D017259DimapritDimaprit inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]11752121|1236486
D017259DimapritDimaprit inhibits the reaction [IL18 protein results in increased expression of TNF protein]11752121
D004128DimethylnitrosamineCSF3 protein affects the reaction [Dimethylnitrosamine affects the expression of IL18 mRNA]17869372
D004128DimethylnitrosamineDimethylnitrosamine affects the expression of IL18 mRNA17869372
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IL18 protein23063874|2758566
D004137DinitrochlorobenzenePRDM1 protein promotes the reaction [Dinitrochlorobenzene results in increased expression of IL18 protein]27585668
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased activity of IL18 protein15840424
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of IL18 mRNA11708898
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [IL18 protein results in increased abundance of Reactive Oxygen Species]19561311
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [IL18 protein results in increased expression of BSG mRNA]19561311
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]27311643
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein]27311643
C509867E804 bisindole[Lipopolysaccharides co-treated with E804 bisindole] results in decreased expression of IL18 mRNA23107598
C414690eplerenoneeplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D004967EstrogensEstrogens inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]17850464
D004967Estrogens[fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]]17850464
D004967Estrogens[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]17850464
D000431Ethanolacanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA]28964808
D000431Ethanolacanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]28964808
D000431Ethanolacanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]28964808
D000431Ethanol[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA28964808
D000431Ethanol[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 protein28964808
D000431EthanolEthanol results in increased expression of IL18 mRNA28964808
D000431EthanolEthanol results in increased expression of IL18 protein28964808
D000431EthanolIL18 gene SNP affects the susceptibility to Ethanol24349532
D000431EthanolPRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]]28964808
D000431Ethanolacanthoic acid inhibits the reaction [Ethanol results in increased expression of IL18 mRNA]28964808
D000431EthanolEthanol results in increased expression of IL18 mRNA28964808
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IL18 mRNA12075121
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IL18 mRNA15576828|1735126
C024565ethylene dichlorideethylene dichloride results in decreased expression of IL18 mRNA28189721
D005054EugenolEugenol results in increased expression of IL18 protein23063874
C562064EVP 4593EVP 4593 inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL18 protein]26431797
C562064EVP 4593EVP 4593 inhibits the reaction [irinotecan results in increased expression of and results in increased secretion of IL18 protein]26431797
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]"18660453
D015025ZearalenoneZearalenone results in increased expression of IL18 mRNA25455459
D015738FamotidineFamotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]16723495
D015738FamotidineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]11752121
D015738FamotidineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]11752121|1236486
D015738FamotidineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]11752121|1236486
D015738FamotidineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]11752121|1236486
D015738FamotidineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]11752121
C049347fasudilfasudil inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D015736FelodipineFelodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]18504504
D015736FelodipineFelodipine inhibits the reaction [Fructose results in increased expression of IL18 protein]18504504
D005472Fluorouracil[Fluorouracil co-treated with irinotecan] results in decreased expression of IL18 mRNA16391804
D005472FluorouracilFluorouracil promotes the reaction [IL18 protein modified form results in increased expression of IFNG protein]15162350
D005472FluorouracilFluorouracil results in increased cleavage of and results in increased secretion of IL18 protein15162350
D005472FluorouracilFluorouracil affects the expression of IL18 mRNA20421339
D005557FormaldehydeFormaldehyde results in increased expression of IL18 mRNA12161283
C075391fraxinellonefraxinellone inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]25448682
C075391fraxinellonefraxinellone inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]25448682
C075391fraxinellonefraxinellone inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]25448682
D005632FructoseAllopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]22426011
D005632FructoseFelodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]18504504
D005632FructoseFelodipine inhibits the reaction [Fructose results in increased expression of IL18 protein]18504504
D005632FructoseFructose results in increased expression of IL18 mRNA18504504
D005632FructoseFructose results in increased expression of IL18 protein18504504|2242601
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of IL18 protein]22426011
D005632FructoseRutin inhibits the reaction [Fructose results in increased expression of IL18 protein]22426011
C070081fulvestrant[fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]]17850464
C039281furanfuran results in decreased expression of IL18 mRNA20194422
D005688GalactosamineGalactosamine results in increased expression of IL18 mRNA20102673
D005688GalactosamineGalactosamine results in increased expression of IL18 protein20102673
D005688Galactosamine[LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL18 mRNA19913045
D005688Galactosamine[LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL18 protein19913045
D005688Galactosamine[LEPR gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL1819913045
D005688Galactosamine[LEPR gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL18 mRNA19913045
D005688Galactosamine[LEPR gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL18 protein19913045
D005688GalactosaminePlant Preparations inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA]20102673
D005688GalactosaminePlant Preparations inhibits the reaction [Galactosamine results in increased expression of IL18 protein]20102673
D005688GalactosamineGalactosamine results in increased expression of IL18 mRNA22310181
D005688Galactosaminemangiferin inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA]22310181
C043055gallium arsenidegallium arsenide results in increased expression of IL18 mRNA14560044
C043055gallium arsenidegallium arsenide results in increased secretion of IL18 protein14560044
D019833GenisteinGenistein results in decreased expression of IL18 mRNA12075121
D005938Glucocorticoids[Methotrexate co-treated with Glucocorticoids] results in decreased expression of IL18 mRNA22133036
D005905GlyburideGlyburide inhibits the reaction [Paraquat results in increased secretion of IL18 protein]25338942
D005905GlyburideGlyburide inhibits the reaction [Paraquat results in increased expression of IL18 protein]25338942
D006037GlyoxalGlyoxal results in increased expression of IL18 protein23063874
C054591hachimijioganhachimijiogan results in decreased expression of IL18 mRNA12022442
D006427HeminHemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein]18215737
D006427HeminHemin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]18215737
D006427HeminHemin inhibits the reaction [IL18 protein results in increased expression of MAPK14 protein]18215737
D006427HeminHemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein]18215737
D006427HeminHemin results in decreased susceptibility to IL18 protein18215737
D006427HeminHMOX1 protein promotes the reaction [Hemin results in decreased susceptibility to IL18 protein]18215737
D006427Heminzinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein]18215737
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of IL18 mRNA15159207
D006632HistamineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]11752121
D006632HistamineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]11752121|1236486
D006632HistamineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]11752121|1236486
D006632HistamineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]11752121|1236486
D006632HistamineFamotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]11752121
D006632HistamineHistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]11752121
D006632HistamineHistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]11752121|1236486
D006632HistamineHistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]11752121|1236486
D006632HistamineHistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]11752121|1236486
D006632HistamineHistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]11752121
D006632HistamineHistamine results in increased expression of IL18 protein16723495
D006632HistamineHRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]11752121
D006632HistamineHRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]11752121
D006632HistamineHRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]11752121
D006632HistamineHRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]11752121
D006632HistamineHRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]11752121
D006632Histamine[IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]11752121
D006632Histamine[IL12A protein binds to IL12B protein] inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]11752121
D006632HistamineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of IL18 protein]16723495
D006632HistamineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]11752121
D006632HistamineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]11752121
D006632HistamineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]11752121
D006632HistamineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]11752121
D006632HistamineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]11752121
D006632HistamineHistamine results in increased expression of IL18 protein16723495
D006632HistamineHRH2 protein affects the reaction [Histamine results in increased expression of IL18 protein]16723495
C005499honokiolhonokiol inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]21147091
D017313FenretinideFenretinide results in decreased expression of IL18 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of IL18 mRNA21179406
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of IL18 mRNA12419474|2633960
D006861Hydrogen PeroxideTheophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]18951874
C492448ICG 001ICG 001 results in increased expression of IL18 mRNA26191083
C026777ICI 118551ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA]15178407
C026777ICI 118551ICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 protein]15178407
D007213IndomethacinIndomethacin results in increased expression of IL18 mRNA18996434
D007213IndomethacinIndomethacin results in increased expression of IL18 protein18996434
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL18 mRNA25613284
C051890irinotecanEVP 4593 inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL18 protein]26431797
C051890irinotecan[Fluorouracil co-treated with irinotecan] results in decreased expression of IL18 mRNA16391804
C051890irinotecan[irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein26431797
C051890irinotecan[irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA26431797
C051890irinotecanpyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL18 protein]26431797
C051890irinotecanEVP 4593 inhibits the reaction [irinotecan results in increased expression of and results in increased secretion of IL18 protein]26431797
C051890irinotecan[irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein26431797
C051890irinotecan[irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA26431797
C051890irinotecanirinotecan results in increased expression of IL18 mRNA26431797
C051890irinotecanirinotecan results in increased expression of IL18 protein26431797
C051890irinotecanpyrazolanthrone inhibits the reaction [irinotecan results in increased expression of and results in increased secretion of IL18 protein]26431797
D007501IronIron affects the reaction [IL18 protein results in increased secretion of IFNG protein]15799959
D007502Iron Chelating AgentsIron Chelating Agents analog inhibits the reaction [IL18 protein results in increased secretion of IFNG protein]15799959
D058085Iron CompoundsIron Compounds results in increased expression of IL18 protein28483490
C036643isoeugenolisoeugenol results in increased expression of IL18 protein23063874
D007545IsoproterenolADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA]15178407
D007545Isoproterenolbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]15178407
D007545IsoproterenolICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA]15178407
D007545IsoproterenolICI 118551 inhibits the reaction [Isoproterenol results in increased expression of IL18 protein]15178407
D007545IsoproterenolIsoproterenol results in decreased expression of IL18 mRNA21335049
D007545IsoproterenolIsoproterenol results in increased expression of and results in increased secretion of IL18 protein15178407
D007545IsoproterenolIsoproterenol results in increased expression of and results in increased stability of IL18 mRNA15178407
D007545IsoproterenolPertussis Toxin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]15178407
D007545Isoproterenolpyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL18 protein]15178407
D007545Isoproterenolpyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA]15178407
D007545Isoproterenolwortmannin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]15178407
D007545IsoproterenolIsoproterenol results in increased expression of IL18 protein24286936
C544151jinfukangjinfukang results in decreased expression of IL18 mRNA27392435
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL18 mRNA]"24799421
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]26582142
C114999K-12 lipopolysaccharide[Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein17404311
C114999K-12 lipopolysaccharide"[Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein"17404311
C114999K-12 lipopolysaccharide[Alum Compounds co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein17404311
C114999K-12 lipopolysaccharide[aluminum phosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein17404311
C114999K-12 lipopolysaccharide"CASP1 protein affects the reaction [[Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein]"17404311
C114999K-12 lipopolysaccharideCASP1 protein affects the reaction [[Alum Compounds co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein]17404311
D007840LatexLatex analog results in increased expression of IL18 mRNA24768652
D007840LatexLatex results in increased expression of IL18 protein18938192
C008261lead acetatelead acetate affects the expression of IL18 protein21322097
D008050Lipid ALipid A results in increased expression of IL18 mRNA16299289
D008055Lipids[Methotrexate analog binds to Lipids] which results in decreased expression of IL18 mRNA24065615
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased secretion of IL18 protein"17630318
C482199lipopolysaccharide, E coli O55-B5"[CSTB gene mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased secretion of IL18 protein"25288807
C482199lipopolysaccharide, E coli O55-B5"IL18 protein results in increased susceptibility to [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5]"18930950
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 protein"18930950
C482199lipopolysaccharide, E coli O55-B5"trovafloxacin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 protein]"18930950
C440499lipopolysaccharide, Escherichia coli O111 B4"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL18 mRNA]"24799421
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL18 mRNA"24799421
D008070Lipopolysaccharidesacanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA]28964808
D008070Lipopolysaccharidesacanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]28964808
D008070LipopolysaccharidesCurcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]17399992
D008070LipopolysaccharidesCurcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]17399992
D008070Lipopolysaccharides[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA28964808
D008070Lipopolysaccharides[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL18 protein28964808
D008070LipopolysaccharidesEVP 4593 inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL18 protein]26431797
D008070Lipopolysaccharidesfraxinellone inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]25448682
D008070Lipopolysaccharideshonokiol inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]21147091
D008070LipopolysaccharidesIL18 protein promotes the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]17399992
D008070LipopolysaccharidesIL18 protein promotes the reaction [Lipopolysaccharides results in increased expression of IFNG protein]17399992
D008070Lipopolysaccharides[irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein26431797
D008070Lipopolysaccharides[irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA26431797
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein26431797
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA24149798|2643179
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein24149798
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]17399992
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]17399992
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL18 mRNA16100009|1739999
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL18 protein16100009|1739999
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of IL18 protein15289356|2042121
D008070Lipopolysaccharidespyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL18 protein]26431797
D008070Lipopolysaccharidesresveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA]24149798
D008070Lipopolysaccharidesresveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]24149798
D008070Lipopolysaccharides[usnic acid co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA22777745
D008070LipopolysaccharidesDCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL18 protein]21677146
D008070LipopolysaccharidesDCB-SLE1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]21677146
D008070LipopolysaccharidesEstrogens inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]17850464
D008070Lipopolysaccharidesfraxinellone inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein]25448682
D008070Lipopolysaccharides[fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]]17850464
D008070Lipopolysaccharides[irinotecan co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of IL18 protein26431797
D008070Lipopolysaccharides[irinotecan co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA26431797
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]26582142
D008070LipopolysaccharidesLipopolysaccharides affects the expression of IL18 protein21055422
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein26431797
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA26431797
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with E804 bisindole] results in decreased expression of IL18 mRNA23107598
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of and results in increased secretion of IL18 protein21677146
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL18 mRNA17321000|1785046
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL18 protein22147977|2544868
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]15933225
D008070Lipopolysaccharides[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]17850464
D008070LipopolysaccharidesProgesterone inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]17850464
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL18 mRNA21882482|2869388
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IL18 protein21882482
D008154LucanthoneLucanthone results in decreased expression of IL18 mRNA21148553
C018091maduramicinmaduramicin results in increased expression of IL18 mRNA29128925
C025340manganese chlorideacetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA]28539244
C025340manganese chloridemanganese chloride results in increased expression of IL18 mRNA28539244
C013592mangiferinmangiferin inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA]22310181
D008555MelittenAIM2 protein promotes the reaction [Melitten results in increased expression of IL18 protein]22973906
D008555MelittenMelitten results in increased expression of IL18 protein22973906
D008727Methotrexate[Methotrexate co-treated with Glucocorticoids] results in decreased expression of IL18 mRNA22133036
D008727MethotrexateMethotrexate results in increased expression of IL18 mRNA17400583
D008727Methotrexate[Methotrexate analog binds to Lipids] which results in decreased expression of IL18 mRNA24065615
C013598methoxyacetic acidmethoxyacetic acid affects the expression of IL18 mRNA20421339
D008748MethylcholanthreneMethylcholanthrene results in increased expression of IL18 mRNA14993811
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]15933225
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]18660453
D015735Mifepristone[fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]]17850464
D016685MitomycinMitomycin results in decreased expression of IL1817021654
D016685MitomycinMitomycin results in decreased expression of IL18 protein16019139
C028577monobutyl phthalatemonobutyl phthalate affects the expression of IL18 mRNA20421339
D016686Monocrotaline[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA21224054
D009151Mustard GasMustard Gas results in decreased expression of IL18 mRNA18955075
D009173Mycophenolic AcidMycophenolic Acid results in decreased expression of IL18 mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of IL18 mRNA19818335
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cimetidine results in increased expression of IL18 protein]16723495
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of IL18 protein]16723495
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IL18 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IL18 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of IL18 protein"19371758
D009532NickelNickel results in decreased expression of IL18 mRNA24768652
D009532Nickel[Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA22198552
C022838nickel chloridenickel chloride affects the expression of IL18 mRNA24670797
C022838nickel chloridenickel chloride affects the expression of IL18 mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of IL18 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of IL18 mRNA18651567
C029938nickel sulfatenickel sulfate results in increased expression of IL18 protein23063874
C013150nifuroxazidenifuroxazide inhibits the reaction [Streptozocin results in increased expression of IL18 mRNA]29291386
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of IL18 mRNA17616710
C437965olmesartanolmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D009942Organometallic Compounds[Cobalt co-treated with Organometallic Compounds] results in increased expression of IL18 mRNA22147119
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of IL18 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of IL18 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of IL18 protein23063874
D010100Oxygen[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 mRNA26464617
D010100Oxygen[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 protein26464617
D010100Oxygenresveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 mRNA]26464617
D010100Oxygenresveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 protein]26464617
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of IL18 mRNA18636392
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of IL18 mRNA20705681
D000073878Palm OilPalm Oil results in decreased expression of IL18 protein19680557
C519374Panax notoginseng extractPanax notoginseng extract analog results in decreased expression of IL18 protein18637019
D010269ParaquatParaquat results in increased expression of IL18 mRNA20883675
D010269ParaquatGlyburide inhibits the reaction [Paraquat results in increased secretion of IL18 protein]25338942
D010269ParaquatParaquat results in increased secretion of IL18 protein25338942|2905469
D010269ParaquatSilymarin inhibits the reaction [Paraquat results in increased secretion of IL18 protein]29054699
D010269ParaquatGlyburide inhibits the reaction [Paraquat results in increased expression of IL18 protein]25338942
D010269ParaquatParaquat results in increased expression of IL18 protein25338942
D052638Particulate MatterParticulate Matter results in increased secretion of IL18 protein17630318
D052638Particulate MatterParticulate Matter results in decreased expression of IL18 protein11936774
D052638Particulate MatterParticulate Matter results in increased expression of IL18 mRNA27158778|2737705
C506614PD 0325901PD 0325901 inhibits the reaction [[IL15 protein co-treated with IL18 protein] results in increased secretion of IFNG protein]27563819
D010400Penicillin GPenicillin G results in increased expression of IL18 protein23063874
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]15178407
D010672Phenytoin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA21224054
C043103phthalic anhydridephthalic anhydride results in increased activity of IL18 protein15840424
D010844PicibanilPicibanil results in increased secretion of IL18 protein15289356
C060836pioglitazonepioglitazone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
C060836pioglitazonepioglitazone inhibits the reaction [AGT protein alternative form results in increased expression of IL18 mRNA]18660453
C060836pioglitazonepioglitazone inhibits the reaction [EDN1 protein results in increased expression of IL18 mRNA]18660453
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of IL18 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of IL18 mRNA17321000|1742611
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of IL18 mRNA]17321000
D028321Plant PreparationsPlant Preparations affects the expression of IL18 mRNA16046712
D028321Plant PreparationsPlant Preparations inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA]20102673
D028321Plant PreparationsPlant Preparations inhibits the reaction [Acetaminophen results in increased expression of IL18 protein]20102673
D028321Plant PreparationsPlant Preparations inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA]20102673
D028321Plant PreparationsPlant Preparations inhibits the reaction [Galactosamine results in increased expression of IL18 protein]20102673
C531249Poly(amidoamine)Poly(amidoamine) analog results in increased expression of IL18 mRNA23806026
D011239PrednisolonePrednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]16442096
D011374Progesterone[Progesterone co-treated with Testosterone] results in increased expression of IL18 mRNA22226936
D011374Progesterone[Progesterone co-treated with Testosterone] results in increased secretion of IL18 protein22226936
D011374ProgesteroneProgesterone results in increased expression of IL18 mRNA22226936
D011374ProgesteroneProgesterone results in increased secretion of IL18 protein22226936
D011374Progesterone[fulvestrant co-treated with Mifepristone] inhibits the reaction [[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]]17850464
D011374Progesterone[Progesterone co-treated with Estrogens] inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]17850464
D011374ProgesteroneProgesterone inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 mRNA]17850464
C066229prolinedithiocarbamateprolinedithiocarbamate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [IL18 protein results in increased expression of IFNG protein]28003376
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with irinotecan] results in increased expression of and results in increased secretion of IL18 protein]26431797
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [irinotecan results in increased expression of and results in increased secretion of IL18 protein]26431797
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Picryl Chloride results in increased expression of IL18 mRNA]20381601
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Picryl Chloride results in increased secretion of IL18 protein]20381601
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL18 protein]15178407
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased expression of IL18 mRNA]15178407
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of IL18 protein]22426011
D011794QuercetinQuercetin inhibits the reaction [Streptozocin results in increased expression of IL18 protein]23647015
D011899RanitidineRanitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]16723495
D011899RanitidineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]11752121
D011899RanitidineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]11752121
D011899RanitidineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]11752121
D011899RanitidineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]11752121
D011899RanitidineRanitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]11752121
D017382Reactive Oxygen Speciesdiphenyleneiodonium inhibits the reaction [IL18 protein results in increased abundance of Reactive Oxygen Species]19561311
D017382Reactive Oxygen SpeciesIL18 protein results in increased abundance of Reactive Oxygen Species19561311
D017382Reactive Oxygen Speciesresveratrol inhibits the reaction [IL18 protein results in increased abundance of Reactive Oxygen Species]19561311
C052785rebamipiderebamipide results in increased expression of IL18 mRNA18299717
D012110ReserpineReserpine results in increased expression of IL18 mRNA8999896
C031389resorcinolresorcinol results in increased expression of IL18 protein23063874
C059514resveratrolresveratrol inhibits the reaction [BSG protein results in increased expression of and results in increased secretion of IL18 protein]19561311
C059514resveratrolresveratrol inhibits the reaction [BSG protein results in increased expression of IL18 mRNA]19561311
C059514resveratrolresveratrol inhibits the reaction [IL18 protein results in increased abundance of Reactive Oxygen Species]19561311
C059514resveratrolresveratrol inhibits the reaction [IL18 protein results in increased expression of BSG mRNA]19561311
C059514resveratrolresveratrol inhibits the reaction [IL18 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]19561311
C059514resveratrolresveratrol inhibits the reaction [IL18 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]19561311
C059514resveratrolresveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of IL18 mRNA]24149798
C059514resveratrolresveratrol promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]24149798
C059514resveratrolresveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of IL18 mRNA]27070252
C059514resveratrolresveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 mRNA]26464617
C059514resveratrolresveratrol inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 protein]26464617
D012293Rifampin[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA21224054
D020889RolipramRolipram inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]16442096
C089730rosiglitazonerosiglitazone results in decreased expression of IL18 protein16644639
C089730rosiglitazonerosiglitazone results in decreased expression of IL18 mRNA18541527
D012431RutinRutin inhibits the reaction [Fructose results in increased expression of IL18 protein]22426011
D012431RutinRutin results in decreased expression of IL18 mRNA28693884
D012503SaponinsSaponins analog results in decreased expression of IL18 protein18637019
C064294sarpogrelatesarpogrelate results in decreased expression of IL18 protein15080020
C093642SB 203580SB 203580 inhibits the reaction [IL18 protein results in increased expression of PTEN mRNA]18215737
C093642SB 203580SB 203580 inhibits the reaction [IL18 protein results in increased phosphorylation of and results in increased activity of RELA protein]18215737
C093642SB 203580SB 203580 inhibits the reaction [IL18 protein results in increased phosphorylation of ATF2 protein]18215737
C110822SDZ CPI 975SDZ CPI 975 results in decreased expression of IL18 mRNA19234235
C094089SDZ FOX 988SDZ FOX 988 results in decreased expression of IL18 mRNA19234235
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of IL18 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of IL18 mRNA23806026
D012822Silicon Dioxide"3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein]"27311643
D012822Silicon DioxideAcetylcysteine inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein]27311643
D012822Silicon Dioxidediphenyleneiodonium inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein]27311643
D012822Silicon DioxideSilicon Dioxide analog results in increased secretion of IL18 protein27311643
D012834SilverSilver results in decreased expression of IL18 mRNA27131904
D012838SilymarinSilymarin inhibits the reaction [Paraquat results in increased secretion of IL18 protein]29054699
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]18660453
D019821SimvastatinSimvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D012906SmokeSmoke affects the expression of IL18 mRNA23693141
C118258SN50 peptideSN50 peptide inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
C017947sodium arsenitesodium arsenite results in decreased expression of IL18 mRNA21911445
C016104sodium bichromatesodium bichromate results in increased expression of IL18 mRNA22561333
D018038Sodium SeleniteSodium Selenite inhibits the reaction [bisphenol A results in increased expression of IL18 mRNA]28285737
D012999SomanSoman results in increased expression of IL18 mRNA19281266
D053260SootSoot results in increased expression of IL18 mRNA21914721
D013148SpironolactoneSpironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]18660453
D013241SterigmatocystinSterigmatocystin results in increased expression of IL18 mRNA19818335
D013311StreptozocinAllopurinol inhibits the reaction [Streptozocin results in increased expression of IL18 protein]23647015
D013311Streptozocinnifuroxazide inhibits the reaction [Streptozocin results in increased expression of IL18 mRNA]29291386
D013311StreptozocinQuercetin inhibits the reaction [Streptozocin results in increased expression of IL18 protein]23647015
D013311StreptozocinStreptozocin results in increased expression of IL18 mRNA29291386
D013311StreptozocinStreptozocin results in increased expression of IL18 protein23647015
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of IL18 mRNA16214533
C005741sulfamic acidsulfamic acid results in increased expression of IL18 protein23063874
D013458Sulfur DioxideSulfur Dioxide results in increased expression of IL18 protein27565714
C013698tallowtallow results in decreased expression of IL18 protein19680557
D013739Testosterone[Progesterone co-treated with Testosterone] results in increased expression of IL18 mRNA22226936
D013739Testosterone[Progesterone co-treated with Testosterone] results in increased secretion of IL18 protein22226936
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of IL18 mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL18 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL18 mRNA16039398
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL18 mRNA12167310|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL18 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IL18 mRNA20959002|2121527
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IL18 mRNA25613284
D013792ThalidomideThalidomide results in increased expression of IL1817089043
D013806TheophyllineTheophylline inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]18951874
D013806TheophyllineTheophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]18951874
D013893ThiramThiram results in increased expression of IL18 protein23063874
C402696TMC 120ATMC 120A results in increased expression of IL18 mRNA19818335
D014028Tobacco Smoke PollutionTheophylline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]]18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution inhibits the reaction [Dexamethasone inhibits the reaction [TNF protein results in increased secretion of IL18 protein]]18951874
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of IL18 mRNA24096154
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of IL18 protein24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of IL18 protein]24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of and results in increased secretion of IL18 protein26609137
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IL18 protein27793746
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of IL18 mRNA25729387
D019772TopotecanTopotecan results in increased expression of IL18 mRNA25729387
D014212TretinoinTretinoin affects the expression of IL18 mRNA20421339
C012589trichostatin Atrichostatin A results in increased expression of IL18 mRNA24935251
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of IL18 mRNA15973123
D010853Picryl ChlorideCASP1 protein promotes the reaction [Picryl Chloride results in increased cleavage of IL18 protein]17429439
D010853Picryl ChloridePicryl Chloride results in increased cleavage of IL18 protein17429439
D010853Picryl ChlorideCyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]16442096
D010853Picryl ChloridePicryl Chloride results in increased expression of IL18 mRNA20381601
D010853Picryl ChloridePicryl Chloride results in increased expression of IL18 protein15734285|1644209
D010853Picryl ChloridePicryl Chloride results in increased secretion of IL18 protein20381601
D010853Picryl ChloridePrednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]16442096
D010853Picryl Chloridepyrazolanthrone inhibits the reaction [Picryl Chloride results in increased expression of IL18 mRNA]20381601
D010853Picryl Chloridepyrazolanthrone inhibits the reaction [Picryl Chloride results in increased secretion of IL18 protein]20381601
D010853Picryl ChlorideRolipram inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein]16442096
C080163trovafloxacin"IL18 protein results in increased susceptibility to [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5]"18930950
C080163trovafloxacin"trovafloxacin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 protein]"18930950
C080163trovafloxacintrovafloxacin promotes the reaction [TNF protein results in increased expression of IL18 protein]19638433
D014414Tungsten[Nickel co-treated with Cobalt co-treated with Tungsten] results in decreased expression of IL18 mRNA22198552
D014501UraniumUranium results in decreased secretion of IL18 protein23659960
C073339usnic acid[usnic acid co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA22777745
D014612VaccinesIL18 gene mutant form affects the susceptibility to Vaccines22967010
D014635Valproic AcidValproic Acid results in increased expression of IL18 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of IL18 mRNA20421339
D001335Vehicle EmissionsVehicle Emissions results in increased secretion of IL18 protein17630318
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of IL18 protein11936774
C025643vinclozolinvinclozolin affects the expression of IL18 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of IL18 mRNA18629315
C111237vorinostatvorinostat results in decreased expression of IL18 protein17593366
C009687wortmanninwortmannin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]15178407
C017803zinc protoporphyrinzinc protoporphyrin inhibits the reaction [Hemin results in decreased susceptibility to IL18 protein]18215737
D015040ZirconiumZirconium results in increased expression of IL18 protein16100009
C067172zopolrestat"zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL18 mRNA]"21334316

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IDA14528293  25500532  
GO:0005125cytokine activity-ISS-  
GO:0005125cytokine activity-TAS11598150  
GO:0005515protein binding-IPI19104048  25261253  
GO:0045515interleukin-18 receptor binding-IDA14528293  25500532  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IMP21147091  
GO:0001525angiogenesis-IDA11466388  
GO:0006954inflammatory response-IDA21147091  
GO:0007267cell-cell signaling-TAS9792649  
GO:0008283cell proliferation-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010744positive regulation of macrophage derived foam cell differentiation-ISS-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IDA21321938  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030101natural killer cell activation-IEA-  
GO:0030155regulation of cell adhesion-IDA11477102  
GO:0030431sleep-ISS11506998  
GO:0031663lipopolysaccharide-mediated signaling pathway-IDA21147091  
GO:0032148activation of protein kinase B activity-IDA21321938  
GO:0032635interleukin-6 production-IEA-  
GO:0032725positive regulation of granulocyte macrophage colony-stimulating factor production-IDA20027291  
GO:0032729positive regulation of interferon-gamma production-IDA10653850  14528293  19088061  20027291  
GO:0032740positive regulation of interleukin-17 production-IDA16482511  
GO:0032819positive regulation of natural killer cell proliferation-IDA19088061  
GO:0034105positive regulation of tissue remodeling-IC16482511  
GO:0035655interleukin-18-mediated signaling pathway-IDA21321938  25500532  
GO:0035655interleukin-18-mediated signaling pathway-TAS-  
GO:0035744T-helper 1 cell cytokine production-IEA-  
GO:0042033chemokine biosynthetic process-TAS11598150  
GO:0042088T-helper 1 type immune response-IDA8766574  
GO:0042092type 2 immune response-TAS11905033  
GO:0042094interleukin-2 biosynthetic process-TAS10653850  
GO:0042095interferon-gamma biosynthetic process-TAS10227975  
GO:0042104positive regulation of activated T cell proliferation-IDA8766574  
GO:0042119neutrophil activation-IEA-  
GO:0042231interleukin-13 biosynthetic process-TAS10227975  
GO:0042253granulocyte macrophage colony-stimulating factor biosynthetic process-TAS10653850  
GO:0042267natural killer cell mediated cytotoxicity-IEA-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IDA10903731  
GO:0042632cholesterol homeostasis-ISS-  
GO:0045630positive regulation of T-helper 2 cell differentiation-ISS-  
GO:0045662negative regulation of myoblast differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA24615654  
GO:0048661positive regulation of smooth muscle cell proliferation-IDA21321938  
GO:0050729positive regulation of inflammatory response-IC16482511  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA25500532  
GO:0051142positive regulation of NK T cell proliferation-IDA19088061  
GO:0051897positive regulation of protein kinase B signaling-IDA21321938  
GO:0070328triglyceride homeostasis-ISS-  
GO:0071407cellular response to organic cyclic compound-IDA21147091  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IEA-  
GO:2000556positive regulation of T-helper 1 cell cytokine production-IDA10653850  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS11598150  
GO:0005615extracellular space-IDA21323571  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04621NOD-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05143African trypanosomiasis
hsa05144Malaria
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-448706Interleukin-1 processingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6783783Interleukin-10 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-9012546Interleukin-18 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29129846The IL18 Promoter Polymorphism, rs1946518, Is Associated with the Risk of Periodontitis in Japanese Women: The Kyushu Okinawa Maternal and Child Health Study. (2017 Nov)Tanaka KTohoku J Exp Med
26079218Tumor necrosis factor (TNF) alpha and interleukin (IL) 18 genes polymorphisms are correlated with susceptibility to HPV infection in patients with and without cervical intraepithelial lesion. (2016 May)Tavares MCAnn Hum Biol
25496999Genes expressed in coronary thrombi are associated with ischemic time in patients with acute myocardial infarction. (2015 Feb)Helseth RThromb Res
19473509Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. (2009 May 27)Grisoni MLBMC Med Genet
21269700Role of inflammation-related gene polymorphisms in patients with central retinal vein occlusion. (2011 Jun)Maier ROphthalmology
16971411IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. (2006 Dec)Nadif REur Respir J
25363549Early and exudative age-related macular degeneration is associated with increased plasma levels of soluble TNF receptor II. (2015 May)Faber CActa Ophthalmol